{"id":"https://openalex.org/W22320995","doi":"https://doi.org/10.1253/circj.cj-10-0673","title":"N-Acetylcysteine Suppresses the Progression of Ventricular Remodeling in Acute Myocarditis - Studies in an Experimental Autoimmune Myocarditis (EAM) Model -","display_name":"N-Acetylcysteine Suppresses the Progression of Ventricular Remodeling in Acute Myocarditis - Studies in an Experimental Autoimmune Myocarditis (EAM) Model -","publication_year":2010,"publication_date":"2010-12-24","ids":{"openalex":"https://openalex.org/W22320995","doi":"https://doi.org/10.1253/circj.cj-10-0673","mag":"22320995","pmid":"https://pubmed.ncbi.nlm.nih.gov/21187656"},"language":"en","primary_location":{"id":"doi:10.1253/circj.cj-10-0673","doi":"https://doi.org/10.1253/circj.cj-10-0673","is_oa":true,"landing_page_url":"https://doi.org/10.1253/circj.cj-10-0673","pdf_url":"https://www.jstage.jst.go.jp/article/circj/75/3/75_CJ-10-0673/_pdf","source":{"id":"https://openalex.org/S4210176241","display_name":"Circulation Journal","issn_l":"1346-9843","issn":["1346-9843","1347-4820"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/circj/75/3/75_CJ-10-0673/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052401062","display_name":"Shinichi Niwano","orcid":"https://orcid.org/0000-0002-0702-0800","observed_orcids":["https://orcid.org/0000-0002-0702-0800"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichi Niwano","raw_affiliation_strings":["Department of Cardio-Angiology, Kitasato University School of Medicine","Department of Cardio-Angiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Angiology, Kitasato University School of Medicine","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"Department of Cardio-Angiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062611184","display_name":"Hiroe Niwano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroe Niwano","raw_affiliation_strings":["Department of Cardio-Angiology, Kitasato University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Angiology, Kitasato University, School of Medicine","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100520936","display_name":"Sae Sasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sae Sasaki","raw_affiliation_strings":["Department of Cardio-Angiology, Kitasato University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Angiology, Kitasato University, School of Medicine","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046761063","display_name":"Hidehira Fukaya","orcid":"https://orcid.org/0000-0002-7588-554X","observed_orcids":["https://orcid.org/0000-0002-7588-554X"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidehira Fukaya","raw_affiliation_strings":["Department of Cardio-Angiology, Kitasato University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Angiology, Kitasato University, School of Medicine","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103444704","display_name":"Masaru Yuge","orcid":"https://orcid.org/0009-0002-3986-3519","observed_orcids":["https://orcid.org/0009-0002-3986-3519"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Yuge","raw_affiliation_strings":["Department of Cardio-Angiology, Kitasato University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Angiology, Kitasato University, School of Medicine","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089084611","display_name":"Ryuta Imaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuta Imaki","raw_affiliation_strings":["Department of Cardio-Angiology, Kitasato University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Angiology, Kitasato University, School of Medicine","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108440701","display_name":"Yoji Machida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoji Machida","raw_affiliation_strings":["Department of Cardio-Angiology, Kitasato University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Angiology, Kitasato University, School of Medicine","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100826204","display_name":"Tohru Izumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Izumi","raw_affiliation_strings":["Department of Cardio-Angiology, Kitasato University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Angiology, Kitasato University, School of Medicine","institution_ids":["https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I64189623"],"apc_list":null,"apc_paid":null,"fwci":0.8488,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.72604895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"75","issue":"3","first_page":"662","last_page":"671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":1.0},{"id":"https://openalex.org/keywords/ventricular-remodeling","display_name":"ventricular remodeling","score":0.843999981880188},{"id":"https://openalex.org/keywords/acute-myocarditis","display_name":"acute myocarditis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/experimental-autoimmune-myocarditis","display_name":"experimental autoimmune myocarditis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9290000200271606},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/action-potential-duration","display_name":"action potential duration","score":0.8029999732971191},{"id":"https://openalex.org/keywords/kv4-2-potassium-channel","display_name":"Kv4.2 potassium channel","score":0.875},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"cardiac electrophysiology","score":0.6930000185966492},{"id":"https://openalex.org/keywords/lewis-rats","display_name":"Lewis rats","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.8963260054588318},{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.6874865889549255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6314666867256165},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.5615332126617432},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5462796092033386},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.48045438528060913},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.45101219415664673},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.38417208194732666},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34025973081588745},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24095436930656433},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.21502476930618286},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07185009121894836},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.07039308547973633},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1253/circj.cj-10-0673","doi":"https://doi.org/10.1253/circj.cj-10-0673","is_oa":true,"landing_page_url":"https://doi.org/10.1253/circj.cj-10-0673","pdf_url":"https://www.jstage.jst.go.jp/article/circj/75/3/75_CJ-10-0673/_pdf","source":{"id":"https://openalex.org/S4210176241","display_name":"Circulation Journal","issn_l":"1346-9843","issn":["1346-9843","1347-4820"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Journal","raw_type":"journal-article"},{"id":"pmid:21187656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21187656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation journal : official journal of the Japanese Circulation Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1253/circj.cj-10-0673","doi":"https://doi.org/10.1253/circj.cj-10-0673","is_oa":true,"landing_page_url":"https://doi.org/10.1253/circj.cj-10-0673","pdf_url":"https://www.jstage.jst.go.jp/article/circj/75/3/75_CJ-10-0673/_pdf","source":{"id":"https://openalex.org/S4210176241","display_name":"Circulation Journal","issn_l":"1346-9843","issn":["1346-9843","1347-4820"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324670","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W22320995.pdf","grobid_xml":"https://content.openalex.org/works/W22320995.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W172109738","https://openalex.org/W207789239","https://openalex.org/W1939850337","https://openalex.org/W1965057305","https://openalex.org/W1968607661","https://openalex.org/W1977500527","https://openalex.org/W1984535953","https://openalex.org/W1985637866","https://openalex.org/W1986222003","https://openalex.org/W1994557100","https://openalex.org/W2003912653","https://openalex.org/W2005513283","https://openalex.org/W2013981701","https://openalex.org/W2016986936","https://openalex.org/W2048300672","https://openalex.org/W2059007582","https://openalex.org/W2061465302","https://openalex.org/W2068705524","https://openalex.org/W2078256260","https://openalex.org/W2080361811","https://openalex.org/W2084265884","https://openalex.org/W2087318947","https://openalex.org/W2089356084","https://openalex.org/W2091134353","https://openalex.org/W2101642689","https://openalex.org/W2115258460","https://openalex.org/W2131463171","https://openalex.org/W2135233290","https://openalex.org/W2139424224","https://openalex.org/W2140199727","https://openalex.org/W2157944478","https://openalex.org/W2167525963","https://openalex.org/W2170776096"],"related_works":["https://openalex.org/W2030506516","https://openalex.org/W2132442581","https://openalex.org/W1972748137","https://openalex.org/W2366229841","https://openalex.org/W2385697423","https://openalex.org/W7120665894","https://openalex.org/W4394625322","https://openalex.org/W2360457364","https://openalex.org/W2030870634","https://openalex.org/W2140199727"],"abstract_inverted_index":{"BACKGROUND:":[0],"Electrical":[1],"and":[2,14,86,97,124,133,176,204],"structural":[3],"remodeling,":[4,43],"characterized":[5],"by":[6,106,139],"prolonged":[7,122],"action":[8],"potential":[9],"duration":[10],"(APD),":[11],"Kv4.2":[12,126,177],"downregulation":[13],"cellular":[15],"infiltration":[16],"were":[17,63,95,104,136],"studied":[18],"in":[19,38,141,189,201,207],"rat":[20],"experimental":[21],"autoimmune":[22],"myocarditis":[23,120,132,152,169,205],"(EAM).":[24],"Because":[25],"the":[26,39,44,50,73,92,98,102,151,158,166,190,196,208],"reactive":[27],"oxygen":[28],"species":[29],"(ROS)":[30],"has":[31],"been":[32],"speculated":[33],"to":[34,84],"play":[35],"a":[36,117,142],"role":[37,197],"promotion":[40],"of":[41,46,52,101,168,198,211],"such":[42],"effect":[45],"N-acetylcysteine":[47],"(NAC)":[48],"on":[49],"progression":[51],"ventricular":[53,187],"remodeling":[54,188,203],"was":[55,81,153,170,179],"evaluated.":[56],"METHODS":[57],"AND":[58],"RESULTS:":[59],"Six-week-old":[60],"Lewis":[61],"rats":[62,115,147,162],"immunized":[64],"with":[65,121,148,163],"porcine":[66],"cardiac":[67],"myosin.":[68],"On":[69,89],"Days":[70],"10-11":[71],"after":[72],"immunization,":[74],"NAC":[75,184],"(0,":[76],"1,":[77],"10,":[78],"or":[79],"100mg)":[80],"injected":[82],"intraperitoneally":[83],"EAM":[85,114,191],"control":[87],"rats.":[88,192],"Day":[90],"14,":[91],"electrophysiological":[93],"parameters":[94],"evaluated":[96],"expression":[99,127],"levels":[100],"mRNA":[103],"examined":[105],"quantitative":[107],"real-time":[108],"reverse-transcription":[109],"polymerase":[110],"chain":[111],"reaction":[112],"(RT-PCR).The":[113],"exhibited":[116],"typical":[118],"acute":[119,209],"APD":[123,174],"reduced":[125],"as":[128],"previously":[129],"reported.":[130],"The":[131,183],"electrical":[134],"changes":[135],"significantly":[137],"suppressed":[138,186],"NAC-treatment":[140],"dose-dependent":[143],"manner":[144],"(P<0.05).":[145,181],"In":[146,161],"100mg":[149],"NAC,":[150,165],"almost":[154],"totally":[155],"negated":[156],"although":[157],"mortality":[159],"increased.":[160],"1mg":[164],"suppression":[167],"not":[171],"obvious,":[172],"but":[173],"prolongation":[175],"reduction":[178],"attenuated":[180],"CONCLUSIONS:":[182],"treatment":[185],"This":[193],"may":[194],"indicate":[195],"oxidative":[199],"stress":[200],"causing":[202],"itself":[206],"phase":[210],"myocarditis.":[212]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}