{"id":"https://openalex.org/W2228326720","doi":"https://doi.org/10.1007/s00213-015-4194-5","title":"Escitalopram reversed the traumatic stress-induced depressed and anxiety-like symptoms but not the deficits of fear memory","display_name":"Escitalopram reversed the traumatic stress-induced depressed and anxiety-like symptoms but not the deficits of fear memory","publication_year":2016,"publication_date":"2016-01-07","ids":{"openalex":"https://openalex.org/W2228326720","doi":"https://doi.org/10.1007/s00213-015-4194-5","mag":"2228326720","pmid":"https://pubmed.ncbi.nlm.nih.gov/26740318"},"language":"en","primary_location":{"id":"doi:10.1007/s00213-015-4194-5","doi":"https://doi.org/10.1007/s00213-015-4194-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00213-015-4194-5","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012757479","display_name":"Chen-Cheng Lin","orcid":"https://orcid.org/0000-0001-6018-0654","observed_orcids":["https://orcid.org/0000-0001-6018-0654"]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen-Cheng Lin","raw_affiliation_strings":["Department of Physiology and Biophysics, National Defense Medical Center, Taipei, 11490, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, National Defense Medical Center, Taipei, 11490, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008613472","display_name":"Che\u2010Se Tung","orcid":"https://orcid.org/0000-0002-2216-6226","observed_orcids":["https://orcid.org/0000-0002-2216-6226"]},"institutions":[{"id":"https://openalex.org/I4210101378","display_name":"Cheng Hsin General Hospital","ror":"https://ror.org/014f77s28","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210101378"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Che-Se Tung","raw_affiliation_strings":["Division of Medical Research and Education, Cheng Hsin General Hospital, Taipei, 11220, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Research and Education, Cheng Hsin General Hospital, Taipei, 11220, Taiwan","institution_ids":["https://openalex.org/I4210101378"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018733032","display_name":"Yia\u2010Ping Liu","orcid":"https://orcid.org/0000-0003-3250-6850","observed_orcids":["https://orcid.org/0000-0003-3250-6850","https://orcid.org/0000-0002-1171-6560"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yia-Ping Liu","raw_affiliation_strings":["Department of Physiology and Biophysics, National Defense Medical Center, Taipei, 11490, Taiwan. yiaping@ms75.hinet.net","Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, 11490, Taiwan. yiaping@ms75.hinet.net","Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, 11490, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, National Defense Medical Center, Taipei, 11490, Taiwan. yiaping@ms75.hinet.net","institution_ids":["https://openalex.org/I68171755"]},{"raw_affiliation_string":"Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, 11490, Taiwan. yiaping@ms75.hinet.net","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]},{"raw_affiliation_string":"Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, 11490, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018733032"],"corresponding_institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":15.1591,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.99163537,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"233","issue":"7","first_page":"1135","last_page":"1146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escitalopram","display_name":"escitalopram","score":0.9819999933242798},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.9779999852180481},{"id":"https://openalex.org/keywords/single-prolonged-stress","display_name":"single prolonged stress","score":0.8700000047683716},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.847000002861023},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6510000228881836},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.871999979019165},{"id":"https://openalex.org/keywords/fear-extinction","display_name":"fear extinction","score":0.8080000281333923},{"id":"https://openalex.org/keywords/fear-memory","display_name":"fear memory","score":0.8669999837875366},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.8109999895095825},{"id":"https://openalex.org/keywords/monoamines","display_name":"monoamines","score":0.8130000233650208},{"id":"https://openalex.org/keywords/infralimbic-cortex","display_name":"infralimbic cortex","score":0.9070000052452087},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7269999980926514},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.6589999794960022},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/anhedonia","display_name":"anhedonia","score":0.8140000104904175},{"id":"https://openalex.org/keywords/avoidance-behavior","display_name":"avoidance behavior","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.6760988235473633},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6374937295913696},{"id":"https://openalex.org/C2779583969","wikidata":"https://www.wikidata.org/wiki/Q423757","display_name":"Escitalopram","level":4,"score":0.6069897413253784},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.5686649680137634},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5625623464584351},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.4771974980831146},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.43145692348480225},{"id":"https://openalex.org/C2778941446","wikidata":"https://www.wikidata.org/wiki/Q545365","display_name":"Anhedonia","level":3,"score":0.4242759346961975},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.42018482089042664},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.41765347123146057},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.4158608913421631},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4052043855190277},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.3892558515071869},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3774178624153137},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3504522144794464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31709885597229004},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2692505121231079},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.12498641014099121},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015283","descriptor_name":"Citalopram","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015283","descriptor_name":"Citalopram","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00213-015-4194-5","doi":"https://doi.org/10.1007/s00213-015-4194-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00213-015-4194-5","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:26740318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26740318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W42266823","https://openalex.org/W162706120","https://openalex.org/W1530873853","https://openalex.org/W1536317835","https://openalex.org/W1582748228","https://openalex.org/W1967887989","https://openalex.org/W1968434317","https://openalex.org/W1973801497","https://openalex.org/W1977406433","https://openalex.org/W1977430165","https://openalex.org/W1978971276","https://openalex.org/W1988800128","https://openalex.org/W1999867718","https://openalex.org/W2001092446","https://openalex.org/W2006578293","https://openalex.org/W2008083196","https://openalex.org/W2008992063","https://openalex.org/W2013871694","https://openalex.org/W2018346570","https://openalex.org/W2019438546","https://openalex.org/W2026836897","https://openalex.org/W2027418676","https://openalex.org/W2030441588","https://openalex.org/W2035094975","https://openalex.org/W2038369591","https://openalex.org/W2039009537","https://openalex.org/W2039047753","https://openalex.org/W2039207414","https://openalex.org/W2040624569","https://openalex.org/W2041134333","https://openalex.org/W2048263888","https://openalex.org/W2051279483","https://openalex.org/W2055310634","https://openalex.org/W2055621130","https://openalex.org/W2060210617","https://openalex.org/W2061559918","https://openalex.org/W2061601835","https://openalex.org/W2061896629","https://openalex.org/W2064431700","https://openalex.org/W2069825985","https://openalex.org/W2074597381","https://openalex.org/W2078706623","https://openalex.org/W2079922358","https://openalex.org/W2080103278","https://openalex.org/W2080467478","https://openalex.org/W2087740775","https://openalex.org/W2103558642","https://openalex.org/W2105815100","https://openalex.org/W2108888119","https://openalex.org/W2113485684","https://openalex.org/W2114221514","https://openalex.org/W2125074758","https://openalex.org/W2132043925","https://openalex.org/W2133388683","https://openalex.org/W2140201388","https://openalex.org/W2140500194","https://openalex.org/W2144370027","https://openalex.org/W2144491415","https://openalex.org/W2144859687","https://openalex.org/W2153060632","https://openalex.org/W2153437877","https://openalex.org/W2156152261","https://openalex.org/W2156870567","https://openalex.org/W2159450883","https://openalex.org/W2163815564","https://openalex.org/W2165354335","https://openalex.org/W2165937541","https://openalex.org/W2281440875","https://openalex.org/W2906253013","https://openalex.org/W3139830724","https://openalex.org/W4241715325","https://openalex.org/W4247665917"],"related_works":["https://openalex.org/W4385605509","https://openalex.org/W2334311442","https://openalex.org/W2502404802","https://openalex.org/W2996945381","https://openalex.org/W2070687897","https://openalex.org/W2156152261","https://openalex.org/W2908450252","https://openalex.org/W7097217021","https://openalex.org/W2132706865","https://openalex.org/W1972506325"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}