{"id":"https://openalex.org/W2231261069","doi":null,"title":"Nitrite and nitrotyrosine concentrations in articular cartilage, subchondral bone, and trabecular bone of normal juvenile, normal adult, and osteoarthritic adult equine metacarpophalangeal joints.","display_name":"Nitrite and nitrotyrosine concentrations in articular cartilage, subchondral bone, and trabecular bone of normal juvenile, normal adult, and osteoarthritic adult equine metacarpophalangeal joints.","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2231261069","mag":"2231261069","pmid":"https://pubmed.ncbi.nlm.nih.gov/16881122"},"language":"en","primary_location":{"id":"pmid:16881122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16881122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082148098","display_name":"Mark R. van der Harst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mark van der Harst","raw_affiliation_strings":["Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. markvanderharst@hetnet.nl","Department of Equine Sciences Faculty of Veterinary Medicine, Utrecht University Utrecht The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. markvanderharst@hetnet.nl","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Department of Equine Sciences Faculty of Veterinary Medicine, Utrecht University Utrecht The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025638336","display_name":"Sarah Bull","orcid":"https://orcid.org/0000-0003-1547-0569","observed_orcids":["https://orcid.org/0000-0003-1547-0569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah Bull","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087791380","display_name":"Pieter A.J. Brama","orcid":"https://orcid.org/0000-0003-3405-0551","observed_orcids":["https://orcid.org/0000-0003-3405-0551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pieter A J Brama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111688266","display_name":"A. Barneveld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A B Barneveld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067150314","display_name":"P. Ren\u00e9 van Weeren","orcid":"https://orcid.org/0000-0002-6654-1817","observed_orcids":["https://orcid.org/0000-0002-6654-1817"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Ren\u00e9 van Weeren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070135934","display_name":"Chris H.A. van de Lest","orcid":"https://orcid.org/0000-0003-2143-2825","observed_orcids":["https://orcid.org/0000-0003-2143-2825"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris van de Lest","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.722,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.8302778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"33","issue":"8","first_page":"1662","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10872","display_name":"Veterinary Equine Medical Research","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/3402","display_name":"Equine"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/equine-osteoarthritis","display_name":"equine osteoarthritis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/nitrite","display_name":"nitrite","score":0.8600000143051147},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9259999990463257},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.9710000157356262},{"id":"https://openalex.org/keywords/subchondral-bone","display_name":"subchondral bone","score":1.0},{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"trabecular bone","score":1.0},{"id":"https://openalex.org/keywords/metacarpophalangeal-joint","display_name":"metacarpophalangeal joint","score":0.8980000019073486},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7239999771118164},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.5889999866485596},{"id":"https://openalex.org/keywords/young-horses","display_name":"young horses","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.6930000185966492},{"id":"https://openalex.org/keywords/bearing-surfaces","display_name":"bearing surfaces","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8146311044692993},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7373210787773132},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6932032704353333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4451505243778229},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4190274775028229},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3843155801296234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3649168014526367},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008662","descriptor_name":"Metacarpophalangeal Joint","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008662","descriptor_name":"Metacarpophalangeal Joint","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008662","descriptor_name":"Metacarpophalangeal Joint","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16881122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16881122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"mag:2231261069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16881122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W37424924","https://openalex.org/W123183995","https://openalex.org/W589649572","https://openalex.org/W1522890520","https://openalex.org/W1775749144","https://openalex.org/W1821918060","https://openalex.org/W1883906051","https://openalex.org/W1963593333","https://openalex.org/W1964710354","https://openalex.org/W1966975416","https://openalex.org/W1967194752","https://openalex.org/W1980157244","https://openalex.org/W1981673806","https://openalex.org/W1987034833","https://openalex.org/W1988737738","https://openalex.org/W1990068732","https://openalex.org/W1990802251","https://openalex.org/W2001270166","https://openalex.org/W2012744172","https://openalex.org/W2013395096","https://openalex.org/W2014296063","https://openalex.org/W2018428699","https://openalex.org/W2019249650","https://openalex.org/W2019433800","https://openalex.org/W2021862667","https://openalex.org/W2026742645","https://openalex.org/W2040856583","https://openalex.org/W2040879571","https://openalex.org/W2053108974","https://openalex.org/W2054221638","https://openalex.org/W2057509009","https://openalex.org/W2068711793","https://openalex.org/W2071823872","https://openalex.org/W2074016034","https://openalex.org/W2090593219","https://openalex.org/W2093665893","https://openalex.org/W2109385120","https://openalex.org/W2127874165","https://openalex.org/W2135740279","https://openalex.org/W2394660791"],"related_works":["https://openalex.org/W2100139721","https://openalex.org/W7046462898","https://openalex.org/W4234944174","https://openalex.org/W2044397338","https://openalex.org/W2356501336","https://openalex.org/W2372885907","https://openalex.org/W1927395281","https://openalex.org/W1964665919","https://openalex.org/W1541386572","https://openalex.org/W1972426221"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Osteoarthritis":[1],"(OA)":[2],"is":[3,15,290],"a":[4,78,249,257,299],"chronic":[5],"debilitating":[6],"joint":[7,247],"disorder":[8],"in":[9,41,56,86,163,184,204,220,280,292,304],"which":[10],"the":[11,22,26,33,42,61,65,92,97,102,149,158,234,239,242,246,305,308],"importance":[12],"of":[13,36,45,64,70,96,101,105,179,189,207,223,241,245,260,283,301,307],"inflammation":[14],"increasingly":[16],"recognized.":[17],"In":[18,154],"advanced":[19],"cases,":[20],"both":[21],"articular":[23,87,99],"cartilage":[24,144,185],"and":[25,38,72,82,91,128,171,186,271,297],"underlying":[27,93],"bony":[28],"layers":[29,58,157,237],"are":[30],"affected,":[31],"but":[32,217,264],"exact":[34],"sequence":[35],"events":[37],"their":[39],"localization":[40],"initial":[43],"phase":[44],"pathogenesis":[46],"remain":[47],"uncertain.":[48],"We":[49],"measured":[50,85],"nitric":[51],"oxide":[52],"(NO)":[53],"end":[54],"products":[55],"tissue":[57,236,261],"that":[59,287],"constitute":[60],"bearing":[62,243],"surface":[63,100,244],"joint,":[66],"as":[67,77,146,248],"possible":[68],"indicators":[69],"physiological":[71,268],"pathological":[73,272],"processes.":[74,275],"METHODS:":[75],"Nitrite":[76,252],"measure":[79],"for":[80],"NO":[81],"nitrotyrosine":[83,278],"was":[84,161,181],"cartilage,":[88],"subchondral":[89,170,187,205,281],"bone,":[90,173],"trabecular":[94,172,221],"bone":[95,188,206,222,282],"proximal":[98],"first":[103],"phalanx":[104],"healthy":[106,212],"mature":[107,116,194],"horses":[108,117,131,191,195,209,225],"(n":[109,121,132],"=":[110,122,133],"15;":[111,123],"age":[112,124,135],"range":[113,125,136],"5-18":[114],"yrs),":[115,127],"affected":[118],"by":[119,148],"OA":[120,164,208],"8-22":[126],"unaffected":[129],"juvenile":[130,190,224],"13;":[134],"6":[137],"months-4":[138],"yrs).":[139],"Data":[140],"were":[141,201],"correlated":[142],"with":[143,193,211],"damage,":[145],"quantified":[147],"Cartilage":[150],"Degeneration":[151],"Index.":[152],"RESULTS:":[153],"all":[155],"3":[156,235],"nitrite":[159,180],"concentration":[160,178,253],"higher":[162,183,203],"joints":[165],"(cartilage,":[166],"p":[167,174],"<":[168,175,197,215,227],"0.001;":[169],"0.05).":[176],"The":[177,230,276],"significantly":[182,202,218],"compared":[192,210],"(p":[196,214,226],"0.001).":[198],"Nitrotyrosine":[199],"concentrations":[200],"controls":[213],"0.001),":[216],"lower":[219],"0.01).":[228],"CONCLUSION:":[229],"similarities":[231],"observed":[232],"over":[233],"support":[238],"concept":[240],"functional":[250],"entity.":[251],"seems":[254],"to":[255],"be":[256],"good":[258],"indicator":[259],"metabolic":[262],"activity,":[263],"cannot":[265],"discriminate":[266],"between":[267],"(juvenile":[269],"animals)":[270],"(OA":[273],"cases)":[274],"increased":[277],"levels":[279],"OA-affected":[284],"animals":[285],"suggest":[286],"this":[288],"layer":[289],"important":[291],"early":[293],"or":[294],"moderate":[295],"OA,":[296],"implies":[298],"role":[300],"oxidative":[302],"stress":[303],"development":[306],"disease.":[309]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
