{"id":"https://openalex.org/W22344070","doi":null,"title":"Finding the pathology of major depression through effects on gene interaction networks","display_name":"Finding the pathology of major depression through effects on gene interaction networks","publication_year":2011,"publication_date":"2011-03-18","ids":{"openalex":"https://openalex.org/W22344070","mag":"22344070"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:6453","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6453/1/Chris_Gaiteri_thesis_2011.pdf","pdf_url":"http://d-scholarship.pitt.edu/6453/1/Chris_Gaiteri_thesis_2011.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/6453/1/Chris_Gaiteri_thesis_2011.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072516895","display_name":"Chris Gaiteri","orcid":"https://orcid.org/0000-0001-7838-8664","observed_orcids":["https://orcid.org/0000-0001-7838-8664"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chris Gaiteri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7838-8664","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072516895"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.42480000853538513,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.42480000853538513,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.37619999051094055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gene-interaction-networks","display_name":"gene interaction networks","score":0.9639999866485596},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.796999990940094},{"id":"https://openalex.org/keywords/anterior-cingulate-cortex","display_name":"anterior cingulate cortex","score":1.0},{"id":"https://openalex.org/keywords/cross-species-gene-expression","display_name":"cross-species gene expression","score":0.6010000109672546},{"id":"https://openalex.org/keywords/neuropsychiatric-disorders","display_name":"neuropsychiatric disorders","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6469568014144897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4934610426425934},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.490744948387146},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4661947786808014},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.46455830335617065},{"id":"https://openalex.org/C2778402161","wikidata":"https://www.wikidata.org/wiki/Q2121931","display_name":"Anterior cingulate cortex","level":3,"score":0.4575771987438202},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4336080849170685},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42170625925064087},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.41123831272125244},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3739698529243469},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34098756313323975},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32406365871429443},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2708825469017029},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26714766025543213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23263958096504211},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.16074299812316895},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14416110515594482},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:6453","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6453/1/Chris_Gaiteri_thesis_2011.pdf","pdf_url":"http://d-scholarship.pitt.edu/6453/1/Chris_Gaiteri_thesis_2011.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:22344070","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/6453/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:6453","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6453/1/Chris_Gaiteri_thesis_2011.pdf","pdf_url":"http://d-scholarship.pitt.edu/6453/1/Chris_Gaiteri_thesis_2011.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1012154629","display_name":"Inhibition, Oscillations and Information Processing in Schizophrenia","funder_award_id":"P50MH084053","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7588311130","display_name":"Corticolimbic Somatostatin-Related Inhibitory Dysfunction in Major Depression","funder_award_id":"R01MH077159","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8057162315","display_name":"Cortical Circuitry and Cognition in Schizophrenia","funder_award_id":"P50MH045156","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8352182201","display_name":"Molecular characterization of a corticolimbic network in depression","funder_award_id":"K02MH084060","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W22344070.pdf","grobid_xml":"https://content.openalex.org/works/W22344070.grobid-xml"},"referenced_works_count":401,"referenced_works":["https://openalex.org/W59530324","https://openalex.org/W75008966","https://openalex.org/W130211469","https://openalex.org/W181499380","https://openalex.org/W1483572459","https://openalex.org/W1490291762","https://openalex.org/W1501572782","https://openalex.org/W1503121454","https://openalex.org/W1534046497","https://openalex.org/W1537847405","https://openalex.org/W1566958459","https://openalex.org/W1569413811","https://openalex.org/W1575385540","https://openalex.org/W1588911128","https://openalex.org/W1637197683","https://openalex.org/W1656703530","https://openalex.org/W1671833268","https://openalex.org/W1734364191","https://openalex.org/W1769690510","https://openalex.org/W1868235462","https://openalex.org/W1899723374","https://openalex.org/W1905334019","https://openalex.org/W1923830127","https://openalex.org/W1932560099","https://openalex.org/W1963604994","https://openalex.org/W1963670337","https://openalex.org/W1964147606","https://openalex.org/W1964415611","https://openalex.org/W1965055200","https://openalex.org/W1965636455","https://openalex.org/W1965930842","https://openalex.org/W1966556202","https://openalex.org/W1966581051","https://openalex.org/W1966891747","https://openalex.org/W1967769642","https://openalex.org/W1968682237","https://openalex.org/W1968837585","https://openalex.org/W1969392677","https://openalex.org/W1969495575","https://openalex.org/W1970080702","https://openalex.org/W1970577624","https://openalex.org/W1971421925","https://openalex.org/W1972293558","https://openalex.org/W1972551033","https://openalex.org/W1972777532","https://openalex.org/W1973125755","https://openalex.org/W1974028339","https://openalex.org/W1974034780","https://openalex.org/W1974044347","https://openalex.org/W1974800864","https://openalex.org/W1975634667","https://openalex.org/W1977410909","https://openalex.org/W1978703935","https://openalex.org/W1980719669","https://openalex.org/W1980870198","https://openalex.org/W1981236168","https://openalex.org/W1981637710","https://openalex.org/W1982754908","https://openalex.org/W1984120803","https://openalex.org/W1984249061","https://openalex.org/W1985321863","https://openalex.org/W1985445017","https://openalex.org/W1985966076","https://openalex.org/W1986974894","https://openalex.org/W1987472752","https://openalex.org/W1987473536","https://openalex.org/W1988105902","https://openalex.org/W1990454576","https://openalex.org/W1990894640","https://openalex.org/W1991815925","https://openalex.org/W1991960999","https://openalex.org/W1992543421","https://openalex.org/W1994345197","https://openalex.org/W1994674729","https://openalex.org/W1994730852","https://openalex.org/W1995556701","https://openalex.org/W1996039326","https://openalex.org/W1996116694","https://openalex.org/W1996598113","https://openalex.org/W1996813363","https://openalex.org/W1996826305","https://openalex.org/W1997170756","https://openalex.org/W1997715717","https://openalex.org/W1998218335","https://openalex.org/W1999653836","https://openalex.org/W1999682854","https://openalex.org/W2000495354","https://openalex.org/W2000793812","https://openalex.org/W2000799395","https://openalex.org/W2001003353","https://openalex.org/W2002250647","https://openalex.org/W2002466684","https://openalex.org/W2002698073","https://openalex.org/W2003337582","https://openalex.org/W2003931365","https://openalex.org/W2004164421","https://openalex.org/W2004331086","https://openalex.org/W2004799137","https://openalex.org/W2004975621","https://openalex.org/W2005668937","https://openalex.org/W2006218562","https://openalex.org/W2006367501","https://openalex.org/W2006683252","https://openalex.org/W2007636259","https://openalex.org/W2008620264","https://openalex.org/W2010269783","https://openalex.org/W2011794262","https://openalex.org/W2012391942","https://openalex.org/W2012964562","https://openalex.org/W2016517867","https://openalex.org/W2016619393","https://openalex.org/W2017549616","https://openalex.org/W2017796808","https://openalex.org/W2018045523","https://openalex.org/W2018302367","https://openalex.org/W2018831144","https://openalex.org/W2020977183","https://openalex.org/W2022951276","https://openalex.org/W2023308612","https://openalex.org/W2024087252","https://openalex.org/W2024309355","https://openalex.org/W2024862524","https://openalex.org/W2025129891","https://openalex.org/W2026743859","https://openalex.org/W2026858722","https://openalex.org/W2027721376","https://openalex.org/W2028101242","https://openalex.org/W2028679671","https://openalex.org/W2030868131","https://openalex.org/W2031360902","https://openalex.org/W2031496082","https://openalex.org/W2031704537","https://openalex.org/W2032510252","https://openalex.org/W2033193852","https://openalex.org/W2033249125","https://openalex.org/W2033713094","https://openalex.org/W2034562270","https://openalex.org/W2034767261","https://openalex.org/W2034784092","https://openalex.org/W2035892583","https://openalex.org/W2037241563","https://openalex.org/W2040625982","https://openalex.org/W2040956707","https://openalex.org/W2041899662","https://openalex.org/W2042045791","https://openalex.org/W2042215048","https://openalex.org/W2043893734","https://openalex.org/W2044101547","https://openalex.org/W2044191726","https://openalex.org/W2044710410","https://openalex.org/W2044890688","https://openalex.org/W2045102260","https://openalex.org/W2045571228","https://openalex.org/W2045799043","https://openalex.org/W2046075803","https://openalex.org/W2047564831","https://openalex.org/W2048205572","https://openalex.org/W2048258507","https://openalex.org/W2048595403","https://openalex.org/W2048738245","https://openalex.org/W2049644955","https://openalex.org/W2050460585","https://openalex.org/W2050771980","https://openalex.org/W2052025169","https://openalex.org/W2052445727","https://openalex.org/W2053472601","https://openalex.org/W2053914079","https://openalex.org/W2054818459","https://openalex.org/W2055747883","https://openalex.org/W2056182546","https://openalex.org/W2056254608","https://openalex.org/W2056551165","https://openalex.org/W2056574935","https://openalex.org/W2056602748","https://openalex.org/W2057369088","https://openalex.org/W2057823239","https://openalex.org/W2058065669","https://openalex.org/W2058732516","https://openalex.org/W2059793861","https://openalex.org/W2060705109","https://openalex.org/W2062571913","https://openalex.org/W2062746952","https://openalex.org/W2063698739","https://openalex.org/W2064133502","https://openalex.org/W2064611362","https://openalex.org/W2065313926","https://openalex.org/W2066162643","https://openalex.org/W2066457796","https://openalex.org/W2067049849","https://openalex.org/W2067580080","https://openalex.org/W2067723253","https://openalex.org/W2068229930","https://openalex.org/W2068315875","https://openalex.org/W2068352644","https://openalex.org/W2068461117","https://openalex.org/W2068465151","https://openalex.org/W2069733150","https://openalex.org/W2069898971","https://openalex.org/W2070058327","https://openalex.org/W2071986516","https://openalex.org/W2073216156","https://openalex.org/W2074531605","https://openalex.org/W2075757880","https://openalex.org/W2076331738","https://openalex.org/W2078035790","https://openalex.org/W2079269482","https://openalex.org/W2079574756","https://openalex.org/W2080302031","https://openalex.org/W2080503102","https://openalex.org/W2081070804","https://openalex.org/W2081351662","https://openalex.org/W2081837126","https://openalex.org/W2082649645","https://openalex.org/W2083045667","https://openalex.org/W2083268412","https://openalex.org/W2083730492","https://openalex.org/W2083739539","https://openalex.org/W2085758661","https://openalex.org/W2087526026","https://openalex.org/W2088928744","https://openalex.org/W2089770153","https://openalex.org/W2089817566","https://openalex.org/W2089933457","https://openalex.org/W2090037139","https://openalex.org/W2091546930","https://openalex.org/W2092245844","https://openalex.org/W2092247630","https://openalex.org/W2092499931","https://openalex.org/W2092669597","https://openalex.org/W2092828854","https://openalex.org/W2092902275","https://openalex.org/W2093093078","https://openalex.org/W2093431562","https://openalex.org/W2094008098","https://openalex.org/W2094347708","https://openalex.org/W2094661673","https://openalex.org/W2095330158","https://openalex.org/W2095438393","https://openalex.org/W2095629588","https://openalex.org/W2095787168","https://openalex.org/W2095898243","https://openalex.org/W2096143087","https://openalex.org/W2098412979","https://openalex.org/W2098607364","https://openalex.org/W2099601400","https://openalex.org/W2099760358","https://openalex.org/W2099803844","https://openalex.org/W2100122916","https://openalex.org/W2100235169","https://openalex.org/W2101296410","https://openalex.org/W2102043440","https://openalex.org/W2102140136","https://openalex.org/W2102471334","https://openalex.org/W2102889645","https://openalex.org/W2102999073","https://openalex.org/W2103017472","https://openalex.org/W2103113767","https://openalex.org/W2104460069","https://openalex.org/W2104576729","https://openalex.org/W2104693064","https://openalex.org/W2104783138","https://openalex.org/W2106623141","https://openalex.org/W2107363136","https://openalex.org/W2108043630","https://openalex.org/W2108480332","https://openalex.org/W2108819694","https://openalex.org/W2108994487","https://openalex.org/W2110042475","https://openalex.org/W2110511835","https://openalex.org/W2110921107","https://openalex.org/W2111726505","https://openalex.org/W2111937809","https://openalex.org/W2112090702","https://openalex.org/W2112609377","https://openalex.org/W2113605030","https://openalex.org/W2114954827","https://openalex.org/W2115398984","https://openalex.org/W2115772919","https://openalex.org/W2116153150","https://openalex.org/W2116609981","https://openalex.org/W2116629441","https://openalex.org/W2117345428","https://openalex.org/W2118323338","https://openalex.org/W2118636185","https://openalex.org/W2118957830","https://openalex.org/W2119261704","https://openalex.org/W2119412782","https://openalex.org/W2120027330","https://openalex.org/W2120051475","https://openalex.org/W2121195642","https://openalex.org/W2121651624","https://openalex.org/W2121995533","https://openalex.org/W2122459678","https://openalex.org/W2123231299","https://openalex.org/W2123828448","https://openalex.org/W2126669894","https://openalex.org/W2126795224","https://openalex.org/W2127087678","https://openalex.org/W2127119742","https://openalex.org/W2127376676","https://openalex.org/W2127888717","https://openalex.org/W2128186498","https://openalex.org/W2128314959","https://openalex.org/W2129378637","https://openalex.org/W2129579709","https://openalex.org/W2130034650","https://openalex.org/W2130685024","https://openalex.org/W2130790725","https://openalex.org/W2131533686","https://openalex.org/W2131706188","https://openalex.org/W2131820654","https://openalex.org/W2131930552","https://openalex.org/W2132731742","https://openalex.org/W2133471348","https://openalex.org/W2133747068","https://openalex.org/W2133863540","https://openalex.org/W2134441514","https://openalex.org/W2135000328","https://openalex.org/W2135573014","https://openalex.org/W2136403062","https://openalex.org/W2136869363","https://openalex.org/W2137296158","https://openalex.org/W2137683543","https://openalex.org/W2139329624","https://openalex.org/W2139807849","https://openalex.org/W2139939149","https://openalex.org/W2140948740","https://openalex.org/W2140973156","https://openalex.org/W2141408320","https://openalex.org/W2141701184","https://openalex.org/W2142106331","https://openalex.org/W2142635246","https://openalex.org/W2143515089","https://openalex.org/W2144101679","https://openalex.org/W2144538553","https://openalex.org/W2145025818","https://openalex.org/W2145338045","https://openalex.org/W2145584780","https://openalex.org/W2145840919","https://openalex.org/W2146659162","https://openalex.org/W2146699327","https://openalex.org/W2146828510","https://openalex.org/W2147351252","https://openalex.org/W2148239264","https://openalex.org/W2148337554","https://openalex.org/W2149318206","https://openalex.org/W2149594317","https://openalex.org/W2149997622","https://openalex.org/W2150002111","https://openalex.org/W2150414518","https://openalex.org/W2150813685","https://openalex.org/W2150926065","https://openalex.org/W2151027504","https://openalex.org/W2151029688","https://openalex.org/W2151431569","https://openalex.org/W2151720121","https://openalex.org/W2151820055","https://openalex.org/W2152285853","https://openalex.org/W2152674565","https://openalex.org/W2152790483","https://openalex.org/W2153403353","https://openalex.org/W2153566421","https://openalex.org/W2153981891","https://openalex.org/W2154013799","https://openalex.org/W2154265420","https://openalex.org/W2154297838","https://openalex.org/W2155686640","https://openalex.org/W2156423826","https://openalex.org/W2156615630","https://openalex.org/W2156743186","https://openalex.org/W2156933633","https://openalex.org/W2157217643","https://openalex.org/W2158327608","https://openalex.org/W2158910699","https://openalex.org/W2160513989","https://openalex.org/W2160756148","https://openalex.org/W2161316685","https://openalex.org/W2161503382","https://openalex.org/W2162196924","https://openalex.org/W2162933869","https://openalex.org/W2163452266","https://openalex.org/W2163480486","https://openalex.org/W2164071776","https://openalex.org/W2164242630","https://openalex.org/W2165532730","https://openalex.org/W2168911501","https://openalex.org/W2168926247","https://openalex.org/W2169890964","https://openalex.org/W2169940916","https://openalex.org/W2170760271","https://openalex.org/W2170826437","https://openalex.org/W2171230529","https://openalex.org/W2171927996","https://openalex.org/W2172113254","https://openalex.org/W2262507053","https://openalex.org/W2415540009","https://openalex.org/W2440429974","https://openalex.org/W2497184447","https://openalex.org/W3103071483","https://openalex.org/W3148487900","https://openalex.org/W4320300929"],"related_works":["https://openalex.org/W6982650070","https://openalex.org/W2154265420","https://openalex.org/W3005520578","https://openalex.org/W2996948187","https://openalex.org/W2104576729","https://openalex.org/W4403449788","https://openalex.org/W3130269760","https://openalex.org/W2956319076","https://openalex.org/W1978420707","https://openalex.org/W3128208866"],"abstract_inverted_index":{"The":[0],"disease":[1],"signature":[2,144],"of":[3,68,81,89,108,131,137,145,151,178,185,193,207,221,245],"major":[4,120],"depressive":[5],"disorder":[6],"is":[7],"distributed":[8],"across":[9],"multiple":[10],"physical":[11],"scales":[12],"and":[13,19,57,71,153,159,172,187,198,235,274],"investigative":[14],"specialties,":[15],"including":[16,119],"genes,":[17,69,233],"cells":[18],"brain":[20,72,236],"regions.":[21],"No":[22],"single":[23,223],"mechanism":[24],"or":[25],"pathway":[26],"currently":[27],"implicated":[28],"in":[29,41,105,116,218,238,263,272],"depression":[30,53,146,225,273],"can":[31,92],"reproduce":[32],"its":[33],"diverse":[34],"clinical":[35],"presentation,":[36],"which":[37,264],"compounds":[38],"the":[39,66,87,100,109,129,135,176,191,196,219,242,267],"difficulty":[40],"finding":[42],"consistently":[43],"disrupted":[44],"molecular":[45,143],"functions.":[46],"We":[47],"confront":[48],"these":[49,162,252],"key":[50],"roadblocks":[51],"to":[52,77,128,169,265],"research":[54],"-":[55,60],"multi-scale":[56],"multi-factor":[58],"pathology":[59,98],"by":[61,229],"conducting":[62],"parallel":[63],"investigations":[64],"at":[65],"levels":[67],"neurons":[70],"regions,":[73,237],"using":[74],"transcriptome":[75],"networks":[76,258],"identify":[78],"collective":[79],"patterns":[80],"dysfunction.":[82],"Our":[83],"findings":[84],"highlight":[85],"how":[86],"collusion":[88],"multi-system":[90],"deficits":[91],"form":[93,164],"a":[94,106,142,165,183,204,222,260],"broad-based,":[95],"yet":[96],"variable":[97],"behind":[99],"depressed":[101],"phenotype.":[102],"For":[103],"instance,":[104],"variant":[107],"classic":[110],"lethality-centrality":[111],"relationship,":[112],"we":[113,140,181,240],"show":[114,160],"that":[115,161,217,255],"neuropsychiatric":[117,276],"disorders":[118],"depression,":[121],"differentially":[122],"expressed":[123],"genes":[124,163,186],"are":[125,259],"pushed":[126],"out":[127],"periphery":[130],"gene":[132,256],"networks.":[133],"At":[134,175],"level":[136,177],"cellular":[138],"function,":[139],"develop":[141],"based":[147,202],"on":[148,203],"cross-species":[149],"analysis":[150],"human":[152],"mouse":[154],"microarrays":[155],"from":[156],"depression-affected":[157],"areas,":[158],"tight":[166],"module":[167],"related":[168],"oligodendrocyte":[170],"function":[171],"neuronal":[173],"growth/structure.":[174],"brain-region":[179],"communication,":[180],"find":[182],"set":[184],"hormones":[188],"associated":[189],"with":[190],"loss":[192],"feedback":[194],"between":[195],"amygdala":[197],"anterior":[199],"cingulate":[200],"cortex,":[201],"novel":[205],"assay":[206],"interregional":[208],"expression":[209,269],"synchronization":[210],"termed":[211],"\"gene":[212],"coordination\".":[213],"These":[214],"results":[215],"indicate":[216,254],"absence":[220],"pathology,":[224],"may":[226],"be":[227],"created":[228],"dysynergistic":[230],"effects":[231],"among":[232],"cell-types":[234],"what":[239],"term":[241],"\"floodgate\"":[243],"model":[244],"depression.":[246],"Beyond":[247],"our":[248],"specific":[249],"biological":[250],"findings,":[251],"studies":[253],"interaction":[257],"coherent":[261],"framework":[262],"understand":[266],"faint":[268],"changes":[270],"found":[271],"complex":[275],"disorders.":[277]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}