{"id":"https://openalex.org/W2234032154","doi":null,"title":"La metformina inhibe el crecimiento de c\u00e9lulas de carcinoma de tiroides, suprime la autorrenovaci\u00f3n de las c\u00e9lulas madre del c\u00e1ncer y potencia el efecto de los agentes quimioterap\u00e9uticos","display_name":"La metformina inhibe el crecimiento de c\u00e9lulas de carcinoma de tiroides, suprime la autorrenovaci\u00f3n de las c\u00e9lulas madre del c\u00e1ncer y potencia el efecto de los agentes quimioterap\u00e9uticos","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2234032154","mag":"2234032154"},"language":"es","primary_location":{"id":"mag:2234032154","doi":null,"is_oa":false,"landing_page_url":"https://new.medigraphic.com/cgi-bin/resumen.cgi?IDARTICULO=44400","pdf_url":null,"source":{"id":"https://openalex.org/S4306526701","display_name":"Revista de Endocrinolog\u00eda y Nutrici\u00f3n","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista de Endocrinolog\u00eda y Nutrici\u00f3n","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110755170","display_name":"Dulce Cynthia Fraire Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dulce Cynthia Fraire Gonz\u00e1lez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110755170"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14522445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"3","first_page":"131","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.6909999847412109},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/doxorubicin-resistance","display_name":"doxorubicin resistance","score":0.9459999799728394},{"id":"https://openalex.org/keywords/chemotherapy-potentiation","display_name":"chemotherapy potentiation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.8320000171661377},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7900000214576721},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.5959486961364746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5443053841590881},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5238330960273743},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4812995493412018},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.467856228351593},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3005220293998718},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.24737077951431274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2131696343421936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12394899129867554}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2234032154","doi":null,"is_oa":false,"landing_page_url":"https://new.medigraphic.com/cgi-bin/resumen.cgi?IDARTICULO=44400","pdf_url":null,"source":{"id":"https://openalex.org/S4306526701","display_name":"Revista de Endocrinolog\u00eda y Nutrici\u00f3n","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista de Endocrinolog\u00eda y Nutrici\u00f3n","raw_type":null},{"id":"mag:2597483490","doi":null,"is_oa":false,"landing_page_url":"https://www.medigraphic.com/pdfs/endoc/er-2012/er123g.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306526701","display_name":"Revista de Endocrinolog\u00eda y Nutrici\u00f3n","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista de Endocrinolog\u00eda y Nutrici\u00f3n","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2002267624","https://openalex.org/W2058725063","https://openalex.org/W2156370651","https://openalex.org/W2163691729"],"related_works":["https://openalex.org/W2124231104","https://openalex.org/W4239662839","https://openalex.org/W7018638188","https://openalex.org/W1513319051","https://openalex.org/W4224023290","https://openalex.org/W2611906948","https://openalex.org/W3028598944","https://openalex.org/W2909950950","https://openalex.org/W3025222881","https://openalex.org/W2073183536"],"abstract_inverted_index":{"Antecedentes":[0],"y":[1,5,30,46,87,115],"objetivo:":[2],"La":[3,32],"hiperinsulinemia":[4,45],"la":[6,9,41,44,60,95,110],"resistencia":[7],"a":[8],"insulina":[10],"son":[11],"factores":[12],"de":[13,19,25,43,59,65,70,72,75,78,81,83,94,101],"riesgo":[14],"para":[15],"una":[16,47],"alta":[17],"prevalencia":[18],"cancer":[20,68,135],"en":[21,97],"pacientes":[22],"con":[23,67,99],"diagnostico":[24],"diabetes":[26],"mellitus":[27],"tipo":[28],"2":[29],"obesidad.":[31],"metformina":[33,61,96],"ejerce":[34],"un":[35],"efecto":[36,92],"inhibidor":[37],"del":[38,53,105,107,112],"crecimiento":[39,64,108],"mediante":[40],"reduccion":[42],"accion":[48],"celular":[49,114],"directa.":[50],"El":[51],"objetivo":[52],"estudio":[54,90],"fue":[55],"investigar":[56],"los":[57],"efectos":[58],"sobre":[62],"el":[63,91],"celulas":[66,74,80,98],"diferenciado":[69],"tiroides":[71,84,102],"humanos,":[73],"carcinoma":[76,82,100,129],"anaplasico":[77],"tiroides,":[79],"doxorrubicina-resistentes.":[85],"Diseno":[86],"metodos:":[88],"Se":[89],"antimitogenico":[93],"por":[103],"medio":[104],"analisis":[106],"celular,":[109],"progresion":[111],"ciclo":[113],"apopChen":[116],"G,":[117],"Xu":[118],"S,":[119],"Renko":[120],"K,":[121],"Derwahl":[122],"M.":[123],"Metformin":[124],"inhibits":[125],"growth":[126],"of":[127,133,143],"thyroid":[128],"cells,":[130,137],"suppresses":[131],"self-renewal":[132],"derived":[134],"stem":[136],"and":[138],"potentiates":[139],"the":[140],"eff":[141],"ect":[142],"chemotherapeutic":[144],"agents.":[145],"J":[146],"Clin":[147],"Endocrinol":[148],"Metab.":[149],"2012;":[150],"97:":[151],"E510-E520.":[152]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}