{"id":"https://openalex.org/W2231652816","doi":null,"title":"Small molecule inhibitors of lactate dehydrogenase A as an anticancer strategy","display_name":"Small molecule inhibitors of lactate dehydrogenase A as an anticancer strategy","publication_year":2015,"publication_date":"2015-01-21","ids":{"openalex":"https://openalex.org/W2231652816","mag":"2231652816"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/72952","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/72952","pdf_url":"http://hdl.handle.net/2142/72952","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2142/72952","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050328849","display_name":"Emilia C. Calvaresi","orcid":"https://orcid.org/0000-0001-7562-2988","observed_orcids":["https://orcid.org/0000-0001-7562-2988"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emilia Calvaresi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7562-2988","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5050328849"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07279378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ldha","display_name":"LDHA","score":0.9959999918937683},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.875},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.8059999942779541},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.8389999866485596},{"id":"https://openalex.org/keywords/nad-regeneration","display_name":"NAD+ regeneration","score":0.6449999809265137},{"id":"https://openalex.org/keywords/tumor-microenvironment-acidification","display_name":"tumor microenvironment acidification","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cellular-thermal-shift-assay","display_name":"cellular thermal shift assay","score":0.8460000157356262},{"id":"https://openalex.org/keywords/double-asteroid-redirection-test","display_name":"DART","score":0.9729999899864197},{"id":"https://openalex.org/keywords/glycolytic-enzymes","display_name":"glycolytic enzymes","score":0.5929999947547913},{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.4969156086444855},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4573885500431061},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3227544128894806},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21736887097358704}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/72952","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/72952","pdf_url":"http://hdl.handle.net/2142/72952","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2231652816","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/bitstream/2142/72952/1/Emilia_Calvaresi.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/72952","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/72952","pdf_url":"http://hdl.handle.net/2142/72952","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.5}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2231652816.pdf","grobid_xml":"https://content.openalex.org/works/W2231652816.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W569561726","https://openalex.org/W1536886974","https://openalex.org/W1981258651","https://openalex.org/W1993251792","https://openalex.org/W2003930217","https://openalex.org/W2017022422","https://openalex.org/W2017631560","https://openalex.org/W2034447474","https://openalex.org/W2048776985","https://openalex.org/W2063466831","https://openalex.org/W2063850127","https://openalex.org/W2070719504","https://openalex.org/W2080024320","https://openalex.org/W2084039169","https://openalex.org/W2085936959","https://openalex.org/W2086827109","https://openalex.org/W2096854682","https://openalex.org/W2101923545","https://openalex.org/W2161999722"],"related_works":["https://openalex.org/W3153890857","https://openalex.org/W2739292196","https://openalex.org/W7130546635","https://openalex.org/W6990733081","https://openalex.org/W2777087903","https://openalex.org/W2072719987","https://openalex.org/W2577430486","https://openalex.org/W2727332470","https://openalex.org/W2283268070","https://openalex.org/W2464420324"],"abstract_inverted_index":{"Embargo":[0],"set":[1],"by:":[2],"Seth":[3],"Robbins":[4],"for":[5],"item":[6],"73141":[7],"Lift":[8],"date:":[9],"2017-01-21T19:56:18Z":[10],"Reason:":[11],"Author":[12],"requested":[13],"U":[14],"of":[15],"Illinois":[16],"access":[17],"only":[18],"(OA":[19],"after":[20],"2yrs)":[21],"in":[22],"Vireo":[23],"ETD":[24],"system":[25]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}