{"id":"https://openalex.org/W2228992136","doi":"https://doi.org/10.1371/journal.pone.0146314","title":"Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells","display_name":"Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells","publication_year":2016,"publication_date":"2016-01-05","ids":{"openalex":"https://openalex.org/W2228992136","doi":"https://doi.org/10.1371/journal.pone.0146314","mag":"2228992136","pmid":"https://pubmed.ncbi.nlm.nih.gov/26731332","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4701422"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0146314","doi":"https://doi.org/10.1371/journal.pone.0146314","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0146314","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0146314&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0146314&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012889950","display_name":"Reina Sasaki","orcid":"https://orcid.org/0000-0003-2681-0776","observed_orcids":["https://orcid.org/0000-0003-2681-0776"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reina Sasaki","raw_affiliation_strings":["Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058145589","display_name":"Tatsuo Kanda","orcid":"https://orcid.org/0000-0002-1654-5385","observed_orcids":["https://orcid.org/0000-0002-1654-5385"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tatsuo Kanda","raw_affiliation_strings":["Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001002762","display_name":"Masato Nakamura","orcid":"https://orcid.org/0000-0003-4080-2967","observed_orcids":["https://orcid.org/0000-0003-4080-2967"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Nakamura","raw_affiliation_strings":["Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050720566","display_name":"Shingo Nakamoto","orcid":"https://orcid.org/0000-0002-7241-219X","observed_orcids":["https://orcid.org/0000-0002-7241-219X"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shingo Nakamoto","raw_affiliation_strings":["Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan","Department of Molecular Virology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Molecular Virology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060263711","display_name":"Yuki Haga","orcid":"https://orcid.org/0000-0002-0070-2091","observed_orcids":["https://orcid.org/0000-0002-0070-2091"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Haga","raw_affiliation_strings":["Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100653340","display_name":"Shuang Wu","orcid":"https://orcid.org/0000-0001-8925-4610","observed_orcids":["https://orcid.org/0000-0001-8925-4610"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuang Wu","raw_affiliation_strings":["Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019832552","display_name":"Hiroshi Shirasawa","orcid":"https://orcid.org/0000-0001-5213-7242","observed_orcids":["https://orcid.org/0000-0001-5213-7242"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Shirasawa","raw_affiliation_strings":["Department of Molecular Virology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102927536","display_name":"Osamu Yokosuka","orcid":"https://orcid.org/0000-0002-1763-9439","observed_orcids":["https://orcid.org/0000-0002-1763-9439"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Yokosuka","raw_affiliation_strings":["Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, 260-8670, Japan","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058145589"],"corresponding_institution_ids":["https://openalex.org/I159385669"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.6149,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.82303098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"e0146314","last_page":"e0146314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9850000143051147},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.8740000128746033},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hbeag","display_name":"HBeAg","score":0.8679999709129333},{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hepatitis-b","display_name":"hepatitis B","score":0.492000013589859},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.4620000123977661},{"id":"https://openalex.org/keywords/inhibin-beta-a","display_name":"inhibin beta A","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.7620968818664551},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5930991172790527},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.5580475926399231},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5395459532737732},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.43728744983673096},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4195230007171631},{"id":"https://openalex.org/C184652730","wikidata":"https://www.wikidata.org/wiki/Q2357982","display_name":"Attenuation","level":2,"score":0.41083455085754395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3872765898704529},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37492144107818604},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23400554060935974},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13760575652122498},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05784955620765686},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007976","descriptor_name":"Leupeptins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0146314","doi":"https://doi.org/10.1371/journal.pone.0146314","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0146314","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0146314&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3688930","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4701422","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26731332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26731332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4701422","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4701422/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:01450:0004953753","doi":null,"is_oa":true,"landing_page_url":"https://opac.ll.chiba-u.jp/da/curator/102039/","pdf_url":"https://opac.ll.chiba-u.jp/da/curator/102039/FHA_1263_Y.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.807.1326","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.807.1326","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/76/97/pone.0146314.PMC4701422.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5c2cedab52a446dd94929076c75a8d69","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5c2cedab52a446dd94929076c75a8d69","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 11, Iss 1, p e0146314 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0146314","doi":"https://doi.org/10.1371/journal.pone.0146314","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0146314","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0146314&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7683188712","display_name":"The effect of sirtuin on the pathogenesis of hepatitis B virus-related liver disease","funder_award_id":"26860491","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320321625","display_name":"Daiichi-Sankyo","ror":"https://ror.org/027y26122"},{"id":"https://openalex.org/F4320333003","display_name":"Chugai Pharmaceutical","ror":"https://ror.org/01vepzj85"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2228992136.pdf","grobid_xml":"https://content.openalex.org/works/W2228992136.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W626007882","https://openalex.org/W959896788","https://openalex.org/W1506856062","https://openalex.org/W1552539137","https://openalex.org/W1595610660","https://openalex.org/W1923206005","https://openalex.org/W1965253007","https://openalex.org/W1968460020","https://openalex.org/W1975694876","https://openalex.org/W1977142640","https://openalex.org/W1982691378","https://openalex.org/W1993340412","https://openalex.org/W1997192714","https://openalex.org/W2000694500","https://openalex.org/W2001030268","https://openalex.org/W2001497311","https://openalex.org/W2004054613","https://openalex.org/W2005726042","https://openalex.org/W2009474584","https://openalex.org/W2009639774","https://openalex.org/W2010034646","https://openalex.org/W2010338556","https://openalex.org/W2020997672","https://openalex.org/W2025817084","https://openalex.org/W2033029728","https://openalex.org/W2038102205","https://openalex.org/W2049052313","https://openalex.org/W2064391231","https://openalex.org/W2073213047","https://openalex.org/W2077880395","https://openalex.org/W2085390667","https://openalex.org/W2090738619","https://openalex.org/W2093549375","https://openalex.org/W2096613043","https://openalex.org/W2100193879","https://openalex.org/W2104389844","https://openalex.org/W2108472288","https://openalex.org/W2111288662","https://openalex.org/W2111437705","https://openalex.org/W2112996635","https://openalex.org/W2114360920","https://openalex.org/W2116509216","https://openalex.org/W2121263677","https://openalex.org/W2121329898","https://openalex.org/W2121691792","https://openalex.org/W2127623403","https://openalex.org/W2127687001","https://openalex.org/W2140921924","https://openalex.org/W2140925895","https://openalex.org/W2142174965","https://openalex.org/W2143824108","https://openalex.org/W2165062244","https://openalex.org/W2165064047","https://openalex.org/W2416490991"],"related_works":["https://openalex.org/W7101057437","https://openalex.org/W2623554959","https://openalex.org/W2912101187","https://openalex.org/W1977356362","https://openalex.org/W2410361936","https://openalex.org/W149878256","https://openalex.org/W2071459839","https://openalex.org/W2525258509","https://openalex.org/W1993340412","https://openalex.org/W1998793469"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,22,57],"induction":[2],"of":[3,25,34,42,59,118,121,129,153,175,200,217,225],"apoptosis":[4,26,45,66,167,226],"in":[5,27,52,73,79,126,150,168,197,219,229],"hepatic":[6,20,230,258],"stellate":[7],"cells":[8,208],"(HSCs)":[9],"is":[10,147,157],"a":[11,253],"promising":[12],"therapeutic":[13],"strategy":[14,255],"against":[15],"hepatitis":[16],"B":[17],"virus":[18],"(HBV)-related":[19],"fibrosis.":[21,231,244,259],"underlying":[23],"mechanisms":[24],"HSCs,":[28,220],"however,":[29],"are":[30],"unknown":[31],"under":[32],"consideration":[33],"HBV":[35,43,144,213,232],"infection.":[36],"In":[37,83,108,137],"this":[38],"study,":[39],"the":[40,69,89,116,127,151,173,198,215,223],"effects":[41,58],"on":[44,65,165,252],"and":[46,75,105,123,191,227,243],"endoplasmic":[47,101],"reticulum":[48,102],"(ER)":[49,103],"stress":[50,104,237],"signaling":[51],"HSCs":[53],"were":[54,77,135,142],"examined.":[55],"METHODS:":[56],"conditioned":[60],"media":[61],"(CM)":[62],"from":[63,131,202,206],"HepG2.2.15":[64],"induced":[67],"by":[68],"proteasome":[70],"inhibitor":[71],"MG132":[72,111],"LX-2":[74,109],"HHSteC":[76,138],"studied":[78],"regard":[80],"to":[81,96,222],"c-Jun.":[82],"combination":[84],"with":[85,115,210,240],"c-Fos,":[86],"c-Jun":[87],"forms":[88],"AP-1":[90,97,122],"early":[91],"response":[92],"transcription":[93],"factor,":[94],"leading":[95],"activation,":[98],"signal":[99],"transduction,":[100],"apoptosis.":[106,124,155],"RESULTS:":[107],"cells,":[110,139],"treatment":[112,254],"was":[113],"associated":[114,239],"phosphorylation":[117],"c-Jun,":[119],"activation":[120,216],"However,":[125],"presence":[128,199],"CM":[130,201,205],"HepG2.2.15,":[132,203],"these":[133],"phenomena":[134],"attenuated.":[136],"similar":[140],"results":[141],"observed.":[143],"genomic":[145],"DNA":[146],"not":[148],"involved":[149],"process":[152],"HSC":[154],"It":[156],"possible":[158],"that":[159],"HBeAg":[160],"has":[161],"an":[162],"inhibitory":[163],"effect":[164],"MG132-induced":[166],"LX-2.":[169],"We":[170],"also":[171,233],"observed":[172],"upregulation":[174],"several":[176,235],"ER":[177,236],"stress-associated":[178],"genes,":[179],"such":[180],"as":[181],"cAMP":[182],"responsive":[183],"element":[184],"binding":[185],"protein":[186],"3-like":[187],"3,":[188],"inhibin-beta":[189],"A":[190],"solute":[192],"carrier":[193],"family":[194],"17-member":[195],"2,":[196],"or":[204],"PXB":[207],"infected":[209],"HBV.":[211],"CONCLUSIONS:":[212],"inhibits":[214],"c-Jun/AP-1":[218],"contributing":[221],"attenuation":[224],"resulting":[228],"up-regulated":[234],"genes":[238],"cell":[241],"growth":[242],"These":[245],"mechanistic":[246],"insights":[247],"might":[248],"shed":[249],"new":[250],"light":[251],"for":[256],"HBV-associated":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
