{"id":"https://openalex.org/W2233947737","doi":"https://doi.org/10.1152/jappl.1987.62.1.175","title":"cAMP suppresses CA2+-dependent electrical activity of airway smooth muscle induced by TEA","display_name":"cAMP suppresses CA2+-dependent electrical activity of airway smooth muscle induced by TEA","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2233947737","doi":"https://doi.org/10.1152/jappl.1987.62.1.175","mag":"2233947737","pmid":"https://pubmed.ncbi.nlm.nih.gov/3031001"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1987.62.1.175","doi":"https://doi.org/10.1152/jappl.1987.62.1.175","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1987.62.1.175","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108210000","display_name":"Ira S. Richards","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. S. Richards","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025910665","display_name":"Julia M. Ousterhout","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Ousterhout","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110173626","display_name":"Nicholas Sperelakis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Sperelakis","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111750017","display_name":"Christopher G. Murlas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. G. Murlas","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6264,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.84306116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":"1","first_page":"175","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.04340000078082085,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7699999809265137},{"id":"https://openalex.org/keywords/tetraethylammonium","display_name":"tetraethylammonium","score":0.824999988079071},{"id":"https://openalex.org/keywords/airway-smooth-muscle","display_name":"airway smooth muscle","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tracheal-smooth-muscle","display_name":"tracheal smooth muscle","score":0.8809999823570251},{"id":"https://openalex.org/keywords/calcium-dependence","display_name":"calcium dependence","score":0.4620000123977661},{"id":"https://openalex.org/keywords/spontaneous-action-potentials","display_name":"spontaneous action potentials","score":0.7620000243186951},{"id":"https://openalex.org/keywords/membrane-depolarization","display_name":"membrane depolarization","score":0.8550000190734863},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.8240000009536743},{"id":"https://openalex.org/keywords/inward-current","display_name":"inward current","score":0.722000002861023},{"id":"https://openalex.org/keywords/electrogenesis","display_name":"electrogenesis","score":0.7009999752044678},{"id":"https://openalex.org/keywords/calcium-channel-blockade","display_name":"calcium channel blockade","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.800291895866394},{"id":"https://openalex.org/C2781295685","wikidata":"https://www.wikidata.org/wiki/Q410728","display_name":"Tetraethylammonium","level":3,"score":0.737409234046936},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.6966421604156494},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5992852449417114},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5902266502380371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5883143544197083},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5479578375816345},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.511658251285553},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5024645328521729},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4970543682575226},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.484923392534256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27963560819625854},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.21882304549217224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1831406056880951},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1758027970790863},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.15735697746276855},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013757","descriptor_name":"Tetraethylammonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019789","descriptor_name":"Tetraethylammonium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1987.62.1.175","doi":"https://doi.org/10.1152/jappl.1987.62.1.175","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1987.62.1.175","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:3031001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3031001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1936390486","display_name":null,"funder_award_id":"HL-01535","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2259226119","display_name":null,"funder_award_id":"HL 34228-04","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2037221413","https://openalex.org/W184897408","https://openalex.org/W2410030361","https://openalex.org/W1926988878","https://openalex.org/W2055305077","https://openalex.org/W1969819722","https://openalex.org/W1997560222","https://openalex.org/W2000009369","https://openalex.org/W1990544120","https://openalex.org/W2024688253"],"abstract_inverted_index":{"Using":[0],"intracellular":[1],"microelectrodes,":[2],"we":[3],"investigated":[4],"whether":[5],"exogenous":[6],"dibutyryl":[7],"adenosine":[8,143],"3',5'-cyclic":[9,144],"monophosphate":[10,145],"(DBcAMP)":[11],"or":[12],"forskolin":[13],"influenced":[14],"the":[15,84,92,107,124,129,134,148],"electrical":[16,89],"effects":[17],"of":[18,43,86,109,150],"tetraethylammonium":[19],"(TEA)":[20],"on":[21,104],"canine":[22],"tracheal":[23],"smooth":[24,34,139],"muscle.":[25],"We":[26],"found":[27],"that":[28,121,142],"20":[29],"mM":[30],"TEA":[31,110],"depolarized":[32],"airway":[33,138],"muscle":[35],"cells":[36],"from":[37],"a":[38],"resting":[39],"membrane":[40],"potential":[41],"(Em)":[42],"-59":[44],"+/-":[45,49,53,67],"4":[46],"mV":[47,55,69],"(mean":[48],"SD)":[50],"to":[51,62,97],"-45":[52],"2":[54,68],"and":[56,91,141],"caused":[57],"spontaneous":[58],"action":[59],"potentials":[60],"(AP's)":[61],"develop,":[63],"which":[64],"were":[65,73],"33":[66],"in":[70,76,106,137],"amplitude.":[71],"These":[72],"totally":[74],"abolished":[75],"0":[77],"Ca2+":[78,122],"solution.":[79],"DBcAMP":[80,99],"(1":[81,113],"mM)":[82],"suppressed":[83],"development":[85],"this":[87,151],"TEA-induced":[88,135],"activity":[90],"phasic":[93],"contractions":[94],"electrically":[95],"coupled":[96],"it.":[98],"had":[100],"no":[101],"significant":[102],"effect":[103],"Em":[105],"absence":[108],"however.":[111],"Forskolin":[112],"microM)":[114],"produced":[115],"similar":[116],"effects.":[117],"Our":[118],"findings":[119],"suggest":[120],"is":[123],"principal":[125],"ion":[126],"responsible":[127],"for":[128],"inward":[130],"current":[131],"associated":[132],"with":[133],"AP's":[136],"muscle,":[140],"may":[146],"suppress":[147],"electrogenesis":[149],"current.":[152]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}