{"id":"https://openalex.org/W2229608907","doi":null,"title":"The Rapid Effects of the G-protein Coupled Estrogen Receptor in Various Brain Regions on Learning and Memory in Female Mice","display_name":"The Rapid Effects of the G-protein Coupled Estrogen Receptor in Various Brain Regions on Learning and Memory in Female Mice","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2229608907","mag":"2229608907"},"language":"en","primary_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/8947","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/8947","pdf_url":"http://hdl.handle.net/10214/8947","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10214/8947","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073851483","display_name":"Jennifer Lymer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer Lymer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073851483"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.7103999853134155,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.7103999853134155,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.20909999310970306,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-estrogen-receptor","display_name":"G protein-coupled estrogen receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.9520000219345093},{"id":"https://openalex.org/keywords/social-recognition","display_name":"social recognition","score":0.8640000224113464},{"id":"https://openalex.org/keywords/object-recognition","display_name":"object recognition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dorsal-hippocampus","display_name":"dorsal hippocampus","score":0.7649999856948853},{"id":"https://openalex.org/keywords/medial-amygdala","display_name":"medial amygdala","score":0.871999979019165},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ca1","display_name":"CA1","score":0.6700000166893005},{"id":"https://openalex.org/keywords/g1-agonist","display_name":"G1 agonist","score":0.8669999837875366},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C166471694","wikidata":"https://www.wikidata.org/wiki/Q18268232","display_name":"GPER","level":5,"score":0.9531279802322388},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6611460447311401},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5920998454093933},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5723437070846558},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.502938449382782},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47428327798843384},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.4706753194332123},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4368636906147003},{"id":"https://openalex.org/C90269970","wikidata":"https://www.wikidata.org/wiki/Q7302606","display_name":"Recognition memory","level":3,"score":0.4265858829021454},{"id":"https://openalex.org/C2993892105","wikidata":"https://www.wikidata.org/wiki/Q7302601","display_name":"Social recognition","level":2,"score":0.41632869839668274},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3966139554977417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3472197353839874},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33445870876312256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30622994899749756},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.15555313229560852},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.15438160300254822},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/8947","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/8947","pdf_url":"http://hdl.handle.net/10214/8947","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2229608907","doi":null,"is_oa":false,"landing_page_url":"https://atrium.lib.uoguelph.ca/xmlui/bitstream/10214/8947/1/Lymer_Jennifer_201507_PhD.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/8947","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/8947","pdf_url":"http://hdl.handle.net/10214/8947","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2229608907.pdf","grobid_xml":"https://content.openalex.org/works/W2229608907.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W201609710","https://openalex.org/W317238995","https://openalex.org/W1486681857","https://openalex.org/W1522048223","https://openalex.org/W1597086984","https://openalex.org/W1964082418","https://openalex.org/W1964606698","https://openalex.org/W1966660173","https://openalex.org/W1967479320","https://openalex.org/W1969884618","https://openalex.org/W1970207114","https://openalex.org/W1970227809","https://openalex.org/W1972086601","https://openalex.org/W1972211929","https://openalex.org/W1972814152","https://openalex.org/W1976678368","https://openalex.org/W1977409527","https://openalex.org/W1977520596","https://openalex.org/W1977529472","https://openalex.org/W1978609825","https://openalex.org/W1980944036","https://openalex.org/W1981467972","https://openalex.org/W1982038091","https://openalex.org/W1987549073","https://openalex.org/W1989069744","https://openalex.org/W1989470448","https://openalex.org/W1992312419","https://openalex.org/W1993176591","https://openalex.org/W1994574623","https://openalex.org/W1996405087","https://openalex.org/W1997996573","https://openalex.org/W2002090514","https://openalex.org/W2002452662","https://openalex.org/W2003392460","https://openalex.org/W2004057308","https://openalex.org/W2004598179","https://openalex.org/W2005139532","https://openalex.org/W2005602845","https://openalex.org/W2005744880","https://openalex.org/W2009057820","https://openalex.org/W2009343153","https://openalex.org/W2010409400","https://openalex.org/W2011223610","https://openalex.org/W2012302074","https://openalex.org/W2014160624","https://openalex.org/W2014213229","https://openalex.org/W2015778360","https://openalex.org/W2017010924","https://openalex.org/W2017181431","https://openalex.org/W2018384424","https://openalex.org/W2019626637","https://openalex.org/W2025176554","https://openalex.org/W2025829580","https://openalex.org/W2027010243","https://openalex.org/W2027171515","https://openalex.org/W2027429481","https://openalex.org/W2028330147","https://openalex.org/W2028893107","https://openalex.org/W2029530971","https://openalex.org/W2029817026","https://openalex.org/W2029989204","https://openalex.org/W2032133490","https://openalex.org/W2032679251","https://openalex.org/W2034261103","https://openalex.org/W2035685439","https://openalex.org/W2037790468","https://openalex.org/W2038813826","https://openalex.org/W2039698855","https://openalex.org/W2041183073","https://openalex.org/W2042143038","https://openalex.org/W2042346683","https://openalex.org/W2042355949","https://openalex.org/W2042733452","https://openalex.org/W2042894225","https://openalex.org/W2048310604","https://openalex.org/W2048822470","https://openalex.org/W2048937021","https://openalex.org/W2049111053","https://openalex.org/W2049116118","https://openalex.org/W2051026082","https://openalex.org/W2053682040","https://openalex.org/W2054446024","https://openalex.org/W2055907375","https://openalex.org/W2057973131","https://openalex.org/W2064200220","https://openalex.org/W2068972835","https://openalex.org/W2069519651","https://openalex.org/W2072441360","https://openalex.org/W2074687017","https://openalex.org/W2075133445","https://openalex.org/W2076908209","https://openalex.org/W2079118147","https://openalex.org/W2080544322","https://openalex.org/W2081896689","https://openalex.org/W2085918017","https://openalex.org/W2086249380","https://openalex.org/W2086529234","https://openalex.org/W2087321410","https://openalex.org/W2088259542","https://openalex.org/W2092184448","https://openalex.org/W2092338494","https://openalex.org/W2094674781","https://openalex.org/W2096665423","https://openalex.org/W2096790979","https://openalex.org/W2100695238","https://openalex.org/W2104184356","https://openalex.org/W2105088884","https://openalex.org/W2106787391","https://openalex.org/W2110887671","https://openalex.org/W2110900924","https://openalex.org/W2116806542","https://openalex.org/W2119225964","https://openalex.org/W2120770581","https://openalex.org/W2121134774","https://openalex.org/W2122015809","https://openalex.org/W2123476163","https://openalex.org/W2123652060","https://openalex.org/W2128270206","https://openalex.org/W2130923723","https://openalex.org/W2135910109","https://openalex.org/W2136011008","https://openalex.org/W2136061660","https://openalex.org/W2136827845","https://openalex.org/W2137788215","https://openalex.org/W2140179339","https://openalex.org/W2142854066","https://openalex.org/W2144436995","https://openalex.org/W2147156400","https://openalex.org/W2149713530","https://openalex.org/W2151968717","https://openalex.org/W2156989552","https://openalex.org/W2160212383","https://openalex.org/W2161695527","https://openalex.org/W2164671673","https://openalex.org/W2170915093","https://openalex.org/W2209257886","https://openalex.org/W2216094174","https://openalex.org/W3143219166"],"related_works":["https://openalex.org/W1597086984","https://openalex.org/W2552243614","https://openalex.org/W2606220587","https://openalex.org/W820795504","https://openalex.org/W2913393042","https://openalex.org/W7047566365","https://openalex.org/W3035041337","https://openalex.org/W2939411370","https://openalex.org/W3188757082","https://openalex.org/W2778161403"],"abstract_inverted_index":{"This":[0],"thesis":[1],"investigates":[2],"the":[3,6,37,49,53,62,88,91,108,117,128,132,137,146,162,165,169,173,184,226,237,251,254,257,273,280,285,297,300,305,318,324,327,336],"role":[4,163,252],"of":[5,52,64,79,87,119,122,131,164,177,183,210,225,253,272,289,307,320,339],"G-protein":[7],"coupled":[8],"estrogen":[9,39],"receptor":[10],"(GPER)":[11],"in":[12,16,101,107,127,141,145,154,168,172,197,221,246,256,263,284,293,299,304,317,326,335],"learning":[13,28,56,75,97,155,178,290],"and":[14,29,42,57,72,98,156,179,190,216,291,310,313],"memory":[15,30,99,292],"female":[17,102,199,264,294],"mice.":[18,103,265,295],"It":[19],"has":[20],"recently":[21],"been":[22],"shown":[23],"that":[24,84,136,207,268],"estrogens":[25],"can":[26],"affect":[27],"on":[31,55,67,124,260],"a":[32,148,222],"rapid":[33,50,174,286],"time":[34],"scale":[35],"through":[36],"classic":[38],"receptors,":[40],"\u03b1":[41],"\u03b2.":[43],"Very":[44],"little":[45],"is":[46,139,240,282,302],"known":[47,242],"about":[48],"effects":[51,63,111,118],"GPER":[54,65,138,185,255,274,281,298,325],"memory,":[58],"so":[59],"we":[60,115,159,205,249],"investigated":[61,161],"activation":[66,86,182,271],"social":[68,188,214,247,261,277,308,340],"recognition,":[69,71,192,248,312],"object":[70,73,191,195,217,311],"placement":[74,196],"within":[76,201],"40":[77,202],"minutes":[78],"drug":[80],"administration.":[81],"We":[82,134,266],"found":[83,135,206,267],"systemic":[85,120],"GPER,":[89,166],"with":[90],"agonist":[92],"G-1,":[93],"improved":[94,187,213,276],"all":[95],"three":[96],"paradigms":[100],"To":[104],"determine":[105],"where":[106,229],"brain":[109],"these":[110],"might":[112],"be":[113,152,244,333],"mediated,":[114],"examined":[116,250],"administration":[121,209],"G-1":[123,211],"dendritic":[125,143],"spines":[126],"CA1":[129],"region":[130],"hippocampus.":[133],"involved":[140,153,245,283,303,316,334],"increasing":[142],"spine":[144],"hippocampus,":[147,171],"process":[149],"thought":[150],"to":[151,243,331],"memory.":[157,180],"Therefore,":[158,279],"next":[160],"specifically":[167],"dorsal":[170],"estrogenic":[175,287,337],"facilitation":[176,288,306,338],"Intrahippocampal":[181],"rapidly":[186,212,275],"recognition":[189,215,218,262,309],"but":[193],"not":[194,314],"ovariectomized":[198],"mice":[200],"minutes.":[203],"Additionally,":[204,323],"intrahippocampal":[208],"when":[219],"tested":[220],"Y-apparatus,":[223],"instead":[224],"home":[227],"cage,":[228],"there":[230],"were":[231],"minimal":[232],"spatial":[233,321],"cures":[234],"present.":[235],"As":[236],"medial":[238,258,328],"amygdala":[239,259,270,329],"also":[241,332],"intra-medial":[269],"recognition.":[278,341],"Specifically,":[296],"hippocampus":[301],"necessarily":[315],"processing":[319],"information.":[322],"appears":[330]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
