{"id":"https://openalex.org/W2233250281","doi":"https://doi.org/10.1387/ijdb.150220zz","title":"What cell death does in development","display_name":"What cell death does in development","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2233250281","doi":"https://doi.org/10.1387/ijdb.150220zz","mag":"2233250281","pmid":"https://pubmed.ncbi.nlm.nih.gov/26374521"},"language":"en","primary_location":{"id":"doi:10.1387/ijdb.150220zz","doi":"https://doi.org/10.1387/ijdb.150220zz","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.150220zz","pdf_url":"https://ijdb.ehu.eus/article/pdf/150220zz","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ijdb.ehu.eus/article/pdf/150220zz","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107845325","display_name":"Zahra Zakeri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111455621","display_name":"Queens College, CUNY","ror":"https://ror.org/03v8adn41","country_code":"US","type":"education","lineage":["https://openalex.org/I111455621"]},{"id":"https://openalex.org/I121847817","display_name":"The Graduate Center, CUNY","ror":"https://ror.org/00awd9g61","country_code":"US","type":"education","lineage":["https://openalex.org/I121847817"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zahra Zakeri","raw_affiliation_strings":["College and Graduate Center, Department of Biology, City University of New York, NY. zahra_zakeri@hotmail.com","Queens College and Graduate Center, Department of Biology, City University of New York, NY, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College and Graduate Center, Department of Biology, City University of New York, NY. zahra_zakeri@hotmail.com","institution_ids":["https://openalex.org/I121847817","https://openalex.org/I174216632"]},{"raw_affiliation_string":"Queens College and Graduate Center, Department of Biology, City University of New York, NY, and","institution_ids":["https://openalex.org/I111455621","https://openalex.org/I121847817","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042254247","display_name":"Carlos G. Penaloza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111455621","display_name":"Queens College, CUNY","ror":"https://ror.org/03v8adn41","country_code":"US","type":"education","lineage":["https://openalex.org/I111455621"]},{"id":"https://openalex.org/I121847817","display_name":"The Graduate Center, CUNY","ror":"https://ror.org/00awd9g61","country_code":"US","type":"education","lineage":["https://openalex.org/I121847817"]},{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I2802733791","display_name":"SUNY Schenectady County Community College","ror":"https://ror.org/03ncxj847","country_code":"US","type":"education","lineage":["https://openalex.org/I2802733791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos G. Penaloza","raw_affiliation_strings":["Queens College and Graduate Center, Department of Biology, City University of New York, NY, and","Schenectady County Community College, State University of New York, NY and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queens College and Graduate Center, Department of Biology, City University of New York, NY, and","institution_ids":["https://openalex.org/I111455621","https://openalex.org/I121847817","https://openalex.org/I174216632"]},{"raw_affiliation_string":"Schenectady County Community College, State University of New York, NY and","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I2802733791"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kyle Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111455621","display_name":"Queens College, CUNY","ror":"https://ror.org/03v8adn41","country_code":"US","type":"education","lineage":["https://openalex.org/I111455621"]},{"id":"https://openalex.org/I121847817","display_name":"The Graduate Center, CUNY","ror":"https://ror.org/00awd9g61","country_code":"US","type":"education","lineage":["https://openalex.org/I121847817"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Smith","raw_affiliation_strings":["Queens College and Graduate Center, Department of Biology, City University of New York, NY, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queens College and Graduate Center, Department of Biology, City University of New York, NY, and","institution_ids":["https://openalex.org/I111455621","https://openalex.org/I121847817","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018807647","display_name":"Yixia Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111455621","display_name":"Queens College, CUNY","ror":"https://ror.org/03v8adn41","country_code":"US","type":"education","lineage":["https://openalex.org/I111455621"]},{"id":"https://openalex.org/I121847817","display_name":"The Graduate Center, CUNY","ror":"https://ror.org/00awd9g61","country_code":"US","type":"education","lineage":["https://openalex.org/I121847817"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yixia Ye","raw_affiliation_strings":["Queens College and Graduate Center, Department of Biology, City University of New York, NY, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queens College and Graduate Center, Department of Biology, City University of New York, NY, and","institution_ids":["https://openalex.org/I111455621","https://openalex.org/I121847817","https://openalex.org/I174216632"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090780293","display_name":"Richard A. Lockshin","orcid":"https://orcid.org/0000-0002-4389-4898","observed_orcids":["https://orcid.org/0000-0002-4389-4898"]},"institutions":[{"id":"https://openalex.org/I111455621","display_name":"Queens College, CUNY","ror":"https://ror.org/03v8adn41","country_code":"US","type":"education","lineage":["https://openalex.org/I111455621"]},{"id":"https://openalex.org/I121847817","display_name":"The Graduate Center, CUNY","ror":"https://ror.org/00awd9g61","country_code":"US","type":"education","lineage":["https://openalex.org/I121847817"]},{"id":"https://openalex.org/I142823887","display_name":"St. John's University","ror":"https://ror.org/00bgtad15","country_code":"US","type":"education","lineage":["https://openalex.org/I142823887"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Lockshin","raw_affiliation_strings":["Queens College and Graduate Center, Department of Biology, City University of New York, NY, and","St. John's University, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queens College and Graduate Center, Department of Biology, City University of New York, NY, and","institution_ids":["https://openalex.org/I111455621","https://openalex.org/I121847817","https://openalex.org/I174216632"]},{"raw_affiliation_string":"St. John's University, NY, USA","institution_ids":["https://openalex.org/I142823887"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5107845325"],"corresponding_institution_ids":["https://openalex.org/I111455621","https://openalex.org/I121847817","https://openalex.org/I174216632"],"apc_list":null,"apc_paid":null,"fwci":0.1616,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.13231613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"59","issue":"1-2-3","first_page":"11","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.7820000052452087},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6179999709129333},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.8140000104904175},{"id":"https://openalex.org/keywords/gametogenesis","display_name":"gametogenesis","score":0.746999979019165},{"id":"https://openalex.org/keywords/trophoblast","display_name":"trophoblast","score":0.6959999799728394},{"id":"https://openalex.org/keywords/inner-cell-mass","display_name":"inner cell mass","score":0.9480000138282776},{"id":"https://openalex.org/keywords/organogenesis","display_name":"organogenesis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/maternal-to-zygotic-transition","display_name":"maternal-to-zygotic transition","score":0.7929999828338623},{"id":"https://openalex.org/keywords/caenorhabditis","display_name":"Caenorhabditis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/lysosomal-cell-death","display_name":"lysosomal cell death","score":0.6320000290870667},{"id":"https://openalex.org/keywords/phagocytes","display_name":"phagocytes","score":0.703000009059906},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.90351402759552},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.8500021696090698},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6715995073318481},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.635587215423584},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5230754017829895},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5201083421707153},{"id":"https://openalex.org/C28748434","wikidata":"https://www.wikidata.org/wiki/Q170145","display_name":"Zygote","level":4,"score":0.5199426412582397},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.49481743574142456},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4328412115573883},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43192464113235474},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.41517555713653564},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.28219911456108093},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12426072359085083},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002107","descriptor_name":"Caenorhabditis","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D005718","descriptor_name":"Gametogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1387/ijdb.150220zz","doi":"https://doi.org/10.1387/ijdb.150220zz","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.150220zz","pdf_url":"https://ijdb.ehu.eus/article/pdf/150220zz","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},{"id":"pmid:26374521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26374521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of developmental biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1387/ijdb.150220zz","doi":"https://doi.org/10.1387/ijdb.150220zz","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.150220zz","pdf_url":"https://ijdb.ehu.eus/article/pdf/150220zz","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G166888597","display_name":"MARC Undergraduate Student Training in Academic Research at Queens College","funder_award_id":"T34GM070387","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309594","display_name":"Utah Science Technology and Research","ror":"https://ror.org/00h6set76"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2233250281.pdf","grobid_xml":"https://content.openalex.org/works/W2233250281.grobid-xml"},"referenced_works_count":121,"referenced_works":["https://openalex.org/W26337794","https://openalex.org/W175783626","https://openalex.org/W1213026117","https://openalex.org/W1486502659","https://openalex.org/W1519250999","https://openalex.org/W1536293876","https://openalex.org/W1581184243","https://openalex.org/W1585483493","https://openalex.org/W1880652286","https://openalex.org/W1963692720","https://openalex.org/W1964590507","https://openalex.org/W1965277605","https://openalex.org/W1965849508","https://openalex.org/W1966687534","https://openalex.org/W1968210150","https://openalex.org/W1969331809","https://openalex.org/W1975728036","https://openalex.org/W1977099212","https://openalex.org/W1980331623","https://openalex.org/W1980792888","https://openalex.org/W1985696913","https://openalex.org/W1986420650","https://openalex.org/W1987785848","https://openalex.org/W1989647261","https://openalex.org/W1990937181","https://openalex.org/W1993772997","https://openalex.org/W1994081180","https://openalex.org/W1996809518","https://openalex.org/W1997831655","https://openalex.org/W1998594680","https://openalex.org/W2000352412","https://openalex.org/W2001082792","https://openalex.org/W2001562379","https://openalex.org/W2001720542","https://openalex.org/W2003749297","https://openalex.org/W2005034673","https://openalex.org/W2005630031","https://openalex.org/W2006942464","https://openalex.org/W2012458212","https://openalex.org/W2014364936","https://openalex.org/W2016499148","https://openalex.org/W2017581149","https://openalex.org/W2018412575","https://openalex.org/W2023655063","https://openalex.org/W2024232113","https://openalex.org/W2024795929","https://openalex.org/W2025065961","https://openalex.org/W2025824234","https://openalex.org/W2034591877","https://openalex.org/W2036241108","https://openalex.org/W2036457027","https://openalex.org/W2037084194","https://openalex.org/W2045780506","https://openalex.org/W2048135038","https://openalex.org/W2052726485","https://openalex.org/W2053148264","https://openalex.org/W2054222157","https://openalex.org/W2056650897","https://openalex.org/W2056663185","https://openalex.org/W2057112578","https://openalex.org/W2057697250","https://openalex.org/W2058321650","https://openalex.org/W2060271719","https://openalex.org/W2064772676","https://openalex.org/W2066068720","https://openalex.org/W2066727453","https://openalex.org/W2066800765","https://openalex.org/W2069312900","https://openalex.org/W2069531075","https://openalex.org/W2070532728","https://openalex.org/W2070543094","https://openalex.org/W2074280352","https://openalex.org/W2080865728","https://openalex.org/W2080893376","https://openalex.org/W2081053802","https://openalex.org/W2081057817","https://openalex.org/W2082202018","https://openalex.org/W2083440174","https://openalex.org/W2085006338","https://openalex.org/W2085601531","https://openalex.org/W2087840510","https://openalex.org/W2089173809","https://openalex.org/W2089843919","https://openalex.org/W2090451352","https://openalex.org/W2092999710","https://openalex.org/W2093517377","https://openalex.org/W2093797314","https://openalex.org/W2095208811","https://openalex.org/W2097830998","https://openalex.org/W2101910352","https://openalex.org/W2109223747","https://openalex.org/W2110028199","https://openalex.org/W2115772647","https://openalex.org/W2116836791","https://openalex.org/W2119457612","https://openalex.org/W2119502220","https://openalex.org/W2120595804","https://openalex.org/W2122371316","https://openalex.org/W2123112488","https://openalex.org/W2126032058","https://openalex.org/W2133669258","https://openalex.org/W2138443476","https://openalex.org/W2143214850","https://openalex.org/W2146887271","https://openalex.org/W2150539937","https://openalex.org/W2150837125","https://openalex.org/W2150912846","https://openalex.org/W2156708806","https://openalex.org/W2157815025","https://openalex.org/W2163142681","https://openalex.org/W2164813975","https://openalex.org/W2164943291","https://openalex.org/W2186079830","https://openalex.org/W2315458562","https://openalex.org/W2334154551","https://openalex.org/W2338543817","https://openalex.org/W2410981017","https://openalex.org/W4253066643","https://openalex.org/W6628999006","https://openalex.org/W6807619098","https://openalex.org/W7073765624"],"related_works":["https://openalex.org/W1777429727","https://openalex.org/W82064366","https://openalex.org/W1856219015","https://openalex.org/W2133931950","https://openalex.org/W2138443476","https://openalex.org/W7099812298","https://openalex.org/W2093582718","https://openalex.org/W2163282583","https://openalex.org/W123794703","https://openalex.org/W1501452286"],"abstract_inverted_index":{"Cell":[0],"death":[1,20,95,146,229],"is":[2,240],"prominent":[3],"in":[4,27,74,78,114,117,136,192,198,230],"gametogenesis":[5],"and":[6,8,43,69,77,89,102,167,178],"shapes":[7],"sculpts":[9],"embryos.":[10],"In":[11],"non-mammalian":[12],"embryos":[13,119],"one":[14,33],"sees":[15],"little":[16],"or":[17,34,161,194,197],"no":[18,162],"cell":[19,56,65,71,145,209,212],"prior":[21],"to":[22,129,184,246,251,263],"the":[23,39,48,51,54,61,75,79,97,120,124,134,144,155,174,199,203,223,236,256],"maternal-zygotic":[24],"transition,":[25],"but,":[26],"mammalian":[28],"embryos,":[29],"characteristic":[30],"deaths":[31,66,125,175,213],"of":[32,41,50,60,87,91,96,105,123,143,154,169,173,208,225,238],"two":[35],"cells":[36,88,107,138,196,259,262],"occur":[37],"at":[38],"end":[40],"compaction":[42],"are":[44,82,176,179,218],"apparently":[45],"necessary":[46],"for":[47],"separation":[49],"trophoblast":[52],"from":[53],"inner":[55],"mass.":[57],"Considerable":[58],"sculpting":[59],"embryo":[62],"occurs":[63],"by":[64,84,181],"during":[67],"organogenesis,":[68],"appropriate":[70],"numbers,":[72],"especially":[73],"CNS":[76],"immune":[80],"system,":[81],"generated":[83],"massive":[85],"overproduction":[86],"selection":[90],"a":[92,227,231],"few,":[93],"with":[94],"rest.":[98],"The":[99],"timing,":[100],"identity,":[101],"genetic":[103],"control":[104],"specific":[106,232],"that":[108,201,214,222,248,260],"die":[109],"have":[110],"been":[111],"well":[112],"documented":[113],"Caenorhabditis,":[115],"but":[116,151,187],"other":[118],"stochastic":[121],"nature":[122],"limit":[126],"our":[127],"ability":[128],"do":[130],"more":[131,254],"than":[132,235],"identify":[133],"regions":[135],"which":[137],"will":[139],"die.":[140],"Complete":[141],"disruption":[142],"machinery":[147,157],"can":[148],"be":[149],"lethal,":[150],"many":[152],"mutations":[153],"regulatory":[156,170],"yield":[158],"only":[159],"modest":[160],"phenotypes,":[163],"indicating":[164,221],"substantial":[165],"redundancy":[166],"compensation":[168],"mechanisms.":[171],"Most":[172],"apoptotic":[177],"identified":[180],"techniques":[182,188],"used":[183],"recognize":[185],"apoptosis,":[186],"identifying":[189],"lysosomes":[190],"(whether":[191],"dying":[193],"involuting":[195],"phagocytes":[200],"invade":[202],"tissue)":[204],"also":[205],"reveal":[206],"patterns":[207],"death.":[210],"Aberrant":[211],"produce":[215],"known":[216],"phenotypes":[217],"typically":[219],"localized,":[220],"mechanism":[224,237],"activating":[226],"programmed":[228],"region,":[233],"rather":[234],"death,":[239],"aberrant.":[241],"These":[242],"results":[243],"lead":[244,261],"us":[245],"conclude":[247],"we":[249],"need":[250],"know":[252],"much":[253],"about":[255],"conversations":[257],"among":[258],"commit":[264],"suicide.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}