{"id":"https://openalex.org/W2228699448","doi":"https://doi.org/10.1161/circ.130.suppl_2.17726","title":"Abstract 17726: Comprehensive Evaluation of QT Interval During Abrupt Changes in Heart Rate and Associated Neurohormonal and Inflammatory Markers","display_name":"Abstract 17726: Comprehensive Evaluation of QT Interval During Abrupt Changes in Heart Rate and Associated Neurohormonal and Inflammatory Markers","publication_year":2014,"publication_date":"2014-11-25","ids":{"openalex":"https://openalex.org/W2228699448","doi":"https://doi.org/10.1161/circ.130.suppl_2.17726","mag":"2228699448"},"language":"en","primary_location":{"id":"doi:10.1161/circ.130.suppl_2.17726","doi":"https://doi.org/10.1161/circ.130.suppl_2.17726","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.130.suppl_2.17726","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047313476","display_name":"Matthew J. Kolek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J Kolek","raw_affiliation_strings":["Cardiovascular Medicine, Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046745226","display_name":"Babar Parvez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Babar Parvez","raw_affiliation_strings":["Cardiovascular Medicine, Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111777587","display_name":"Yanna Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanna Song","raw_affiliation_strings":["Biostatistics, Vanderbilt Univ, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics, Vanderbilt Univ, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070982135","display_name":"Robert L. Abraham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L Abraham","raw_affiliation_strings":["Cardiovascular Medicine, Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058141203","display_name":"Dan M. Roden","orcid":"https://orcid.org/0000-0002-6302-0389","observed_orcids":["https://orcid.org/0000-0002-6302-0389"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan M Roden","raw_affiliation_strings":["Cardiovascular Medicine and Clinical Pharmacology, Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine and Clinical Pharmacology, Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030984711","display_name":"Dawood Darbar","orcid":"https://orcid.org/0000-0002-4103-5977","observed_orcids":["https://orcid.org/0000-0002-4103-5977"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawood Darbar","raw_affiliation_strings":["Cardiovascular Medicine and Clinical Pharmacology, Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine and Clinical Pharmacology, Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"130","issue":"suppl_2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.06310000270605087,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/qt-interval-prolongation","display_name":"QT prolongation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/torsades-de-pointes","display_name":"torsades de pointes","score":0.777999997138977},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/atrial-pacing","display_name":"atrial pacing","score":0.6190000176429749},{"id":"https://openalex.org/keywords/heart-rate-reduction","display_name":"heart rate reduction","score":0.5559999942779541},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.953000009059906},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.972000002861023},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9649999737739563},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9860000014305115},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.8539999723434448},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9196414351463318},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.7470685243606567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7373002171516418},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6310524940490723},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.58484947681427},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.5324944257736206},{"id":"https://openalex.org/C2780486423","wikidata":"https://www.wikidata.org/wiki/Q1625433","display_name":"Torsades de pointes","level":3,"score":0.5096440315246582},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.506330132484436},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.30536791682243347},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.15903478860855103}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.130.suppl_2.17726","doi":"https://doi.org/10.1161/circ.130.suppl_2.17726","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.130.suppl_2.17726","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2149150880","https://openalex.org/W2055489520","https://openalex.org/W52503369","https://openalex.org/W2015335884","https://openalex.org/W1988210113","https://openalex.org/W3102018516","https://openalex.org/W1979709134","https://openalex.org/W2117987504","https://openalex.org/W2077787588","https://openalex.org/W1976172316"],"abstract_inverted_index":{"Background:":[0],"QT":[1,34,63,117,136,170,234,236],"interval":[2,35,52,148,171,237],"prolongation":[3],"and":[4,42,58,64,67,77,90,98,107,127,162,188,219,243,256],"risk":[5,266],"of":[6,55,141,267,273],"torsades":[7],"de":[8,269],"pointes":[9],"have":[10],"been":[11],"associated":[12,174,193,232],"with":[13,37,73,112,175,194,233,240],"abrupt":[14,38],"heart":[15],"rate":[16],"(HR)":[17],"slowing":[18],"after":[19,99,131,139,151,158,166,220,257,271],"cardioversion":[20],"from":[21,276],"atrial":[22,195],"fibrillation":[23],"(AF)":[24],"or":[25,205],"AV":[26,79],"nodal":[27],"ablation.":[28],"The":[29,101],"degree":[30],"to":[31],"which":[32],"the":[33,43,60,122,264],"prolongs":[36],"changes":[39,238],"in":[40,214,229,252],"HR,":[41],"underlying":[44],"mechanisms,":[45],"are":[46],"poorly":[47],"understood.":[48],"We":[49],"quantified":[50],"\u0394QT":[51],"during":[53,97],"cessation":[54,140],"rapid":[56,142],"pacing":[57,105,133,221],"examined":[59],"relationship":[61],"between":[62,103],"circulating":[65],"neurohormonal":[66],"inflammatory":[68,244],"markers.":[69],"Methods:":[70],"Eleven":[71],"subjects":[72],"dual":[74],"chamber":[75],"pacemakers":[76],"intact":[78],"conduction":[80],"were":[81,95,110,119,209,231,248],"atrially-paced":[82],"at":[83],"90/min":[84],"for":[85,121,223],"10":[86,152],"min,":[87,89],"60":[88,159],"1":[91,167],"week":[92,168],"(Figure).":[93],"Biomarkers":[94],"sampled":[96],"pacing.":[100,258],"relationships":[102],"QT,":[104],"stage,":[106],"biomarker":[108,215,253],"levels":[109,216,254],"analyzed":[111],"a":[113],"mixed":[114],"effect":[115],"model.":[116],"intervals":[118,125,130,137],"compared":[120],"20":[123],"RR":[124,129],"before":[126,218,255],"100":[128],"each":[132],"stage.":[134],"Results:":[135],"prolonged":[138],"pacing:":[143],"6.4":[144],"ms":[145],"(95%":[146],"confidence":[147],"4.9-7.8":[149],"ms)":[150,157,165],"min":[153,160],"(P<0.0001),":[154,161,180,184,190],"6.1ms":[155],"(4.6-7.5":[156],"2.2ms":[163],"(0.9-3.6":[164],"(P=0.002).":[169],"was":[172],"significantly":[173],"angiotensin":[176],"II":[177],"(P=0.002),":[178],"epinephrine":[179],"norepinephrine":[181],"(P=0.03),":[182],"dopamine":[183],"C-reactive":[185],"protein":[186],"(P=0.0005),":[187],"interleukin-6":[189],"but":[191],"not":[192],"natriuretic":[196,200],"peptide":[197,201],"(P=0.26),":[198],"B-type":[199],"(P=0.08),":[202],"renin":[203],"(P=0.25),":[204],"aldosterone":[206],"(P=0.42).":[207],"There":[208],"no":[210,249],"significant":[211],"inter-individual":[212,250],"differences":[213,251],"drawn":[217],"(P>0.1":[222],"all":[224],"comparisons).":[225],"Conclusion:":[226],"Abrupt":[227],"decreases":[228],"HR":[230],"prolongation.":[235],"correlated":[239],"several":[241],"neuroendocrine":[242],"biomarkers,":[245],"though":[246],"there":[247],"These":[259],"findings":[260],"may":[261],"partially":[262],"explain":[263],"increased":[265],"torsade":[268],"points":[270],"restoration":[272],"sinus":[274],"rhythm":[275],"AF.":[277]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
