{"id":"https://openalex.org/W2225570835","doi":null,"title":"Stress differentially modulates behavioral responses to the cannabinoid agonist, WIN 55,212-2, in adult rats","display_name":"Stress differentially modulates behavioral responses to the cannabinoid agonist, WIN 55,212-2, in adult rats","publication_year":2014,"publication_date":"2014-08-12","ids":{"openalex":"https://openalex.org/W2225570835","mag":"2225570835"},"language":"pt","primary_location":{"id":"mag:2225570835","doi":null,"is_oa":false,"landing_page_url":"http://revistaadmmade.estacio.br/index.php/saudesantacatarina/article/view/1052/558","pdf_url":null,"source":{"id":"https://openalex.org/S4306527238","display_name":"Revista Eletr\u00f4nica Est\u00e1cio Sa\u00fade","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista Eletr\u00f4nica Est\u00e1cio Sa\u00fade","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039308674","display_name":"Fabr\u00edcio Luiz Assini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabr\u00edcio Luiz Assini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109812830","display_name":"Reinaldo Naoto Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Reinaldo Naoto Takahashia","raw_affiliation_strings":["UNIVERSIDADE FEDERAL DE SANTA CATARINA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSIDADE FEDERAL DE SANTA CATARINA","institution_ids":["https://openalex.org/I4104125"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"2","first_page":"12","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.7699999809265137},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.7889999747276306},{"id":"https://openalex.org/keywords/win-55-212-2","display_name":"WIN 55,212-2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cb1-receptor-agonists","display_name":"CB1 receptor agonists","score":0.9620000123977661},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.7720000147819519},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.8242120742797852},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.808681309223175},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.717854380607605},{"id":"https://openalex.org/C2910065304","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid Receptor Agonists","level":5,"score":0.5784139633178711},{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.547416090965271},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47829538583755493},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43779346346855164},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4313771724700928},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.3731423020362854},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36370649933815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36195439100265503},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3595620095729828},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09964802861213684}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2225570835","doi":null,"is_oa":false,"landing_page_url":"http://revistaadmmade.estacio.br/index.php/saudesantacatarina/article/view/1052/558","pdf_url":null,"source":{"id":"https://openalex.org/S4306527238","display_name":"Revista Eletr\u00f4nica Est\u00e1cio Sa\u00fade","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista Eletr\u00f4nica Est\u00e1cio Sa\u00fade","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1579700485","https://openalex.org/W1901285090","https://openalex.org/W1965117109","https://openalex.org/W1968406900","https://openalex.org/W1971949279","https://openalex.org/W1978971276","https://openalex.org/W1979485705","https://openalex.org/W1981448374","https://openalex.org/W1981670902","https://openalex.org/W1982291289","https://openalex.org/W1988471261","https://openalex.org/W1991842644","https://openalex.org/W2000040230","https://openalex.org/W2013941753","https://openalex.org/W2015829020","https://openalex.org/W2018660905","https://openalex.org/W2031023109","https://openalex.org/W2036824041","https://openalex.org/W2044364684","https://openalex.org/W2047039299","https://openalex.org/W2057969028","https://openalex.org/W2058307969","https://openalex.org/W2062408214","https://openalex.org/W2063859365","https://openalex.org/W2064324204","https://openalex.org/W2070397769","https://openalex.org/W2084770788","https://openalex.org/W2089353347","https://openalex.org/W2103477492","https://openalex.org/W2108632842","https://openalex.org/W2158607186","https://openalex.org/W2168003262","https://openalex.org/W2252880195","https://openalex.org/W2301030979","https://openalex.org/W2423881860","https://openalex.org/W2465523478"],"related_works":["https://openalex.org/W2047039299","https://openalex.org/W2037437186","https://openalex.org/W2065711685","https://openalex.org/W2026035330","https://openalex.org/W1978508391","https://openalex.org/W2800088279","https://openalex.org/W1963745928","https://openalex.org/W3106842758","https://openalex.org/W2427182478","https://openalex.org/W1995501464"],"abstract_inverted_index":{"There":[0],"has":[1],"been":[2],"a":[3,123],"growing":[4],"interest":[5],"in":[6,14,88,111,122,163,173,221,240],"the":[7,10,15,34,53,61,108,112,132,150,164,177,180,198,222,234,245,254],"role":[8],"of":[9,17,59,131,152,159,179,200,237,251,256],"endogenous":[11],"cannabinoid":[12,157,217],"system":[13],"regulation":[16],"emotional":[18],"states.":[19],"The":[20,67,129,167,226],"behavioral":[21,211],"interaction":[22,247],"between":[23,248],"stress":[24,35,114,195,208,252],"and":[25,51,64,142,253],"cannabinoids":[26],"seems":[27],"to":[28,80,148,192,196,213],"have":[29],"different":[30,249],"patterns":[31],"depending":[32],"on":[33],"carried":[36],"out,":[37],"i.e.:":[38],"acute,":[39],"repeated":[40],"or":[41],"variable":[42],"stress.":[43,66],"In":[46],"this":[47,204,214],"study,":[48],"we":[49],"evaluated":[50],"compared":[52],"alterations":[54],"induced":[55],"by":[56],"two":[57,154],"types":[58,250],"stress,":[60],"neonatal":[62,68],"isolation":[63,69],"restraint":[65,113,174],"procedure":[70],"was":[71,86,146,170,190],"performed":[72],"for":[73,98,126],"7":[74],"days":[75,117],"\u2013":[76,186],"post-natal":[77],"day":[78],"2":[79,127],"9":[81],"-":[82,189],"when":[83],"each":[84],"pup":[85],"placed":[87],"an":[89],"individual":[90],"round":[91],"plastic":[92],"container,":[93],"with":[94,194],"no":[95],"bedding,":[96],"remaining":[97],"1":[99,134,182],"h":[100],"at":[101],"30\u00b0C.":[102],"On":[107],"other":[109],"hand,":[110],"procedure,":[115],"80":[116],"old":[118],"rats":[119,161],"were":[120],"immobilized":[121],"wire":[124],"chamber":[125],"h.":[128],"administration":[130,178],"CB":[133,181],"receptor":[136,184],"agonist":[137,185,218],"WIN":[138,187],"55,212-2":[139,188],"(0.25;":[140],"0.75":[141],"1.25":[143],"mg/kg":[144],"i.p.)":[145],"used":[147],"evaluate":[149],"effects":[151,255],"these":[153],"stress-procedures":[155],"over":[156],"responses":[158,212],"adult":[160,201],"tested":[162],"elevated":[165,223],"plus-maze.":[166],"main":[168],"finding":[169],"that":[171,207,230],"only":[172],"stressed":[175],"animals":[176],"able":[191],"interact":[193],"alter":[197],"behavior":[199],"rats.":[202],"Hence,":[203],"effect":[205],"indicates":[206],"differentially":[209],"modulates":[210],"plus":[224],"maze.":[225],"present":[227],"study":[228],"suggests":[229],"future":[231],"research":[232],"evaluating":[233],"potential":[235],"use":[236],"cannabis":[238],"derivates":[239],"anti-anxiety":[241],"therapies":[242],"should":[243],"consider":[244],"distinct":[246],"cannabinoids.":[257]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}