{"id":"https://openalex.org/W2225289751","doi":null,"title":"Developing Innovative Metallomics Approaches to Characterize Trace Biometals","display_name":"Developing Innovative Metallomics Approaches to Characterize Trace Biometals","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2225289751","mag":"2225289751"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:ucin1298044208","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298044208","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298044208","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298044208","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298044208","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036710074","display_name":"Qilin Chan","orcid":"https://orcid.org/0000-0003-3918-5578","observed_orcids":["https://orcid.org/0000-0003-3918-5578"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qilin Chan","raw_affiliation_strings":["University of Cincinnati**"],"raw_orcid":"https://orcid.org/0000-0003-3918-5578","affiliations":[{"raw_affiliation_string":"University of Cincinnati**","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036710074"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24690521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metallomics","display_name":"metallomics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.8009999990463257},{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.9629999995231628},{"id":"https://openalex.org/keywords/selenium-containing-proteins","display_name":"selenium-containing proteins","score":0.6359999775886536},{"id":"https://openalex.org/keywords/histoplasma-capsulatum","display_name":"Histoplasma capsulatum","score":0.7979999780654907},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7390000224113464},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.9279999732971191},{"id":"https://openalex.org/keywords/selenium-metabolites","display_name":"selenium metabolites","score":0.6100000143051147},{"id":"https://openalex.org/keywords/kale","display_name":"kale","score":0.8880000114440918},{"id":"https://openalex.org/keywords/soybean","display_name":"soybean","score":0.9869999885559082},{"id":"https://openalex.org/keywords/metal-speciation","display_name":"metal speciation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/hplc-icp-ms","display_name":"HPLC-ICP-MS","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lc-ms-ms-proteomics","display_name":"LC-MS/MS proteomics","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C75291252","wikidata":"https://www.wikidata.org/wiki/Q1315756","display_name":"TRACE (psycholinguistics)","level":2,"score":0.5078199505805969},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.44802364706993103},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3601740598678589},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:ucin1298044208","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298044208","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298044208","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298044208","raw_type":"text"},{"id":"pmh:oai:pqdtoai.proquest.com:3450616","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3450616","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3450616","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"mag:2225289751","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298044208","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:ucin1298044208","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298044208","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298044208","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298044208","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2225289751.pdf","grobid_xml":"https://content.openalex.org/works/W2225289751.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2063899787","https://openalex.org/W2041471158","https://openalex.org/W2803696458","https://openalex.org/W2122480139","https://openalex.org/W3025986392","https://openalex.org/W2325088267","https://openalex.org/W7097610939","https://openalex.org/W2887772532","https://openalex.org/W1600622471","https://openalex.org/W2165924170"],"abstract_inverted_index":{"Many":[0],"elements":[1,111],"have":[2,26],"been":[3,27],"claimed":[4],"as":[5,228],"essential":[6],"for":[7],"health":[8],"but":[9,216],"their":[10],"precise":[11,50,207],"roles":[12,208],"in":[13,20,67,79,105,117,123,127,136,166,183,209,214],"life":[14],"are":[15],"largely":[16],"uncharacterized.The":[17],"increasing":[18],"interests":[19],"the":[21,29,39,81,100,154,160,179,185,195,219],"metals/metalloids":[22,42],"within":[23],"biological":[24,53,69],"systems":[25,70],"driving":[28],"fast":[30],"growth":[31],"of":[32,46,52,57,62,102,163],"metallomics,":[33],"a":[34,133,144],"subject":[35],"originated":[36],"to":[37,98,150,204],"establish":[38],"links":[40],"between":[41,221],"and":[43,92,107,120,143,170,174,211,223,230],"life.The":[44],"foundation":[45],"metallomics":[47,73,125,222],"relies":[48],"on":[49],"determination":[51],"metal(loid)":[54],"species.The":[55],"aim":[56],"this":[58],"dissertation":[59],"is":[60],"characterization":[61,104],"such":[63,227],"species,":[64],"primarily":[65],"metalloproteins,":[66],"various":[68],"using":[71],"innovative":[72],"approaches.These":[74],"include":[75],"several":[76],"multi-technique":[77],"methods":[78],"which":[80],"traditional":[82],"elemental":[83],"speciation":[84],"with":[85],"HPLC-ICPMS":[86],"(inductively":[87],"coupled":[88],"plasma":[89],"mass":[90],"spectrometry)":[91],"LC-MS/MS":[93],"based":[94],"proteomics":[95],"were":[96,112],"combined":[97],"meet":[99],"challenges":[101],"metalloprotein":[103],"animals":[106],"plants.Two":[108],"biologically":[109],"important":[110],"intensively":[113],"studied,":[114],"zinc":[115],"(Zn)":[116],"murine":[118],"macrophages":[119,128],"selenium":[121],"(Se)":[122],"plants.The":[124],"study":[126,158,205],"revealed":[129],"that":[130],"Zn":[131],"played":[132],"fundamental":[134],"role":[135],"host":[137],"defense":[138],"against":[139],"Histoplasma":[140],"capsulatum":[141],"infection,":[142],"few":[145],"Zn-binding":[146],"proteins":[147,213],"selectively":[148],"responded":[149],"macrophage":[151],"activation":[152],"or":[153],"pathogen":[155],"infection.The":[156],"Se":[157,164],"elucidated":[159],"complete":[161],"profiles":[162],"metabolites":[165],"kale":[167],"(Brassica":[168],"oleracea)":[169],"soybean":[171],"(Glycine":[172],"max)":[173],"more":[175],"importantly,":[176],"it":[177],"discovered":[178],"first":[180],"Se-containing":[181,186,212],"protein":[182],"plants,":[184,215],"Bowman-Birk":[187],"proteinase":[188],"isoinhibitor":[189],"D-II":[190],"[Glycine":[191],"max]":[192],"derived":[193],"from":[194],"Se-enriched":[196],"soybean.These":[197],"findings":[198],"not":[199],"only":[200],"opened":[201],"new":[202],"avenues":[203],"Zn's":[206],"immunity":[210],"also":[217],"lead":[218],"interactions":[220],"other":[224],"research":[225],"areas,":[226],"immunology":[229],"proteomics.//":[231],"///":[232]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
