{"id":"https://openalex.org/W22305678","doi":"https://doi.org/10.4049/jimmunol.178.supp.b112","title":"TSLP-TSLPR interactions regulate CD4+ T cell-dependent immunity and inflammation in the intestine (B112)","display_name":"TSLP-TSLPR interactions regulate CD4+ T cell-dependent immunity and inflammation in the intestine (B112)","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W22305678","doi":"https://doi.org/10.4049/jimmunol.178.supp.b112","mag":"22305678"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.178.supp.b112","doi":"https://doi.org/10.4049/jimmunol.178.supp.b112","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.b112","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002549481","display_name":"Betsy C. Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betsy C Taylor","raw_affiliation_strings":["Pathobiology, university of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104","1Pathobiology, university of Pennsylvania, 380 South University Ave, Philadelphia, PA, 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathobiology, university of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"1Pathobiology, university of Pennsylvania, 380 South University Ave, Philadelphia, PA, 19104,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050096713","display_name":"Colby Zaph","orcid":"https://orcid.org/0000-0002-9889-9848","observed_orcids":["https://orcid.org/0000-0002-9889-9848"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colby Zaph","raw_affiliation_strings":["Pathobiology, university of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104","1Pathobiology, university of Pennsylvania, 380 South University Ave, Philadelphia, PA, 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathobiology, university of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"1Pathobiology, university of Pennsylvania, 380 South University Ave, Philadelphia, PA, 19104,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080814280","display_name":"Amy E. Troy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Troy","raw_affiliation_strings":["Pathobiology, university of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104","1Pathobiology, university of Pennsylvania, 380 South University Ave, Philadelphia, PA, 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathobiology, university of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"1Pathobiology, university of Pennsylvania, 380 South University Ave, Philadelphia, PA, 19104,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059929283","display_name":"Lisa D. Berman-Booty","orcid":"https://orcid.org/0000-0002-4421-142X","observed_orcids":["https://orcid.org/0000-0002-4421-142X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Berman-Booty","raw_affiliation_strings":["Pathobiology, university of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104","1Pathobiology, university of Pennsylvania, 380 South University Ave, Philadelphia, PA, 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathobiology, university of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"1Pathobiology, university of Pennsylvania, 380 South University Ave, Philadelphia, PA, 19104,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083984647","display_name":"Yurong Du","orcid":"https://orcid.org/0009-0008-7784-6510","observed_orcids":["https://orcid.org/0009-0008-7784-6510"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yurong Du","raw_affiliation_strings":["Pathobiology, University of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathobiology, University of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005500510","display_name":"David Artis","orcid":"https://orcid.org/0000-0002-1753-4100","observed_orcids":["https://orcid.org/0000-0002-1753-4100","https://orcid.org/0000-0003-3608-1044"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Artis","raw_affiliation_strings":["Pathobiology, university of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104","1Pathobiology, university of Pennsylvania, 380 South University Ave, Philadelphia, PA, 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathobiology, university of Pennsylvania , 380 South University Ave, Philadelphia, PA, 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"1Pathobiology, university of Pennsylvania, 380 South University Ave, Philadelphia, PA, 19104,","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"178","issue":"1_Supplement","first_page":"LB23","last_page":"LB23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.6596999764442444,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.6596999764442444,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.2184000015258789,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymic-stromal-lymphopoietin","display_name":"thymic stromal lymphopoietin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tslp-receptor","display_name":"TSLP receptor","score":0.8849999904632568},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cd4-t-cell-immunity","display_name":"CD4+ T cell immunity","score":0.6830000281333923},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.9079999923706055},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9049999713897705},{"id":"https://openalex.org/keywords/il-12-23p40","display_name":"IL-12/23p40","score":0.9700000286102295},{"id":"https://openalex.org/keywords/gut-associated-lymphoid-tissue","display_name":"gut-associated lymphoid tissue","score":0.7919999957084656},{"id":"https://openalex.org/keywords/intestinal-nematode-infection","display_name":"intestinal nematode infection","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2778070265","wikidata":"https://www.wikidata.org/wiki/Q18048067","display_name":"Thymic stromal lymphopoietin","level":3,"score":0.873409628868103},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7426542043685913},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6938597559928894},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6678237318992615},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5603867769241333},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.506372332572937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4627295732498169},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.46066537499427795},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44626399874687195},{"id":"https://openalex.org/C2779861936","wikidata":"https://www.wikidata.org/wiki/Q738375","display_name":"Trichuris","level":3,"score":0.43296879529953003},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.4104643166065216},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18100574612617493},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.084967702627182},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05307275056838989},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.178.supp.b112","doi":"https://doi.org/10.4049/jimmunol.178.supp.b112","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.b112","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W77834560","https://openalex.org/W2137561439","https://openalex.org/W1490955585","https://openalex.org/W2052281931","https://openalex.org/W1641771393","https://openalex.org/W1992740365","https://openalex.org/W2140299259","https://openalex.org/W1593640666","https://openalex.org/W2063466198","https://openalex.org/W2159760583"],"abstract_inverted_index":{"Abstract":[0],"Thymic":[1],"stromal":[2],"lymphopoeitin":[3],"(TSLP)":[4],"is":[5],"an":[6,61],"IL-7-like":[7],"cytokine":[8],"expressed":[9],"by":[10],"epithelial":[11],"cells":[12,105],"that":[13,189],"has":[14,41],"been":[15,43],"implicated":[16],"in":[17,22,33,38,63,76,96,171,183,186],"promoting":[18],"Th2":[19,94],"cytokine-dependent":[20],"inflammation":[21,37],"the":[23,28,39,48,70,77,97,146,187,191],"skin":[24],"and":[25,80,101,116],"lung.":[26],"However,":[27],"role":[29,72,179],"of":[30,65,73,92,150,162,193],"IEC-derived":[31,134],"TSLP":[32,66,135],"regulating":[34],"immunity":[35],"and/or":[36],"intestine":[40,188],"not":[42],"tested.":[44],"Following":[45],"exposure":[46],"to":[47],"intestinal-dwelling":[49],"nematode":[50],"pathogen":[51],"Trichuris,":[52],"IECs":[53],"isolated":[54,106,144],"from":[55,107,145],"genetically":[56],"resistant":[57],"C57BL/6":[58],"mice":[59,82,89,109,118,125,152],"exhibit":[60],"upregulation":[62],"expression":[64,91,192],"mRNA.":[67],"To":[68],"address":[69],"functional":[71],"TSLP-TSLPR":[74,181],"interactions":[75,182],"intestine,":[78],"WT":[79,88,114,157,163],"TSLPR\u2212/\u2212":[81,108,124,151],"were":[83],"infected":[84,123],"with":[85,141,165],"Trichuris.":[86],"While":[87],"exhibited":[90,153],"Trichuris-specific":[93],"cytokines":[95],"mesenteric":[98],"LN":[99],"(mLN)":[100],"cleared":[102],"infection,":[103],"mLN":[104],"secreted":[110],"increased":[111],"IFN\u03b3":[112],"over":[113],"controls":[115],"these":[117,175],"harbored":[119],"persistent":[120],"infection.":[121],"Further,":[122],"developed":[126],"infection-induced":[127],"intestinal":[128],"inflammation.":[129],"In":[130,159],"vitro":[131],"studies":[132,176],"suggest":[133],"can":[136],"influence":[137],"DC":[138,143],"function.":[139],"Consistent":[140],"this,":[142],"gut-associated":[147],"lymphoid":[148],"tissue":[149],"more":[154],"IL-12/23p40":[155,170],"than":[156],"DC.":[158],"addition,":[160],"conditioning":[161],"BMDC":[164],"rTSLP":[166],"inhibited":[167],"LPS":[168],"induced":[169],"vitro.":[172],"Taken":[173],"together,":[174],"implicate":[177],"a":[178],"for":[180],"IEC-DC":[184],"cross-talk":[185],"limits":[190],"proinflammatory":[194],"cytokines.":[195]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}