{"id":"https://openalex.org/W2233686346","doi":"https://doi.org/10.1080/2162402x.2015.1061176","title":"Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis","display_name":"Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis","publication_year":2015,"publication_date":"2015-06-24","ids":{"openalex":"https://openalex.org/W2233686346","doi":"https://doi.org/10.1080/2162402x.2015.1061176","mag":"2233686346","pmid":"https://pubmed.ncbi.nlm.nih.gov/26942074","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4760294"},"language":"en","primary_location":{"id":"doi:10.1080/2162402x.2015.1061176","doi":"https://doi.org/10.1080/2162402x.2015.1061176","is_oa":true,"landing_page_url":"https://doi.org/10.1080/2162402x.2015.1061176","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2015.1061176?needAccess=true&role=button","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2015.1061176?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029266414","display_name":"H\u00e9l\u00e8ne Bonsang\u2010Kitzis","orcid":"https://orcid.org/0000-0002-5594-2965","observed_orcids":["https://orcid.org/0000-0002-5594-2965"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210109573","display_name":"Immunit\u00e9 et Cancer","ror":"https://ror.org/01zefvs55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H Bonsang-Kitzis","raw_affiliation_strings":["Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France; Department of Surgery; Institut Curie; Paris, France","Department of Surgery","INSERM","Institut Curie","Paris, France","RT2Lab","Residual Tumor & Response to Treatment Laboratory","Translational Research Department","U932 Immunity and Cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France; Department of Surgery; Institut Curie; Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"]},{"raw_affiliation_string":"Department of Surgery","institution_ids":[]},{"raw_affiliation_string":"INSERM","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Curie","institution_ids":["https://openalex.org/I80043"]},{"raw_affiliation_string":"Paris, France","institution_ids":[]},{"raw_affiliation_string":"RT2Lab","institution_ids":[]},{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory","institution_ids":[]},{"raw_affiliation_string":"Translational Research Department","institution_ids":[]},{"raw_affiliation_string":"U932 Immunity and Cancer","institution_ids":["https://openalex.org/I4210109573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037165643","display_name":"Benjamin Sadacca","orcid":"https://orcid.org/0000-0001-5843-618X","observed_orcids":["https://orcid.org/0000-0001-5843-618X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097372","display_name":"\u00c9cole Nationale Sup\u00e9rieure d\u2019Informatique pour l\u2019Industrie et l\u2019Entreprise","ror":"https://ror.org/00tx98v53","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210097372"]},{"id":"https://openalex.org/I4210109573","display_name":"Immunit\u00e9 et Cancer","ror":"https://ror.org/01zefvs55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"]},{"id":"https://openalex.org/I4387153769","display_name":"Laboratoire de Math\u00e9matiques et Mod\u00e9lisation d'\u00c9vry","ror":"https://ror.org/03jca6281","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210097372","https://openalex.org/I4387153769","https://openalex.org/I88467170"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]},{"id":"https://openalex.org/I88467170","display_name":"Universit\u00e9 d'\u00c9vry Val-d'Essonne","ror":"https://ror.org/00e96v939","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954","https://openalex.org/I88467170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B Sadacca","raw_affiliation_strings":["Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France; Laboratoire de Math\u00e9matiques et Mod\u00e9lisation d'Evry, Universit\u00e9 d'\u00c9vry Val d'Essonne; UMR CNRS 8071, ENSIIE, USC INRA, France","INSERM","Institut Curie","Laboratoire de Math\u00e9matiques et Mod\u00e9lisation d'Evry, Universit\u00e9 d'\u00c9vry Val d'Essonne","Paris, France","RT2Lab","Residual Tumor & Response to Treatment Laboratory","Translational Research Department","U932 Immunity and Cancer","UMR CNRS 8071, ENSIIE, USC INRA, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France; Laboratoire de Math\u00e9matiques et Mod\u00e9lisation d'Evry, Universit\u00e9 d'\u00c9vry Val d'Essonne; UMR CNRS 8071, ENSIIE, USC INRA, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210097372","https://openalex.org/I4210109573","https://openalex.org/I4387153769","https://openalex.org/I4387154544","https://openalex.org/I80043","https://openalex.org/I88467170"]},{"raw_affiliation_string":"INSERM","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Curie","institution_ids":["https://openalex.org/I80043"]},{"raw_affiliation_string":"Laboratoire de Math\u00e9matiques et Mod\u00e9lisation d'Evry, Universit\u00e9 d'\u00c9vry Val d'Essonne","institution_ids":["https://openalex.org/I4387153769","https://openalex.org/I88467170"]},{"raw_affiliation_string":"Paris, France","institution_ids":[]},{"raw_affiliation_string":"RT2Lab","institution_ids":[]},{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory","institution_ids":[]},{"raw_affiliation_string":"Translational Research Department","institution_ids":[]},{"raw_affiliation_string":"U932 Immunity and Cancer","institution_ids":["https://openalex.org/I4210109573"]},{"raw_affiliation_string":"UMR CNRS 8071, ENSIIE, USC INRA, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210097372","https://openalex.org/I4387153769","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002180432","display_name":"Anne\u2010Sophie Hamy","orcid":"https://orcid.org/0000-0003-4430-3022","observed_orcids":["https://orcid.org/0000-0003-4430-3022"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210109573","display_name":"Immunit\u00e9 et Cancer","ror":"https://ror.org/01zefvs55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"AS Hamy-Petit","raw_affiliation_strings":["Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France","INSERM","Institut Curie","Paris, France","RT2Lab","Residual Tumor & Response to Treatment Laboratory","Translational Research Department","U932 Immunity and Cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"]},{"raw_affiliation_string":"INSERM","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Curie","institution_ids":["https://openalex.org/I80043"]},{"raw_affiliation_string":"Paris, France","institution_ids":[]},{"raw_affiliation_string":"RT2Lab","institution_ids":[]},{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory","institution_ids":[]},{"raw_affiliation_string":"Translational Research Department","institution_ids":[]},{"raw_affiliation_string":"U932 Immunity and Cancer","institution_ids":["https://openalex.org/I4210109573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050542670","display_name":"Matahi Moarii","orcid":"https://orcid.org/0000-0001-6011-9212","observed_orcids":["https://orcid.org/0000-0001-6011-9212"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4405253156","display_name":"Centre de Bio-Informatique","ror":"https://ror.org/00c00ys31","country_code":"FR","type":"facility","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4405253156","https://openalex.org/I70768539"]},{"id":"https://openalex.org/I70768539","display_name":"\u00c9cole Nationale Sup\u00e9rieure des Mines de Paris","ror":"https://ror.org/04y8cs423","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Moarii","raw_affiliation_strings":["Mines Paristech; PSL-Research University; CBIO-Centre for Computational Biology; Mines ParisTech; Fontainebleau, France; U900, INSERM; Institut Curie; Paris, France","CBIO-Centre for Computational Biology","Fontainebleau, France","Institut Curie","Mines Paristech","PSL-Research University","Paris, France","U900, INSERM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mines Paristech; PSL-Research University; CBIO-Centre for Computational Biology; Mines ParisTech; Fontainebleau, France; U900, INSERM; Institut Curie; Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580","https://openalex.org/I4405253156","https://openalex.org/I70768539","https://openalex.org/I80043"]},{"raw_affiliation_string":"CBIO-Centre for Computational Biology","institution_ids":["https://openalex.org/I4405253156"]},{"raw_affiliation_string":"Fontainebleau, France","institution_ids":[]},{"raw_affiliation_string":"Institut Curie","institution_ids":["https://openalex.org/I80043"]},{"raw_affiliation_string":"Mines Paristech","institution_ids":["https://openalex.org/I70768539"]},{"raw_affiliation_string":"PSL-Research University","institution_ids":["https://openalex.org/I2746051580"]},{"raw_affiliation_string":"Paris, France","institution_ids":[]},{"raw_affiliation_string":"U900, INSERM","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103144779","display_name":"Alice Pinheiro","orcid":"https://orcid.org/0000-0002-7297-6892","observed_orcids":["https://orcid.org/0000-0002-7297-6892","https://orcid.org/0000-0003-0430-7387"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210109573","display_name":"Immunit\u00e9 et Cancer","ror":"https://ror.org/01zefvs55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Pinheiro","raw_affiliation_strings":["Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France","INSERM","Institut Curie","Paris, France","RT2Lab","Residual Tumor & Response to Treatment Laboratory","Translational Research Department","U932 Immunity and Cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"]},{"raw_affiliation_string":"INSERM","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Curie","institution_ids":["https://openalex.org/I80043"]},{"raw_affiliation_string":"Paris, France","institution_ids":[]},{"raw_affiliation_string":"RT2Lab","institution_ids":[]},{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory","institution_ids":[]},{"raw_affiliation_string":"Translational Research Department","institution_ids":[]},{"raw_affiliation_string":"U932 Immunity and Cancer","institution_ids":["https://openalex.org/I4210109573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032987120","display_name":"C\u00e9cile Laurent","orcid":"https://orcid.org/0000-0002-3022-2283","observed_orcids":["https://orcid.org/0000-0002-3022-2283"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210109573","display_name":"Immunit\u00e9 et Cancer","ror":"https://ror.org/01zefvs55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Laurent","raw_affiliation_strings":["Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France","INSERM","Institut Curie","Paris, France","RT2Lab","Residual Tumor & Response to Treatment Laboratory","Translational Research Department","U932 Immunity and Cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"]},{"raw_affiliation_string":"INSERM","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Curie","institution_ids":["https://openalex.org/I80043"]},{"raw_affiliation_string":"Paris, France","institution_ids":[]},{"raw_affiliation_string":"RT2Lab","institution_ids":[]},{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory","institution_ids":[]},{"raw_affiliation_string":"Translational Research Department","institution_ids":[]},{"raw_affiliation_string":"U932 Immunity and Cancer","institution_ids":["https://openalex.org/I4210109573"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003301011","display_name":"Fabien Reyal","orcid":"https://orcid.org/0000-0002-2318-3589","observed_orcids":["https://orcid.org/0000-0002-2318-3589"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210109573","display_name":"Immunit\u00e9 et Cancer","ror":"https://ror.org/01zefvs55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"F Reyal","raw_affiliation_strings":["Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France; Department of Surgery; Institut Curie; Paris, France","Department of Surgery","INSERM","Institut Curie","Paris, France","RT2Lab","Residual Tumor & Response to Treatment Laboratory","Translational Research Department","U932 Immunity and Cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory; RT2Lab; Translational Research Department; Institut Curie; Paris, France; U932 Immunity and Cancer; INSERM; Institut Curie; Paris, France; Department of Surgery; Institut Curie; Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"]},{"raw_affiliation_string":"Department of Surgery","institution_ids":[]},{"raw_affiliation_string":"INSERM","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Curie","institution_ids":["https://openalex.org/I80043"]},{"raw_affiliation_string":"Paris, France","institution_ids":[]},{"raw_affiliation_string":"RT2Lab","institution_ids":[]},{"raw_affiliation_string":"Residual Tumor & Response to Treatment Laboratory","institution_ids":[]},{"raw_affiliation_string":"Translational Research Department","institution_ids":[]},{"raw_affiliation_string":"U932 Immunity and Cancer","institution_ids":["https://openalex.org/I4210109573"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5003301011"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210109573","https://openalex.org/I80043"],"apc_list":{"value":2375,"currency":"GBP","value_usd":2913},"apc_paid":{"value":2375,"currency":"GBP","value_usd":2913},"fwci":1.2824,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.76082104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"e1061176","last_page":"e1061176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prognostic-gene-signature","display_name":"prognostic gene signature","score":0.8199999928474426},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.7689999938011169},{"id":"https://openalex.org/keywords/gene-co-expression-network","display_name":"gene co-expression network","score":0.6499999761581421},{"id":"https://openalex.org/keywords/gene-clusters","display_name":"gene clusters","score":0.47600001096725464},{"id":"https://openalex.org/keywords/tnbc-subtypes","display_name":"TNBC subtypes","score":0.7310000061988831},{"id":"https://openalex.org/keywords/disease-specific-survival","display_name":"disease-specific survival","score":0.9649999737739563},{"id":"https://openalex.org/keywords/breast-cancer-classification","display_name":"breast cancer classification","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.762692928314209},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.617965042591095},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5925125479698181},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5000009536743164},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4778827726840973},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46435192227363586},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.449769526720047},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3859422504901886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3786715567111969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3619028329849243},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3347092270851135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19638589024543762}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1080/2162402x.2015.1061176","doi":"https://doi.org/10.1080/2162402x.2015.1061176","is_oa":true,"landing_page_url":"https://doi.org/10.1080/2162402x.2015.1061176","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2015.1061176?needAccess=true&role=button","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3881968","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4760294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26942074","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26942074","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoimmunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4760294","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4760294/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoimmunology","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-02632136v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-02632136","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OncoImmunology, 2016, 5 (1), ⟨10.1080/2162402X.2015.1061176⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1080/2162402x.2015.1061176","doi":"https://doi.org/10.1080/2162402x.2015.1061176","is_oa":true,"landing_page_url":"https://doi.org/10.1080/2162402x.2015.1061176","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2015.1061176?needAccess=true&role=button","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2658974192","display_name":"Paris Sciences et Lettres","funder_award_id":"ANR-10-IDEX-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3898041522","display_name":null,"funder_award_id":"INCa\u2010DGOS\u20104654","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G4190806336","display_name":null,"funder_award_id":"ANR-10-IDEX0001-02.","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G471331628","display_name":null,"funder_award_id":"ANR-10-IDEX","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5554728744","display_name":"Biologie des cellules dendritiques","funder_award_id":"ANR-11-LABX-0043","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6759105742","display_name":null,"funder_award_id":"ANR10IDEX000102 PSL","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G782245399","display_name":null,"funder_award_id":"IDEX-0001-02","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8697348301","display_name":null,"funder_award_id":"ANR-11-LABX-0043","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G937427620","display_name":null,"funder_award_id":"ANR-10-IDEX-0001-02 PSL*","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"},{"id":"https://openalex.org/F4320325668","display_name":"Direction G\u00e9n\u00e9rale de l\u2019offre de Soins","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2233686346.pdf","grobid_xml":"https://content.openalex.org/works/W2233686346.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1546709038","https://openalex.org/W1550884756","https://openalex.org/W1967197894","https://openalex.org/W1974496157","https://openalex.org/W1978818883","https://openalex.org/W1989663680","https://openalex.org/W1989938935","https://openalex.org/W1992885568","https://openalex.org/W1994829495","https://openalex.org/W1998847259","https://openalex.org/W2004377796","https://openalex.org/W2005895632","https://openalex.org/W2007997332","https://openalex.org/W2008714016","https://openalex.org/W2009098155","https://openalex.org/W2015177938","https://openalex.org/W2024010804","https://openalex.org/W2033751993","https://openalex.org/W2043152591","https://openalex.org/W2043398720","https://openalex.org/W2049491375","https://openalex.org/W2056556973","https://openalex.org/W2058132464","https://openalex.org/W2062725167","https://openalex.org/W2075894019","https://openalex.org/W2085181480","https://openalex.org/W2086837512","https://openalex.org/W2088160256","https://openalex.org/W2096027508","https://openalex.org/W2101017424","https://openalex.org/W2109220814","https://openalex.org/W2111225997","https://openalex.org/W2112526783","https://openalex.org/W2113613985","https://openalex.org/W2114264989","https://openalex.org/W2114505219","https://openalex.org/W2116830437","https://openalex.org/W2118605519","https://openalex.org/W2120261416","https://openalex.org/W2124640147","https://openalex.org/W2125789330","https://openalex.org/W2125885282","https://openalex.org/W2127925738","https://openalex.org/W2130598050","https://openalex.org/W2131994307","https://openalex.org/W2132619562","https://openalex.org/W2134539328","https://openalex.org/W2139795964","https://openalex.org/W2143459396","https://openalex.org/W2145259857","https://openalex.org/W2145552137","https://openalex.org/W2146750548","https://openalex.org/W2147415463","https://openalex.org/W2149668671","https://openalex.org/W2154453972","https://openalex.org/W2157058802","https://openalex.org/W2158348986","https://openalex.org/W2158545805","https://openalex.org/W2159175636","https://openalex.org/W2160928966","https://openalex.org/W2161634102","https://openalex.org/W2162765338","https://openalex.org/W2163035374","https://openalex.org/W2163808882","https://openalex.org/W2169360530","https://openalex.org/W2169555947","https://openalex.org/W2171632978","https://openalex.org/W2340301267"],"related_works":["https://openalex.org/W2054524338","https://openalex.org/W2322940201","https://openalex.org/W2139795964","https://openalex.org/W2159175636","https://openalex.org/W2247198853","https://openalex.org/W4253221738","https://openalex.org/W4322774292","https://openalex.org/W4398155706","https://openalex.org/W7097417932","https://openalex.org/W3024673181"],"abstract_inverted_index":{"Triple-negative":[0],"breast":[1,10,43],"cancer":[2,44],"(TNBC)":[3],"is":[4,17],"a":[5,52,110,143,209],"heterogeneous":[6],"group":[7],"of":[8,30,57,69,76,83,96,105,117,131,183,249],"aggressive":[9],"cancers":[11],"for":[12,21,180,246],"which":[13,149],"no":[14],"targeted":[15],"treatment":[16],"available.":[18],"Robust":[19],"tools":[20],"TNBC":[22,58,72,184,230],"classification":[23],"are":[24],"required,":[25],"to":[26,33,120],"improve":[27],"the":[28,70,77,94,115,150,181,247],"prediction":[29],"prognosis":[31,211],"and":[32,65,86,100,171,199],"develop":[34],"novel":[35],"therapeutic":[36,251],"interventions.":[37,252],"We":[38,112],"analyzed":[39],"3,247":[40],"primary":[41],"human":[42],"samples":[45,59],"from":[46,138],"21":[47,139],"publicly":[48],"available":[49],"datasets,":[50],"using":[51],"five-step":[53],"method:":[54],"(1)":[55],"selection":[56,75,89],"by":[60],"bimodal":[61],"filtering":[62],"on":[63,93,123],"ER-HER2":[64],"PR,":[66],"(2)":[67],"normalization":[68],"selected":[71],"samples,":[73],"(3)":[74],"most":[78],"variant":[79],"genes,":[80],"(4)":[81],"identification":[82,182],"gene":[84,88,91,107,132,156,159],"clusters":[85,92,160,173],"biological":[87],"within":[90],"basis":[95],"String\u00a9":[97],"database":[98],"connections":[99],"gene-expression":[101],"correlations,":[102],"(5)":[103],"summarization":[104],"each":[106],"cluster":[108],"in":[109,135,148,154],"metagene.":[111],"then":[113],"assessed":[114],"ability":[116],"these":[118],"metagenes":[119,151],"predict":[121],"prognosis,":[122],"an":[124],"external":[125],"public":[126,140],"dataset":[127],"(METABRIC).":[128],"Our":[129],"analysis":[130],"expression":[133,205],"(GE)":[134],"557":[136],"TNBCs":[137],"datasets":[141,188],"identified":[142],"six-metagene":[144,222],"signature":[145,176,223],"(167":[146,224],"genes)":[147,225],"were":[152,161],"enriched":[153],"different":[155],"ontologies.":[157],"The":[158,221,232],"named":[162],"as":[163],"follows:":[164],"Immunity1,":[165],"Immunity2,":[166],"Proliferation/DNA":[167],"damage,":[168],"AR-like,":[169],"Matrix/Invasion1":[170],"Matrix2":[172],"respectively.":[174],"This":[175],"was":[177,206,226],"particularly":[178],"robust":[179],"subtypes":[185],"across":[186],"many":[187],"(n":[189],"=":[190,215,219],"1,125":[191,229],"samples),":[192],"despite":[193],"technology":[194],"differences":[195],"(Affymetrix\u00a9":[196],"A,":[197],"Plus2":[198],"Illumina\u00a9).":[200],"Weak":[201],"Immunity":[202,233],"two":[203,234],"metagene":[204,235],"associated":[207],"with":[208],"poor":[210],"(disease-specific":[212],"survival;":[213],"HR":[214],"2.68":[216],"[1.59\u20134.52],":[217],"p":[218],"0.0002).":[220],"validated":[227],"over":[228],"samples.":[231],"had":[236],"strong":[237],"prognostic":[238],"value.":[239],"These":[240],"findings":[241],"open":[242],"up":[243],"interesting":[244],"possibilities":[245],"development":[248],"new":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}