{"id":"https://openalex.org/W2231908034","doi":null,"title":"The role of surfactant protein A and B genes in heritable susceptibility to neonatal respiratory distress syndrome","display_name":"The role of surfactant protein A and B genes in heritable susceptibility to neonatal respiratory distress syndrome","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2231908034","mag":"2231908034"},"language":"en","primary_location":{"id":"mag:2231908034","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514265254.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111486073","display_name":"Ritva Haataja","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ritva Haataja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111486073"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7497,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.71993603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11586","display_name":"Congenital Diaphragmatic Hernia Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-respiratory-distress-syndrome","display_name":"neonatal respiratory distress syndrome","score":0.9610000252723694},{"id":"https://openalex.org/keywords/surfactant-protein-a","display_name":"surfactant protein A","score":0.9700000286102295},{"id":"https://openalex.org/keywords/surfactant-protein-b","display_name":"surfactant protein B","score":0.9860000014305115},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8759999871253967},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.7519999742507935},{"id":"https://openalex.org/keywords/twin-concordance","display_name":"twin concordance","score":0.8389999866485596},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.6060000061988831},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.7110000252723694},{"id":"https://openalex.org/keywords/multiple-pregnancy","display_name":"multiple pregnancy","score":0.4779999852180481},{"id":"https://openalex.org/keywords/birth-order","display_name":"birth order","score":0.7599999904632568},{"id":"https://openalex.org/keywords/very-preterm-infants","display_name":"very preterm infants","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6715307235717773},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.5900751352310181},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.513673722743988},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4905340075492859},{"id":"https://openalex.org/C2778721537","wikidata":"https://www.wikidata.org/wiki/Q922640","display_name":"Bronchopulmonary dysplasia","level":4,"score":0.48899972438812256},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.4632019102573395},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.45255035161972046},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.4309804439544678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4258645176887512},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.42439010739326477},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.42343616485595703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4002181589603424},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33845093846321106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3071363866329193},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.15227222442626953},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.11173668503761292},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2231908034","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514265254.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":213,"referenced_works":["https://openalex.org/W25816947","https://openalex.org/W53510971","https://openalex.org/W63679317","https://openalex.org/W118666362","https://openalex.org/W124486129","https://openalex.org/W145109048","https://openalex.org/W167775893","https://openalex.org/W184268326","https://openalex.org/W191038895","https://openalex.org/W949992685","https://openalex.org/W1488145695","https://openalex.org/W1490103016","https://openalex.org/W1500634278","https://openalex.org/W1504213234","https://openalex.org/W1511341262","https://openalex.org/W1521863806","https://openalex.org/W1525915159","https://openalex.org/W1527773184","https://openalex.org/W1538141077","https://openalex.org/W1540257390","https://openalex.org/W1543868019","https://openalex.org/W1545502161","https://openalex.org/W1547874286","https://openalex.org/W1547943040","https://openalex.org/W1576489564","https://openalex.org/W1595806145","https://openalex.org/W1607610170","https://openalex.org/W1663580765","https://openalex.org/W1738317710","https://openalex.org/W1756173277","https://openalex.org/W1766443795","https://openalex.org/W1771618251","https://openalex.org/W1829364146","https://openalex.org/W1858962045","https://openalex.org/W1884476348","https://openalex.org/W1894887521","https://openalex.org/W1939664693","https://openalex.org/W1945686552","https://openalex.org/W1963712708","https://openalex.org/W1963936426","https://openalex.org/W1965404488","https://openalex.org/W1969650622","https://openalex.org/W1971636172","https://openalex.org/W1972215873","https://openalex.org/W1972866603","https://openalex.org/W1973402680","https://openalex.org/W1974977343","https://openalex.org/W1975821342","https://openalex.org/W1975887994","https://openalex.org/W1980137392","https://openalex.org/W1980615053","https://openalex.org/W1982050479","https://openalex.org/W1982645590","https://openalex.org/W1982877581","https://openalex.org/W1983741470","https://openalex.org/W1988828500","https://openalex.org/W1989159174","https://openalex.org/W1989675620","https://openalex.org/W1990176269","https://openalex.org/W1990402565","https://openalex.org/W1991464867","https://openalex.org/W1993335885","https://openalex.org/W1993446768","https://openalex.org/W1993875709","https://openalex.org/W1994204296","https://openalex.org/W1994663386","https://openalex.org/W1996389622","https://openalex.org/W1996421710","https://openalex.org/W1997535214","https://openalex.org/W1998344495","https://openalex.org/W1998426214","https://openalex.org/W1999536049","https://openalex.org/W2000319181","https://openalex.org/W2000580510","https://openalex.org/W2001759120","https://openalex.org/W2002859881","https://openalex.org/W2003368868","https://openalex.org/W2004176673","https://openalex.org/W2007486281","https://openalex.org/W2007603804","https://openalex.org/W2008395942","https://openalex.org/W2008512736","https://openalex.org/W2010175471","https://openalex.org/W2011788706","https://openalex.org/W2014743041","https://openalex.org/W2016244626","https://openalex.org/W2017241568","https://openalex.org/W2018452136","https://openalex.org/W2019094071","https://openalex.org/W2020012047","https://openalex.org/W2020986301","https://openalex.org/W2022973204","https://openalex.org/W2024881522","https://openalex.org/W2027306950","https://openalex.org/W2029115935","https://openalex.org/W2032895487","https://openalex.org/W2033450022","https://openalex.org/W2033491834","https://openalex.org/W2034520317","https://openalex.org/W2036734671","https://openalex.org/W2037535960","https://openalex.org/W2039516989","https://openalex.org/W2039946863","https://openalex.org/W2040957336","https://openalex.org/W2044279773","https://openalex.org/W2044693293","https://openalex.org/W2048719418","https://openalex.org/W2050418199","https://openalex.org/W2052715391","https://openalex.org/W2053172745","https://openalex.org/W2053674447","https://openalex.org/W2056567933","https://openalex.org/W2057675072","https://openalex.org/W2060850202","https://openalex.org/W2061076213","https://openalex.org/W2061527703","https://openalex.org/W2063310038","https://openalex.org/W2063793648","https://openalex.org/W2067499063","https://openalex.org/W2068050957","https://openalex.org/W2068476800","https://openalex.org/W2068808582","https://openalex.org/W2070364452","https://openalex.org/W2070739144","https://openalex.org/W2070860646","https://openalex.org/W2071496092","https://openalex.org/W2071949957","https://openalex.org/W2071993331","https://openalex.org/W2073917725","https://openalex.org/W2073937565","https://openalex.org/W2077135198","https://openalex.org/W2080993165","https://openalex.org/W2081202307","https://openalex.org/W2081589751","https://openalex.org/W2082598365","https://openalex.org/W2084296824","https://openalex.org/W2085295869","https://openalex.org/W2086309846","https://openalex.org/W2089949767","https://openalex.org/W2090430011","https://openalex.org/W2092438643","https://openalex.org/W2093118781","https://openalex.org/W2093178095","https://openalex.org/W2093314252","https://openalex.org/W2093782142","https://openalex.org/W2102214682","https://openalex.org/W2105114931","https://openalex.org/W2105147141","https://openalex.org/W2105381893","https://openalex.org/W2106171015","https://openalex.org/W2106554167","https://openalex.org/W2109360657","https://openalex.org/W2116046790","https://openalex.org/W2120634007","https://openalex.org/W2121247884","https://openalex.org/W2123053105","https://openalex.org/W2123466824","https://openalex.org/W2124277514","https://openalex.org/W2126194236","https://openalex.org/W2127619636","https://openalex.org/W2128551817","https://openalex.org/W2129224957","https://openalex.org/W2129416468","https://openalex.org/W2130703491","https://openalex.org/W2132869897","https://openalex.org/W2134099801","https://openalex.org/W2137776860","https://openalex.org/W2140288971","https://openalex.org/W2144787356","https://openalex.org/W2147034448","https://openalex.org/W2148816954","https://openalex.org/W2149465851","https://openalex.org/W2153409356","https://openalex.org/W2159055946","https://openalex.org/W2160686569","https://openalex.org/W2161157806","https://openalex.org/W2164511664","https://openalex.org/W2165853056","https://openalex.org/W2172048985","https://openalex.org/W2175359745","https://openalex.org/W2179225990","https://openalex.org/W2186131328","https://openalex.org/W2202934396","https://openalex.org/W2210235875","https://openalex.org/W2226179892","https://openalex.org/W2229144421","https://openalex.org/W2236977373","https://openalex.org/W2238687933","https://openalex.org/W2257146252","https://openalex.org/W2271842402","https://openalex.org/W2286256313","https://openalex.org/W2303372456","https://openalex.org/W2313220264","https://openalex.org/W2315096416","https://openalex.org/W2324548857","https://openalex.org/W2327547894","https://openalex.org/W2331089332","https://openalex.org/W2339550260","https://openalex.org/W2339974765","https://openalex.org/W2346089892","https://openalex.org/W2398180612","https://openalex.org/W2406269117","https://openalex.org/W2407666212","https://openalex.org/W2411930589","https://openalex.org/W2414030173","https://openalex.org/W2414110983","https://openalex.org/W2416209345","https://openalex.org/W2416359930","https://openalex.org/W2417791778","https://openalex.org/W2418651081","https://openalex.org/W2418728026","https://openalex.org/W2419007504","https://openalex.org/W2466432544"],"related_works":["https://openalex.org/W2138605912","https://openalex.org/W2087055451","https://openalex.org/W2016894107","https://openalex.org/W2044571502","https://openalex.org/W2136389174","https://openalex.org/W2552540370","https://openalex.org/W7097807890","https://openalex.org/W1983502555","https://openalex.org/W2071063769","https://openalex.org/W2165561060"],"abstract_inverted_index":{"Respiratory":[0],"distress":[1],"syndrome":[2],"(RDS)":[3],"is":[4,13,23,40,300],"a":[5,17,24,112,147,207,244,321],"disease":[6,99,246,329],"characterized":[7],"by":[8,16],"neonatal":[9],"respiratory":[10],"failure.":[11],"It":[12],"principally":[14],"caused":[15],"deficiency":[18],"of":[19,36,50,55,74,92,135,163,209,228,260,272,311,342],"pulmonary":[20],"surfactant,":[21],"which":[22],"lipoprotein":[25],"mixture":[26],"essential":[27],"for":[28,340],"reducing":[29],"surface":[30],"tension":[31],"at":[32],"the":[33,37,41,53,59,75,89,98,104,133,175,183,186,212,249,254,258,270,273,284,289,334,343],"air-liquid":[34],"interface":[35],"alveolus.":[38],"Prematurity":[39],"major":[42],"risk":[43],"factor":[44],"predisposing":[45],"to":[46,61,70,87,97,131,145,152,206,298],"RDS.":[47,138,153],"Several":[48],"pieces":[49],"evidence":[51],"suggest":[52],"role":[54,149],"genetic":[56,93,307,344],"factors":[57,96,267],"in":[58,123,137,150,221,236,239,283,288,320,333],"susceptibility":[60,151,297],"this":[62],"multifactorial":[63],"disease.":[64],"The":[65,292,309],"present":[66,250,293],"study":[67,119,251],"was":[68,129,198,232,279],"performed":[69],"determine":[71,328],"whether":[72],"polymorphisms":[73],"surfactant":[76],"protein":[77],"SP-A1,":[78],"SP-A2":[79,167],"and":[80,86,94,107,114,117,140,166,196,306,317,336],"SP-B":[81,141,176,201,276,337],"genes":[82,106,142,338],"associate":[83],"with":[84,172,281],"RDS":[85,108,197,230,282,299],"evaluate":[88],"relative":[90],"contributions":[91],"environmental":[95,266,305,325],"etiology.":[100,247],"Allelic":[101],"associations":[102,218],"between":[103,185],"candidate":[105],"were":[109,143,170,219],"investigated":[110],"using":[111],"matched":[113],"unmatched":[115],"case-control":[116],"family-based":[118],"design.":[120],"Disease":[121],"concordance":[122,231,255],"monozygotic":[124,237],"vs.":[125,314],"dizygotic":[126,240],"twin":[127,241],"pairs":[128],"determined":[130],"measure":[132],"impact":[134],"heredity":[136],"SP-A":[139,194,335],"shown":[144],"play":[146],"significant":[148],"In":[154],"very":[155],"premature":[156,222],"singleton":[157,313],"infants":[158,210,223],"born":[159,224],"before":[160],"32":[161,226],"weeks":[162,227],"gestation,":[164],"SP-A1":[165],"allelic":[168,217],"variations":[169,332],"associated":[171,280],"RDS,":[173],"whereas":[174],"gene":[177],"showed":[178],"no":[179],"direct":[180],"association.":[181],"Instead,":[182],"association":[184],"high-risk":[187],"(6A2,":[188],"1A0)":[189],"or":[190],"low-risk":[191],"(6A3,":[192],"1A1/1A2)":[193],"alleles":[195],"dependent":[199],"on":[200],"Ile131Thr":[202,277],"variation,":[203],"being":[204],"restricted":[205],"subset":[208],"carrying":[211],"homozygous":[213],"genotype":[214],"Thr/Thr.":[215],"No":[216],"evident":[220],"after":[225],"gestation.":[229],"not":[233,287],"significantly":[234],"higher":[235],"than":[238],"pairs,":[242],"implying":[243],"non-genetic":[245],"However,":[248],"suggests":[252],"that":[253,268,296,327],"difference":[256],"underestimates":[257],"extent":[259],"heredity.":[261],"Twin":[262],"pregnancies":[263],"include":[264],"intrauterine":[265],"complicate":[269],"interpretation":[271],"hereditary":[274],"impact.":[275],"variation":[278],"first-born,":[285],"but":[286],"second-born":[290],"twins.":[291],"results":[294],"indicate":[295],"highly":[301],"heterogeneous,":[302],"involving":[303],"complex":[304],"interactions.":[308],"degree":[310],"prematurity,":[312],"multiple":[315,322],"pregnancy,":[316],"birth":[318,323],"order":[319],"are":[324],"confounders":[326],"subgroups.":[330],"Genetic":[331],"account":[339],"part":[341],"component":[345]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
