{"id":"https://openalex.org/W2229640146","doi":"https://doi.org/10.2337/db15-0647","title":"Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK","display_name":"Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK","publication_year":2015,"publication_date":"2015-09-17","ids":{"openalex":"https://openalex.org/W2229640146","doi":"https://doi.org/10.2337/db15-0647","mag":"2229640146","pmid":"https://pubmed.ncbi.nlm.nih.gov/26384382","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4686944"},"language":"en","primary_location":{"id":"doi:10.2337/db15-0647","doi":"https://doi.org/10.2337/db15-0647","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db15-0647","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4686944","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049277889","display_name":"Xing Fu","orcid":"https://orcid.org/0000-0001-5419-2691","observed_orcids":["https://orcid.org/0000-0001-5419-2691"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Fu","raw_affiliation_strings":["Washington Center for Muscle Biology, Department of Animal Sciences and Department of Pharmaceutical Sciences, Washington State University, Pullman, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington Center for Muscle Biology, Department of Animal Sciences and Department of Pharmaceutical Sciences, Washington State University, Pullman, WA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049104586","display_name":"Meijun J. Zhu","orcid":"https://orcid.org/0000-0001-8027-1780","observed_orcids":["https://orcid.org/0000-0001-8027-1780"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meijun Zhu","raw_affiliation_strings":["School of Food Science, Washington State University, Pullman, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science, Washington State University, Pullman, WA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuming Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuming Zhang","raw_affiliation_strings":["School of Food Science, Washington State University, Pullman, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science, Washington State University, Pullman, WA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043636167","display_name":"Marc Foretz","orcid":"https://orcid.org/0000-0001-7017-9032","observed_orcids":["https://orcid.org/0000-0001-7017-9032"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Foretz","raw_affiliation_strings":["CNRS UMR 8104, Paris, France","INSERM U1016, Institut Cochin, Paris, France","Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 8104, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"INSERM U1016, Institut Cochin, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045765280","display_name":"Beno\u0131\u0302t Viollet","orcid":"https://orcid.org/0000-0002-0121-0224","observed_orcids":["https://orcid.org/0000-0002-0121-0224"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benoit Viollet","raw_affiliation_strings":["CNRS UMR 8104, Paris, France","INSERM U1016, Institut Cochin, Paris, France","Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 8104, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"INSERM U1016, Institut Cochin, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I4387156284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074270918","display_name":"\u202cMin Du","orcid":"https://orcid.org/0000-0002-7232-072X","observed_orcids":["https://orcid.org/0000-0002-7232-072X"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Min Du","raw_affiliation_strings":["Washington Center for Muscle Biology, Department of Animal Sciences and Department of Pharmaceutical Sciences, Washington State University, Pullman, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington Center for Muscle Biology, Department of Animal Sciences and Department of Pharmaceutical Sciences, Washington State University, Pullman, WA","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5074270918"],"corresponding_institution_ids":["https://openalex.org/I72951846"],"apc_list":null,"apc_paid":null,"fwci":4.8456,"has_fulltext":false,"cited_by_count":162,"citation_normalized_percentile":{"value":0.9660573,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"65","issue":"1","first_page":"188","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":1.0},{"id":"https://openalex.org/keywords/skeletal-muscle-regeneration","display_name":"skeletal muscle regeneration","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9679999947547913},{"id":"https://openalex.org/keywords/ampkalpha1","display_name":"AMPK\u03b11","score":0.9959999918937683},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/satellite-cell-activation","display_name":"satellite cell activation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/muscle-injury","display_name":"muscle damage","score":0.6290000081062317},{"id":"https://openalex.org/keywords/aicar","display_name":"AICAR","score":0.777999997138977},{"id":"https://openalex.org/keywords/ampk-activation","display_name":"AMPK activation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.746999979019165},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.9388684034347534},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.8090531229972839},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6428104639053345},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5043646097183228},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4695323705673218},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.46421197056770325},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4280482530593872},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34841257333755493},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3275214731693268},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.14546340703964233},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.08187851309776306}],"mesh":[{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012265","descriptor_name":"Ribonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024510","descriptor_name":"Muscle Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024510","descriptor_name":"Muscle Development","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2337/db15-0647","doi":"https://doi.org/10.2337/db15-0647","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db15-0647","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4686944","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4686944","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Text"},{"id":"pmid:26384382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26384382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.lsu.edu:animalsciences_pubs-1616","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lsu.edu/animalsciences_pubs/617","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:repository.lsu.edu:animalsciences_pubs-1616","doi":null,"is_oa":false,"landing_page_url":"https://repository.lsu.edu/animalsciences_pubs/617","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4686944","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4686944","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000917054","display_name":"Maternal obesity, AMPK and Developmental Programming","funder_award_id":"R01HD067449","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1503238830","https://openalex.org/W1964124818","https://openalex.org/W1964607854","https://openalex.org/W1967667786","https://openalex.org/W1974607532","https://openalex.org/W1975031413","https://openalex.org/W1975884987","https://openalex.org/W1976242359","https://openalex.org/W1980898941","https://openalex.org/W1984419476","https://openalex.org/W1988393390","https://openalex.org/W1995800951","https://openalex.org/W1999382977","https://openalex.org/W1999902156","https://openalex.org/W2007938249","https://openalex.org/W2010253303","https://openalex.org/W2011001343","https://openalex.org/W2025957803","https://openalex.org/W2028194205","https://openalex.org/W2030509917","https://openalex.org/W2038961236","https://openalex.org/W2042742511","https://openalex.org/W2043967275","https://openalex.org/W2054460914","https://openalex.org/W2061434701","https://openalex.org/W2065563639","https://openalex.org/W2088755431","https://openalex.org/W2093469696","https://openalex.org/W2097070825","https://openalex.org/W2097304128","https://openalex.org/W2102453677","https://openalex.org/W2112039060","https://openalex.org/W2125516734","https://openalex.org/W2127953913","https://openalex.org/W2128258266","https://openalex.org/W2129613706","https://openalex.org/W2135504542","https://openalex.org/W2142924698","https://openalex.org/W2142930789","https://openalex.org/W2145163771","https://openalex.org/W2149928685","https://openalex.org/W2153217835","https://openalex.org/W2159119036","https://openalex.org/W2159630063","https://openalex.org/W2167460186","https://openalex.org/W2170880090","https://openalex.org/W6681172661"],"related_works":["https://openalex.org/W2105129043","https://openalex.org/W3175833626","https://openalex.org/W4311301881","https://openalex.org/W2896374260","https://openalex.org/W194443284","https://openalex.org/W1632759563","https://openalex.org/W3048868971","https://openalex.org/W3162758977","https://openalex.org/W2247011864","https://openalex.org/W1273667222"],"abstract_inverted_index":{"Obesity":[0],"is":[1,6,18,35,97,134,175],"increasing":[2],"rapidly":[3],"worldwide":[4],"and":[5,64,79,84,93,169,181],"accompanied":[7],"by":[8,136],"many":[9],"complications,":[10],"including":[11],"impaired":[12,65,117,182],"muscle":[13,41,66,95,103,122,129,150,170,183,192],"regeneration.":[14,67,171],"The":[15],"obese":[16,44,107,132,153,195],"condition":[17],"known":[19],"to":[20,148,190],"inhibit":[21],"AMPK":[22,33,51],"activity":[23,34,52],"in":[24,43,53,106,120,131,152,165,194],"multiple":[25],"tissues.":[26],"We":[27,46,124],"hypothesized":[28],"that":[29,48,81,94,127,140],"the":[30,70,161],"loss":[31],"of":[32,73,86,101,163],"a":[36,138,176,186],"major":[37],"reason":[38],"for":[39],"hampered":[40,102],"regeneration":[42,96,104,130,151,193],"subjects.":[45,108],"found":[47,80,126],"obesity":[49,180],"inhibits":[50],"regenerating":[54,121],"muscle,":[55],"which":[56],"was":[57],"associated":[58],"with":[59,112,155],"impeded":[60],"satellite":[61,87,110,156,166],"cell":[62,167],"activation":[63,168],"To":[68],"test":[69],"mediatory":[71],"role":[72],"AMPK\u03b11,":[74],"we":[75],"knocked":[76],"out":[77],"AMPK\u03b11":[78,113,158,164,174],"both":[82],"proliferation":[83],"differentiation":[85],"cells":[88,111],"are":[89],"reduced":[90],"after":[91],"injury":[92],"severely":[98,116],"impeded,":[99],"reminiscent":[100],"seen":[105],"Transplanted":[109],"deficiency":[114],"had":[115],"myogenic":[118],"capacity":[119],"fibers.":[123],"also":[125],"attenuated":[128],"mice":[133,154],"rescued":[135],"AICAR,":[137],"drug":[139,188],"specifically":[141],"activates":[142],"AMPK,":[143],"but":[144],"AICAR":[145],"treatment":[146],"failed":[147],"improve":[149],"cell-specific":[157],"knockout,":[159],"demonstrating":[160],"importance":[162],"In":[172],"summary,":[173],"key":[177],"mediator":[178],"linking":[179],"regeneration,":[184],"providing":[185],"convenient":[187],"target":[189],"facilitate":[191],"populations.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}