{"id":"https://openalex.org/W2233653072","doi":"https://doi.org/10.1152/ajpcell.1986.250.3.c413","title":"Failure of extracellular digestive enzymes to alter in vitro secretion by rat pancreas","display_name":"Failure of extracellular digestive enzymes to alter in vitro secretion by rat pancreas","publication_year":1986,"publication_date":"1986-03-01","ids":{"openalex":"https://openalex.org/W2233653072","doi":"https://doi.org/10.1152/ajpcell.1986.250.3.c413","mag":"2233653072","pmid":"https://pubmed.ncbi.nlm.nih.gov/2420194"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.1986.250.3.c413","doi":"https://doi.org/10.1152/ajpcell.1986.250.3.c413","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1986.250.3.c413","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090882752","display_name":"A. Saluja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Saluja","raw_affiliation_strings":["","Harvard University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Harvard University ,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110099492","display_name":"M. Saluja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Saluja","raw_affiliation_strings":["","Harvard University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Harvard University ,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111200209","display_name":"Robert E. Powers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. E. Powers","raw_affiliation_strings":["","Harvard University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Harvard University ,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109133138","display_name":"Mary Jane Houlihan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. J. Houlihan","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089990723","display_name":"Michael L. Steer","orcid":"https://orcid.org/0000-0002-5365-8215","observed_orcids":["https://orcid.org/0000-0002-5365-8215"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. L. Steer","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1241,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.35870756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"250","issue":"3","first_page":"C413","last_page":"C417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.08479999750852585,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-amylase-secretion","display_name":"pancreatic amylase secretion","score":0.9010000228881836},{"id":"https://openalex.org/keywords/equilibrium-hypothesis","display_name":"equilibrium hypothesis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/pancreatic-lobules","display_name":"pancreatic lobules","score":0.8360000252723694},{"id":"https://openalex.org/keywords/pancreatic-acini","display_name":"pancreatic acini","score":0.9200000166893005},{"id":"https://openalex.org/keywords/digestive-enzyme-secretion","display_name":"digestive enzyme secretion","score":0.7839999794960022},{"id":"https://openalex.org/keywords/rat-pancreas","display_name":"rat pancreas","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C170835558","wikidata":"https://www.wikidata.org/wiki/Q17153","display_name":"Amylase","level":3,"score":0.8831861615180969},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7626214027404785},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7483397126197815},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5963248014450073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5771169662475586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.562227189540863},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5494446754455566},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.544475257396698},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5419332981109619},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5187889933586121},{"id":"https://openalex.org/C2780010897","wikidata":"https://www.wikidata.org/wiki/Q419557","display_name":"Digestive enzyme","level":4,"score":0.49454447627067566},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4761245846748352},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.47257936000823975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35057011246681213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.250537633895874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05880081653594971},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.05561760067939758}],"mesh":[{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.1986.250.3.c413","doi":"https://doi.org/10.1152/ajpcell.1986.250.3.c413","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1986.250.3.c413","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:2420194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2420194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6641771780","display_name":"ACUTE PANCREATITIS","funder_award_id":"5r01am031396-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8897400802","display_name":"STIMULUS-SECRETION COUPLING IN THE EXOCRINE PANCREAS","funder_award_id":"5r01am031914-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2074204712","https://openalex.org/W2088249891","https://openalex.org/W2150612129"],"related_works":["https://openalex.org/W2474290717","https://openalex.org/W4214877910","https://openalex.org/W2050728575","https://openalex.org/W2043572123","https://openalex.org/W1978814709","https://openalex.org/W2414112844","https://openalex.org/W2008571597","https://openalex.org/W1965811373","https://openalex.org/W2006329375","https://openalex.org/W1975784603"],"abstract_inverted_index":{"The":[0,157],"basal":[1,84,151,181,195],"rate":[2,149,179,193],"of":[3,24,29,38,58,97,109,150,180,194,209,221],"amylase":[4,25,39,59,68,81,182,196],"secretion":[5,82,138,197],"from":[6,160,198],"rat":[7,87,199],"pancreatic":[8,88],"lobules":[9,89],"was":[10],"found":[11],"to":[12,22,35,72,102,206],"diminish":[13,176],"with":[14,168,201],"time.":[15],"This":[16,56],"decline,":[17],"which":[18],"is":[19,77,203],"not":[20,165,175,204],"due":[21,205],"depletion":[23],"stores":[26],"or":[27,115],"loss":[28,208],"tissue":[30],"integrity,":[31],"has":[32],"been":[33],"attributed":[34],"the":[36,41,66,73,95,103,107,120,133,147,177,189,192,207,219,222],"build-up":[37],"in":[40,62,65,142,146,152,166,191],"extracellular":[42],"space":[43],"[Ho":[44],"and":[45,90,139],"Rothman,":[46],"Am.":[47],"J.":[48],"Physiol.":[49,52],"245":[50],"(Cell":[51],"14):":[53],"C21-C27,":[54],"1983].":[55],"accumulation":[57],"would":[60,124,130,140],"result":[61,141],"a":[63,210],"decrease":[64,190],"intracellular-extracellular":[67],"gradient,":[69],"which,":[70],"according":[71],"so-called":[74],"equilibrium":[75,121,223],"hypothesis,":[76,122],"responsible":[78],"for":[79],"net":[80,137],"under":[83],"conditions.":[85],"Using":[86],"acini,":[91],"we":[92],"have":[93,125],"tested":[94],"validity":[96,220],"this":[98],"hypothesis":[99],"by":[100],"adding":[101],"incubation":[104,110],"medium":[105],"at":[106],"onset":[108],"either":[111],"collected":[112],"secretory":[113],"products":[114],"purified":[116],"amylase.":[117],"Based":[118],"on":[119],"one":[123],"predicted":[126],"that":[127,188],"these":[128,161,172],"additions":[129,173],"also":[131],"reduce":[132],"concentration":[134,211],"gradient":[135,212],"favoring":[136,213],"an":[143],"apparent":[144],"reduction":[145],"initial":[148,178],"vitro":[153],"digestive":[154],"enzyme":[155],"secretion.":[156,183],"results":[158,216],"obtained":[159],"studies,":[162],"however,":[163],"were":[164],"accord":[167],"those":[169],"predictions,":[170],"since":[171],"did":[174],"Our":[184],"observations":[185],"therefore":[186],"indicate":[187],"pancreas":[200],"time":[202],"efflux.":[214],"These":[215],"argue":[217],"against":[218],"hypothesis.":[224]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
