{"id":"https://openalex.org/W2230110077","doi":null,"title":"The experimental evolution of host adaptation of the emerging pathogen Burkholderia cenocepacia","display_name":"The experimental evolution of host adaptation of the emerging pathogen Burkholderia cenocepacia","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2230110077","mag":"2230110077"},"language":"en","primary_location":{"id":"pmh:oai:scholars.unh.edu:thesis-1362","doi":null,"is_oa":true,"landing_page_url":"https://scholars.unh.edu/thesis/363","pdf_url":"https://scholars.unh.edu/thesis/363","source":{"id":"https://openalex.org/S4377196362","display_name":"University of New Hampshire Scholars Repository (University of New Hampshire at Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179093154","host_organization_name":"University of New Hampshire at Manchester","host_organization_lineage":["https://openalex.org/I179093154"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses and Capstones","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholars.unh.edu/thesis/363","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075942387","display_name":"Crystal N. Ellis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Crystal N. Ellis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075942387"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12951","display_name":"Burkholderia infections and melioidosis","score":0.04259999841451645,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/burkholderia-cenocepacia","display_name":"Burkholderia cenocepacia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/host-adaptation","display_name":"host adaptation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"experimental evolution","score":0.9100000262260437},{"id":"https://openalex.org/keywords/virulence-trade-offs","display_name":"virulence trade-offs","score":0.8130000233650208},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.7870000004768372},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8730000257492065},{"id":"https://openalex.org/keywords/allium-cepa","display_name":"onion","score":0.8370000123977661},{"id":"https://openalex.org/keywords/pathogenic-bacteria","display_name":"pathogenic bacteria","score":0.5540000200271606},{"id":"https://openalex.org/keywords/opportunistic-pathogens","display_name":"opportunistic pathogens","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2777979451","wikidata":"https://www.wikidata.org/wiki/Q4810500","display_name":"Burkholderia cenocepacia","level":4,"score":0.9292720556259155},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.6199949383735657},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.6076310873031616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.582530677318573},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5694332122802734},{"id":"https://openalex.org/C3020434087","wikidata":"https://www.wikidata.org/wiki/Q835718","display_name":"Opportunistic pathogen","level":4,"score":0.5447242856025696},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4271458387374878},{"id":"https://openalex.org/C2780855054","wikidata":"https://www.wikidata.org/wiki/Q135239","display_name":"Burkholderia","level":3,"score":0.3827509582042694},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.32693928480148315},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2242116928100586},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21313443779945374},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.17905762791633606},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.1563887894153595},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholars.unh.edu:thesis-1362","doi":null,"is_oa":true,"landing_page_url":"https://scholars.unh.edu/thesis/363","pdf_url":"https://scholars.unh.edu/thesis/363","source":{"id":"https://openalex.org/S4377196362","display_name":"University of New Hampshire Scholars Repository (University of New Hampshire at Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179093154","host_organization_name":"University of New Hampshire at Manchester","host_organization_lineage":["https://openalex.org/I179093154"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses and Capstones","raw_type":"text"},{"id":"mag:2230110077","doi":null,"is_oa":false,"landing_page_url":"https://scholars.unh.edu/cgi/viewcontent.cgi?article=1362&context=thesis","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholars.unh.edu:thesis-1362","doi":null,"is_oa":true,"landing_page_url":"https://scholars.unh.edu/thesis/363","pdf_url":"https://scholars.unh.edu/thesis/363","source":{"id":"https://openalex.org/S4377196362","display_name":"University of New Hampshire Scholars Repository (University of New Hampshire at Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179093154","host_organization_name":"University of New Hampshire at Manchester","host_organization_lineage":["https://openalex.org/I179093154"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses and Capstones","raw_type":"text"},"sustainable_development_goals":[{"score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"},{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2230110077.pdf","grobid_xml":"https://content.openalex.org/works/W2230110077.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W22337813","https://openalex.org/W88723141","https://openalex.org/W97156783","https://openalex.org/W162032234","https://openalex.org/W1480307447","https://openalex.org/W1499416105","https://openalex.org/W1564219524","https://openalex.org/W1588066949","https://openalex.org/W1785785489","https://openalex.org/W1826812957","https://openalex.org/W1913859964","https://openalex.org/W1919203668","https://openalex.org/W1940453590","https://openalex.org/W1966253610","https://openalex.org/W1967600116","https://openalex.org/W1974522161","https://openalex.org/W1976680916","https://openalex.org/W1978046264","https://openalex.org/W1981535644","https://openalex.org/W1984042713","https://openalex.org/W1985197728","https://openalex.org/W1989612064","https://openalex.org/W1990152286","https://openalex.org/W1992220823","https://openalex.org/W1992685903","https://openalex.org/W2000855346","https://openalex.org/W2008338708","https://openalex.org/W2015020878","https://openalex.org/W2016766429","https://openalex.org/W2017645955","https://openalex.org/W2020057555","https://openalex.org/W2022910577","https://openalex.org/W2024167594","https://openalex.org/W2026873010","https://openalex.org/W2028971251","https://openalex.org/W2032563322","https://openalex.org/W2039572436","https://openalex.org/W2041110364","https://openalex.org/W2047256415","https://openalex.org/W2055903497","https://openalex.org/W2055983073","https://openalex.org/W2056446617","https://openalex.org/W2058947392","https://openalex.org/W2061667681","https://openalex.org/W2068543331","https://openalex.org/W2082389567","https://openalex.org/W2085034589","https://openalex.org/W2095650382","https://openalex.org/W2096641887","https://openalex.org/W2096653826","https://openalex.org/W2099899467","https://openalex.org/W2101019518","https://openalex.org/W2102062604","https://openalex.org/W2104241316","https://openalex.org/W2106801743","https://openalex.org/W2112945902","https://openalex.org/W2113581461","https://openalex.org/W2116067373","https://openalex.org/W2116386244","https://openalex.org/W2116791869","https://openalex.org/W2117014883","https://openalex.org/W2117610438","https://openalex.org/W2118549950","https://openalex.org/W2119072027","https://openalex.org/W2121378139","https://openalex.org/W2121670000","https://openalex.org/W2121924886","https://openalex.org/W2123057006","https://openalex.org/W2125467063","https://openalex.org/W2129542887","https://openalex.org/W2130574269","https://openalex.org/W2130952076","https://openalex.org/W2132666490","https://openalex.org/W2133806838","https://openalex.org/W2134212466","https://openalex.org/W2135877084","https://openalex.org/W2136273040","https://openalex.org/W2136900135","https://openalex.org/W2137906281","https://openalex.org/W2138334384","https://openalex.org/W2138506519","https://openalex.org/W2139638142","https://openalex.org/W2143094150","https://openalex.org/W2144634347","https://openalex.org/W2148703390","https://openalex.org/W2149328638","https://openalex.org/W2151454974","https://openalex.org/W2153103884","https://openalex.org/W2154741848","https://openalex.org/W2154963941","https://openalex.org/W2164217177","https://openalex.org/W2164919336","https://openalex.org/W2165529552","https://openalex.org/W2165955930","https://openalex.org/W2168943945","https://openalex.org/W2287459411","https://openalex.org/W2319126975"],"related_works":["https://openalex.org/W2164030784","https://openalex.org/W4381885035","https://openalex.org/W2097053151","https://openalex.org/W3138427244","https://openalex.org/W2990246430","https://openalex.org/W567808897","https://openalex.org/W7096349176","https://openalex.org/W7096425266","https://openalex.org/W7100591924","https://openalex.org/W7098744192"],"abstract_inverted_index":{"I":[0,31,50,62,76,105,121,133],"investigated":[1,27],"the":[2,44],"ability":[3,45],"of":[4,34,66,111,126,137],"Burkholderia":[5],"cenocepacia,":[6],"an":[7],"opportunistic":[8],"bacterial":[9],"pathogen,":[10],"to":[11,13,39,46,54,93,129,140],"adapt":[12],"a":[14,116],"host.":[15,149],"Studies":[16],"have":[17,26],"identified":[18],"trade-offs":[19],"associated":[20],"with":[21],"environmental":[22],"adaptation,":[23],"but":[24],"few":[25],"host":[28,142],"adaptation.":[29],"Consequently,":[30],"studied":[32],"effects":[33,125],"adaptation":[35,53,127,136],"by":[36,85],"B.":[37,138],"cenocepacia":[38,139],"onions":[40,55],"(Allium":[41],"cepa)":[42],"on":[43],"kill":[47],"Caenorhabditis":[48],"elegans.":[49,61],"hypothesized":[51],"that":[52,135],"would":[56],"reduce":[57],"virulence":[58,107,146],"in":[59,68,101,144,147],"C.":[60,109],"evolved":[63,81],"twelve":[64],"populations":[65,84],"bacteria":[67],"onion":[69],"tissue":[70],"medium":[71],"for":[72],"500":[73],"generations.":[74],"Then,":[75],"quantified":[77,123],"fitness":[78,99],"differences":[79],"between":[80],"and":[82,114],"ancestral":[83],"direct":[86],"competition,":[87],"having":[88],"developed":[89],"molecular":[90],"marking":[91],"techniques":[92],"discriminate":[94],"among":[95],"competitors.":[96],"Competitions":[97],"revealed":[98],"increases":[100],"nine":[102],"populations.":[103],"Next,":[104],"measured":[106],"against":[108],"elegans":[110],"each":[112],"population":[113],"observed":[115],"reduced":[117],"worm":[118],"killing":[119],"ability.":[120],"also":[122],"pleiotropic":[124],"related":[128],"virulence.":[130],"In":[131],"conclusion,":[132],"supported":[134],"one":[141],"resulted":[143],"decreased":[145],"another":[148]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2016-06-24T00:00:00"}