{"id":"https://openalex.org/W2234486997","doi":"https://doi.org/10.1016/j.bbrc.2016.01.077","title":"High inorganic phosphate causes DNMT1 phosphorylation and subsequent fibrotic fibroblast activation","display_name":"High inorganic phosphate causes DNMT1 phosphorylation and subsequent fibrotic fibroblast activation","publication_year":2016,"publication_date":"2016-01-14","ids":{"openalex":"https://openalex.org/W2234486997","doi":"https://doi.org/10.1016/j.bbrc.2016.01.077","mag":"2234486997","pmid":"https://pubmed.ncbi.nlm.nih.gov/26774342"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2016.01.077","doi":"https://doi.org/10.1016/j.bbrc.2016.01.077","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2016.01.077","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5149240688","display_name":"Xiaoying Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Xiaoying Tan","raw_affiliation_strings":["Department of Nephrology and Rheumatology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany; Department of Cardiology and Pneumology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany","Department of Cardiology and Pneumology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany; Department of Cardiology and Pneumology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]},{"raw_affiliation_string":"Department of Cardiology and Pneumology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025662877","display_name":"Xingbo Xu","orcid":"https://orcid.org/0000-0002-8249-5507","observed_orcids":["https://orcid.org/0000-0002-8249-5507"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Xingbo Xu","raw_affiliation_strings":["Department of Cardiology and Pneumology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and Pneumology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042273614","display_name":"Elisabeth Maria Zeisberg","orcid":"https://orcid.org/0000-0001-5184-0497","observed_orcids":["https://orcid.org/0000-0001-5184-0497"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Elisabeth M. Zeisberg","raw_affiliation_strings":["Department of Cardiology and Pneumology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany; German Center for Cardiovascular Research (DZHK), G\u00f6ttingen, Germany","Department of Cardiology and Pneumology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany","German Center for Cardiovascular Research (DZHK), G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and Pneumology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany; German Center for Cardiovascular Research (DZHK), G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I4210127591","https://openalex.org/I74656192"]},{"raw_affiliation_string":"Department of Cardiology and Pneumology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]},{"raw_affiliation_string":"German Center for Cardiovascular Research (DZHK), G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041974767","display_name":"Michael Zeisberg","orcid":"https://orcid.org/0000-0001-5826-738X","observed_orcids":["https://orcid.org/0000-0001-5826-738X"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michael Zeisberg","raw_affiliation_strings":["Department of Nephrology and Rheumatology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany; German Center for Cardiovascular Research (DZHK), G\u00f6ttingen, Germany. Electronic address: mzeisberg@med.uni-goettingen.de","Department of Nephrology and Rheumatology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany","German Center for Cardiovascular Research (DZHK), G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany; German Center for Cardiovascular Research (DZHK), G\u00f6ttingen, Germany. Electronic address: mzeisberg@med.uni-goettingen.de","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I4210127591","https://openalex.org/I74656192"]},{"raw_affiliation_string":"Department of Nephrology and Rheumatology, G\u00f6ttingen University Medical Center, Georg August University, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]},{"raw_affiliation_string":"German Center for Cardiovascular Research (DZHK), G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210127591"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041974767","https://openalex.org/A5042273614"],"corresponding_institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I4210127591","https://openalex.org/I74656192"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":2.0094,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.85271716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"472","issue":"3","first_page":"459","last_page":"464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.10379999876022339,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inorganic-phosphate","display_name":"inorganic phosphate","score":0.9039999842643738},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9520000219345093},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8569999933242798},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.824999988079071},{"id":"https://openalex.org/keywords/fibroblast-proliferation","display_name":"fibroblast proliferation","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.698320209980011},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6189700365066528},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.507436215877533},{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.5005602836608887},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.4817938208580017},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.47570285201072693},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.4665866494178772},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4648508131504059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42313605546951294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41228705644607544},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3487023115158081},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34260398149490356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3193510174751282},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.16199979186058044},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.14303496479988098},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07723128795623779},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000076123","descriptor_name":"DNA (Cytosine-5-)-Methyltransferase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bbrc.2016.01.077","doi":"https://doi.org/10.1016/j.bbrc.2016.01.077","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2016.01.077","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:26774342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26774342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/40839","doi":null,"is_oa":false,"landing_page_url":"https://sfb1002.med.uni-goettingen.de/production/literature/publications/138","pdf_url":null,"source":{"id":"https://openalex.org/S7407055187","display_name":"GRO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2092439215","display_name":null,"funder_award_id":"SFB 1002","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4512786623","display_name":null,"funder_award_id":"ZE523/4-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5927534437","display_name":null,"funder_award_id":"SFB1002/TPC01","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321870","display_name":"Georg-August-Universit\u00e4t G\u00f6ttingen","ror":"https://ror.org/01y9bpm73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1576362854","https://openalex.org/W1894355534","https://openalex.org/W1966538528","https://openalex.org/W1967604492","https://openalex.org/W1983097616","https://openalex.org/W1994429625","https://openalex.org/W2026745607","https://openalex.org/W2029837757","https://openalex.org/W2038393248","https://openalex.org/W2040057440","https://openalex.org/W2052092179","https://openalex.org/W2053569167","https://openalex.org/W2063369009","https://openalex.org/W2078234036","https://openalex.org/W2080281663","https://openalex.org/W2080719056","https://openalex.org/W2087836641","https://openalex.org/W2098796476","https://openalex.org/W2108579114","https://openalex.org/W2109353818","https://openalex.org/W2116810261","https://openalex.org/W2124981079","https://openalex.org/W2126411597","https://openalex.org/W2134584253","https://openalex.org/W2150201934","https://openalex.org/W2155043966","https://openalex.org/W2156615378","https://openalex.org/W2169669025","https://openalex.org/W2170153758","https://openalex.org/W2170783508","https://openalex.org/W2171483748"],"related_works":["https://openalex.org/W1994429625","https://openalex.org/W4396992018","https://openalex.org/W4224309692","https://openalex.org/W2276937735","https://openalex.org/W4401209146","https://openalex.org/W3166868350","https://openalex.org/W3033751322","https://openalex.org/W4417304934","https://openalex.org/W4229042665","https://openalex.org/W4283008571"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}