{"id":"https://openalex.org/W2233494281","doi":null,"title":"Novel CD4-immunoglobulin fusion proteins as HIV-1 immunotherapeutics","display_name":"Novel CD4-immunoglobulin fusion proteins as HIV-1 immunotherapeutics","publication_year":2013,"publication_date":"2013-03-19","ids":{"openalex":"https://openalex.org/W2233494281","mag":"2233494281"},"language":"en","primary_location":{"id":"pmh:oai:wiredspace.wits.ac.za:10539/12558","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10539/12558","pdf_url":"https://wiredspace.wits.ac.za/bitstreams/1977b9f0-2fbc-4e92-8864-2dd555eb21a5/download","source":{"id":"https://openalex.org/S4306400603","display_name":"University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192619145","host_organization_name":"University of the Witwatersrand","host_organization_lineage":["https://openalex.org/I192619145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://wiredspace.wits.ac.za/bitstreams/1977b9f0-2fbc-4e92-8864-2dd555eb21a5/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108008779","display_name":"Katlego Sojane","orcid":"https://orcid.org/0000-0002-1662-8711","observed_orcids":["https://orcid.org/0000-0002-1662-8711"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katlego Sojane","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1662-8711","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108008779"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gp120-cd4-interaction","display_name":"gp120-CD4 interaction","score":0.8299999833106995},{"id":"https://openalex.org/keywords/soluble-cd4","display_name":"soluble CD4","score":0.9079999923706055},{"id":"https://openalex.org/keywords/hiv-entry-inhibition","display_name":"HIV entry inhibition","score":0.5870000123977661},{"id":"https://openalex.org/keywords/hiv-immunotherapy","display_name":"HIV immunotherapy","score":0.5009999871253967},{"id":"https://openalex.org/keywords/fc-effector-functions","display_name":"Fc effector functions","score":0.7170000076293945},{"id":"https://openalex.org/keywords/viral-load-reduction","display_name":"viral load reduction","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6147841215133667},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5292052030563354},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5145213007926941},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.4325031638145447},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40084463357925415},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38448482751846313},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3816165030002594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35079312324523926},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14178523421287537},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.06814679503440857},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0626416802406311},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:wiredspace.wits.ac.za:10539/12558","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10539/12558","pdf_url":"https://wiredspace.wits.ac.za/bitstreams/1977b9f0-2fbc-4e92-8864-2dd555eb21a5/download","source":{"id":"https://openalex.org/S4306400603","display_name":"University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192619145","host_organization_name":"University of the Witwatersrand","host_organization_lineage":["https://openalex.org/I192619145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2233494281","doi":null,"is_oa":false,"landing_page_url":"https://wiredspace.wits.ac.za/bitstream/10539/12558/1/Katli%20MSc%20dissert.-corrected%20final.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:wiredspace.wits.ac.za:10539/12558","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10539/12558","pdf_url":"https://wiredspace.wits.ac.za/bitstreams/1977b9f0-2fbc-4e92-8864-2dd555eb21a5/download","source":{"id":"https://openalex.org/S4306400603","display_name":"University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192619145","host_organization_name":"University of the Witwatersrand","host_organization_lineage":["https://openalex.org/I192619145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320673","display_name":"Poliomyelitis Research Foundation","ror":"https://ror.org/02d540t02"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2233494281.pdf","grobid_xml":"https://content.openalex.org/works/W2233494281.grobid-xml"},"referenced_works_count":224,"referenced_works":["https://openalex.org/W70475835","https://openalex.org/W71370004","https://openalex.org/W85920738","https://openalex.org/W100591816","https://openalex.org/W191242174","https://openalex.org/W201001125","https://openalex.org/W1482670006","https://openalex.org/W1491954563","https://openalex.org/W1513893286","https://openalex.org/W1533335912","https://openalex.org/W1541302075","https://openalex.org/W1542320852","https://openalex.org/W1543687584","https://openalex.org/W1576970669","https://openalex.org/W1607434342","https://openalex.org/W1617145831","https://openalex.org/W1628484047","https://openalex.org/W1715834776","https://openalex.org/W1786960389","https://openalex.org/W1828543531","https://openalex.org/W1928433960","https://openalex.org/W1958071693","https://openalex.org/W1963855922","https://openalex.org/W1967050458","https://openalex.org/W1968873679","https://openalex.org/W1969190686","https://openalex.org/W1970622835","https://openalex.org/W1971057735","https://openalex.org/W1974273518","https://openalex.org/W1975932650","https://openalex.org/W1976584377","https://openalex.org/W1977230507","https://openalex.org/W1979502204","https://openalex.org/W1981726195","https://openalex.org/W1982498479","https://openalex.org/W1983925230","https://openalex.org/W1984646317","https://openalex.org/W1985722970","https://openalex.org/W1986652140","https://openalex.org/W1986865717","https://openalex.org/W1988527797","https://openalex.org/W1990282886","https://openalex.org/W1990971245","https://openalex.org/W1991053746","https://openalex.org/W1992332315","https://openalex.org/W1992471537","https://openalex.org/W1992566288","https://openalex.org/W1992698880","https://openalex.org/W1993366615","https://openalex.org/W1993370938","https://openalex.org/W1995355944","https://openalex.org/W1995407171","https://openalex.org/W1997677784","https://openalex.org/W1997989849","https://openalex.org/W1998298921","https://openalex.org/W1998987175","https://openalex.org/W1999048558","https://openalex.org/W2000625719","https://openalex.org/W2001578549","https://openalex.org/W2004669329","https://openalex.org/W2007249947","https://openalex.org/W2009137826","https://openalex.org/W2009151161","https://openalex.org/W2010725536","https://openalex.org/W2010996470","https://openalex.org/W2012451048","https://openalex.org/W2013330052","https://openalex.org/W2015349792","https://openalex.org/W2015642465","https://openalex.org/W2015721441","https://openalex.org/W2017551575","https://openalex.org/W2018123062","https://openalex.org/W2018643676","https://openalex.org/W2019010081","https://openalex.org/W2022322687","https://openalex.org/W2023966753","https://openalex.org/W2024054409","https://openalex.org/W2024353108","https://openalex.org/W2025005245","https://openalex.org/W2026066319","https://openalex.org/W2026245568","https://openalex.org/W2028787913","https://openalex.org/W2029052791","https://openalex.org/W2029804942","https://openalex.org/W2031498672","https://openalex.org/W2032104932","https://openalex.org/W2035761707","https://openalex.org/W2036282594","https://openalex.org/W2039795021","https://openalex.org/W2040506780","https://openalex.org/W2040557088","https://openalex.org/W2040714143","https://openalex.org/W2041055896","https://openalex.org/W2042347713","https://openalex.org/W2043237700","https://openalex.org/W2043293013","https://openalex.org/W2044046899","https://openalex.org/W2049012017","https://openalex.org/W2049883310","https://openalex.org/W2052675730","https://openalex.org/W2053127269","https://openalex.org/W2056261693","https://openalex.org/W2056382918","https://openalex.org/W2056723350","https://openalex.org/W2059576950","https://openalex.org/W2059627765","https://openalex.org/W2060204419","https://openalex.org/W2060281141","https://openalex.org/W2062204035","https://openalex.org/W2063701397","https://openalex.org/W2066407814","https://openalex.org/W2067694850","https://openalex.org/W2067752117","https://openalex.org/W2068184858","https://openalex.org/W2068305325","https://openalex.org/W2068488535","https://openalex.org/W2069869101","https://openalex.org/W2072470381","https://openalex.org/W2072564682","https://openalex.org/W2073173905","https://openalex.org/W2074009425","https://openalex.org/W2074948867","https://openalex.org/W2074969682","https://openalex.org/W2075032293","https://openalex.org/W2075683739","https://openalex.org/W2075892193","https://openalex.org/W2077010256","https://openalex.org/W2080089116","https://openalex.org/W2081291921","https://openalex.org/W2081550246","https://openalex.org/W2082117225","https://openalex.org/W2082686302","https://openalex.org/W2083966567","https://openalex.org/W2084015527","https://openalex.org/W2084176286","https://openalex.org/W2084426169","https://openalex.org/W2085721436","https://openalex.org/W2087272863","https://openalex.org/W2087343656","https://openalex.org/W2087794838","https://openalex.org/W2088877697","https://openalex.org/W2090198182","https://openalex.org/W2090763940","https://openalex.org/W2091847883","https://openalex.org/W2092620639","https://openalex.org/W2092769125","https://openalex.org/W2092790596","https://openalex.org/W2093009072","https://openalex.org/W2095089993","https://openalex.org/W2095180354","https://openalex.org/W2096387523","https://openalex.org/W2096497391","https://openalex.org/W2097810423","https://openalex.org/W2098781795","https://openalex.org/W2099031713","https://openalex.org/W2099308199","https://openalex.org/W2100837269","https://openalex.org/W2102170426","https://openalex.org/W2102466252","https://openalex.org/W2102559570","https://openalex.org/W2103382078","https://openalex.org/W2106255998","https://openalex.org/W2108385781","https://openalex.org/W2108425968","https://openalex.org/W2112129496","https://openalex.org/W2112214013","https://openalex.org/W2113282092","https://openalex.org/W2115906128","https://openalex.org/W2118391212","https://openalex.org/W2118617693","https://openalex.org/W2118784070","https://openalex.org/W2119876117","https://openalex.org/W2120704770","https://openalex.org/W2122210861","https://openalex.org/W2122617162","https://openalex.org/W2123055341","https://openalex.org/W2124569623","https://openalex.org/W2126431223","https://openalex.org/W2129106897","https://openalex.org/W2131589943","https://openalex.org/W2132783668","https://openalex.org/W2132936712","https://openalex.org/W2133649749","https://openalex.org/W2133856346","https://openalex.org/W2135151522","https://openalex.org/W2137162710","https://openalex.org/W2138260290","https://openalex.org/W2140534639","https://openalex.org/W2141861391","https://openalex.org/W2143298530","https://openalex.org/W2145909184","https://openalex.org/W2147009832","https://openalex.org/W2148168112","https://openalex.org/W2150484278","https://openalex.org/W2151963339","https://openalex.org/W2152089409","https://openalex.org/W2155361244","https://openalex.org/W2157820405","https://openalex.org/W2159795515","https://openalex.org/W2162071888","https://openalex.org/W2164573600","https://openalex.org/W2164701456","https://openalex.org/W2167559307","https://openalex.org/W2170412417","https://openalex.org/W2171488159","https://openalex.org/W2177796734","https://openalex.org/W2206956227","https://openalex.org/W2221415330","https://openalex.org/W2248336029","https://openalex.org/W2303094513","https://openalex.org/W2312642584","https://openalex.org/W2312801091","https://openalex.org/W2314893245","https://openalex.org/W2329309100","https://openalex.org/W2334860476","https://openalex.org/W2396438395","https://openalex.org/W2401170345","https://openalex.org/W2411210757","https://openalex.org/W2414631166","https://openalex.org/W2415905866","https://openalex.org/W2465268856","https://openalex.org/W2916516961","https://openalex.org/W4211132279","https://openalex.org/W4249165012"],"related_works":["https://openalex.org/W2788531530","https://openalex.org/W2029976935","https://openalex.org/W2038301711","https://openalex.org/W2015349792","https://openalex.org/W2966044372","https://openalex.org/W2036282594","https://openalex.org/W2021023399","https://openalex.org/W2136595144","https://openalex.org/W2037106171","https://openalex.org/W2041216529"],"abstract_inverted_index":{"The":[0,180,318,446],"initial":[1],"step":[2],"of":[3,13,29,42,52,59,66,76,86,96,130,137,148,158,166,182,187,195,218,227,314,340,345,373,390,404,430,468,492,524,532,537],"HIV":[4,33,67,129,149,577],"entry":[5],"into":[6],"host":[7,30,119],"cells":[8,31,333],"involves":[9],"the":[10,18,40,63,135,145,155,162,193,210,224,371,384,402,427,488,506,530,538,548,583],"specific":[11],"binding":[12,116,200,490,509,534],"gp120":[14,90,115,142,199,307,377,413,467,493,498,578],"envelope":[15,132],"glycoprotein":[16],"to":[17,35,46,62,89,103,109,154,178,232,300,305,375,400,409,459,466,496,535,552,563],"cell-surface":[19,112,138],"CD4":[20,77,87,93,113,123,139,160,184,196,221,434,441],"protein,":[21,94],"expressed":[22,327,525],"by":[23,32,127,141,150,312,513],"antigen-presenting":[24],"cells.":[25],"Extensive":[26],"systemic":[27],"infection":[28,64],"leads":[34],"immune":[36,205],"dysfunction":[37],"and":[38,68,84,99,117,143,201,236,323,334,342,387,407,436,474,481,503,520,561,570],"ultimately":[39],"demise":[41],"infected":[43],"individuals":[44],"due":[45],"AIDS.":[47],"\\nThe":[48],"gp120-CD4":[49],"interaction":[50],"(KD":[51],"approximately":[53],"2":[54,85,100],"X":[55],"10-9":[56],"M)":[57],"is":[58],"primary":[60],"importance":[61],"process":[65],"poses":[69],"a":[70,279,285,290,302,455],"validated":[71],"therapeutic":[72],"target.":[73],"Mutational":[74],"analyses":[75],"show":[78],"that":[79,361,547],"residues":[80],"in":[81,161,185,269,284,328,336,559,586],"domains":[82,97],"1":[83,98,102],"contribute":[88,203],"binding.":[91],"Soluble":[92,122],"composed":[95,217],"or":[101],"4":[104],"only,":[105],"has":[106],"been":[107,169],"shown":[108],"compete":[110],"with":[111,308,574],"for":[114,198],"inhibit":[118],"cell":[120],"infection.":[121],"achieves":[124],"viral":[125,267],"inhibition":[126],"uncoating":[128],"its":[131],"proteins,":[133],"reducing":[134],"amount":[136],"recognition":[140],"preventing":[144],"cell-to-cell":[146],"spread":[147],"syncytium":[151],"formation.":[152],"Due":[153],"short":[156],"serum-lifetime":[157],"soluble":[159,183,240,243],"blood,":[163],"modified":[164],"forms":[165],"it":[167,262],"have":[168,233],"generated":[170,299,581],"which":[171,277,486,556],"contain":[172],"life-time":[173],"extending":[174],"immunoglobulin":[175,188],"portions":[176,364],"attached":[177],"them.":[179],"attachment":[181],"place":[186],"variable":[189,225],"regions":[190,226],"may":[191,202,579],"increase":[192],"valence":[194,235],"available":[197],"extra":[204],"effector":[206,237],"functions":[207,238],"depending":[208],"on":[209],"Fc":[211,363],"portion":[212],"type.":[213],"\\nPRO":[214],"542":[215,246,359,382,424],"(CD4-IgG2),":[216],"four":[219],"two-domain":[220,433,440],"molecules":[222,414,573],"replacing":[223],"antibody":[228,484],"IgG2,":[229],"was":[230,247,344,452,494,511,557],"found":[231],"greater":[234],"than":[239],"CD4.":[241],"Like":[242],"CD4,":[244],"PRO":[245,280,293,358,381,423,478,517,565],"deemed":[248],"safe":[249],"at":[250],"all":[251],"concentrations":[252,523],"tested":[253,539],"during":[254],"clinical":[255],"trials;":[256],"however":[257,348],"tests":[258,369],"were":[259,297,326,365,398,567],"halted":[260],"as":[261,443,454],"could":[263,351],"not":[264,528],"significantly":[265],"reduce":[266],"load":[268],"patients.":[270],"In":[271],"this":[272,544,587],"study,":[273],"we":[274],"designed":[275],"constructs":[276],"produced":[278,320],"542-like":[281,294],"protein":[282],"(kCD4-IgG2wt)":[283],"novel":[286,549],"way.":[287],"Constructs":[288],"encoding":[289],"mutant":[291,439],"S60C":[292,438],"molecule":[295],"(kCD4-IgG2S60C)":[296],"also":[298],"produce":[301,553],"heterotetramer":[303],"intended":[304],"bind":[306,352,376,410,497],"even":[309],"higher":[310],"affinity":[311],"virtue":[313],"intermolecular":[315],"redox-disulphide":[316],"exchange.":[317],"uniquely":[319],"heterotetrameric":[321,554],"kCD4-IgG2wt":[322,341,374,406,463],"kCD4-IgG2S60C":[324,343,408,533],"proteins":[325,350],"Human":[329],"Embryonic":[330],"Kidney":[331],"293T":[332],"collected":[335],"culture":[337,447],"supernatant.":[338],"Purification":[339],"limited":[346],"success;":[347],"both":[349],"Protein-A":[353],"agarose":[354],"beads":[355],"like":[356,380,476],"NIH":[357,477,516,564],"implying":[360],"their":[362],"fully":[366],"folded.":[367],"Immunoprecipitation":[368],"showed":[370,546],"ability":[372,403],"from":[378,415,426,449,499,543],"HIV-1Bal":[379,475],"confirming":[383],"high":[385],"structural":[386],"functional":[388,571],"integrity":[389],"kCD4-IgG2wt.":[391],"Finally,":[392],"surface":[393],"plasmon":[394],"resonance":[395],"studies":[396,420],"(SPR)":[397],"conducted":[399],"evaluate":[401],"supernatant-contained":[405,514],"six":[411],"different":[412],"genetically":[416],"diverse":[417],"viruses.":[418],"SPR":[419,460],"included":[421],"purified":[422],"obtained":[425,542],"National":[428],"Institutes":[429],"Health":[431],"(NIH),":[432],"(2dCD4wt)":[435],"an":[437],"(2dCD4S60C)":[442],"positive":[444],"controls.":[445],"supernatant":[448],"mock":[450],"transfections":[451],"used":[453],"negative":[456],"control.":[457],"According":[458],"data,":[461],"supernatant-containing":[462],"binds":[464,487],"specifically":[465],"HIV-1CN54,":[469],"HIV-1SF162,":[470,500],"HIV-1IN25925,":[471,501],"HIV-1ZA706010164,":[472],"HIV-196ZM651":[473],"542,":[479,518,566],"2dsCD4wt":[480,519],"2dsCD4S60C.":[482,521],"Monoclonal":[483],"17b,":[485],"co-receptor":[489,508],"site":[491,510],"observed":[495],"HIV-1ZA706010164":[502],"HIV-1Bal,":[504],"after":[505],"gp120s":[507],"exposed":[512],"kCD4-IgG2wt,":[515,555],"Low":[522],"kCD4-IgGS60C":[526],"did":[527],"permit":[529],"observation":[531],"any":[536],"gp120s.":[540],"\\nResults":[541],"study":[545],"strategies":[550,584],"employed":[551],"identical":[558],"structure":[560],"function":[562],"successful.":[568],"Novel":[569],"CD4-based":[572],"activity":[575],"against":[576],"be":[580],"using":[582],"described":[585],"study.":[588]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}