{"id":"https://openalex.org/W2227294641","doi":"https://doi.org/10.1603/me11171","title":"Cloning and Sequence Analysis of the Circadian Clock GenesperiodandtimelessinAedes albopictus(Diptera: Culicidae)","display_name":"Cloning and Sequence Analysis of the Circadian Clock GenesperiodandtimelessinAedes albopictus(Diptera: Culicidae)","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W2227294641","doi":"https://doi.org/10.1603/me11171","mag":"2227294641","pmid":"https://pubmed.ncbi.nlm.nih.gov/22679889"},"language":"en","primary_location":{"id":"doi:10.1603/me11171","doi":"https://doi.org/10.1603/me11171","is_oa":true,"landing_page_url":"https://doi.org/10.1603/me11171","pdf_url":"https://academic.oup.com/jme/article-pdf/49/3/777/18219923/jmedent49-0777.pdf","source":{"id":"https://openalex.org/S80921037","display_name":"Journal of Medical Entomology","issn_l":"0022-2585","issn":["0022-2585","1938-2928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Entomology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jme/article-pdf/49/3/777/18219923/jmedent49-0777.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026205750","display_name":"Keith C. Summa","orcid":"https://orcid.org/0000-0001-9541-8458","observed_orcids":["https://orcid.org/0000-0001-9541-8458"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Summa","raw_affiliation_strings":["Department of Biology, Reiss 406, Georgetown University, 37th and O Streets NW, Washington, DC 20057-1229, USA","Department of Biology, Reiss 406, Georgetown University, 37th and O Streets NW, Washington, DC 20057-1229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Reiss 406, Georgetown University, 37th and O Streets NW, Washington, DC 20057-1229, USA","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"Department of Biology, Reiss 406, Georgetown University, 37th and O Streets NW, Washington, DC 20057-1229","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054562566","display_name":"Jennifer M. Urbanski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Urbanski","raw_affiliation_strings":["Department of Biology, Reiss 406, Georgetown University, 37 th and O Streets NW, Washington, DC 20057-1229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Reiss 406, Georgetown University, 37 th and O Streets NW, Washington, DC 20057-1229","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100529260","display_name":"Xiumei Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiumei Zhao","raw_affiliation_strings":["Department of Biology, Reiss 406, Georgetown University, 37 th and O Streets NW, Washington, DC 20057-1229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Reiss 406, Georgetown University, 37 th and O Streets NW, Washington, DC 20057-1229","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077698266","display_name":"Monica F. Poelchau","orcid":"https://orcid.org/0000-0002-4584-6056","observed_orcids":["https://orcid.org/0000-0002-4584-6056"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Poelchau","raw_affiliation_strings":["Department of Biology, Reiss 406, Georgetown University, 37 th and O Streets NW, Washington, DC 20057-1229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Reiss 406, Georgetown University, 37 th and O Streets NW, Washington, DC 20057-1229","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069323728","display_name":"Peter Armbruster","orcid":"https://orcid.org/0000-0002-8183-3842","observed_orcids":["https://orcid.org/0000-0002-8183-3842"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Armbruster","raw_affiliation_strings":["Department of Biology , Reiss 406 , Georgetown University , 37 th and O Streets NW , Washington , DC 20057-1229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology , Reiss 406 , Georgetown University , 37 th and O Streets NW , Washington , DC 20057-1229","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184565670"],"apc_list":{"value":4328,"currency":"USD","value_usd":4328},"apc_paid":{"value":4328,"currency":"USD","value_usd":4328},"fwci":0.4252,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.60632802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"49","issue":"3","first_page":"777","last_page":"782"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aedes-albopictus","display_name":"Aedes albopictus","score":0.9449999928474426},{"id":"https://openalex.org/keywords/clock-genes","display_name":"clock genes","score":0.7950000166893005},{"id":"https://openalex.org/keywords/period-gene","display_name":"period gene","score":0.9639999866485596},{"id":"https://openalex.org/keywords/timeless-gene","display_name":"timeless gene","score":1.0},{"id":"https://openalex.org/keywords/period-protein","display_name":"PERIOD protein","score":0.8420000076293945},{"id":"https://openalex.org/keywords/aedes-aegypti","display_name":"Aedes aegypti","score":0.8830000162124634},{"id":"https://openalex.org/keywords/introns","display_name":"introns","score":0.6179999709129333},{"id":"https://openalex.org/keywords/phylogenetic-analysis","display_name":"phylogenetic analysis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/purifying-selection","display_name":"purifying selection","score":0.6880000233650208},{"id":"https://openalex.org/keywords/orthology","display_name":"orthology","score":0.7099999785423279},{"id":"https://openalex.org/keywords/phylogeography","display_name":"phylogeography","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9468369483947754},{"id":"https://openalex.org/C2776853612","wikidata":"https://www.wikidata.org/wiki/Q477918","display_name":"Aedes albopictus","level":4,"score":0.7820237874984741},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7054967880249023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5872109532356262},{"id":"https://openalex.org/C2778880379","wikidata":"https://www.wikidata.org/wiki/Q7805543","display_name":"Timeless","level":3,"score":0.5236560702323914},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.46053412556648254},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.4364601969718933},{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.43084901571273804},{"id":"https://openalex.org/C2777775583","wikidata":"https://www.wikidata.org/wiki/Q1148004","display_name":"Aedes aegypti","level":3,"score":0.3485032916069031},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.27988192439079285},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.27918127179145813},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.06580919027328491},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000330","descriptor_name":"Aedes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058974","descriptor_name":"Phylogeography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1603/me11171","doi":"https://doi.org/10.1603/me11171","is_oa":true,"landing_page_url":"https://doi.org/10.1603/me11171","pdf_url":"https://academic.oup.com/jme/article-pdf/49/3/777/18219923/jmedent49-0777.pdf","source":{"id":"https://openalex.org/S80921037","display_name":"Journal of Medical Entomology","issn_l":"0022-2585","issn":["0022-2585","1938-2928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Entomology","raw_type":"journal-article"},{"id":"pmid:22679889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22679889","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical entomology","raw_type":"Journal Article"},{"id":"pmh:10.1603/ME11171","doi":null,"is_oa":false,"landing_page_url":"http://www.bioone.org/doi/10.1603/ME11171","pdf_url":null,"source":{"id":"https://openalex.org/S4306402358","display_name":"BioOne Complete (BioOne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210111627","host_organization_name":"BioOne","host_organization_lineage":["https://openalex.org/I4210111627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1603/me11171","doi":"https://doi.org/10.1603/me11171","is_oa":true,"landing_page_url":"https://doi.org/10.1603/me11171","pdf_url":"https://academic.oup.com/jme/article-pdf/49/3/777/18219923/jmedent49-0777.pdf","source":{"id":"https://openalex.org/S80921037","display_name":"Journal of Medical Entomology","issn_l":"0022-2585","issn":["0022-2585","1938-2928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Entomology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310223","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2227294641.pdf","grobid_xml":"https://content.openalex.org/works/W2227294641.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W56346502","https://openalex.org/W1484069803","https://openalex.org/W1498681083","https://openalex.org/W1527374249","https://openalex.org/W1592870802","https://openalex.org/W1845170918","https://openalex.org/W1947483389","https://openalex.org/W1964802479","https://openalex.org/W1968410906","https://openalex.org/W1977019112","https://openalex.org/W1979385177","https://openalex.org/W1982200938","https://openalex.org/W1984390786","https://openalex.org/W2007915206","https://openalex.org/W2018873867","https://openalex.org/W2023831182","https://openalex.org/W2034492280","https://openalex.org/W2040561723","https://openalex.org/W2045416867","https://openalex.org/W2046183549","https://openalex.org/W2064994413","https://openalex.org/W2069849645","https://openalex.org/W2073415159","https://openalex.org/W2090943813","https://openalex.org/W2114427883","https://openalex.org/W2125121305","https://openalex.org/W2139624496","https://openalex.org/W2139819456","https://openalex.org/W2144575647","https://openalex.org/W2144634347","https://openalex.org/W2145517507","https://openalex.org/W2147192293","https://openalex.org/W2147739177","https://openalex.org/W2151305846","https://openalex.org/W2154519035","https://openalex.org/W2154845780","https://openalex.org/W2175604508","https://openalex.org/W2176275638","https://openalex.org/W2178110902","https://openalex.org/W2179975011","https://openalex.org/W2504851667","https://openalex.org/W2804007336","https://openalex.org/W3001777699"],"related_works":["https://openalex.org/W4249857599","https://openalex.org/W4242128090","https://openalex.org/W4248510883","https://openalex.org/W4251240485","https://openalex.org/W2133346443","https://openalex.org/W2041695877","https://openalex.org/W2007915206","https://openalex.org/W2531586183","https://openalex.org/W2137079664","https://openalex.org/W2378379954"],"abstract_inverted_index":{"The":[0],"genes":[1,57,158],"period":[2],"(per)":[3],"and":[4,23,28,37,46,55,109,111,119,128,141,156,171,195,207],"timeless":[5],"(tim)":[6],"are":[7],"core":[8],"components":[9],"of":[10,19,40,51,68,84,96,101,130,136,145,189,202],"the":[11,48,53,65,69,81,85,116,123,134,137,154,167,186],"circadian":[12,190,204],"clock":[13,205],"that":[14,152,180],"regulates":[15],"a":[16],"wide":[17],"range":[18],"rhythmic":[20],"biochemical,":[21],"physiological,":[22],"behavioral":[24],"processes":[25],"in":[26,58,88,115,122,192],"prokaryotes":[27],"eukaryotes.":[29],"We":[30,62,92],"used":[31,64,183],"degenerate":[32],"polymerase":[33],"chain":[34],"reaction":[35],"(PCR)":[36],"Rapid":[38],"Amplification":[39],"cDNA":[41,73],"Ends":[42],"(RACE)":[43],"to":[44,74,147,166,184,198,209],"clone":[45],"sequence":[47,78],"entire":[49],"cDNAs":[50],"both":[52,153],"per":[54,72,117,140,155],"tim":[56,124,142,157],"Aedes":[59,89],"albopictus":[60,71,170,194],"(Skuse).":[61],"also":[63,208],"5'":[66],"end":[67],"Ae.":[70,172,193],"identify":[75],"previously":[76],"unannotated":[77],"coding":[79],"for":[80],"N-terminal":[82],"region":[83],"PERIOD":[86],"protein":[87],"aegypti":[90],"L.":[91],"sequenced":[93],"genomic":[94],"DNA":[95],"one":[97],"mosquito":[98],"from":[99],"each":[100],"three":[102,113],"geographically":[103],"distinct":[104],"populations":[105],"(New":[106],"Jersey,":[107],"Florida,":[108],"Brazil),":[110],"identified":[112,139],"introns":[114,121],"gene":[118],"eight":[120],"gene.":[125],"Phylogenetic":[126],"analyses":[127,201,212],"comparison":[129],"functional":[131],"domains":[132],"support":[133],"orthology":[135],"newly":[138],"genes.":[143],"Analysis":[144],"nonsynonymous":[146],"synonymous":[148],"substitution":[149],"rates":[150],"indicates":[151],"have":[159],"evolved":[160],"under":[161],"strong":[162],"selective":[163],"constraint":[164],"subsequent":[165],"divergence":[168],"ofAe.":[169],"aegypti.":[173],"Taken":[174],"together,":[175],"these":[176],"results":[177],"provide":[178],"resources":[179],"can":[181],"be":[182],"investigate":[185],"molecular":[187],"genetics":[188],"phenotypes":[191],"other":[196],"culicids,":[197],"perform":[199],"comparative":[200],"insect":[203],"function,":[206],"conduct":[210],"phylogeographic":[211],"using":[213],"single-copy":[214],"nuclear":[215],"introns.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
