{"id":"https://openalex.org/W2224980959","doi":"https://doi.org/10.1039/c5mb00751h","title":"Cyclic dinucleotide detection with riboswitch\u2013G-quadruplex hybrid","display_name":"Cyclic dinucleotide detection with riboswitch\u2013G-quadruplex hybrid","publication_year":2015,"publication_date":"2015-12-21","ids":{"openalex":"https://openalex.org/W2224980959","doi":"https://doi.org/10.1039/c5mb00751h","mag":"2224980959","pmid":"https://pubmed.ncbi.nlm.nih.gov/26739090"},"language":"en","primary_location":{"id":"doi:10.1039/c5mb00751h","doi":"https://doi.org/10.1039/c5mb00751h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c5mb00751h","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2016/mb/c5mb00751h","source":{"id":"https://openalex.org/S169293703","display_name":"Molecular BioSystems","issn_l":"1742-2051","issn":["1742-2051","1742-206X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-100"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular BioSystems","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2016/mb/c5mb00751h","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054326732","display_name":"Genichiro Tsuji","orcid":"https://orcid.org/0000-0002-2826-3852","observed_orcids":["https://orcid.org/0000-0002-2826-3852"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Genichiro Tsuji","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Maryland a , College Park, MD 20742, USA","College Park","Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA","University of Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Maryland a , College Park, MD 20742, USA","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"College Park","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"University of Maryland","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037299132","display_name":"Herman O. Sintim","orcid":"https://orcid.org/0000-0002-2280-9359","observed_orcids":["https://orcid.org/0000-0002-2280-9359"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Herman O Sintim","raw_affiliation_strings":["Center for Drug Discovery, Purdue University b , West Lafayette, IN 47907, USA \u00a0 hsintim@purdue.edu","Department of Chemistry and Biochemistry, University of Maryland a , College Park, MD 20742, USA","Center for Drug Discovery","Center for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA","College Park","Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Discovery, Purdue University b , West Lafayette, IN 47907, USA \u00a0 hsintim@purdue.edu","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Maryland a , College Park, MD 20742, USA","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Center for Drug Discovery","institution_ids":[]},{"raw_affiliation_string":"Center for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"College Park","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA","institution_ids":["https://openalex.org/I66946132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037299132"],"corresponding_institution_ids":["https://openalex.org/I219193219","https://openalex.org/I66946132"],"apc_list":null,"apc_paid":null,"fwci":0.5783,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6713861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"3","first_page":"773","last_page":"777"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.15549999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.07069999724626541,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-di-gmp","display_name":"c-di-GMP","score":0.8769999742507935},{"id":"https://openalex.org/keywords/riboswitches","display_name":"riboswitches","score":0.949999988079071},{"id":"https://openalex.org/keywords/g-quadruplex","display_name":"G-quadruplex","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fluorogenic-substrates","display_name":"fluorogenic substrates","score":0.7670000195503235},{"id":"https://openalex.org/keywords/colorimetric-detection","display_name":"colorimetric sensing","score":0.828000009059906},{"id":"https://openalex.org/keywords/signal-to-noise-ratio","display_name":"signal-to-noise ratio","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C148625055","wikidata":"https://www.wikidata.org/wiki/Q418840","display_name":"Riboswitch","level":5,"score":0.9796528816223145},{"id":"https://openalex.org/C83762044","wikidata":"https://www.wikidata.org/wiki/Q411641","display_name":"G-quadruplex","level":3,"score":0.7293161153793335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.509261965751648},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.42779749631881714},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35543835163116455},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3537292182445526},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34191030263900757},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.314116895198822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3052433133125305},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1986466348171234},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.16545572876930237},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.09675487875938416},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09547445178031921}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009692","descriptor_name":"Nucleic Acid Heteroduplexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014439","descriptor_name":"Tyramine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054856","descriptor_name":"G-Quadruplexes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058928","descriptor_name":"Riboswitch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/c5mb00751h","doi":"https://doi.org/10.1039/c5mb00751h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c5mb00751h","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2016/mb/c5mb00751h","source":{"id":"https://openalex.org/S169293703","display_name":"Molecular BioSystems","issn_l":"1742-2051","issn":["1742-2051","1742-206X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-100"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular BioSystems","raw_type":"journal-article"},{"id":"pmid:26739090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26739090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular bioSystems","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/c5mb00751h","doi":"https://doi.org/10.1039/c5mb00751h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c5mb00751h","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2016/mb/c5mb00751h","source":{"id":"https://openalex.org/S169293703","display_name":"Molecular BioSystems","issn_l":"1742-2051","issn":["1742-2051","1742-206X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-100"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular BioSystems","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2068493009","display_name":"New Receptors for signaling bacterial nucleotides","funder_award_id":"1307218","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2801098644","display_name":null,"funder_award_id":"CHEM1307218","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306315","display_name":"Camille and Henry Dreyfus Foundation","ror":"https://ror.org/019p8h045"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2224980959.pdf","grobid_xml":"https://content.openalex.org/works/W2224980959.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W120532893","https://openalex.org/W219967909","https://openalex.org/W1556554299","https://openalex.org/W1594189146","https://openalex.org/W1897633092","https://openalex.org/W1972029787","https://openalex.org/W1974067967","https://openalex.org/W1976135176","https://openalex.org/W1976647752","https://openalex.org/W1979004301","https://openalex.org/W1979886953","https://openalex.org/W1985673757","https://openalex.org/W1988513870","https://openalex.org/W2001266050","https://openalex.org/W2012980766","https://openalex.org/W2015503736","https://openalex.org/W2019325003","https://openalex.org/W2019438117","https://openalex.org/W2021191052","https://openalex.org/W2025706856","https://openalex.org/W2036006498","https://openalex.org/W2038929178","https://openalex.org/W2040914684","https://openalex.org/W2048055667","https://openalex.org/W2048706341","https://openalex.org/W2068222743","https://openalex.org/W2073869585","https://openalex.org/W2076483052","https://openalex.org/W2082159746","https://openalex.org/W2087017025","https://openalex.org/W2091997361","https://openalex.org/W2093369467","https://openalex.org/W2097033244","https://openalex.org/W2109109004","https://openalex.org/W2112789978","https://openalex.org/W2132665880","https://openalex.org/W2141168641","https://openalex.org/W2143583668","https://openalex.org/W2146429915","https://openalex.org/W2148304771","https://openalex.org/W2154379876","https://openalex.org/W2167358549","https://openalex.org/W2324217022","https://openalex.org/W2401307106","https://openalex.org/W2491458126"],"related_works":["https://openalex.org/W2791386754","https://openalex.org/W2603856555","https://openalex.org/W2295703212","https://openalex.org/W2294727127","https://openalex.org/W219967909","https://openalex.org/W1862523212","https://openalex.org/W2143531283","https://openalex.org/W2790358881","https://openalex.org/W2175154535","https://openalex.org/W4283363320"],"abstract_inverted_index":{"A":[0],"cyclic":[1],"dinucleotide":[2],"riboswitch":[3],"has":[4],"been":[5],"fused":[6],"with":[7],"a":[8,13,39],"G-quadruplex":[9,45],"motif":[10],"to":[11],"produce":[12],"conditional":[14,48],"riboswitch-peroxidase-mimicking":[15],"sensor":[16],"that":[17,31],"oxidizes":[18],"both":[19],"colorimetric":[20],"and":[21],"fluorogenic":[22],"substrates":[23],"in":[24],"the":[25],"presence":[26],"of":[27],"c-di-GMP.":[28],"We":[29],"find":[30],"signal-to-noise":[32],"ratio":[33],"could":[34],"be":[35],"improved":[36],"by":[37],"using":[38],"two-,":[40],"not":[41],"three-,":[42],"floor":[43],"split":[44],"for":[46],"this":[47],"peroxidase-mimicking":[49],"riboswitch.":[50]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
