{"id":"https://openalex.org/W2228513682","doi":"https://doi.org/10.1016/j.etp.2015.12.005","title":"Histopathological image analysis of chemical-induced hepatocellular hypertrophy in mice","display_name":"Histopathological image analysis of chemical-induced hepatocellular hypertrophy in mice","publication_year":2016,"publication_date":"2016-01-08","ids":{"openalex":"https://openalex.org/W2228513682","doi":"https://doi.org/10.1016/j.etp.2015.12.005","mag":"2228513682","pmid":"https://pubmed.ncbi.nlm.nih.gov/26776450"},"language":"en","primary_location":{"id":"doi:10.1016/j.etp.2015.12.005","doi":"https://doi.org/10.1016/j.etp.2015.12.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.etp.2015.12.005","pdf_url":null,"source":{"id":"https://openalex.org/S93526581","display_name":"Experimental and Toxicologic Pathology","issn_l":"0940-2993","issn":["0940-2993","1618-1433"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046319306","display_name":"Yoshiji Asaoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115317","display_name":"Toray Industries, Inc. (Japan)","ror":"https://ror.org/029xh1r47","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiji Asaoka","raw_affiliation_strings":["Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan","institution_ids":["https://openalex.org/I4210115317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070183777","display_name":"Yuko Togashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115317","display_name":"Toray Industries, Inc. (Japan)","ror":"https://ror.org/029xh1r47","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Togashi","raw_affiliation_strings":["Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan","institution_ids":["https://openalex.org/I4210115317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019375179","display_name":"Mayu Mutsuga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115317","display_name":"Toray Industries, Inc. (Japan)","ror":"https://ror.org/029xh1r47","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayu Mutsuga","raw_affiliation_strings":["Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan","institution_ids":["https://openalex.org/I4210115317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014070193","display_name":"Naoko Imura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115317","display_name":"Toray Industries, Inc. (Japan)","ror":"https://ror.org/029xh1r47","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko Imura","raw_affiliation_strings":["Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan","institution_ids":["https://openalex.org/I4210115317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022087054","display_name":"Tomoya Miyoshi","orcid":"https://orcid.org/0000-0002-5777-1821","observed_orcids":["https://orcid.org/0000-0002-5777-1821"]},"institutions":[{"id":"https://openalex.org/I4210115317","display_name":"Toray Industries, Inc. (Japan)","ror":"https://ror.org/029xh1r47","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoya Miyoshi","raw_affiliation_strings":["Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan","institution_ids":["https://openalex.org/I4210115317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109195984","display_name":"Yohei Miyamoto","orcid":"https://orcid.org/0009-0003-6659-7954","observed_orcids":["https://orcid.org/0009-0003-6659-7954"]},"institutions":[{"id":"https://openalex.org/I4210115317","display_name":"Toray Industries, Inc. (Japan)","ror":"https://ror.org/029xh1r47","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115317"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yohei Miyamoto","raw_affiliation_strings":["Pharmaceutical Clinical Research Department, Toray Industries, Inc., 1-1, Nihonbashi-muromachi 2-chome, Chuo-ku, Tokyo 103-8666, Japan. Electronic address: Youhei_Miyamoto@nts.toray.co.jp","Pharmaceutical Clinical Research Department, Toray Industries, Inc., 1-1, Nihonbashi-muromachi 2-chome, Chuo-ku, Tokyo 103-8666, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Clinical Research Department, Toray Industries, Inc., 1-1, Nihonbashi-muromachi 2-chome, Chuo-ku, Tokyo 103-8666, Japan. Electronic address: Youhei_Miyamoto@nts.toray.co.jp","institution_ids":["https://openalex.org/I4210115317"]},{"raw_affiliation_string":"Pharmaceutical Clinical Research Department, Toray Industries, Inc., 1-1, Nihonbashi-muromachi 2-chome, Chuo-ku, Tokyo 103-8666, Japan","institution_ids":["https://openalex.org/I4210115317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109195984"],"corresponding_institution_ids":["https://openalex.org/I4210115317"],"apc_list":null,"apc_paid":null,"fwci":2.9166,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.88394858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"68","issue":"4","first_page":"233","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.4805000126361847,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.4805000126361847,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.3684000074863434,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-hypertrophy","display_name":"hepatocyte hypertrophy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chemical-induced-liver-injury","display_name":"chemical-induced liver injury","score":0.6579999923706055},{"id":"https://openalex.org/keywords/image-analysis-algorithms","display_name":"image analysis algorithms","score":0.652999997138977},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.9070000052452087},{"id":"https://openalex.org/keywords/clofibrate","display_name":"clofibrate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-weight","display_name":"liver weight","score":0.8299999833106995},{"id":"https://openalex.org/keywords/h-e-staining","display_name":"H&E staining","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6825148463249207},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.6353601217269897},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.45472729206085205},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.4471908211708069},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.44677308201789856},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42030516266822815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41120046377182007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34834784269332886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32535892724990845},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3123599588871002},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2929689288139343},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14370033144950867},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002994","descriptor_name":"Clofibrate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006529","descriptor_name":"Hepatomegaly","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006529","descriptor_name":"Hepatomegaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.etp.2015.12.005","doi":"https://doi.org/10.1016/j.etp.2015.12.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.etp.2015.12.005","pdf_url":null,"source":{"id":"https://openalex.org/S93526581","display_name":"Experimental and Toxicologic Pathology","issn_l":"0940-2993","issn":["0940-2993","1618-1433"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:26776450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26776450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1489925880","https://openalex.org/W1563662477","https://openalex.org/W1993669821","https://openalex.org/W1997752162","https://openalex.org/W2004308169","https://openalex.org/W2008550590","https://openalex.org/W2025623420","https://openalex.org/W2025963017","https://openalex.org/W2027241866","https://openalex.org/W2034928579","https://openalex.org/W2055574904","https://openalex.org/W2062795135","https://openalex.org/W2064025720","https://openalex.org/W2065107673","https://openalex.org/W2072696720","https://openalex.org/W2077969705","https://openalex.org/W2082724230","https://openalex.org/W2088014510","https://openalex.org/W2096945589","https://openalex.org/W2099339438","https://openalex.org/W2099540110","https://openalex.org/W2101225650","https://openalex.org/W2101979288","https://openalex.org/W2102743276","https://openalex.org/W2115298024","https://openalex.org/W2125739220","https://openalex.org/W2130900820","https://openalex.org/W2132147596","https://openalex.org/W2137410673","https://openalex.org/W2137773299","https://openalex.org/W2144989123","https://openalex.org/W2145732035","https://openalex.org/W2151753845","https://openalex.org/W2166327262","https://openalex.org/W2168300082","https://openalex.org/W2265863159","https://openalex.org/W2328922887","https://openalex.org/W2766368224","https://openalex.org/W4246256927"],"related_works":["https://openalex.org/W2119018298","https://openalex.org/W4403080135","https://openalex.org/W2020689520","https://openalex.org/W2037124819","https://openalex.org/W4256376815","https://openalex.org/W1585003308","https://openalex.org/W2549953203","https://openalex.org/W6903760251","https://openalex.org/W2032758443","https://openalex.org/W2083312885"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
