{"id":"https://openalex.org/W2232640294","doi":null,"title":"Erytropoietin treatment for human stroke is safe and beneficial","display_name":"Erytropoietin treatment for human stroke is safe and beneficial","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2232640294","mag":"2232640294"},"language":"en","primary_location":{"id":"pmh:oai:edoc.mpg.de:18786","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/18786","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacology of cerebral ischemia, 515-519 (2002)","raw_type":"InBook"},"volume":null,"type":"book","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069268891","display_name":"Hannelore Ehrenreich","orcid":"https://orcid.org/0000-0001-8371-5711","observed_orcids":["https://orcid.org/0000-0001-8371-5711"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210137682","display_name":"Max Planck Institute of Experimental Medicine","ror":"https://ror.org/04a7f6w43","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210137682","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hannelore Ehrenreich","raw_affiliation_strings":["Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society"],"raw_orcid":"https://orcid.org/0000-0001-8371-5711","affiliations":[{"raw_affiliation_string":"Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210137682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024124953","display_name":"Martin Hasselblatt","orcid":"https://orcid.org/0000-0003-2707-8484","observed_orcids":["https://orcid.org/0000-0003-2707-8484"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210137682","display_name":"Max Planck Institute of Experimental Medicine","ror":"https://ror.org/04a7f6w43","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210137682","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Hasselblatt","raw_affiliation_strings":["Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society"],"raw_orcid":"https://orcid.org/0000-0003-2707-8484","affiliations":[{"raw_affiliation_string":"Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210137682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028321858","display_name":"Lukas Cepek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lukas Cepek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029447564","display_name":"Sajish Jacob","orcid":"https://orcid.org/0000-0003-0882-5501","observed_orcids":["https://orcid.org/0000-0003-0882-5501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sajish Jacob","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0882-5501","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022636919","display_name":"Friederike Knerlich\u2010Lukoschus","orcid":"https://orcid.org/0000-0003-4907-015X","observed_orcids":["https://orcid.org/0000-0003-4907-015X"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210137682","display_name":"Max Planck Institute of Experimental Medicine","ror":"https://ror.org/04a7f6w43","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210137682","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friederike Knerlich\u2010Lukoschus","raw_affiliation_strings":["Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210137682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051891351","display_name":"Anna\u2010Leena Sir\u00e9n","orcid":"https://orcid.org/0000-0002-2217-0081","observed_orcids":["https://orcid.org/0000-0002-2217-0081"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210137682","display_name":"Max Planck Institute of Experimental Medicine","ror":"https://ror.org/04a7f6w43","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210137682","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna\u2010Leena Sir\u00e9n","raw_affiliation_strings":["Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society"],"raw_orcid":"https://orcid.org/0000-0002-2217-0081","affiliations":[{"raw_affiliation_string":"Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210137682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23611111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"515","last_page":"519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.05400000140070915,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.8370000123977661},{"id":"https://openalex.org/keywords/recombinant-human-erythropoietin","display_name":"recombinant human erythropoietin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8840000033378601},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.7910000085830688},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.8199999928474426},{"id":"https://openalex.org/keywords/s100beta","display_name":"S100\u03b2","score":0.925000011920929},{"id":"https://openalex.org/keywords/middle-cerebral-artery-infarction","display_name":"middle cerebral artery infarction","score":0.7099999785423279},{"id":"https://openalex.org/keywords/diffusion-weighted-imaging","display_name":"diffusion-weighted imaging","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5509282350540161},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4041144549846649},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38283205032348633},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3506537079811096},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14615005254745483},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:edoc.mpg.de:18786","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/18786","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacology of cerebral ischemia, 515-519 (2002)","raw_type":"InBook"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/7224","doi":null,"is_oa":false,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/7224","pdf_url":null,"source":{"id":"https://openalex.org/S7407055187","display_name":"GRO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_2188757","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0029-0BA3-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacology of cerebral ischemia","raw_type":"info:eu-repo/semantics/bookPart"},{"id":"mag:2232640294","doi":null,"is_oa":false,"landing_page_url":"https://pure.mpg.de/pubman/faces/ViewItemOverviewPage.jsp?itemId=item_2188757","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2122965222","https://openalex.org/W7095184019","https://openalex.org/W2170209770","https://openalex.org/W2103320383","https://openalex.org/W2157346069","https://openalex.org/W2391908212","https://openalex.org/W2140855329","https://openalex.org/W1973509095","https://openalex.org/W2096539387","https://openalex.org/W2886782330"],"abstract_inverted_index":{"BACKGROUND:":[0],"Erythropoietin":[1],"(EPO)":[2],"and":[3,20,42,66,132,152,166,172,222,249,282],"its":[4],"receptor":[5],"play":[6],"a":[7,63],"major":[8],"role":[9],"in":[10,16,54,247,257,260,278,287],"embryonic":[11],"brain,":[12],"are":[13],"weakly":[14],"expressed":[15],"normal":[17],"postnatal/adult":[18],"brain":[19],"up-regulated":[21],"upon":[22],"metabolic":[23],"stress.":[24],"EPO":[25,47,185],"protects":[26],"neurons":[27],"from":[28],"hypoxic/":[29],"ischemic":[30,52,113,280],"injury.":[31],"The":[32,59,137],"objective":[33],"of":[34,44,51,62,157,191,212,214,231],"this":[35],"trial":[36,60,297],"is":[37,275,298],"to":[38,187,265],"study":[39,138],"the":[40,71,88,95,116,173,200,203],"safety":[41,64,72,179],"efficacy":[43,68,204],"recombinant":[45],"human":[46],"(rhEPO)":[48],"for":[49,87,234,255],"treatment":[50,241],"stroke":[53,114,135,154,281],"man.":[55],"MATERIALS":[56],"AND":[57],"METHODS:":[58],"consisted":[61],"part":[65],"an":[67,245,285],"part.":[69],"In":[70,94,202],"study,":[73],"13":[74],"patients":[75,101,206,262],"received":[76,102,207],"rhEPO":[77,104,198,208,240,261,274],"intravenously":[78,196],"(3.3":[79],"X":[80],"10(4)":[81],"IU/50":[82],"ml/30":[83],"min)":[84],"once":[85],"daily":[86],"first":[89],"3":[90],"days":[91],"after":[92],"stroke.":[93],"double-blind":[96],"randomized":[97],"proof-of-concept":[98],"trial,":[99,205],"40":[100],"either":[103],"or":[105],"saline.":[106],"Inclusion":[107],"criteria":[108],"were":[109,140,181,226],"age":[110],"<80":[111],"years,":[112],"within":[115,209],"middle":[117],"cerebral":[118],"artery":[119],"territory":[120],"confirmed":[121],"by":[122,269],"diffusion-weighted":[123,164],"MRI,":[124],"symptom":[125],"onset":[126,213],"<8":[127],"hr":[128,211],"before":[129],"drug":[130],"administration,":[131],"deficits":[133],"on":[134],"scales.":[136,251],"endpoints":[139],"functional":[141],"outcome":[142,250,289],"at":[143,290],"day":[144],"30":[145],"(Barthel":[146],"Index,":[147],"modified":[148],"Rankin":[149],"scale),":[150],"NIH":[151],"Scandinavian":[153],"scales,":[155],"evolution":[156],"infarct":[158,258],"size":[159,259],"(sequential":[160],"MRI":[161],"evaluation":[162],"using":[163],"[DWI]":[165],"fluid-attenuated":[167],"inversion":[168],"recovery":[169],"sequences":[170],"[FLAIR])":[171],"damage":[174],"marker":[175],"S100ss.":[176],"RESULTS:":[177],"No":[178],"concerns":[180],"identified.":[182],"Cerebrospinal":[183],"fluid":[184],"increased":[186],"60-100":[188],"times":[189],"that":[190,195,239],"nontreated":[192],"patients,":[193],"proving":[194],"administered":[197],"reaches":[199],"brain.":[201],"5":[210],"symptoms":[215],"(median,":[216],"range":[217],"2:40-7:55).":[218],"Admission":[219],"neurologic":[220],"scores":[221],"serum":[223],"S100beta":[224],"concentrations":[225],"strong":[227,253],"predictors":[228],"ofoutcome.":[229],"Analysis":[230],"covariance":[232],"controlled":[233],"these":[235],"two":[236],"variables":[237],"indicated":[238],"was":[242,267],"associated":[243,283],"with":[244,284],"improvement":[246,286],"follow-up":[248],"A":[252,293],"trend":[254],"reduction":[256],"as":[263],"compared":[264],"controls":[266],"observed":[268],"MRI.":[270],"CONCLUSION:":[271],"Intravenous":[272],"high-dose":[273],"well":[276],"tolerated":[277],"acute":[279],"clinical":[288,296],"1":[291],"month.":[292],"larger":[294],"scale":[295],"warranted.":[299]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
