{"id":"https://openalex.org/W2233909801","doi":"https://doi.org/10.1074/jbc.m115.712380","title":"Matrix-driven Myosin II Mediates the Pro-fibrotic Fibroblast Phenotype","display_name":"Matrix-driven Myosin II Mediates the Pro-fibrotic Fibroblast Phenotype","publication_year":2016,"publication_date":"2016-01-14","ids":{"openalex":"https://openalex.org/W2233909801","doi":"https://doi.org/10.1074/jbc.m115.712380","mag":"2233909801","pmid":"https://pubmed.ncbi.nlm.nih.gov/26763235","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4813589"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m115.712380","doi":"https://doi.org/10.1074/jbc.m115.712380","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.712380","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m115.712380","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082271623","display_name":"Brian D. Southern","orcid":"https://orcid.org/0000-0003-2983-5741","observed_orcids":["https://orcid.org/0000-0003-2983-5741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian D. Southern","raw_affiliation_strings":["From the Department of Pathobiology and Respiratory Institute","From the Department of Pathobiology and","Respiratory Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathobiology and Respiratory Institute","institution_ids":[]},{"raw_affiliation_string":"From the Department of Pathobiology and","institution_ids":[]},{"raw_affiliation_string":"Respiratory Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021625586","display_name":"Lisa M. Grove","orcid":"https://orcid.org/0000-0001-9023-4211","observed_orcids":["https://orcid.org/0000-0001-9023-4211"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa M. Grove","raw_affiliation_strings":["From the Department of Pathobiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathobiology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087912513","display_name":"Shaik O. Rahaman","orcid":"https://orcid.org/0000-0002-6481-392X","observed_orcids":["https://orcid.org/0000-0002-6481-392X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaik O. Rahaman","raw_affiliation_strings":["From the Department of Pathobiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathobiology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113633194","display_name":"Susamma Abraham","orcid":"https://orcid.org/0009-0009-9776-9820","observed_orcids":["https://orcid.org/0009-0009-9776-9820"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susamma Abraham","raw_affiliation_strings":["From the Department of Pathobiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathobiology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008573046","display_name":"Rachel Greenberg Scheraga","orcid":"https://orcid.org/0000-0001-5113-543X","observed_orcids":["https://orcid.org/0000-0001-5113-543X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel G. Scheraga","raw_affiliation_strings":["From the Department of Pathobiology and Respiratory Institute","From the Department of Pathobiology and","Respiratory Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathobiology and Respiratory Institute","institution_ids":[]},{"raw_affiliation_string":"From the Department of Pathobiology and","institution_ids":[]},{"raw_affiliation_string":"Respiratory Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070490062","display_name":"Kathryn A. Niese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathryn A. Niese","raw_affiliation_strings":["From the Department of Pathobiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathobiology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039774753","display_name":"Huanxing Sun","orcid":"https://orcid.org/0000-0003-2397-4652","observed_orcids":["https://orcid.org/0000-0003-2397-4652"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huanxing Sun","raw_affiliation_strings":["Yale ILD Center of Excellence, Yale School of Medicine, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale ILD Center of Excellence, Yale School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025135030","display_name":"Erica L. Herzog","orcid":"https://orcid.org/0000-0002-7508-8575","observed_orcids":["https://orcid.org/0000-0002-7508-8575"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica L. Herzog","raw_affiliation_strings":["Yale ILD Center of Excellence, Yale School of Medicine, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale ILD Center of Excellence, Yale School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115590326","display_name":"Fei Liu","orcid":"https://orcid.org/0009-0000-5188-8546","observed_orcids":["https://orcid.org/0009-0000-5188-8546"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Liu","raw_affiliation_strings":["Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040325695","display_name":"Daniel J. Tschumperlin","orcid":"https://orcid.org/0000-0002-5115-9025","observed_orcids":["https://orcid.org/0000-0002-5115-9025"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Tschumperlin","raw_affiliation_strings":["Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022407492","display_name":"Thomas T. Egelhoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas T. Egelhoff","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020641571","display_name":"Steven S. Rosenfeld","orcid":"https://orcid.org/0000-0003-1909-7116","observed_orcids":["https://orcid.org/0000-0003-1909-7116"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven S. Rosenfeld","raw_affiliation_strings":["Department of Cancer Biology, Cleveland Clinic, Lerner Research Institute, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Cleveland Clinic, Lerner Research Institute, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055224390","display_name":"Mitchell A. Olman","orcid":"https://orcid.org/0000-0003-3262-3598","observed_orcids":["https://orcid.org/0000-0003-3262-3598"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mitchell A. Olman","raw_affiliation_strings":["From the Department of Pathobiology and Respiratory Institute, olmanm@ccf.org","From the Department of Pathobiology and","Respiratory Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathobiology and Respiratory Institute, olmanm@ccf.org","institution_ids":[]},{"raw_affiliation_string":"From the Department of Pathobiology and","institution_ids":[]},{"raw_affiliation_string":"Respiratory Institute,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5055224390"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.3408,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.93605109,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"291","issue":"12","first_page":"6083","last_page":"6095"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.38749998807907104,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myosin-ii","display_name":"myosin II","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fibroblast-phenotype","display_name":"fibroblast phenotype","score":0.7490000128746033},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/myofibroblast-differentiation","display_name":"myofibroblast differentiation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/extracellular-matrix-stiffness","display_name":"extracellular matrix stiffness","score":0.9010000228881836},{"id":"https://openalex.org/keywords/fibroblast-motility","display_name":"fibroblast motility","score":0.8320000171661377},{"id":"https://openalex.org/keywords/myosin-phosphorylation","display_name":"myosin phosphorylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fibroproliferative-disease","display_name":"fibroproliferative disorders","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7456647157669067},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.7281944155693054},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.6272929906845093},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.536176323890686},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5049675107002258},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5023403167724609},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.46243584156036377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4219011664390564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3339039981365204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20389044284820557},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12961795926094055},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10529819130897522},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024462","descriptor_name":"Myosin Type II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m115.712380","doi":"https://doi.org/10.1074/jbc.m115.712380","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.712380","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4205312","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4813589","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4813589","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4813589","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:26763235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26763235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m115.712380","doi":"https://doi.org/10.1074/jbc.m115.712380","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.712380","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2139787978","display_name":"Deranged Coagulation and Fibrinolytic Cascades in Idiopathic Pulmonary Fibrosis","funder_award_id":"R01HL103553","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G519201446","display_name":null,"funder_award_id":"HL085324","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5370800071","display_name":null,"funder_award_id":"HL-119792","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5431048353","display_name":"Myofibroblast differentiation and fibrosis are mediated by TRPV4 mechanosensing","funder_award_id":"R01HL119792","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5489004377","display_name":null,"funder_award_id":"R01-HL-125850","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6110008029","display_name":"Neuronally Active Proteins in IPF","funder_award_id":"R01HL109233","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6357856227","display_name":null,"funder_award_id":"HL-103553","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6968683907","display_name":"The Role of FAK-related-non-kinase (FRNK) in lung fibrosis","funder_award_id":"R01HL085324","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7661915613","display_name":"Neuroimmune Molecules in Scleroderma Lung Fibrosis","funder_award_id":"5r01hl125850-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8685217373","display_name":"Epithelial-Mesenchymal-Transition: roles and regulation of myosin II","funder_award_id":"R01GM050009","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W154856494","https://openalex.org/W1482266658","https://openalex.org/W1507095008","https://openalex.org/W1674332639","https://openalex.org/W1851460509","https://openalex.org/W1918459205","https://openalex.org/W1965926056","https://openalex.org/W1966597513","https://openalex.org/W1966642918","https://openalex.org/W1978164308","https://openalex.org/W1981269419","https://openalex.org/W1992234143","https://openalex.org/W1998849298","https://openalex.org/W2004107033","https://openalex.org/W2009234826","https://openalex.org/W2014182371","https://openalex.org/W2017900646","https://openalex.org/W2026632078","https://openalex.org/W2028457976","https://openalex.org/W2030029307","https://openalex.org/W2030582971","https://openalex.org/W2031074041","https://openalex.org/W2047266588","https://openalex.org/W2052397837","https://openalex.org/W2056563854","https://openalex.org/W2058738554","https://openalex.org/W2062461864","https://openalex.org/W2064412622","https://openalex.org/W2068843251","https://openalex.org/W2071410302","https://openalex.org/W2074684833","https://openalex.org/W2079501680","https://openalex.org/W2082837373","https://openalex.org/W2083463216","https://openalex.org/W2083638734","https://openalex.org/W2090050609","https://openalex.org/W2093008817","https://openalex.org/W2093726551","https://openalex.org/W2098307303","https://openalex.org/W2110971542","https://openalex.org/W2111737077","https://openalex.org/W2112093320","https://openalex.org/W2114589293","https://openalex.org/W2116043657","https://openalex.org/W2126777451","https://openalex.org/W2127779575","https://openalex.org/W2129965189","https://openalex.org/W2131032222","https://openalex.org/W2131445772","https://openalex.org/W2137949291","https://openalex.org/W2141768942","https://openalex.org/W2145392559","https://openalex.org/W2150102283","https://openalex.org/W2156865492","https://openalex.org/W2159731793","https://openalex.org/W2161518005","https://openalex.org/W2162714010","https://openalex.org/W2170332523","https://openalex.org/W2172237567","https://openalex.org/W2328146763","https://openalex.org/W3021764385"],"related_works":["https://openalex.org/W2172237567","https://openalex.org/W1969049128","https://openalex.org/W4410218324","https://openalex.org/W2120736394","https://openalex.org/W2616087011","https://openalex.org/W4389513523","https://openalex.org/W4406693407","https://openalex.org/W2031938767","https://openalex.org/W2058528981","https://openalex.org/W2268418225"],"abstract_inverted_index":{"Pro-fibrotic":[0],"mesenchymal":[1],"cells":[2,10],"are":[3,87,162],"known":[4],"to":[5,30,54,241],"be":[6,31],"the":[7,15,20,26,37,78,102,166,173,183,202,214,236,245],"key":[8,34,231],"effector":[9,233],"of":[11,36,96,104,128,146,169,175,182,185,193,207,218,235,244],"fibroproliferative":[12],"disease,":[13],"but":[14],"specific":[16],"matrix":[17,167,198,211],"signals":[18],"and":[19,57,72,80,110,142,177],"induced":[21],"cellular":[22],"responses":[23],"that":[24,48,66,192,197],"drive":[25],"fibrogenic":[27,39],"phenotype":[28,40,204,215],"remain":[29],"elucidated.":[32],"The":[33,94],"mediators":[35],"fibroblast":[38,50,70,79,203],"were":[41],"characterized":[42],"using":[43],"a":[44,111,230],"novel":[45,224],"assay":[46],"system":[47],"measures":[49],"behavior":[51],"in":[52,107,113,116,138,154,172,239],"response":[53,240],"actual":[55],"normal":[56,67,124,141,176],"fibrotic":[58,75,119,143,157,178],"lung":[59,68,76,179,189],"tissue.":[60,180],"Using":[61],"this":[62],"system,":[63],"we":[64],"demonstrate":[65],"promotes":[69,81],"motility":[71],"polarization,":[73],"while":[74,210],"immobilizes":[77],"myofibroblast":[82,152],"differentiation.":[83],"These":[84],"context-specific":[85],"phenotypes":[86],"surprisingly":[88],"both":[89],"mediated":[90],"by":[91,101,164],"myosin":[92,97,108,129,147,186,227],"II.":[93],"role":[95],"II":[98,130,148,228],"is":[99],"supported":[100],"observation":[103],"an":[105],"increase":[106],"phosphorylation":[109],"change":[112],"intracellular":[114],"distribution":[115],"fibroblasts":[117,139,155],"on":[118,135,140,156,188],"lung,":[120,209],"as":[121,229],"compared":[122],"with":[123,191],"lung.":[125,144,158,220],"Moreover,":[126],"loss":[127],"activity":[131,137],"has":[132],"opposing":[133],"effects":[134,184],"protrusive":[136],"Loss":[145],"also":[149],"selectively":[150],"inhibits":[151],"differentiation":[153],"Importantly,":[159],"these":[160],"findings":[161],"recapitulated":[163],"varying":[165],"stiffness":[168,212],"polyacrylamide":[170,194],"gels":[171,195],"range":[174],"Comparison":[181],"inhibition":[187],"tissue":[190],"suggests":[196],"fiber":[199],"organization":[200],"drives":[201,213],"under":[205,216],"conditions":[206,217],"normal/soft":[208],"fibrotic/stiff":[219],"This":[221],"work":[222],"defines":[223],"roles":[225],"for":[226],"regulatory":[232],"molecule":[234],"pro-fibrotic":[237],"phenotype,":[238],"biophysical":[242],"properties":[243],"matrix.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}