{"id":"https://openalex.org/W2225830682","doi":"https://doi.org/10.1111/jvh.12498","title":"Characterization of hepatitis B virus surface antigen variability and impact on HB s antigen clearance under nucleos(t)ide analogue therapy","display_name":"Characterization of hepatitis B virus surface antigen variability and impact on HB s antigen clearance under nucleos(t)ide analogue therapy","publication_year":2016,"publication_date":"2016-01-06","ids":{"openalex":"https://openalex.org/W2225830682","doi":"https://doi.org/10.1111/jvh.12498","mag":"2225830682","pmid":"https://pubmed.ncbi.nlm.nih.gov/26742490"},"language":"en","primary_location":{"id":"doi:10.1111/jvh.12498","doi":"https://doi.org/10.1111/jvh.12498","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jvh.12498","pdf_url":null,"source":{"id":"https://openalex.org/S164225461","display_name":"Journal of Viral Hepatitis","issn_l":"1352-0504","issn":["1352-0504","1365-2893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Viral Hepatitis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027080443","display_name":"Aur\u00e9lie Velay","orcid":"https://orcid.org/0000-0002-9174-8959","observed_orcids":["https://orcid.org/0000-0002-9174-8959"]},"institutions":[{"id":"https://openalex.org/I4387154726","display_name":"Stress, IMmunit\u00e9, PAthog\u00e8nes","ror":"https://ror.org/04f50n919","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Velay","raw_affiliation_strings":["EA 7300 \u2018Stress, Immunit\u00e9, Pathog\u00e8nes\u2019 Universit\u00e9 de Lorraine Vandoeuvre\u2010les\u2010Nancy France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA 7300 \u2018Stress, Immunit\u00e9, Pathog\u00e8nes\u2019 Universit\u00e9 de Lorraine Vandoeuvre\u2010les\u2010Nancy France","institution_ids":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081411355","display_name":"H\u00e9l\u00e8ne Jeulin","orcid":"https://orcid.org/0000-0001-6861-236X","observed_orcids":["https://orcid.org/0000-0001-6861-236X"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]},{"id":"https://openalex.org/I4387154726","display_name":"Stress, IMmunit\u00e9, PAthog\u00e8nes","ror":"https://ror.org/04f50n919","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H. Jeulin","raw_affiliation_strings":["EA 7300 \u2018Stress, Immunit\u00e9, Pathog\u00e8nes\u2019 Universit\u00e9 de Lorraine Vandoeuvre\u2010les\u2010Nancy France","Laboratoire de Virologie Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA 7300 \u2018Stress, Immunit\u00e9, Pathog\u00e8nes\u2019 Universit\u00e9 de Lorraine Vandoeuvre\u2010les\u2010Nancy France","institution_ids":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]},{"raw_affiliation_string":"Laboratoire de Virologie Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France","institution_ids":["https://openalex.org/I4210100260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027179213","display_name":"Marine Eschlimann","orcid":"https://orcid.org/0000-0003-2758-7318","observed_orcids":["https://orcid.org/0000-0003-2758-7318"]},"institutions":[{"id":"https://openalex.org/I4387154726","display_name":"Stress, IMmunit\u00e9, PAthog\u00e8nes","ror":"https://ror.org/04f50n919","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Eschlimann","raw_affiliation_strings":["EA 7300 \u2018Stress, Immunit\u00e9, Pathog\u00e8nes\u2019 Universit\u00e9 de Lorraine Vandoeuvre\u2010les\u2010Nancy France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA 7300 \u2018Stress, Immunit\u00e9, Pathog\u00e8nes\u2019 Universit\u00e9 de Lorraine Vandoeuvre\u2010les\u2010Nancy France","institution_ids":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084178199","display_name":"Brice Malve","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Malv\u00e9","raw_affiliation_strings":["Laboratoire de Virologie Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Virologie Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France","institution_ids":["https://openalex.org/I4210100260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089971762","display_name":"Fran\u00e7ois Goehringer","orcid":"https://orcid.org/0000-0001-6997-598X","observed_orcids":["https://orcid.org/0000-0001-6997-598X"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Goehringer","raw_affiliation_strings":["Service des Maladies Infectieuses et Tropicales Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service des Maladies Infectieuses et Tropicales Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France","institution_ids":["https://openalex.org/I4210100260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028080806","display_name":"Mouni Bensenane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Bensenane","raw_affiliation_strings":["Service d'H\u00e9pato\u2010gastroent\u00e9rologie Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9pato\u2010gastroent\u00e9rologie Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France","institution_ids":["https://openalex.org/I4210100260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039276492","display_name":"Jean\u2010Pol Frippiat","orcid":"https://orcid.org/0000-0002-4027-6269","observed_orcids":["https://orcid.org/0000-0002-4027-6269"]},"institutions":[{"id":"https://openalex.org/I4387154726","display_name":"Stress, IMmunit\u00e9, PAthog\u00e8nes","ror":"https://ror.org/04f50n919","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J\u2010P. Frippiat","raw_affiliation_strings":["EA 7300 \u2018Stress, Immunit\u00e9, Pathog\u00e8nes\u2019 Universit\u00e9 de Lorraine Vandoeuvre\u2010les\u2010Nancy France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA 7300 \u2018Stress, Immunit\u00e9, Pathog\u00e8nes\u2019 Universit\u00e9 de Lorraine Vandoeuvre\u2010les\u2010Nancy France","institution_ids":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079460809","display_name":"Priya Abraham","orcid":"https://orcid.org/0000-0002-2873-9101","observed_orcids":["https://orcid.org/0000-0002-2873-9101"]},"institutions":[{"id":"https://openalex.org/I172917736","display_name":"Christian Medical College, Vellore","ror":"https://ror.org/00c7kvd80","country_code":"IN","type":"education","lineage":["https://openalex.org/I172917736"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P. Abraham","raw_affiliation_strings":["Department of Clinical Virology Christian Medical College Vellore Tamil Nadu India","Christian Medical College & Hospital (IDA Scudder Road, Sripuram,, Vellore, Tamil Nadu 632004, Inde - India)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Virology Christian Medical College Vellore Tamil Nadu India","institution_ids":["https://openalex.org/I172917736"]},{"raw_affiliation_string":"Christian Medical College & Hospital (IDA Scudder Road, Sripuram,, Vellore, Tamil Nadu 632004, Inde - India)","institution_ids":["https://openalex.org/I172917736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038369722","display_name":"Ashrafali Mohamed Ismail","orcid":"https://orcid.org/0000-0001-8694-7235","observed_orcids":["https://orcid.org/0000-0001-8694-7235"]},"institutions":[{"id":"https://openalex.org/I172917736","display_name":"Christian Medical College, Vellore","ror":"https://ror.org/00c7kvd80","country_code":"IN","type":"education","lineage":["https://openalex.org/I172917736"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A. M. Ismail","raw_affiliation_strings":["Department of Clinical Virology Christian Medical College Vellore Tamil Nadu India","Christian Medical College & Hospital (IDA Scudder Road, Sripuram,, Vellore, Tamil Nadu 632004, Inde - India)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Virology Christian Medical College Vellore Tamil Nadu India","institution_ids":["https://openalex.org/I172917736"]},{"raw_affiliation_string":"Christian Medical College & Hospital (IDA Scudder Road, Sripuram,, Vellore, Tamil Nadu 632004, Inde - India)","institution_ids":["https://openalex.org/I172917736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008902850","display_name":"John M. Murray","orcid":"https://orcid.org/0000-0001-9314-2283","observed_orcids":["https://orcid.org/0000-0001-9314-2283"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J. M. Murray","raw_affiliation_strings":["School of Mathematics and Statistics UNSW Australia Sydney NSW Australia","UNSW - University of New South Wales [Sydney] (High St\r\nKensington, Sydney, NSW 2052 - Australia)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics UNSW Australia Sydney NSW Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"UNSW - University of New South Wales [Sydney] (High St\r\nKensington, Sydney, NSW 2052 - Australia)","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081907019","display_name":"Christophe Combet","orcid":"https://orcid.org/0000-0002-7348-3520","observed_orcids":["https://orcid.org/0000-0002-7348-3520"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210125048","display_name":"Centre de Recherche en Canc\u00e9rologie de Lyon","ror":"https://ror.org/02mgw3155","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210096427","https://openalex.org/I4210105738","https://openalex.org/I4210125048"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Combet","raw_affiliation_strings":["Unit\u00e9 Inserm UI1052 Universit\u00e9 de Lyon Lyon France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 Inserm UI1052 Universit\u00e9 de Lyon Lyon France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063172143","display_name":"Fabien Zoulim","orcid":"https://orcid.org/0000-0002-2245-0083","observed_orcids":["https://orcid.org/0000-0002-2245-0083"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210125048","display_name":"Centre de Recherche en Canc\u00e9rologie de Lyon","ror":"https://ror.org/02mgw3155","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210096427","https://openalex.org/I4210105738","https://openalex.org/I4210125048"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Zoulim","raw_affiliation_strings":["Unit\u00e9 Inserm UI1052 Universit\u00e9 de Lyon Lyon France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 Inserm UI1052 Universit\u00e9 de Lyon Lyon France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210125048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110044180","display_name":"Jean\u2013Pierre Bronowicki","orcid":"https://orcid.org/0000-0003-1631-500X","observed_orcids":["https://orcid.org/0000-0003-1631-500X"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J\u2010P. Bronowicki","raw_affiliation_strings":["Service d'H\u00e9pato\u2010gastroent\u00e9rologie Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9pato\u2010gastroent\u00e9rologie Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France","institution_ids":["https://openalex.org/I4210100260"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105458634","display_name":"\u00c9velyne Schvoerer","orcid":"https://orcid.org/0000-0003-0290-4532","observed_orcids":["https://orcid.org/0000-0003-0290-4532"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]},{"id":"https://openalex.org/I4387154726","display_name":"Stress, IMmunit\u00e9, PAthog\u00e8nes","ror":"https://ror.org/04f50n919","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"E. Schvoerer","raw_affiliation_strings":["EA 7300 \u2018Stress, Immunit\u00e9, Pathog\u00e8nes\u2019 Universit\u00e9 de Lorraine Vandoeuvre\u2010les\u2010Nancy France","Laboratoire de Virologie Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA 7300 \u2018Stress, Immunit\u00e9, Pathog\u00e8nes\u2019 Universit\u00e9 de Lorraine Vandoeuvre\u2010les\u2010Nancy France","institution_ids":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]},{"raw_affiliation_string":"Laboratoire de Virologie Centre Hospitalier Universitaire de Nancy Vandoeuvre\u2010les\u2010Nancy France","institution_ids":["https://openalex.org/I4210100260"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5105458634"],"corresponding_institution_ids":["https://openalex.org/I4210100260","https://openalex.org/I4387154726","https://openalex.org/I90183372"],"apc_list":{"value":4610,"currency":"USD","value_usd":4610},"apc_paid":null,"fwci":4.1621,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.93523473,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"23","issue":"5","first_page":"387","last_page":"398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hbsag-loss","display_name":"HBsAg loss","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hbsag-persistence","display_name":"HBsAg persistence","score":0.8650000095367432},{"id":"https://openalex.org/keywords/nucleos-t-ide-analogues","display_name":"nucleos(t)ide analogues","score":0.859000027179718},{"id":"https://openalex.org/keywords/hbv-genotype-d","display_name":"HBV genotype D","score":0.699999988079071},{"id":"https://openalex.org/keywords/s-gene-mutations","display_name":"S gene mutations","score":0.7149999737739563},{"id":"https://openalex.org/keywords/antigenicity-prediction","display_name":"antigenicity prediction","score":0.5619999766349792},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.8655877709388733},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.769976019859314},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6193768382072449},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6149835586547852},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4737062156200409},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4679129719734192},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4234035611152649},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.41061779856681824},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4105633497238159},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3534606695175171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3380128741264343},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28328004479408264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2737000584602356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.060426682233810425}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/jvh.12498","doi":"https://doi.org/10.1111/jvh.12498","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jvh.12498","pdf_url":null,"source":{"id":"https://openalex.org/S164225461","display_name":"Journal of Viral Hepatitis","issn_l":"1352-0504","issn":["1352-0504","1365-2893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Viral Hepatitis","raw_type":"journal-article"},{"id":"pmid:26742490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26742490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of viral hepatitis","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-01482132v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.univ-lorraine.fr/hal-01482132","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://onlinelibrary.wiley.com/doi/10.1111/jvh.12498/abstract;jsessionid=11532AEA30AA1747323D7597DBBFF453.f02t04","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8024715652","display_name":null,"funder_award_id":"IN\u2010FR\u2010174\u20100217","funder_id":"https://openalex.org/F4320310925","funder_display_name":"Universit\u00e9 de Lorraine"}],"funders":[{"id":"https://openalex.org/F4320310925","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W207152389","https://openalex.org/W1524690903","https://openalex.org/W1568671366","https://openalex.org/W1607552413","https://openalex.org/W1968917877","https://openalex.org/W1974652595","https://openalex.org/W1976625127","https://openalex.org/W1978314081","https://openalex.org/W1993568862","https://openalex.org/W1997815776","https://openalex.org/W1998275928","https://openalex.org/W2004592717","https://openalex.org/W2006788839","https://openalex.org/W2009509017","https://openalex.org/W2011555137","https://openalex.org/W2013038396","https://openalex.org/W2016084168","https://openalex.org/W2022484447","https://openalex.org/W2024574076","https://openalex.org/W2024778473","https://openalex.org/W2032097960","https://openalex.org/W2033351060","https://openalex.org/W2059560167","https://openalex.org/W2063948876","https://openalex.org/W2065011873","https://openalex.org/W2077533125","https://openalex.org/W2083084779","https://openalex.org/W2083998513","https://openalex.org/W2090710125","https://openalex.org/W2098528020","https://openalex.org/W2098576477","https://openalex.org/W2110193386","https://openalex.org/W2112436801","https://openalex.org/W2116678867","https://openalex.org/W2118016924","https://openalex.org/W2119648403","https://openalex.org/W2120426460","https://openalex.org/W2122656069","https://openalex.org/W2126837396","https://openalex.org/W2129088316","https://openalex.org/W2131134210","https://openalex.org/W2132846960","https://openalex.org/W2133663051","https://openalex.org/W2137279862","https://openalex.org/W2146629493","https://openalex.org/W2147894808","https://openalex.org/W2156788047","https://openalex.org/W2160816585","https://openalex.org/W2161722821","https://openalex.org/W2299872562","https://openalex.org/W4322578578"],"related_works":["https://openalex.org/W7128284449","https://openalex.org/W7147509487","https://openalex.org/W2744767102","https://openalex.org/W7084140071","https://openalex.org/W1997128953","https://openalex.org/W7155067613","https://openalex.org/W2092123623","https://openalex.org/W4297387052","https://openalex.org/W2513561101","https://openalex.org/W2328605356"],"abstract_inverted_index":{"For":[0,38],"hepatitis":[1],"B":[2],"virus":[3],"(HBV)-related":[4],"chronic":[5],"infection":[6],"under":[7],"treatment":[8],"by":[9,113],"nucleos(t)ide":[10],"analogues":[11],"(NUCs),":[12],"HBsAg":[13,34,195,216,244],"clearance":[14,35],"is":[15],"the":[16,143,161,165,180,208,232,239],"ultimate":[17],"therapeutic":[18],"goal":[19],"but":[20],"very":[21,80],"infrequent.":[22],"We":[23],"investigated":[24],"how":[25],"HBV":[26,40,69,88,129,209,240],"envelope":[27,70,241],"protein":[28],"variability":[29],"could":[30],"lead":[31],"to":[32,52,67,213],"differential":[33],"on":[36,79,197],"NUCs.":[37],"12":[39],"genotype":[41,89],"D":[42,90],"patients":[43,193],"receiving":[44],"NUCs,":[45],"six":[46,53],"resolvers":[47],"(HBsAg":[48,56],"clearance)":[49],"were":[50,63,84,138,174],"compared":[51,85,212],"matched":[54],"nonresolvers":[55,109],"persistence).":[57],"PreS/S":[58],"amino":[59],"acid":[60],"(aa)":[61],"sequences":[62],"analysed":[64],"with":[65,86,118],"bioinformatics":[66],"predict":[68],"antigenicity":[71,122,226],"and":[72,136,227],"aa":[73,114,169,186,205],"covariance.":[74],"To":[75],"enrich":[76],"our":[77,148],"analyses":[78],"rare":[81],"resolvers,":[82],"these":[83],"other":[87],"strains":[91],"in":[92,107,171,176,179,188,192,200,207,222,231,243],"three":[93,144],"characterized":[94],"clinical":[95],"cohorts":[96],"including":[97],"common":[98],"chronically":[99],"infected":[100],"patients.":[101],"The":[102],"sT125M+sP127T":[103],"combination":[104],"was":[105,158],"observed":[106,159],"four":[108],"of":[110,142,154,202],"six,":[111],"corroborated":[112],"covariance":[115],"analysis,":[116],"associated":[117],"a":[119,150,203,220,236],"lower":[120,151],"predicted":[121],"than":[123],"sT125T+sP127P.":[124],"Concordant":[125],"features":[126,191],"within":[127],"this":[128],"key":[130],"functional":[131],"domain,":[132],"at":[133],"positions":[134],"125":[135],"127,":[137],"reported":[139],"from":[140],"two":[141],"comparative":[145],"cohorts.":[146],"In":[147,164,218],"hands,":[149],"ELISA":[152],"reactivity":[153],"HBV-vaccinated":[155],"mice":[156],"sera":[157],"against":[160],"sT125M":[162],"mutant.":[163],"S":[166,210,233],"gene,":[167],"56":[168],"changes":[170,187],"minor":[172],"variants":[173],"detected":[175],"non-resolvers,":[177],"mainly":[178],"major":[181],"hydrophilic":[182],"region,":[183],"vs":[184],"28":[185],"resolvers.":[189],"Molecular":[190],"showing":[194,215],"persistence":[196],"NUCs":[198],"argue":[199],"favour":[201],"different":[204],"pattern":[206],"gene":[211,234],"those":[214],"clearance.":[217],"nonresolvers,":[219],"decrease":[221],"HBs":[223],"'a'":[224],"determinant":[225],"more":[228],"frequent":[229],"mutations":[230],"suggest":[235],"role":[237],"for":[238],"characteristics":[242],"persistence.":[245]},"counts_by_year":[{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}