{"id":"https://openalex.org/W2226616865","doi":null,"title":"Dipyridamole, cold pressor test, and demonstration of endothelial dysfunction: a PET study of myocardial perfusion in diabetes.","display_name":"Dipyridamole, cold pressor test, and demonstration of endothelial dysfunction: a PET study of myocardial perfusion in diabetes.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2226616865","mag":"2226616865","pmid":"https://pubmed.ncbi.nlm.nih.gov/12515871"},"language":"en","primary_location":{"id":"pmid:12515871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12515871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044660787","display_name":"Andreas Kj\u00e6r","orcid":"https://orcid.org/0000-0002-2706-5547","observed_orcids":["https://orcid.org/0000-0002-2706-5547"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Andreas Kjaer","raw_affiliation_strings":["Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. kjaer@mfi.ku.dk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. kjaer@mfi.ku.dk","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028903791","display_name":"Christian G. Meyer","orcid":"https://orcid.org/0000-0003-0217-3960","observed_orcids":["https://orcid.org/0000-0003-0217-3960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Meyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025644697","display_name":"Flemming Seier Nielsen","orcid":"https://orcid.org/0000-0002-1636-3485","observed_orcids":["https://orcid.org/0000-0002-1636-3485"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Flemming S Nielsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045398531","display_name":"HANS-HENRIK D. PARVING","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans-Henrik Parving","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001073616","display_name":"Birger Hesse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Birger Hesse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5809,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.92394952,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"44","issue":"1","first_page":"19","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.11100000143051147,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9860000014305115},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.7609999775886536},{"id":"https://openalex.org/keywords/myocardial-perfusion","display_name":"myocardial perfusion","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cold-pressor-test","display_name":"cold pressor test","score":0.8880000114440918},{"id":"https://openalex.org/keywords/dipyridamole","display_name":"dipyridamole","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9179999828338623},{"id":"https://openalex.org/keywords/13n-ammonia-pet","display_name":"13N-ammonia PET","score":0.8889999985694885},{"id":"https://openalex.org/keywords/coronary-vasodilation","display_name":"coronary vasodilation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C2776890861","wikidata":"https://www.wikidata.org/wiki/Q419374","display_name":"Dipyridamole","level":2,"score":0.9423794746398926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8204469680786133},{"id":"https://openalex.org/C33971717","wikidata":"https://www.wikidata.org/wiki/Q16679368","display_name":"Cold pressor test","level":4,"score":0.6981023550033569},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6676555275917053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6618063449859619},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5561410784721375},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5262205600738525},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.46740156412124634},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.44442158937454224},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.43846559524536133},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.41413670778274536},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33240562677383423},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2329235076904297},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.13784080743789673}],"mesh":[{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004176","descriptor_name":"Dipyridamole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009590","descriptor_name":"Nitrogen Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:12515871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12515871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.489.8298","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.489.8298","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/44/1/19.full.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/27aaac40-acce-11dd-b538-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/27aaac40-acce-11dd-b538-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kjaer, A, Meyer, C, Nielsen, F S, Parving, H-H & Hesse, B 2003, 'Dipyridamole, cold pressor test, and demonstration of endothelial dysfunction: a PET study of myocardial perfusion in diabetes.', Journal of Nuclear Medicine, vol. 44, no. 1, pp. 19-23.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2226616865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12515871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1484535674","https://openalex.org/W1561466599","https://openalex.org/W1967527761","https://openalex.org/W1982811953","https://openalex.org/W1992965104","https://openalex.org/W1993387626","https://openalex.org/W1995407151","https://openalex.org/W2026395146","https://openalex.org/W2028675920","https://openalex.org/W2065020753","https://openalex.org/W2066605659","https://openalex.org/W2068951483","https://openalex.org/W2089736652","https://openalex.org/W2131835655","https://openalex.org/W2147888053","https://openalex.org/W2158145711","https://openalex.org/W2323688857"],"related_works":["https://openalex.org/W2316408876","https://openalex.org/W2104224883","https://openalex.org/W2808204202","https://openalex.org/W2151457968","https://openalex.org/W2417209826","https://openalex.org/W2050744333","https://openalex.org/W2233291651","https://openalex.org/W7017353032","https://openalex.org/W1988516817","https://openalex.org/W2091120414"],"abstract_inverted_index":{"UNLABELLED:":[0],"Much":[1],"evidence":[2,228],"suggests":[3],"endothelial":[4,233,312],"dysfunction":[5,234,251],"to":[6,15,143,149,200,245,248],"be":[7,16,31],"present":[8],"in":[9,26,33,60,113,117,125,134,145,151,162,166,178,191,202,207,212,242,269,271,294],"non-insulin-dependent":[10],"diabetes":[11],"mellitus":[12],"(NIDDM)":[13],"and":[14,63,86,99,116,147,156,209,247,286],"important":[17],"for":[18,307],"the":[19,27,38,70,79,126,135,192,213,272,274,283,287,297,303,308],"development":[20],"of":[21,40,47,72,229,256,289,296,305,310],"myocardial":[22],"ischemia.":[23],"Endothelial":[24],"function":[25],"coronary":[28,53,231,311],"vessels":[29],"may":[30],"studied":[32,69],"various":[34],"ways.":[35],"We":[36],"compared":[37,281],"effect":[39,71],"cold":[41],"pressor":[42],"testing":[43],"(CPT)":[44],"with":[45,282],"that":[46],"dipyridamole,":[48,196],"a":[49],"pharmacologic":[50],"vasodilator,":[51],"on":[52,78,175],"blood":[54],"flow":[55,80],"(CBF)":[56],"measured":[57],"by":[58,103,123,189,238,254],"PET":[59,104],"NIDDM":[61,84,114,193,225],"patients":[62,85,115,146,179,226],"healthy":[64],"volunteers.":[65],"In":[66,223],"addition,":[67],"we":[68],"acute":[73],"angiotensin-converting":[74],"enzyme":[75],"(ACE)":[76],"inhibition":[77,262,278],"response.":[81],"METHODS:":[82],"Ten":[83],"10":[87,298],"control":[88,118,127,152,163,181,299],"subjects":[89,164,182,300],"participated.":[90],"Myocardial":[91],"perfusion":[92],"was":[93,111,132,252],"determined":[94],"at":[95],"baseline,":[96],"during":[97,219,263,276,292],"CPT,":[98],"after":[100],"dipyridamole":[101,138,246,284],"infusion":[102,255],"using":[105],"intravenous":[106],"(13)N-ammonia.":[107],"RESULTS:":[108],"Resting":[109],"CBF":[110,122,140,158,177,188,197,208,211,243,270,290],"similar":[112],"subjects.":[119,153],"CPT":[120,186,264,293,306],"increased":[121,141,187,198],"20%":[124],"group,":[128],"whereas":[129],"no":[130,173],"increase":[131,155,206,241,291],"observed":[133],"patients.":[136,167],"After":[137,195],"infusion,":[139,170],"2-":[142],"3-fold":[144],"3-":[148,199],"4-fold":[150,201],"The":[154,205],"maximal":[157,210],"were":[159,216,279],"significantly":[160],"higher":[161],"than":[165],"During":[168],"ACE-inhibitor":[169,220],"which":[171],"had":[172],"influence":[174],"resting":[176],"or":[180],"(n":[183],"=":[184],"5),":[185],"14%":[190],"group.":[194],"both":[203,244],"groups.":[204],"2":[214],"groups":[215],"not":[217],"different":[218],"infusion.":[221],"CONCLUSION:":[222],"these":[224],"without":[227],"epicardial":[230],"disease,":[232],"is":[235],"strongly":[236],"suggested":[237],"an":[239,257],"impaired":[240],"CPT.":[249],"This":[250],"reversed":[253],"ACE":[258,261,277],"inhibitor.":[259],"Although":[260],"did":[265],"induce":[266],"significant":[267],"increases":[268],"patients,":[273],"changes":[275],"small":[280],"response,":[285],"absence":[288],"3":[295],"further":[301],"limits":[302],"value":[304],"study":[309],"dysfunction.":[313]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
