{"id":"https://openalex.org/W2229787223","doi":"https://doi.org/10.1007/978-1-60327-931-4_3","title":"Human Trials for Neurodegenerative Disease","display_name":"Human Trials for Neurodegenerative Disease","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2229787223","doi":"https://doi.org/10.1007/978-1-60327-931-4_3","mag":"2229787223","pmid":"https://pubmed.ncbi.nlm.nih.gov/19378194"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60327-931-4_3","doi":"https://doi.org/10.1007/978-1-60327-931-4_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60327-931-4_3","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2476520806","display_name":"Neural Cell Transplantation"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110460676","display_name":"Claire M. Kelly","orcid":"https://orcid.org/0009-0009-0577-0710","observed_orcids":["https://orcid.org/0009-0009-0577-0710"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Claire M. Kelly","raw_affiliation_strings":["Brain Repair Group, School of Biosciences, Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Repair Group, School of Biosciences, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011198841","display_name":"Olivia Handley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"O.J. Handley","raw_affiliation_strings":["Department of Neurology and Medical Genetics, School of Medicine, University of Cardiff, Cardiff, UK","Department of Neurology and Medical Genetics, School of Medicine, University of Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Medical Genetics, School of Medicine, University of Cardiff, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"Department of Neurology and Medical Genetics, School of Medicine, University of Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051896079","display_name":"Anne Rosser","orcid":"https://orcid.org/0000-0002-4716-4753","observed_orcids":["https://orcid.org/0000-0002-4716-4753"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.E. Rosser","raw_affiliation_strings":["Department of Neurology and Medical Genetics, School of Medicine, University of Cardiff, Cardiff, UK","Department of Neurology and Medical Genetics, School of Medicine, University of Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Medical Genetics, School of Medicine, University of Cardiff, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"Department of Neurology and Medical Genetics, School of Medicine, University of Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110460676"],"corresponding_institution_ids":["https://openalex.org/I79510175"],"apc_list":null,"apc_paid":null,"fwci":2.1683,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.9002185,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"549","issue":null,"first_page":"33","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.13590000569820404,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.1340000033378601,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/neural-transplantation","display_name":"neural transplantation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8289999961853027},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.921999990940094},{"id":"https://openalex.org/keywords/fetal-tissue-transplantation","display_name":"fetal tissue transplantation","score":0.5120000243186951},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.8220000267028809},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.765999972820282},{"id":"https://openalex.org/keywords/neural-circuit-reconstruction","display_name":"neural circuit reconstruction","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7754464149475098},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.7718576192855835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5508641004562378},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5248943567276001},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.48219695687294006},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.4799821078777313},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4727533757686615},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4368930160999298},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40587136149406433},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25136762857437134},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.21692946553230286},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.14172327518463135},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D005062","descriptor_name":"European Union","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005062","descriptor_name":"European Union","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005062","descriptor_name":"European Union","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-60327-931-4_3","doi":"https://doi.org/10.1007/978-1-60327-931-4_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60327-931-4_3","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:19378194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19378194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W26184589","https://openalex.org/W1484963557","https://openalex.org/W1513529766","https://openalex.org/W1529892507","https://openalex.org/W1540826485","https://openalex.org/W1551812335","https://openalex.org/W1966476278","https://openalex.org/W1979111877","https://openalex.org/W1983274440","https://openalex.org/W2001066652","https://openalex.org/W2007543609","https://openalex.org/W2011077415","https://openalex.org/W2014525534","https://openalex.org/W2015500392","https://openalex.org/W2027246053","https://openalex.org/W2031379273","https://openalex.org/W2033315224","https://openalex.org/W2048222565","https://openalex.org/W2052302258","https://openalex.org/W2061185374","https://openalex.org/W2073727997","https://openalex.org/W2075453897","https://openalex.org/W2076028515","https://openalex.org/W2083237272","https://openalex.org/W2095212383","https://openalex.org/W2100479578","https://openalex.org/W2101326888","https://openalex.org/W2104793567","https://openalex.org/W2108488819","https://openalex.org/W2120564562","https://openalex.org/W2122191105","https://openalex.org/W2125987139","https://openalex.org/W2126499376","https://openalex.org/W2138340289","https://openalex.org/W2138977668","https://openalex.org/W2142046859","https://openalex.org/W2147015050","https://openalex.org/W2149282858","https://openalex.org/W2155945484","https://openalex.org/W2164012688","https://openalex.org/W2167705610","https://openalex.org/W2168341415","https://openalex.org/W2324050875","https://openalex.org/W2334461448","https://openalex.org/W4231677736","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2018184520","https://openalex.org/W2538892584","https://openalex.org/W4402392135","https://openalex.org/W2002742028","https://openalex.org/W4402374320","https://openalex.org/W4400354343","https://openalex.org/W2900550729","https://openalex.org/W2064023493","https://openalex.org/W4244492395","https://openalex.org/W2015523275"],"abstract_inverted_index":{"The":[0],"lack":[1],"of":[2,33,46,98,110,119],"disease-modifying":[3],"treatments":[4],"currently":[5],"available":[6],"for":[7],"not":[8,105],"just":[9],"some":[10],"but":[11],"most":[12],"neurodegenerative":[13],"diseases,":[14],"including":[15],"Parkinson's":[16,80],"disease,":[17,19,48],"Huntington's":[18,92],"and":[20,117,122],"even":[21],"stroke,":[22],"helps":[23],"explain":[24],"increasing":[25],"interest":[26],"in":[27,61,79,83,91,102,129],"cell-based":[28],"therapies.":[29],"One":[30],"key":[31],"aim":[32],"such":[34],"treatment":[35],"is":[36],"to":[37,52,63,114],"replace":[38],"neurons":[39],"or":[40],"glia":[41],"lost":[42],"as":[43,74],"a":[44,50,75],"result":[45],"the":[47,53,58,84,107,115],"with":[49],"view":[51],"cells":[54],"integrating":[55],"functionally":[56],"within":[57],"host":[59],"tissue":[60,73],"order":[62],"reconstruct":[64],"neural":[65,88],"circuitry.":[66],"Clinical":[67],"trials":[68,90,101],"using":[69],"primary":[70],"human":[71],"fetal":[72],"cell":[76],"source":[77],"commenced":[78],"disease":[81,93],"(PD)":[82],"1980s;":[85],"currently,":[86],"comparable":[87],"transplantation":[89],"are":[94],"underway.":[95],"Disappointing":[96],"results":[97],"later":[99],"controlled":[100],"PD":[103],"illustrated":[104],"least":[106],"vital":[108],"importance":[109],"methodological":[111],"issues":[112,124],"relating":[113],"structure":[116],"implementation":[118],"clinical":[120],"trials,":[121],"these":[123],"will":[125],"be":[126],"considered":[127],"here":[128],"more":[130],"depth.":[131]},"counts_by_year":[{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2025-10-10T00:00:00"}