{"id":"https://openalex.org/W2234053937","doi":"https://doi.org/10.1038/nrn.2015.19","title":"Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis","display_name":"Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis","publication_year":2016,"publication_date":"2016-01-14","ids":{"openalex":"https://openalex.org/W2234053937","doi":"https://doi.org/10.1038/nrn.2015.19","mag":"2234053937","pmid":"https://pubmed.ncbi.nlm.nih.gov/26763624"},"language":"en","primary_location":{"id":"doi:10.1038/nrn.2015.19","doi":"https://doi.org/10.1038/nrn.2015.19","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn.2015.19","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iris.unil.ch/bitstreams/3bc0246e-7a6d-4c62-87e2-d26ecf81c567/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006025723","display_name":"Giles E. Hardingham","orcid":"https://orcid.org/0000-0002-7629-5314","observed_orcids":["https://orcid.org/0000-0002-7629-5314"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Giles E. Hardingham","raw_affiliation_strings":["School of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh, EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh, EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084586573","display_name":"Kim Q.","orcid":"https://orcid.org/0000-0003-1968-1646","observed_orcids":["https://orcid.org/0000-0003-1968-1646"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Kim Q. Do","raw_affiliation_strings":["Department of Psychiatry, Center of Psychiatric Neuroscience, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH-1008, Prilly-Lausanne, Switzerland","Department of Psychiatry, Center of Psychiatric Neuroscience, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Prilly-Lausanne, CH-1008, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Center of Psychiatric Neuroscience, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH-1008, Prilly-Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]},{"raw_affiliation_string":"Department of Psychiatry, Center of Psychiatric Neuroscience, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Prilly-Lausanne, CH-1008, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006025723","https://openalex.org/A5084586573"],"corresponding_institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354","https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":4.6656,"has_fulltext":true,"cited_by_count":310,"citation_normalized_percentile":{"value":0.9804759,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"17","issue":"2","first_page":"125","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.843999981880188},{"id":"https://openalex.org/keywords/nmda-receptor-hypofunction","display_name":"NMDA receptor hypofunction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/parvalbumin-positive-interneurons","display_name":"parvalbumin interneurons","score":0.9269999861717224},{"id":"https://openalex.org/keywords/gabaergic-interneurons","display_name":"GABAergic interneurons","score":0.9110000133514404},{"id":"https://openalex.org/keywords/excitation-inhibition-balance","display_name":"excitation-inhibition balance","score":0.9909999966621399},{"id":"https://openalex.org/keywords/early-life-development","display_name":"early life development","score":0.7850000262260437},{"id":"https://openalex.org/keywords/schizophrenia-pathogenesis","display_name":"schizophrenia pathogenesis","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7181309461593628},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6805419921875},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6241624355316162},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6164734363555908},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.6057953834533691},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5599246025085449},{"id":"https://openalex.org/C141547260","wikidata":"https://www.wikidata.org/wiki/Q2720322","display_name":"Parvalbumin","level":2,"score":0.5355474948883057},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.44938012957572937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38173869252204895},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3551962971687317},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23707208037376404},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18220999836921692},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13197097182273865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10238492488861084},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/nrn.2015.19","doi":"https://doi.org/10.1038/nrn.2015.19","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn.2015.19","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},{"id":"pmid:26763624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26763624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Neuroscience","raw_type":"Research Support, Non-U.S. Gov't"},{"id":"pmh:oai:iris.unil.ch:iris/113448","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/113448","pdf_url":"https://iris.unil.ch/bitstreams/3bc0246e-7a6d-4c62-87e2-d26ecf81c567/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"review article"},{"id":"pmh:oai:serval.unil.ch:BIB_0ECCF75A1F1F","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_0ECCF75A1F1F","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Reviews. Neuroscience, vol. 17, no. 2, pp. 125-134","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":{"id":"pmh:oai:iris.unil.ch:iris/113448","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/113448","pdf_url":"https://iris.unil.ch/bitstreams/3bc0246e-7a6d-4c62-87e2-d26ecf81c567/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"review article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1025988012","display_name":"The synaptic bases of mental diseases","funder_award_id":"125759","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G2708478984","display_name":null,"funder_award_id":"320,030_122,419","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G7241304988","display_name":"Developmental animal model of schizophrenia: Redox dysregulation as susceptibility factor","funder_award_id":"116689","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2234053937.pdf","grobid_xml":"https://content.openalex.org/works/W2234053937.grobid-xml"},"referenced_works_count":119,"referenced_works":["https://openalex.org/W60299113","https://openalex.org/W297523562","https://openalex.org/W1161381116","https://openalex.org/W1494362497","https://openalex.org/W1553535483","https://openalex.org/W1559706924","https://openalex.org/W1718572743","https://openalex.org/W1823204572","https://openalex.org/W1825929091","https://openalex.org/W1872072116","https://openalex.org/W1963479676","https://openalex.org/W1964520338","https://openalex.org/W1964764373","https://openalex.org/W1965970535","https://openalex.org/W1966556202","https://openalex.org/W1970564284","https://openalex.org/W1972579416","https://openalex.org/W1973349067","https://openalex.org/W1977390472","https://openalex.org/W1977941840","https://openalex.org/W1979121076","https://openalex.org/W1980461903","https://openalex.org/W1983202833","https://openalex.org/W1988670106","https://openalex.org/W1988682809","https://openalex.org/W1990653561","https://openalex.org/W1991796066","https://openalex.org/W1996473902","https://openalex.org/W1996517171","https://openalex.org/W1997007516","https://openalex.org/W1999810088","https://openalex.org/W2002231678","https://openalex.org/W2002896974","https://openalex.org/W2003598937","https://openalex.org/W2003906510","https://openalex.org/W2004830149","https://openalex.org/W2005896958","https://openalex.org/W2006569015","https://openalex.org/W2008139571","https://openalex.org/W2008768196","https://openalex.org/W2009307312","https://openalex.org/W2010607311","https://openalex.org/W2011199467","https://openalex.org/W2017270601","https://openalex.org/W2017661386","https://openalex.org/W2017966444","https://openalex.org/W2020509501","https://openalex.org/W2021374816","https://openalex.org/W2021375247","https://openalex.org/W2023235195","https://openalex.org/W2024380057","https://openalex.org/W2025801062","https://openalex.org/W2028884770","https://openalex.org/W2030826687","https://openalex.org/W2032089725","https://openalex.org/W2032564883","https://openalex.org/W2034965090","https://openalex.org/W2035477056","https://openalex.org/W2036650593","https://openalex.org/W2039635263","https://openalex.org/W2041068600","https://openalex.org/W2042914870","https://openalex.org/W2043523067","https://openalex.org/W2043952421","https://openalex.org/W2046173010","https://openalex.org/W2051369940","https://openalex.org/W2053938654","https://openalex.org/W2056901364","https://openalex.org/W2058428720","https://openalex.org/W2058792844","https://openalex.org/W2059143392","https://openalex.org/W2060038783","https://openalex.org/W2062167746","https://openalex.org/W2063765492","https://openalex.org/W2065709540","https://openalex.org/W2066489132","https://openalex.org/W2067929856","https://openalex.org/W2070856797","https://openalex.org/W2072878021","https://openalex.org/W2074096568","https://openalex.org/W2074642179","https://openalex.org/W2078450450","https://openalex.org/W2078552320","https://openalex.org/W2079772279","https://openalex.org/W2081413793","https://openalex.org/W2082642969","https://openalex.org/W2095060637","https://openalex.org/W2101357408","https://openalex.org/W2102092558","https://openalex.org/W2102796622","https://openalex.org/W2103127225","https://openalex.org/W2103535314","https://openalex.org/W2103592460","https://openalex.org/W2106785071","https://openalex.org/W2108909652","https://openalex.org/W2110833962","https://openalex.org/W2111623179","https://openalex.org/W2112492148","https://openalex.org/W2113024198","https://openalex.org/W2114197624","https://openalex.org/W2132870100","https://openalex.org/W2132951361","https://openalex.org/W2134544862","https://openalex.org/W2136925527","https://openalex.org/W2137927355","https://openalex.org/W2138368199","https://openalex.org/W2141711926","https://openalex.org/W2143099403","https://openalex.org/W2146199022","https://openalex.org/W2158137297","https://openalex.org/W2159351939","https://openalex.org/W2164674870","https://openalex.org/W2167170024","https://openalex.org/W2168888447","https://openalex.org/W2169265073","https://openalex.org/W2170029299","https://openalex.org/W2334107882","https://openalex.org/W4211063728","https://openalex.org/W4250629113"],"related_works":["https://openalex.org/W2980754671","https://openalex.org/W2024425201","https://openalex.org/W2469603856","https://openalex.org/W2108696245","https://openalex.org/W2981742297","https://openalex.org/W2132951361","https://openalex.org/W2809185781","https://openalex.org/W2027697116","https://openalex.org/W2043952421","https://openalex.org/W2124433160"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":49},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":32},{"year":2018,"cited_by_count":35},{"year":2017,"cited_by_count":37},{"year":2016,"cited_by_count":16}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
