{"id":"https://openalex.org/W2231291391","doi":null,"title":"Intercellular calcium-mediated cell signaling in keratinocytes cultured from patients with NF1 or psoriasis","display_name":"Intercellular calcium-mediated cell signaling in keratinocytes cultured from patients with NF1 or psoriasis","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2231291391","mag":"2231291391"},"language":"en","primary_location":{"id":"mag:2231291391","doi":null,"is_oa":false,"landing_page_url":"http://herkules.oulu.fi/isbn9514268040/isbn9514268040.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025149264","display_name":"Timo Korkiam\u00e4ki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Timo Korkiam\u00e4ki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025149264"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.5497999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.5497999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.18539999425411224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9459999799728394},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/calcium-waves","display_name":"calcium waves","score":0.8510000109672546},{"id":"https://openalex.org/keywords/intercellular-calcium-signaling","display_name":"intercellular calcium signaling","score":0.6869999766349792},{"id":"https://openalex.org/keywords/neurofibromin","display_name":"neurofibromin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/gap-junctions","display_name":"gap junctions","score":0.7509999871253967},{"id":"https://openalex.org/keywords/capacitative-calcium-influx","display_name":"capacitative calcium influx","score":0.9890000224113464},{"id":"https://openalex.org/keywords/extracellular-calcium-concentration","display_name":"extracellular calcium concentration","score":0.7269999980926514},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7570000290870667},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C170932241","wikidata":"https://www.wikidata.org/wiki/Q411610","display_name":"Neurofibromin 1","level":3,"score":0.8796156048774719},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5761288404464722},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5519164204597473},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.483262836933136},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.48252007365226746},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.46654391288757324},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.44650721549987793},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.44585445523262024},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4406401515007019},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.4155440032482147},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.39489102363586426},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.338978111743927},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3045688271522522},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2599413990974426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25226351618766785},{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.16520842909812927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12828102707862854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10733607411384583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09547972679138184}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2231291391","doi":null,"is_oa":false,"landing_page_url":"http://herkules.oulu.fi/isbn9514268040/isbn9514268040.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":270,"referenced_works":["https://openalex.org/W72738195","https://openalex.org/W87501499","https://openalex.org/W315514815","https://openalex.org/W358832511","https://openalex.org/W1487661416","https://openalex.org/W1497010214","https://openalex.org/W1511104911","https://openalex.org/W1511802341","https://openalex.org/W1513452909","https://openalex.org/W1543013349","https://openalex.org/W1559883839","https://openalex.org/W1563545308","https://openalex.org/W1568328657","https://openalex.org/W1573590097","https://openalex.org/W1584418808","https://openalex.org/W1586709336","https://openalex.org/W1598911721","https://openalex.org/W1602484235","https://openalex.org/W1622746725","https://openalex.org/W1665071864","https://openalex.org/W1766226639","https://openalex.org/W1789729846","https://openalex.org/W1791732177","https://openalex.org/W1800142641","https://openalex.org/W1815757713","https://openalex.org/W1831581272","https://openalex.org/W1851856540","https://openalex.org/W1874327812","https://openalex.org/W1892163163","https://openalex.org/W1912265148","https://openalex.org/W1917849988","https://openalex.org/W1930700863","https://openalex.org/W1963514792","https://openalex.org/W1963621662","https://openalex.org/W1963681491","https://openalex.org/W1966980518","https://openalex.org/W1968243333","https://openalex.org/W1968826282","https://openalex.org/W1970159513","https://openalex.org/W1970328692","https://openalex.org/W1971602793","https://openalex.org/W1971742919","https://openalex.org/W1972859998","https://openalex.org/W1974408717","https://openalex.org/W1974469880","https://openalex.org/W1974839656","https://openalex.org/W1977070397","https://openalex.org/W1977356579","https://openalex.org/W1979705438","https://openalex.org/W1980166477","https://openalex.org/W1982655823","https://openalex.org/W1982813290","https://openalex.org/W1983127589","https://openalex.org/W1983250443","https://openalex.org/W1985189445","https://openalex.org/W1985433092","https://openalex.org/W1985524929","https://openalex.org/W1985579250","https://openalex.org/W1987186315","https://openalex.org/W1987580294","https://openalex.org/W1989667983","https://openalex.org/W1990433146","https://openalex.org/W1990878803","https://openalex.org/W1991259792","https://openalex.org/W1991367422","https://openalex.org/W1992791907","https://openalex.org/W1993163893","https://openalex.org/W1994948311","https://openalex.org/W1996711982","https://openalex.org/W1996971359","https://openalex.org/W1997484127","https://openalex.org/W1998060305","https://openalex.org/W1998606603","https://openalex.org/W1999344800","https://openalex.org/W2000432320","https://openalex.org/W2000690172","https://openalex.org/W2000839363","https://openalex.org/W2002051049","https://openalex.org/W2002785473","https://openalex.org/W2002971054","https://openalex.org/W2004095370","https://openalex.org/W2005041472","https://openalex.org/W2005297217","https://openalex.org/W2007012469","https://openalex.org/W2007219916","https://openalex.org/W2007676864","https://openalex.org/W2007900684","https://openalex.org/W2007910408","https://openalex.org/W2008470915","https://openalex.org/W2010390522","https://openalex.org/W2010955929","https://openalex.org/W2013314696","https://openalex.org/W2014543453","https://openalex.org/W2014903599","https://openalex.org/W2015480034","https://openalex.org/W2016219644","https://openalex.org/W2017178896","https://openalex.org/W2017488060","https://openalex.org/W2017687824","https://openalex.org/W2017688904","https://openalex.org/W2018565553","https://openalex.org/W2019551500","https://openalex.org/W2020231002","https://openalex.org/W2022144539","https://openalex.org/W2022237108","https://openalex.org/W2022280090","https://openalex.org/W2022908241","https://openalex.org/W2022971724","https://openalex.org/W2023022110","https://openalex.org/W2023296704","https://openalex.org/W2023897144","https://openalex.org/W2024863517","https://openalex.org/W2027740042","https://openalex.org/W2028368615","https://openalex.org/W2028415754","https://openalex.org/W2028958278","https://openalex.org/W2029421760","https://openalex.org/W2029952161","https://openalex.org/W2030582314","https://openalex.org/W2032881002","https://openalex.org/W2034621434","https://openalex.org/W2036002745","https://openalex.org/W2037153421","https://openalex.org/W2037944684","https://openalex.org/W2038085058","https://openalex.org/W2038561872","https://openalex.org/W2038658125","https://openalex.org/W2040283676","https://openalex.org/W2041690080","https://openalex.org/W2042387002","https://openalex.org/W2042643687","https://openalex.org/W2042696019","https://openalex.org/W2043736479","https://openalex.org/W2043970026","https://openalex.org/W2044356784","https://openalex.org/W2044965957","https://openalex.org/W2045106617","https://openalex.org/W2046686933","https://openalex.org/W2047358686","https://openalex.org/W2047679835","https://openalex.org/W2048140690","https://openalex.org/W2048700980","https://openalex.org/W2049139595","https://openalex.org/W2050454510","https://openalex.org/W2050913576","https://openalex.org/W2051300061","https://openalex.org/W2052371969","https://openalex.org/W2052880955","https://openalex.org/W2054225000","https://openalex.org/W2054828183","https://openalex.org/W2055484203","https://openalex.org/W2055729102","https://openalex.org/W2059474107","https://openalex.org/W2059642492","https://openalex.org/W2059986841","https://openalex.org/W2061579119","https://openalex.org/W2063365585","https://openalex.org/W2063737893","https://openalex.org/W2064523064","https://openalex.org/W2064576105","https://openalex.org/W2065256692","https://openalex.org/W2065843356","https://openalex.org/W2066505046","https://openalex.org/W2067923067","https://openalex.org/W2068059093","https://openalex.org/W2068877244","https://openalex.org/W2069006282","https://openalex.org/W2069035576","https://openalex.org/W2069230499","https://openalex.org/W2069454620","https://openalex.org/W2070040548","https://openalex.org/W2070287558","https://openalex.org/W2070832223","https://openalex.org/W2071412715","https://openalex.org/W2071893342","https://openalex.org/W2072228548","https://openalex.org/W2072478579","https://openalex.org/W2073204890","https://openalex.org/W2073468932","https://openalex.org/W2073998405","https://openalex.org/W2076118871","https://openalex.org/W2076882136","https://openalex.org/W2077483652","https://openalex.org/W2078663076","https://openalex.org/W2078747821","https://openalex.org/W2079361832","https://openalex.org/W2080202616","https://openalex.org/W2082002047","https://openalex.org/W2082021300","https://openalex.org/W2086150465","https://openalex.org/W2086263346","https://openalex.org/W2086669662","https://openalex.org/W2086735876","https://openalex.org/W2086770062","https://openalex.org/W2087289859","https://openalex.org/W2089101401","https://openalex.org/W2090694642","https://openalex.org/W2090755555","https://openalex.org/W2091230333","https://openalex.org/W2091609235","https://openalex.org/W2091658990","https://openalex.org/W2092929736","https://openalex.org/W2093252544","https://openalex.org/W2093265358","https://openalex.org/W2096437759","https://openalex.org/W2098943564","https://openalex.org/W2099279074","https://openalex.org/W2099684738","https://openalex.org/W2100132948","https://openalex.org/W2101082686","https://openalex.org/W2101590930","https://openalex.org/W2108885540","https://openalex.org/W2110104914","https://openalex.org/W2112718635","https://openalex.org/W2114401576","https://openalex.org/W2118621699","https://openalex.org/W2120180603","https://openalex.org/W2123173962","https://openalex.org/W2131291777","https://openalex.org/W2135011583","https://openalex.org/W2135037844","https://openalex.org/W2135343497","https://openalex.org/W2136621573","https://openalex.org/W2138188799","https://openalex.org/W2142366643","https://openalex.org/W2142875711","https://openalex.org/W2143870059","https://openalex.org/W2145699695","https://openalex.org/W2145903182","https://openalex.org/W2146219350","https://openalex.org/W2150281941","https://openalex.org/W2151067616","https://openalex.org/W2151451197","https://openalex.org/W2151642090","https://openalex.org/W2152901500","https://openalex.org/W2154000971","https://openalex.org/W2156102625","https://openalex.org/W2158246711","https://openalex.org/W2159096148","https://openalex.org/W2160765485","https://openalex.org/W2162790635","https://openalex.org/W2164174276","https://openalex.org/W2165005676","https://openalex.org/W2166809896","https://openalex.org/W2168989575","https://openalex.org/W2169007182","https://openalex.org/W2169067272","https://openalex.org/W2170949021","https://openalex.org/W2173782103","https://openalex.org/W2174190166","https://openalex.org/W2254922455","https://openalex.org/W2286698610","https://openalex.org/W2314958098","https://openalex.org/W2323317437","https://openalex.org/W2335805269","https://openalex.org/W2337836604","https://openalex.org/W2345003741","https://openalex.org/W2406253697","https://openalex.org/W2409122136","https://openalex.org/W2412770089","https://openalex.org/W2416828931","https://openalex.org/W2417739782","https://openalex.org/W2419143470","https://openalex.org/W2420244726","https://openalex.org/W2431621434","https://openalex.org/W2437831636","https://openalex.org/W2463254347","https://openalex.org/W2799503982","https://openalex.org/W2994274795","https://openalex.org/W3026079402"],"related_works":["https://openalex.org/W2022046879","https://openalex.org/W2053909751","https://openalex.org/W2233903032","https://openalex.org/W2028386208","https://openalex.org/W2241607134","https://openalex.org/W762447490","https://openalex.org/W2015661916","https://openalex.org/W2043127179","https://openalex.org/W2086150465","https://openalex.org/W266738618"],"abstract_inverted_index":{"Neurofibromatosis":[0],"type":[1],"1":[2],"syndrome":[3],"(NF1)":[4],"is":[5,21,69,86],"caused":[6],"by":[7,71,77,103,178],"mutations":[8,224],"of":[9,32,52,55,62,64,73,80,106,117,131,191,218,225,234],"the":[10,24,30,50,65,74,129,132,188,219,226],"NF1":[11,14,39,56,66,81,154,167,212,227,235],"gene.":[12,67],"The":[13,38,115,163,216],"protein":[15,26,40],"(neurofibromin)":[16],"contains":[17],"a":[18,46,60,143,172],"domain":[19],"which":[20,139],"related":[22],"to":[23,35,44,113,136,174,184,240],"GTPase-activating":[25],"(GAP)":[27],"and":[28,76,83,95,155,156,168,205,213],"accelerates":[29],"switch":[31],"active":[33],"Ras-GTP":[34],"inactive":[36],"Ras-GDP.":[37],"has":[41],"been":[42,122],"referred":[43],"as":[45],"tumor":[47,228],"suppressor,":[48],"since":[49],"cells":[51],"malignant":[53],"schwannomas":[54],"patients":[57],"may":[58,141,237],"display":[59],"loss":[61],"heterozygosity":[63],"Psoriasis":[68],"characterized":[70,177],"hyperproliferation":[72],"epidermis":[75],"down-regulated":[78],"levels":[79,110,233],"mRNA":[82],"protein.":[84],"Ca2+":[85,146],"an":[87],"universal":[88],"signal":[89],"transduction":[90],"element":[91],"modulating":[92],"cell":[93,98,112,181],"growth":[94],"differentiation.":[96],"Many":[97],"types":[99],"coordinate":[100],"their":[101],"activities":[102],"transmitting":[104],"waves":[105,119],"elevated":[107],"intracellular":[108],"calcium":[109,118,151,202,207],"from":[111],"cell.":[114],"propagation":[116],"had":[120],"not":[121],"studied":[123],"previously":[124],"in":[125,145,153,196,211],"human":[126],"keratinocytes.":[127,162,186,198,215],"Thus,":[128],"aim":[130],"present":[133,220],"study":[134,221],"was":[135,194,209],"find":[137],"out":[138],"pathways":[140],"play":[142],"role":[144],"signaling":[147,182,193,203],"at":[148],"different":[149],"extracellular":[150],"concentrations":[152],"psoriatic":[157,169,214],"keratinocytes":[158,170],"versus":[159],"normal":[160,185,197],"control":[161],"results":[164,217],"demonstrated":[165],"that":[166,223],"have":[171],"tendency":[173],"form":[175],"cultures":[176],"altered":[179,241],"Ca2+-mediated":[180],"compared":[183],"Specifically,":[187],"main":[189],"route":[190],"calcium-mediated":[192],"gap-junctional":[195],"In":[199],"contrast,":[200],"ATP-mediated":[201],"predominated":[204],"capacitative":[206],"influx":[208],"defective":[210],"suggest":[222],"suppressor":[229],"gene":[230],"or":[231],"lowered":[232],"protein/mRNA":[236],"eventually":[238],"lead":[239],"intercellular":[242],"communication.":[243]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}