{"id":"https://openalex.org/W2231735482","doi":"https://doi.org/10.1152/ajpcell.1993.265.3.c781","title":"Histamine stimulates a biphasic calcium response in the human tracheal epithelial cell line CF/T43","display_name":"Histamine stimulates a biphasic calcium response in the human tracheal epithelial cell line CF/T43","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W2231735482","doi":"https://doi.org/10.1152/ajpcell.1993.265.3.c781","mag":"2231735482","pmid":"https://pubmed.ncbi.nlm.nih.gov/8214034"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.1993.265.3.c781","doi":"https://doi.org/10.1152/ajpcell.1993.265.3.c781","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1993.265.3.c781","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R. A. Harris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. A. Harris","raw_affiliation_strings":["Department of Physiology, McGill University, Montreal, Quebec,Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, McGill University, Montreal, Quebec,Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056371233","display_name":"John W. Hanrahan","orcid":"https://orcid.org/0000-0001-9080-2039","observed_orcids":["https://orcid.org/0000-0001-9080-2039"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. W. Hanrahan","raw_affiliation_strings":["Department of Physiology, McGill University, Montreal, Quebec,Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, McGill University, Montreal, Quebec,Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":1.5358,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.83928162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"265","issue":"3","first_page":"C781","last_page":"C791"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.4943999946117401,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.4943999946117401,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.2069000005722046,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biphasic-calcium-response","display_name":"biphasic calcium response","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cytosolic-free-calcium","display_name":"cytosolic free calcium","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.902999997138977},{"id":"https://openalex.org/keywords/tracheal-epithelial-cells","display_name":"tracheal epithelial cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/inositol-1-4-5-trisphosphate","display_name":"inositol 1,4,5-trisphosphate","score":0.968999981880188},{"id":"https://openalex.org/keywords/histamine-h1-receptor","display_name":"histamine H1 receptor","score":0.7739999890327454},{"id":"https://openalex.org/keywords/histamine-h2-receptor","display_name":"histamine H2 receptor","score":0.9279999732971191},{"id":"https://openalex.org/keywords/histamine-h3-receptor","display_name":"histamine H3 receptor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/diphenhydramine","display_name":"diphenhydramine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mepyramine","display_name":"mepyramine","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cimetidine","display_name":"cimetidine","score":0.777999997138977},{"id":"https://openalex.org/keywords/thioperamide","display_name":"thioperamide","score":0.9769999980926514},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neomycin","display_name":"neomycin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.8831748962402344},{"id":"https://openalex.org/C2778997900","wikidata":"https://www.wikidata.org/wiki/Q7784686","display_name":"Thioperamide","level":5,"score":0.8143181204795837},{"id":"https://openalex.org/C2780719153","wikidata":"https://www.wikidata.org/wiki/Q409492","display_name":"Cimetidine","level":2,"score":0.7195435762405396},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6456494331359863},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.6190231442451477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6173263192176819},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.586426854133606},{"id":"https://openalex.org/C2779090179","wikidata":"https://www.wikidata.org/wiki/Q3800087","display_name":"Mepyramine","level":4,"score":0.5186754465103149},{"id":"https://openalex.org/C10335311","wikidata":"https://www.wikidata.org/wiki/Q309513","display_name":"Histamine H1 receptor","level":4,"score":0.5123168230056763},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.48368483781814575},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.46199965476989746},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4345962703227997},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.418820858001709},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34762081503868103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22978544235229492},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.2030167579650879},{"id":"https://openalex.org/C63180777","wikidata":"https://www.wikidata.org/wiki/Q288395","display_name":"Histamine H3 receptor","level":4,"score":0.1749274730682373},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15985164046287537},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1165279746055603}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009355","descriptor_name":"Neomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016257","descriptor_name":"Fura-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.1993.265.3.c781","doi":"https://doi.org/10.1152/ajpcell.1993.265.3.c781","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1993.265.3.c781","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:8214034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8214034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1979308798","https://openalex.org/W1994426569","https://openalex.org/W2011921884","https://openalex.org/W2015670479","https://openalex.org/W2021611583","https://openalex.org/W2021906159","https://openalex.org/W2041272659","https://openalex.org/W2048680763","https://openalex.org/W2049827739","https://openalex.org/W2057241960","https://openalex.org/W2071951434","https://openalex.org/W2080833828","https://openalex.org/W2093113620","https://openalex.org/W2113136096","https://openalex.org/W2119567499","https://openalex.org/W2134918160","https://openalex.org/W2137401824","https://openalex.org/W2181607661"],"related_works":["https://openalex.org/W2410686887","https://openalex.org/W2138533476","https://openalex.org/W1866044439","https://openalex.org/W2415712728","https://openalex.org/W2129579614","https://openalex.org/W1971631582","https://openalex.org/W2414797317","https://openalex.org/W2020010752","https://openalex.org/W2370776659","https://openalex.org/W1999285045"],"abstract_inverted_index":{"We":[0],"have":[1],"studied":[2],"the":[3,118,144,177,189,193,199,218,228,232,239,242,245,252],"cytosolic":[4],"free":[5],"Ca2+":[6,91],"concentration":[7],"([Ca2+]i)":[8],"response":[9,57,165,220],"to":[10,58,108,124,167,187,206,221,249],"histamine":[11,32,60,114,133,145,233,240,257,261],"and":[12,42,51,138,161,176,251,256,268],"other":[13],"inflammatory":[14],"mediators":[15],"in":[16,35],"a":[17,36,77,99,104,150,163],"cystic":[18],"fibrosis":[19],"tracheal":[20],"epithelial":[21],"cell":[22],"line":[23],"(CF/T43)":[24],"using":[25],"digital":[26],"fluorescence":[27],"imaging.":[28],"Brief":[29],"pulses":[30],"of":[31,66,143,192,209,231,238,244,254],"increased":[33],"[Ca2+]i":[34,195,201,219,247,264],"concentration-dependent":[37],"manner":[38],"with":[39,96,113,169],"threshold,":[40],"half-maximal,":[41],"maximal":[43],"responses":[44,258],"at":[45,153],"approximately":[46,71],"5":[47],"microM,":[48,50],"120":[49],"10":[52],"mM,":[53],"respectively.":[54],"The":[55,131,171,235],"calcium":[56],"sustained":[59],"exposure":[61],"was":[62,87,148],"markedly":[63],"biphasic,":[64],"consisting":[65],"an":[67],"early":[68],"peak":[69,80,86,101,202,248],"(to":[70],"2.4":[72],"microM":[73],"[Ca2+]i)":[74],"followed":[75,102],"by":[76,103,127],"smaller":[78],"second":[79,190,200,229,246],"that":[81,168,198,260],"lasted":[82],"45-60":[83],"s.":[84],"Neither":[85],"directly":[88],"dependent":[89],"on":[90],"influx.":[92],"In":[93],"contrast,":[94],"stimulation":[95,223],"bradykinin":[97,119,222,255],"gave":[98,162],"single":[100],"smooth":[105],"decay":[106],"back":[107],"baseline":[109],"levels.":[110],"Sustained":[111],"perfusion":[112],"did":[115,225],"not":[116,204,226],"affect":[117,227],"response,":[120,196,241],"which":[121,212],"is":[122,203],"known":[123],"be":[125],"mediated":[126],"inositol":[128],"1,4,5-trisphosphate":[129],"(IP3).":[130],"H1-type":[132],"receptor":[134,173,179],"blockers":[135],"mepyramine,":[136],"diphenhydramine,":[137],"(+)-chlorpheniramine":[139],"were":[140],"potent":[141],"antagonists":[142],"response.":[146,234],"Diphenhydramine":[147],"also":[149],"weak":[151],"agonist":[152],"high":[154],"concentrations":[155],"(>":[156],"or":[157],"=":[158],"1":[159],"mM)":[160],"biphasic":[164,236],"similar":[166],"histamine.":[170],"H2-type":[172],"blocker":[174,180],"cimetidine":[175],"H3-type":[178],"thioperamide":[181],"had":[182],"no":[183],"effect.":[184],"Indomethacin":[185],"failed":[186],"inhibit":[188],"phase":[191,230],"histamine-stimulated":[194],"suggesting":[197],"due":[205],"secondary":[207],"production":[208],"prostaglandins.":[210],"Neomycin,":[211],"inhibits":[213],"IP3":[214,267],"production,":[215],"completely":[216],"abolished":[217],"but":[224],"nature":[237],"insensitivity":[243],"neomycin,":[250],"independence":[253],"suggest":[259],"may":[262],"modulate":[263],"through":[265],"multiple":[266],"non-IP3":[269],"pathways.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
