{"id":"https://openalex.org/W2228218490","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.4512","title":"Carbonic Anhydrase IX (CAIX) expression predicts for renal cell cancer (RCC) patient response and survival to IL-2 therapy","display_name":"Carbonic Anhydrase IX (CAIX) expression predicts for renal cell cancer (RCC) patient response and survival to IL-2 therapy","publication_year":2004,"publication_date":"2004-07-15","ids":{"openalex":"https://openalex.org/W2228218490","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.4512","mag":"2228218490"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.22.14_suppl.4512","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.4512","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.4512","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052526230","display_name":"Michael B. Atkins","orcid":"https://orcid.org/0000-0003-3901-9924","observed_orcids":["https://orcid.org/0000-0003-3901-9924"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Atkins","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I204250578","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007052233","display_name":"David F. McDermott","orcid":"https://orcid.org/0000-0002-2675-5095","observed_orcids":["https://orcid.org/0000-0002-2675-5095","https://orcid.org/0000-0001-6978-0867"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. McDermott","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I204250578","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017334876","display_name":"Meredith M. Regan","orcid":"https://orcid.org/0000-0002-2428-6109","observed_orcids":["https://orcid.org/0000-0002-2428-6109"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Regan","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I204250578","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052269548","display_name":"Eric J. Stanbridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Stanbridge","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I204250578","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110112941","display_name":"Melissa P. Upton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Upton","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I204250578","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076200984","display_name":"Amanda J. Youmans","orcid":"https://orcid.org/0009-0007-1180-0731","observed_orcids":["https://orcid.org/0009-0007-1180-0731"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Youmans","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I204250578","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058375967","display_name":"Phillip G. Febbo","orcid":"https://orcid.org/0000-0002-6496-4664","observed_orcids":["https://orcid.org/0000-0002-6496-4664"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Febbo","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I204250578","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017403551","display_name":"Mirna Lechpammer","orcid":"https://orcid.org/0000-0002-6235-6227","observed_orcids":["https://orcid.org/0000-0002-6235-6227"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Lechpammer","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I204250578","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046795494","display_name":"Sabina Signoretti","orcid":"https://orcid.org/0000-0002-5000-9105","observed_orcids":["https://orcid.org/0000-0002-5000-9105"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Signoretti","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; University of California Irvine, Irvine, CA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I204250578","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"14_suppl","first_page":"4512","last_page":"4512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbonic-anhydrase-ix","display_name":"carbonic anhydrase IX","score":0.9750000238418579},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/interleukin-2-therapy","display_name":"interleukin-2 therapy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tumor-response-prediction","display_name":"tumor response prediction","score":0.6389999985694885},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.6579999923706055},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tumor-histology","display_name":"tumor histology","score":0.6069999933242798},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.7210000157356262},{"id":"https://openalex.org/keywords/papillary-renal-cell-carcinoma","display_name":"papillary renal cell carcinoma","score":0.8700000047683716},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7419999837875366},{"id":"https://openalex.org/keywords/prognostic-stratification","display_name":"prognostic stratification","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8643538355827332},{"id":"https://openalex.org/C2991767035","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Induction therapy","level":3,"score":0.5122653841972351},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49309584498405457},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47480833530426025},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44832178950309753},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4443003535270691},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.4299105703830719},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.4111519753932953},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.199444979429245}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.22.14_suppl.4512","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.4512","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.4512","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.1200/jco.2004.22.90140.4512","doi":"https://doi.org/10.1200/jco.2004.22.90140.4512","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.90140.4512","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2107765339","https://openalex.org/W29259776","https://openalex.org/W2270972909","https://openalex.org/W2095968776","https://openalex.org/W2050498546","https://openalex.org/W2791855345","https://openalex.org/W2188364086","https://openalex.org/W3044339288","https://openalex.org/W2157037524","https://openalex.org/W3029508204"],"abstract_inverted_index":{"4512":[0],"Background:":[1],"RCC":[2,72,293],"response":[3],"to":[4,14,51,78,105,134,152,174,266,310,344],"IL-2":[5,319],"Rx":[6,297,320],"and":[7,22,24,29,38,53,80,90,140,148,206,256,298,336],"patient":[8],"(pt)":[9],"survival":[10,182],"have":[11],"been":[12],"correlated":[13,84],"histology":[15],"including":[16],"the":[17,25,64,91,127,153,211,227,244,311],"presence":[18],"of":[19,27,71,98,126,164,213,243,261,290],"clear":[20],"cell":[21],"alveolar":[23],"absence":[26],"papillary":[28],"granular":[30],"features":[31],"(Upton":[32],"et":[33,42],"al":[34,43],"Proc":[35],"ASCO,":[36],"2003)":[37],"CAIX":[39,79,99,161,171,195,198,214,235,258,284,338],"expression":[40,81,172,215,236,285],"(Bui":[41],"Clin":[44],"Ca":[45],"Res":[46],"2003;9:802).":[47],"In":[48],"an":[49,76,287],"effort":[50],"confirm":[52],"expand":[54],"these":[55],"findings":[56],"we":[57],"undertook":[58],"a":[59,180,240],"nested":[60],"case-control":[61],"study":[62],"within":[63],"Upton":[65,92,154,245,328],"cohort.":[66],"Methods:":[67],"Paraffin-embedded":[68],"tissue":[69],"sections":[70],"were":[73,83,118,143,216],"immunostained":[74],"with":[75,85,202,250,327],"Ab":[77],"levels":[82],"pathology":[86,204,252,255,305,312,331,335],"findings,":[87],"clinical":[88],"outcome":[89,291],"model":[93,313,329],"relating":[94],"them.":[95],"The":[96,222],"percentage":[97],"positive":[100],"tumor":[101],"cells":[102],"was":[103,184,190,200,225,275],"utilized":[104],"separate":[106],"high":[107,160,170,194,234,257,337],"(>":[108],"85%)":[109,113],"vs":[110],"low":[111],"(\u2264":[112],"expressers.":[114],"Results:":[115],"Tissue":[116],"specimens":[117,157],"obtained":[119,303],"from":[120,304],"66":[121],"pts":[122,129,168,294,326],"(51M,":[123],"15F).":[124],"27":[125,165,262],"selected":[128],"(41%)":[130],"had":[131,159,169],"responded":[132],"(10CR/17PR)":[133],"IL-2.":[135],"24":[136],"(36%),":[137],"31":[138],"(47%)":[139],"11":[141],"(17%)":[142],"classified":[144],"as":[145],"good,":[146],"intermediate,":[147],"poor":[149],"prognosis":[150],"according":[151],"model.":[155,246],"41":[156],"(62%)":[158],"expression.":[162],"21":[163],"(78%)":[166],"responding":[167],"compared":[173,265],"20/39":[175],"(51%)":[176],"non-responders":[177,270],"(OR=3.3;":[178],"p=0.04);":[179],"similar":[181],"benefit":[183,274],"seen":[185,191,277],"(p=0.04).":[186],"Survival":[187,273],">5":[188],"yrs":[189],"only":[192,267],"in":[193,226,292],"expressors.":[196],"High":[197],"staining":[199],"associated":[201],"better":[203],"prognosis,":[205],"when":[207],"stratified":[208],"by":[209],"group,":[210],"ORs":[212],"unequal":[217],"across":[218],"groups":[219],"(p=0.08)":[220],".":[221],"stongest":[223],"association":[224],"intermediate":[228,254,334],"group":[229,249],"where":[230],"9/9":[231],"responders":[232,264],"has":[233],"vs.11/22":[237],"non-responders,":[238],"suggesting":[239],"possible":[241],"refinement":[242,309],"A":[247],"resultant":[248],"good":[251,330],"or":[253,333],"contained":[259],"26":[260],"(96%)":[263],"18/39":[268],"(46%)":[269],"(OR=30;":[271],"p<0.01).":[272],"also":[276],"(p<":[278],"0.01).":[279],"Conclusions:":[280],"We":[281],"conclude":[282],"that":[283,318],"is":[286],"important":[288],"predictor":[289],"receiving":[295],"IL-2-based":[296],"can":[299],"enhance":[300],"prognostic":[301],"information":[302],"specimens.":[306],"While":[307],"this":[308],"requires":[314],"validation,":[315],"data":[316],"suggest":[317],"might":[321],"ultimately":[322],"be":[323],"reserved":[324],"for":[325],"alone":[332],"staining.":[339],"No":[340],"significant":[341],"financial":[342],"relationships":[343],"disclose.":[345]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
