{"id":"https://openalex.org/W223048943","doi":null,"title":"Low Dose Amphetamine Exposure in Adolescence Cross-Sensitizes Adult Mice to Methamphetamine","display_name":"Low Dose Amphetamine Exposure in Adolescence Cross-Sensitizes Adult Mice to Methamphetamine","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W223048943","mag":"223048943"},"language":"en","primary_location":{"id":"mag:223048943","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.northgeorgia.edu/cgi/viewcontent.cgi?article=1004&context=honors_theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051734157","display_name":"Benjamin C. Darnell","orcid":"https://orcid.org/0000-0002-3962-0544","observed_orcids":["https://orcid.org/0000-0002-3962-0544"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Benjamin C Darnell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5051734157"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00124203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amphetamine","display_name":"amphetamine","score":0.8539999723434448},{"id":"https://openalex.org/keywords/methamphetamine","display_name":"methamphetamine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cross-sensitization","display_name":"cross-sensitization","score":0.875},{"id":"https://openalex.org/keywords/behavioral-sensitization","display_name":"behavioral sensitization","score":0.9819999933242798},{"id":"https://openalex.org/keywords/adolescent-drug-exposure","display_name":"adolescent drug exposure","score":0.7829999923706055},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.414000004529953},{"id":"https://openalex.org/keywords/stimulant-dependence","display_name":"stimulant use disorder","score":0.7170000076293945},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9079999923706055},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.7639999985694885},{"id":"https://openalex.org/keywords/open-field-behavior","display_name":"open field behavior","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.8772671222686768},{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.8162987232208252},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6737308502197266},{"id":"https://openalex.org/C50610925","wikidata":"https://www.wikidata.org/wiki/Q1136816","display_name":"Habituation","level":2,"score":0.6474038362503052},{"id":"https://openalex.org/C2780557958","wikidata":"https://www.wikidata.org/wiki/Q211036","display_name":"Stimulant","level":2,"score":0.6321096420288086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5223397016525269},{"id":"https://openalex.org/C3019662062","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Behavioral sensitization","level":4,"score":0.48823311924934387},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.4718708395957947},{"id":"https://openalex.org/C35124327","wikidata":"https://www.wikidata.org/wiki/Q5159285","display_name":"Conditioned place preference","level":3,"score":0.4649796187877655},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.4313928186893463},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39144933223724365},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39012545347213745},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3385747969150543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32215625047683716},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2965611219406128},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2139447033405304},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1656273901462555},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.13023895025253296},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.12499308586120605},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.11667013168334961}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:223048943","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.northgeorgia.edu/cgi/viewcontent.cgi?article=1004&context=honors_theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1579693295","https://openalex.org/W1608909611","https://openalex.org/W1920650151","https://openalex.org/W1938905574","https://openalex.org/W1980789245","https://openalex.org/W1990790222","https://openalex.org/W2013117639","https://openalex.org/W2016899938","https://openalex.org/W2043515921","https://openalex.org/W2064756289","https://openalex.org/W2089471117","https://openalex.org/W2092126179","https://openalex.org/W2102081573","https://openalex.org/W2104492171","https://openalex.org/W2105001140","https://openalex.org/W2113070351","https://openalex.org/W2156623614","https://openalex.org/W2162097305"],"related_works":["https://openalex.org/W2089471117","https://openalex.org/W215426501","https://openalex.org/W4280517322","https://openalex.org/W2606930858","https://openalex.org/W335485851","https://openalex.org/W4308043111","https://openalex.org/W2903639348","https://openalex.org/W2037898221","https://openalex.org/W2008321609","https://openalex.org/W2602120775"],"abstract_inverted_index":{"Amphetamine":[0,311],"(AMPH)":[1],"is":[2,54,67,94,136,194],"a":[3,55,60,68,97,112,116,142,235,247],"central":[4],"nervous":[5],"system":[6],"stimulant":[7],"and":[8,65,124,158,246],"an":[9,34,46,210],"effective":[10],"treatment":[11],"for":[12,126,182],"ADHD":[13],"among":[14],"adolescents,":[15],"in":[16,23,36,79,104,130,202,209,279],"the":[17,24,37,138,146,197,225,258,262,274,282,304],"form":[18],"of":[19,26,28,39,49,71,82,99,120,141,173,196,199,241,266,277],"Adderall\uf0d2.":[20],"The":[21],"rise":[22],"number":[25],"diagnoses":[27],"this":[29,105,155],"disorder,":[30],"however,":[31],"comes":[32],"with":[33,87,164,180,222],"increase":[35],"possibility":[38],"wrongful":[40],"AMPH":[41,50,121,144,200,267,307],"prescription":[42],"as":[43,45,96],"well":[44],"increased":[47,271,295],"prevalence":[48],"abuse.":[51],"Behavioral":[52],"sensitization":[53,272,296],"heightened":[56],"behavioral":[57,69,85],"response":[58],"to":[59,110,128,224,256,273,285,299],"drug":[61],"after":[62],"repeated":[63],"exposure,":[64],"it":[66],"expression":[70],"neurological":[72,75],"changes.":[73],"These":[74],"changes":[76],"are":[77],"important":[78],"current":[80,147],"models":[81],"addiction,":[83],"so":[84],"cross-sensitization":[86,127],"similarly":[88],"acting":[89],"drugs":[90],"(e.g.,":[91],"methamphetamine":[92],"(METH))":[93],"useful":[95],"measure":[98],"addiction.":[100],"A":[101],"previous":[102],"study":[103,148],"lab":[106],"exposed":[107,255,284],"adolescent":[108],"mice":[109,161,283,292],"either":[111,165,234,257],"1.0":[113,134,263,305],"mg/kg":[114,118,135,172,260,264,306],"or":[115,170,179,244,261],"10":[117],"dose":[119,240,265,276],"during":[122,185,268],"adolescence":[123,186,269],"tested":[125],"METH":[129,242,278],"adulthood.":[131],"Considering":[132],"that":[133,253],"at":[137,303],"higher":[139],"end":[140],"therapeutic":[143],"dose,":[145],"examines":[149],"more":[150],"clinically":[151],"relevant":[152],"doses.":[153],"In":[154],"study,":[156],"male":[157],"female":[159],"C57B1/6J":[160],"were":[162,254],"injected":[163],"0.01":[166],"mg/kg,":[167,169],"0.1":[168,259],"1":[171],"dextro-AMPH":[174],"(Sigma-Aldrich,":[175],"St.":[176],"Louis,":[177],"MO)":[178],"saline":[181,245,286],"ten":[183],"days":[184],"beginning":[187],"on":[188],"postnatal":[189],"(P)":[190],"day":[191],"22.":[192],"Dextro-AMPH":[193],"one":[195],"forms":[198],"found":[201],"Adderall\u00ae.":[203],"On":[204],"P90,":[205],"they":[206],"began":[207,221],"testing":[208,226],"open":[211],"field":[212],"chamber":[213],"(OFC;":[214],"Kinder":[215],"Scientific,":[216],"Poway,":[217],"CA).":[218],"Each":[219],"experiment":[220],"acclimation":[223],"environment":[227],"over":[228],"30min":[229],"(i.e.,":[230],"habituation)":[231],"followed":[232],"by":[233],"sub-acute":[236,275],"(0.5mg/kg),":[237],"i.p.":[238],"challenge":[239],"(Sigma)":[243],"70min":[248],"OFC":[249],"test":[250],"session.":[251],"Mice":[252],"demonstrated":[270,294],"adulthood":[280],"while":[281],"had":[287],"no":[288],"such":[289],"response.":[290],"Male":[291],"also":[293],"when":[297],"compared":[298],"females,":[300],"but":[301],"only":[302],"dose.":[308],"Low":[309],"Dose":[310],"4":[312]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
