{"id":"https://openalex.org/W2230330403","doi":null,"title":"Divergent roles for the ERK1/2 signaling pathway in neuronal oxidative stress","display_name":"Divergent roles for the ERK1/2 signaling pathway in neuronal oxidative stress","publication_year":2006,"publication_date":"2006-09-29","ids":{"openalex":"https://openalex.org/W2230330403","mag":"2230330403"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:8679","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/8679/1/Luo_ETD_2006_Final.pdf","pdf_url":"https://d-scholarship.pitt.edu/8679/1/Luo_ETD_2006_Final.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032087542","display_name":"Yue Luo","orcid":"https://orcid.org/0000-0002-9934-5839","observed_orcids":["https://orcid.org/0000-0002-9934-5839"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yue Luo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9934-5839","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5032087542"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.39399999380111694,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.39399999380111694,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.2101999968290329,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.10029999911785126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9850000143051147},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.7829999923706055},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9129999876022339},{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/gamma-glutamylcysteine-synthetase","display_name":"gamma-glutamylcysteine synthetase","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cysteine-depletion","display_name":"cysteine depletion","score":0.9470000267028809},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9179999828338623},{"id":"https://openalex.org/keywords/mek1-2","display_name":"MEK1/2","score":0.7630000114440918},{"id":"https://openalex.org/keywords/ht22-cells","display_name":"HT22 cells","score":0.777999997138977},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.6769999861717224},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6320000290870667},{"id":"https://openalex.org/keywords/erk-nuclear-translocation","display_name":"ERK nuclear translocation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.7315096855163574},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7230874300003052},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.714092493057251},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5966364741325378},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5371909737586975},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5098847150802612},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.47091031074523926},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.46987444162368774},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4678303301334381},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.45656120777130127},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4372524917125702},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.43221762776374817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3513845205307007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3482632040977478},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1992390751838684},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1570003628730774},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:8679","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/8679/1/Luo_ETD_2006_Final.pdf","pdf_url":"https://d-scholarship.pitt.edu/8679/1/Luo_ETD_2006_Final.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:2230330403","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/8679/1/Luo_ETD_2006_Final.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":268,"referenced_works":["https://openalex.org/W111824266","https://openalex.org/W1223981148","https://openalex.org/W1480984787","https://openalex.org/W1486333767","https://openalex.org/W1487093108","https://openalex.org/W1493632498","https://openalex.org/W1498901682","https://openalex.org/W1501657654","https://openalex.org/W1518284854","https://openalex.org/W1529774113","https://openalex.org/W1530284699","https://openalex.org/W1531305298","https://openalex.org/W1535345009","https://openalex.org/W1536483289","https://openalex.org/W1538128477","https://openalex.org/W1548706173","https://openalex.org/W1566451495","https://openalex.org/W1572526443","https://openalex.org/W1578882407","https://openalex.org/W1584917605","https://openalex.org/W1596013286","https://openalex.org/W1669355361","https://openalex.org/W1721669572","https://openalex.org/W1791420399","https://openalex.org/W1854163003","https://openalex.org/W1862623246","https://openalex.org/W1884792319","https://openalex.org/W1891967301","https://openalex.org/W1935475606","https://openalex.org/W1940436875","https://openalex.org/W1942154378","https://openalex.org/W1950417202","https://openalex.org/W1954347758","https://openalex.org/W1964000772","https://openalex.org/W1964671322","https://openalex.org/W1964844927","https://openalex.org/W1965715262","https://openalex.org/W1965869866","https://openalex.org/W1965872376","https://openalex.org/W1966327998","https://openalex.org/W1967318257","https://openalex.org/W1967357725","https://openalex.org/W1967400782","https://openalex.org/W1969294711","https://openalex.org/W1970881264","https://openalex.org/W1971090593","https://openalex.org/W1971465028","https://openalex.org/W1971597564","https://openalex.org/W1972331889","https://openalex.org/W1972863039","https://openalex.org/W1973141016","https://openalex.org/W1973198505","https://openalex.org/W1973610571","https://openalex.org/W1973988298","https://openalex.org/W1974185176","https://openalex.org/W1975481676","https://openalex.org/W1975513971","https://openalex.org/W1975823509","https://openalex.org/W1976230136","https://openalex.org/W1976270928","https://openalex.org/W1976385326","https://openalex.org/W1976955003","https://openalex.org/W1977945477","https://openalex.org/W1978733364","https://openalex.org/W1978916589","https://openalex.org/W1979024805","https://openalex.org/W1979630577","https://openalex.org/W1980056037","https://openalex.org/W1980900081","https://openalex.org/W1981593838","https://openalex.org/W1981664055","https://openalex.org/W1981705617","https://openalex.org/W1981757532","https://openalex.org/W1982651451","https://openalex.org/W1985442766","https://openalex.org/W1987355375","https://openalex.org/W1987785848","https://openalex.org/W1988264669","https://openalex.org/W1990065094","https://openalex.org/W1990362370","https://openalex.org/W1990598806","https://openalex.org/W1991222835","https://openalex.org/W1991265255","https://openalex.org/W1991865867","https://openalex.org/W1991973951","https://openalex.org/W1994148496","https://openalex.org/W1994662389","https://openalex.org/W1995819749","https://openalex.org/W1996886208","https://openalex.org/W1997265216","https://openalex.org/W1998801948","https://openalex.org/W1999357946","https://openalex.org/W2001276434","https://openalex.org/W2001399513","https://openalex.org/W2001447031","https://openalex.org/W2001521752","https://openalex.org/W2002831133","https://openalex.org/W2003867505","https://openalex.org/W2004922458","https://openalex.org/W2005069084","https://openalex.org/W2005390388","https://openalex.org/W2005568856","https://openalex.org/W2006311748","https://openalex.org/W2007411105","https://openalex.org/W2008357339","https://openalex.org/W2008497452","https://openalex.org/W2009620784","https://openalex.org/W2010095588","https://openalex.org/W2011371104","https://openalex.org/W2012797849","https://openalex.org/W2014029333","https://openalex.org/W2014719547","https://openalex.org/W2014928920","https://openalex.org/W2015162533","https://openalex.org/W2015654065","https://openalex.org/W2016377732","https://openalex.org/W2017543176","https://openalex.org/W2018260609","https://openalex.org/W2019438547","https://openalex.org/W2019458917","https://openalex.org/W2019870824","https://openalex.org/W2020583309","https://openalex.org/W2020622209","https://openalex.org/W2021777993","https://openalex.org/W2022183036","https://openalex.org/W2023051284","https://openalex.org/W2023474400","https://openalex.org/W2023627397","https://openalex.org/W2026729610","https://openalex.org/W2027881600","https://openalex.org/W2028766244","https://openalex.org/W2029083682","https://openalex.org/W2032833360","https://openalex.org/W2033802853","https://openalex.org/W2033828028","https://openalex.org/W2034720665","https://openalex.org/W2034733528","https://openalex.org/W2036147144","https://openalex.org/W2036352622","https://openalex.org/W2037127584","https://openalex.org/W2038743154","https://openalex.org/W2041453347","https://openalex.org/W2043033966","https://openalex.org/W2043289488","https://openalex.org/W2043353183","https://openalex.org/W2044001092","https://openalex.org/W2044016951","https://openalex.org/W2044695362","https://openalex.org/W2045753882","https://openalex.org/W2046074852","https://openalex.org/W2046757730","https://openalex.org/W2048475061","https://openalex.org/W2050512725","https://openalex.org/W2051344987","https://openalex.org/W2052325227","https://openalex.org/W2052853635","https://openalex.org/W2053291096","https://openalex.org/W2053350368","https://openalex.org/W2054612378","https://openalex.org/W2055655639","https://openalex.org/W2057021422","https://openalex.org/W2058889292","https://openalex.org/W2059240823","https://openalex.org/W2059826462","https://openalex.org/W2059986551","https://openalex.org/W2060040606","https://openalex.org/W2060090078","https://openalex.org/W2062124189","https://openalex.org/W2065730275","https://openalex.org/W2066439205","https://openalex.org/W2070001154","https://openalex.org/W2070027885","https://openalex.org/W2070425167","https://openalex.org/W2076785040","https://openalex.org/W2076935230","https://openalex.org/W2078336944","https://openalex.org/W2078935283","https://openalex.org/W2079289532","https://openalex.org/W2080435498","https://openalex.org/W2080636088","https://openalex.org/W2080941377","https://openalex.org/W2082171751","https://openalex.org/W2082184369","https://openalex.org/W2082209194","https://openalex.org/W2082255376","https://openalex.org/W2082627560","https://openalex.org/W2083165373","https://openalex.org/W2086062763","https://openalex.org/W2088947382","https://openalex.org/W2089032508","https://openalex.org/W2089843401","https://openalex.org/W2091362651","https://openalex.org/W2091364041","https://openalex.org/W2093090474","https://openalex.org/W2093935707","https://openalex.org/W2093950888","https://openalex.org/W2094302444","https://openalex.org/W2095378987","https://openalex.org/W2096043276","https://openalex.org/W2096386031","https://openalex.org/W2099787805","https://openalex.org/W2103131046","https://openalex.org/W2105536017","https://openalex.org/W2106042714","https://openalex.org/W2110356212","https://openalex.org/W2110402980","https://openalex.org/W2114781493","https://openalex.org/W2115338196","https://openalex.org/W2117551116","https://openalex.org/W2121802881","https://openalex.org/W2122057254","https://openalex.org/W2126399632","https://openalex.org/W2127620446","https://openalex.org/W2130242881","https://openalex.org/W2132480056","https://openalex.org/W2133451731","https://openalex.org/W2134703818","https://openalex.org/W2135250775","https://openalex.org/W2135655204","https://openalex.org/W2138082567","https://openalex.org/W2138315398","https://openalex.org/W2139956257","https://openalex.org/W2142800498","https://openalex.org/W2144171223","https://openalex.org/W2145391370","https://openalex.org/W2147049445","https://openalex.org/W2148464749","https://openalex.org/W2150083975","https://openalex.org/W2151387909","https://openalex.org/W2154556168","https://openalex.org/W2155324869","https://openalex.org/W2156655462","https://openalex.org/W2156666782","https://openalex.org/W2156945415","https://openalex.org/W2157630627","https://openalex.org/W2158065294","https://openalex.org/W2158439853","https://openalex.org/W2158719307","https://openalex.org/W2161584310","https://openalex.org/W2161965319","https://openalex.org/W2161982997","https://openalex.org/W2163393328","https://openalex.org/W2163431685","https://openalex.org/W2163952666","https://openalex.org/W2164036989","https://openalex.org/W2165090556","https://openalex.org/W2165468754","https://openalex.org/W2166155593","https://openalex.org/W2168395641","https://openalex.org/W2168659826","https://openalex.org/W2169294911","https://openalex.org/W2169714384","https://openalex.org/W2170356260","https://openalex.org/W2171234592","https://openalex.org/W2171319214","https://openalex.org/W2171864779","https://openalex.org/W2172011217","https://openalex.org/W2174879024","https://openalex.org/W2175835252","https://openalex.org/W2175898172","https://openalex.org/W2184733840","https://openalex.org/W2199486122","https://openalex.org/W2289623110","https://openalex.org/W2307916770","https://openalex.org/W2317448591","https://openalex.org/W2405894049","https://openalex.org/W2415645842","https://openalex.org/W4319053763"],"related_works":["https://openalex.org/W1985133272","https://openalex.org/W2135250775","https://openalex.org/W93358848","https://openalex.org/W1990362370","https://openalex.org/W2146267072","https://openalex.org/W2151839601","https://openalex.org/W58084357","https://openalex.org/W1992090578","https://openalex.org/W75971021","https://openalex.org/W1988264669"],"abstract_inverted_index":{"In":[0,73],"the":[1,24,80,95,225],"mouse":[2],"HT22":[3,67,131,171,191,249,329],"hippocampal":[4],"cell":[5,40,184,250],"line":[6],"and":[7,23,51,69,87,138,162,176,206,212,309,339,341],"immature":[8,70],"primary":[9,71],"cortical":[10],"neurons,":[11],"excessive":[12],"glutamate":[13,62,127,182,210,237,257,277],"treatment":[14,211,278],"results":[15,137,299],"in":[16,66,129,170,190,306],"intracellular":[17,295],"cysteine":[18,296],"depletion,":[19],"subsequent":[20,342],"glutathione":[21,285,321],"loss":[22],"steady":[25],"accumulation":[26],"of":[27,34,54,79,102,119,124,150,188,209,228,235,265,270,284,294,312,336,344],"reactive":[28],"oxygen":[29],"species":[30],"(ROS).":[31],"This":[32],"form":[33],"oxidative":[35,64,105,146,185,254,332],"stress":[36,106,255],"ultimately":[37],"leads":[38],"to":[39,233,247,253,292,319],"death.":[41],"Previous":[42],"data":[43,134],"from":[44,113,331],"our":[45],"laboratory":[46],"had":[47],"shown":[48],"that":[49,117,140,157,224,288,301],"delayed":[50],"persistent":[52],"activation":[53,86,101,142,161,177,234,243,272,325],"extracellular":[55],"signal-regulated":[56],"kinases-1/2":[57],"(ERK1/2)":[58],"is":[59,143,178,231,260,279],"associated":[60],"with":[61,198],"induced":[63,91,158,183,258],"toxicity":[65,128,169,259,333],"cells":[68,89,192,330],"neurons.":[72],"addition,":[74],"U0126,":[75],"a":[76,120,151,194,213,282],"specific":[77],"inhibitor":[78],"ERK-activating":[81],"kinase,":[82],"MEK-1/2,":[83],"inhibits":[84],"ERK":[85,103,160],"prevents":[88],"death":[90],"by":[92,244,281,326],"glutamate.":[93],"However":[94,148],"mechanisms":[96],"responsible":[97],"for":[98,145,181],"this":[99,114],"chronic":[100],"during":[104],"have":[107],"not":[108,167,179],"been":[109],"well":[110],"characterized.":[111],"Results":[112],"thesis":[115],"demonstrated":[116],"overexpression":[118,149],"dominant":[121],"negative":[122],"mutant":[123],"MEK1":[125],"blocked":[126],"transfected":[130],"cells.":[132,172],"These":[133],"confirmed":[135],"previous":[136],"illustrated":[139],"ERK1/2":[141,174,189,229,242,271,324],"necessary":[144],"toxicity.":[147,186],"constitutively":[152],"active":[153],"MEK1ERK":[154],"chimera":[155],"(LA-MEK1ERK2)":[156],"robust":[159],"translocation":[163],"into":[164],"nucleus":[165],"did":[166],"trigger":[168],"Thus,":[173,323],"phosphorylation":[175],"sufficient":[180],"Activation":[187],"has":[193],"distinct":[195],"kinetic":[196],"profile":[197],"an":[199,248],"initial":[200,226],"peak":[201,215],"occurring":[202],"between":[203],"30":[204],"minutes":[205],"1":[207],"hour":[208],"second":[214],"typically":[216],"emerging":[217],"after":[218,276],"6":[219],"hours.":[220],"I":[221,240],"demonstrate":[222],"here":[223],"phase":[227],"induction":[230],"due":[232,291],"metabotropic":[236],"receptor":[238],"type":[239],"(mGluRI).":[241],"mGluRI":[245,302,327],"contributes":[246],"adaptive":[251],"response":[252],"as":[256],"enhanced":[261,320],"upon":[262],"pharmacological":[263],"inhibition":[264],"mGluRI.":[266],"The":[267],"protective":[268],"effect":[269],"at":[273],"early":[274],"times":[275],"mediated":[280],"restoration":[283],"(GSH)":[286],"levels":[287,311],"are":[289],"reduced":[290],"depletion":[293],"pools.":[297],"Additional":[298],"suggest":[300],"may":[303],"be":[304],"involved":[305],"regulating":[307],"mRNA":[308],"protein":[310],"glutamate-cysteine":[313],"ligase":[314],"(GCL),":[315],"which":[316],"would":[317],"lead":[318],"synthesis.":[322],"protects":[328],"through":[334],"upregulation":[335],"GCL":[337],"transcription":[338],"translation,":[340],"enhancement":[343],"GSH":[345],"levels.":[346]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
