{"id":"https://openalex.org/W2231687288","doi":"https://doi.org/10.1159/000438473","title":"Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma: A Growing Epidemic?","display_name":"Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma: A Growing Epidemic?","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2231687288","doi":"https://doi.org/10.1159/000438473","mag":"2231687288","pmid":"https://pubmed.ncbi.nlm.nih.gov/26398208"},"language":"en","primary_location":{"id":"doi:10.1159/000438473","doi":"https://doi.org/10.1159/000438473","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000438473","pdf_url":null,"source":{"id":"https://openalex.org/S61881601","display_name":"Digestive Diseases","issn_l":"0257-2753","issn":["0257-2753","1421-9875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085283718","display_name":"Adam Charles Yopp","orcid":"https://orcid.org/0000-0002-5887-5315","observed_orcids":["https://orcid.org/0000-0002-5887-5315"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam C. Yopp","raw_affiliation_strings":["Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Tex., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Tex., USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112077099","display_name":"Michael A. Choti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Choti","raw_affiliation_strings":["Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Tex., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Tex., USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":2.7433,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.91239458,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"5","first_page":"642","last_page":"647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.11089999973773956,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cryptogenic-cirrhosis","display_name":"cryptogenic cirrhosis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5950000286102295},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":1.0},{"id":"https://openalex.org/keywords/hcc-incidence","display_name":"HCC incidence","score":0.7730000019073486},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5460000038146973},{"id":"https://openalex.org/keywords/hcc-treatment","display_name":"HCC treatment","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8772797584533691},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.8669843673706055},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8471188545227051},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7855062484741211},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6315319538116455},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6247658133506775},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5654662847518921},{"id":"https://openalex.org/C2777072776","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Viral hepatitis","level":2,"score":0.5595312118530273},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.5208264589309692},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5028826594352722},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.44744449853897095},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37284722924232483},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.24885278940200806},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D058872","descriptor_name":"Epidemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000438473","doi":"https://doi.org/10.1159/000438473","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000438473","pdf_url":null,"source":{"id":"https://openalex.org/S61881601","display_name":"Digestive Diseases","issn_l":"0257-2753","issn":["0257-2753","1421-9875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases","raw_type":"journal-article"},{"id":"pmid:26398208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26398208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive diseases (Basel, Switzerland)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1622799587","https://openalex.org/W1784461125","https://openalex.org/W1975567145","https://openalex.org/W1977036235","https://openalex.org/W1979443397","https://openalex.org/W1984180526","https://openalex.org/W1988208946","https://openalex.org/W1993260392","https://openalex.org/W2001671445","https://openalex.org/W2001869632","https://openalex.org/W2010042995","https://openalex.org/W2011947342","https://openalex.org/W2016987397","https://openalex.org/W2017352677","https://openalex.org/W2029691295","https://openalex.org/W2045084840","https://openalex.org/W2061405430","https://openalex.org/W2065788317","https://openalex.org/W2071991978","https://openalex.org/W2073262537","https://openalex.org/W2085766690","https://openalex.org/W2104183837","https://openalex.org/W2127984104","https://openalex.org/W2129929395","https://openalex.org/W2144178804","https://openalex.org/W2151253117","https://openalex.org/W2163403599","https://openalex.org/W2168311757","https://openalex.org/W2321119966"],"related_works":["https://openalex.org/W2067766028","https://openalex.org/W1955840982","https://openalex.org/W2054278071","https://openalex.org/W2941193136","https://openalex.org/W2101552088","https://openalex.org/W2767241904","https://openalex.org/W1863328478","https://openalex.org/W2045399735","https://openalex.org/W2541394510","https://openalex.org/W1647583707"],"abstract_inverted_index":{"Within":[0],"developed":[1],"countries":[2],"the":[3,31,57,67,77,91],"incidence":[4,29],"of":[5,18,33,50,60,81],"hepatocellular":[6],"carcinoma":[7],"(HCC)":[8],"has":[9],"been":[10],"progressively":[11],"increasing":[12],"despite":[13],"diagnosing":[14],"fewer":[15],"new":[16],"cases":[17],"cirrhosis":[19,71,87],"linked":[20],"to":[21,43,54,84],"viral":[22,85],"hepatitis":[23],"and":[24,36,39,72,79,88,97],"alcohol":[25],"consumption.":[26],"This":[27],"increased":[28],"parallels":[30],"epidemic":[32],"morbid":[34],"obesity":[35],"metabolic":[37],"syndrome":[38],"may":[40],"be":[41],"secondary":[42],"non-alcoholic":[44,61],"steatohepatitis":[45],"(NASH)-related":[46],"HCC.":[47,99],"The":[48],"aims":[49],"this":[51],"chapter":[52],"are":[53],"(1)":[55],"define":[56],"natural":[58],"history":[59],"fatty":[62],"liver":[63],"disease/NASH,":[64],"(2)":[65],"discuss":[66],"relationship":[68],"between":[69],"cryptogenic":[70],"NASH-related":[73,82,98],"cirrhosis,":[74],"(3)":[75],"compare":[76],"presentation":[78],"treatment":[80],"HCC":[83],"hepatitis-related":[86],"(4)":[89],"identify":[90],"genetic":[92],"factors":[93],"associated":[94],"with":[95],"NASH":[96]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}