{"id":"https://openalex.org/W2229434335","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15524","title":"First-line treatment with bevacizumab (B) and high dose (HD) bolus aldesleukin (IL-2) in metastatic renal cell carcinoma (mRCC) patients (Pts)","display_name":"First-line treatment with bevacizumab (B) and high dose (HD) bolus aldesleukin (IL-2) in metastatic renal cell carcinoma (mRCC) patients (Pts)","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2229434335","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15524","mag":"2229434335"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.15524","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15524","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.15524","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089516753","display_name":"Marc S. Ernstoff","orcid":"https://orcid.org/0000-0002-8132-7069","observed_orcids":["https://orcid.org/0000-0002-8132-7069"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. S. Ernstoff","raw_affiliation_strings":["Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I1316535847","https://openalex.org/I1925986","https://openalex.org/I4210117453","https://openalex.org/I4390039299","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017334876","display_name":"Meredith M. Regan","orcid":"https://orcid.org/0000-0002-2428-6109","observed_orcids":["https://orcid.org/0000-0002-2428-6109"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. M. Regan","raw_affiliation_strings":["Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I1316535847","https://openalex.org/I1925986","https://openalex.org/I4210117453","https://openalex.org/I4390039299","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007052233","display_name":"David F. McDermott","orcid":"https://orcid.org/0000-0002-2675-5095","observed_orcids":["https://orcid.org/0000-0002-2675-5095","https://orcid.org/0000-0001-6978-0867"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. F. McDermott","raw_affiliation_strings":["Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I1316535847","https://openalex.org/I1925986","https://openalex.org/I4210117453","https://openalex.org/I4390039299","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075566772","display_name":"Jeffrey Alan Sosman","orcid":"https://orcid.org/0000-0002-0650-9698","observed_orcids":["https://orcid.org/0000-0002-0650-9698"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. A. Sosman","raw_affiliation_strings":["Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I1316535847","https://openalex.org/I1925986","https://openalex.org/I4210117453","https://openalex.org/I4390039299","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033346506","display_name":"Janice P. Dutcher","orcid":"https://orcid.org/0000-0002-2267-9187","observed_orcids":["https://orcid.org/0000-0002-2267-9187"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. P. Dutcher","raw_affiliation_strings":["Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I1316535847","https://openalex.org/I1925986","https://openalex.org/I4210117453","https://openalex.org/I4390039299","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034792001","display_name":"Joseph I. Clark","orcid":"https://orcid.org/0000-0002-0455-2625","observed_orcids":["https://orcid.org/0000-0002-0455-2625"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. I. Clark","raw_affiliation_strings":["Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I1316535847","https://openalex.org/I1925986","https://openalex.org/I4210117453","https://openalex.org/I4390039299","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079825829","display_name":"Todd S. Crocenzi","orcid":"https://orcid.org/0000-0001-8762-1990","observed_orcids":["https://orcid.org/0000-0001-8762-1990"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. S. Crocenzi","raw_affiliation_strings":["Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I1316535847","https://openalex.org/I1925986","https://openalex.org/I4210117453","https://openalex.org/I4390039299","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048642584","display_name":"A. Matas Ochoa","orcid":"https://orcid.org/0000-0001-6457-8029","observed_orcids":["https://orcid.org/0000-0001-6457-8029"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Ochoa","raw_affiliation_strings":["Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I1316535847","https://openalex.org/I1925986","https://openalex.org/I4210117453","https://openalex.org/I4390039299","https://openalex.org/I75420490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052526230","display_name":"Michael B. Atkins","orcid":"https://orcid.org/0000-0003-3901-9924","observed_orcids":["https://orcid.org/0000-0003-3901-9924"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. B. Atkins","raw_affiliation_strings":["Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth Hitchcock Medical Center, Lebanon, NH; Dana-Farber Cancer Institute, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA; Vanderbilt-Ingram Cancer Center, Nashville, TN; Our Lady of Mercy Cancer Center, Bronx, NY; Loyola University, Chicago, IL; Earle A. Chiles Research Institute, Portland, OR; Louisiana State University Health Science Center, New Orleans, LA","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I1316535847","https://openalex.org/I1925986","https://openalex.org/I4210117453","https://openalex.org/I4390039299","https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"15524","last_page":"15524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9380000233650208},{"id":"https://openalex.org/keywords/high-dose-interleukin-2","display_name":"high-dose interleukin-2","score":0.9350000023841858},{"id":"https://openalex.org/keywords/metastatic-renal-cell-carcinoma","display_name":"metastatic renal cell carcinoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/l-ornithine","display_name":"L-ornithine","score":0.8420000076293945},{"id":"https://openalex.org/keywords/arginine-metabolism","display_name":"arginine metabolism","score":0.8550000190734863},{"id":"https://openalex.org/keywords/arginase","display_name":"arginase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.5740000009536743},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.75},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.5529999732971191},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.796999990940094},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.7450000047683716},{"id":"https://openalex.org/keywords/phase-ii-trial-results","display_name":"phase II trial results","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9378514289855957},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.6778735518455505},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5876510143280029},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.509297251701355},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48447537422180176},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.4711410403251648},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.39747995138168335},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3725212514400482},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3462681770324707}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.15524","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15524","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.15524","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2476952618","https://openalex.org/W132049697","https://openalex.org/W2317731611","https://openalex.org/W2954006374","https://openalex.org/W1576822277","https://openalex.org/W2261557873","https://openalex.org/W2892185533","https://openalex.org/W2786122495","https://openalex.org/W2891241962","https://openalex.org/W2232361005"],"abstract_inverted_index":{"15524":[0],"Background:":[1],"The":[2,164],"rationale":[3],"for":[4,19,70,82],"combining":[5],"HD":[6,41,71,124,315],"IL-2":[7,42,118,121,125,215,242,316],"with":[8,51,171,276],"B":[9,44,91,110,200,318],"includes":[10],"potential":[11,18],"synergistic":[12],"immune":[13,327],"interactions,":[14],"non-overlapping":[15],"toxicities,":[16],"and":[17,43,73,148,174,210,317,323],"added":[20],"clinical":[21],"benefit.":[22],"We":[23,151],"have":[24,179,244,306],"initiated":[25],"a":[26,160,180,188,205,220,250,263],"multi-center":[27],"phase":[28],"II":[29],"study":[30],"designed":[31],"to":[32,104,116,273,290,300],"estimate":[33],"the":[34,105,153,156,193,196,211,238,257,310],"efficacy":[35],"of":[36,39,64,88,108,155,159,199,204,214,219,252,265,293,312],"combination":[37],"therapy":[38,45],"standard":[40],"in":[46,285],"mRCC":[47],"pts.":[48,163],"Methods:":[49],"Pts":[50],"histologically":[52],"confirmed":[53],"mRCC,":[54],"predominantly":[55],"clear":[56],"cell":[57],"histology,":[58],"measurable":[59],"or":[60,77],"evaluable":[61],"disease,":[62],"KPS":[63],"=80%,":[65],"adequate":[66],"end":[67],"organ":[68],"function":[69],"IL-2,":[72],"no":[74],"underlying":[75],"coagulopathy":[76],"thrombotic":[78],"event":[79],"are":[80,282],"eligible":[81],"this":[83],"study.":[84],"One":[85],"cycle":[86],"consists":[87],"84":[89],"days.":[90],"(10":[92],"mg/kg)":[93],"IV":[94,128],"is":[95,111,122,134,167],"given":[96,135,321],"every":[97],"2":[98,101],"wks":[99,102],"beginning":[100],"prior":[103,115],"first":[106,157,194],"dose":[107],"IL-2.":[109],"dosed":[112],"1":[113],"hr":[114],"initiating":[117],"on":[119,145,326],"days":[120,143],"given.":[123],"(600,000":[126],"IU/kg)":[127],"Q8":[129],"hours":[130],"(maximum":[131],"28":[132,222],"doses)":[133],"during":[136,237],"two":[137],"5-day":[138],"courses":[139],"separated":[140],"by":[141],"9":[142,172],"(starting":[144],"day":[146],"15":[147,158],"29).":[149],"Results:":[150],"report":[152],"results":[154],"planned":[161,206,221],"60":[162],"median":[165,197,212],"age":[166],"54":[168],"(range":[169,208,223],"40\u201373)":[170],"men":[173],"6":[175],"women.":[176],"14":[177],"pts":[178,287],"MSKCC":[181],"intermediate":[182],"prognostic":[183,190],"score,":[184],"one":[185,228],"pt":[186],"has":[187,226,270],"poor":[189],"score.":[191],"In":[192,296],"cycle,":[195],"number":[198,213],"doses":[201,216],"was":[202,217],"7":[203,207],"2\u20137)":[209],"17":[218],"6\u201326).":[224],"There":[225],"been":[227,245,271],"treatment":[229],"related":[230],"death":[231],"from":[232],"unresponsive":[233],"hypotension":[234],"which":[235],"occurred":[236],"second":[239],"cycle.":[240],"Typical":[241],"toxicities":[243],"noted":[246],"thus":[247],"far.":[248],"Among":[249],"variety":[251],"correlative":[253],"studies,":[254],"we":[255],"evaluated":[256],"serum":[258],"L-":[259],"ornithine":[260],"(L-O)":[261],"level,":[262],"byproduct":[264],"arginase-mediated":[266],"arginine":[267],"metabolism":[268],"that":[269],"shown":[272],"inversely":[274],"correlate":[275],"TCR?":[277],"chain":[278],"expression.":[279],"L-O":[280,304],"level":[281],"significantly":[283],"elevated":[284],"RCC":[286],"possibly":[288],"due":[289],"VEGF":[291],"stimulation":[292],"arginase":[294],"production.":[295],"4":[297],"patients":[298],"tested":[299],"date,":[301],"peripheral":[302],"blood":[303],"levels":[305],"dramatically":[307],"decreased":[308],"over":[309],"course":[311],"therapy.":[313],"Conclusions:":[314],"can":[319],"be":[320],"safely":[322],"may":[324],"impact":[325],"regulatory":[328],"pathways.":[329],"[Table:":[330],"see":[331],"text]":[332]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
