{"id":"https://openalex.org/W2224977404","doi":null,"title":"COMPARISON OF FLUTAMIDE AND METFORMIN IN OVERWEIGHT-OBESE WOMEN WITH POLYCYSTIC OVARY SYNDROME FOLLOWING A HYPOCALORIC DIETING","display_name":"COMPARISON OF FLUTAMIDE AND METFORMIN IN OVERWEIGHT-OBESE WOMEN WITH POLYCYSTIC OVARY SYNDROME FOLLOWING A HYPOCALORIC DIETING","publication_year":2010,"publication_date":"2010-10-10","ids":{"openalex":"https://openalex.org/W2224977404","mag":"2224977404"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:b4aef92ab0214a6da5fabe1a889bcd6d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b4aef92ab0214a6da5fabe1a889bcd6d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Majallah-i D\u0101nishg\u0101h-i \u0312Ul\u016bm-i Pizishk\u012b-i B\u0101bul, Vol 12, Iss 4, Pp 7-13 (2010)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/b4aef92ab0214a6da5fabe1a889bcd6d","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047010981","display_name":"Sedighe Esmaeilzadeh","orcid":"https://orcid.org/0000-0002-1951-1367","observed_orcids":["https://orcid.org/0000-0002-1951-1367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sedighe Esmaeilzadeh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1951-1367","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025727931","display_name":"Leila Ghorbani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leila Ghorbani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077503528","display_name":"Majid Sharbatdaran","orcid":"https://orcid.org/0000-0002-9894-5592","observed_orcids":["https://orcid.org/0000-0002-9894-5592"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Majid Sharbatdaran","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9894-5592","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059806121","display_name":"Ali Bijani","orcid":"https://orcid.org/0000-0003-2233-8726","observed_orcids":["https://orcid.org/0000-0003-2233-8726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali Bijani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2233-8726","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022802361","display_name":"P Sajadi","orcid":"https://orcid.org/0000-0003-1655-8909","observed_orcids":["https://orcid.org/0000-0003-1655-8909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Sajadi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1655-8909","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.28307459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"457","first_page":"7","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/flutamide","display_name":"flutamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7459999918937683},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6690000295639038},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hirsutism","display_name":"hirsutism","score":0.9850000143051147},{"id":"https://openalex.org/keywords/total-testosterone","display_name":"total testosterone","score":0.6079999804496765},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.7789999842643738},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.578000009059906},{"id":"https://openalex.org/keywords/waist-circumference","display_name":"waist circumference","score":0.7009999752044678},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.6779999732971191},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.5090000033378601},{"id":"https://openalex.org/keywords/diabetes-risk","display_name":"diabetes risk","score":0.453000009059906},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8209999799728394},{"id":"https://openalex.org/keywords/infertility","display_name":"infertility","score":0.7639999985694885},{"id":"https://openalex.org/keywords/menstrual-disorders","display_name":"menstrual disorders","score":0.4009999930858612},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.36500000953674316},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9596605896949768},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.8343067169189453},{"id":"https://openalex.org/C2781277698","wikidata":"https://www.wikidata.org/wiki/Q861974","display_name":"Dieting","level":4,"score":0.7704956531524658},{"id":"https://openalex.org/C2778313021","wikidata":"https://www.wikidata.org/wiki/Q418669","display_name":"Flutamide","level":5,"score":0.7531391382217407},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.6980183124542236},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.6553385853767395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5305303335189819},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43174657225608826},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.39929091930389404},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.3268960416316986},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.32334235310554504},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.16683241724967957},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.12364748120307922},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.0},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:b4aef92ab0214a6da5fabe1a889bcd6d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b4aef92ab0214a6da5fabe1a889bcd6d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Majallah-i D\u0101nishg\u0101h-i \u0312Ul\u016bm-i Pizishk\u012b-i B\u0101bul, Vol 12, Iss 4, Pp 7-13 (2010)","raw_type":"article"},{"id":"mag:2224977404","doi":null,"is_oa":true,"landing_page_url":"http://jbums.org/browse.php?a_id=3661&slc_lang=en&sid=1&printcase=1&hbnr=1&hmb=1","pdf_url":null,"source":{"id":"https://openalex.org/S4306537842","display_name":"\u0645\u062c\u0644\u0647 \u0639\u0644\u0645\u06cc \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0628\u0627\u0628\u0644","issn_l":"1561-4107","issn":["1561-4107"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Majallah-i d\u0101nishg\u0101h-i \u0312ul\u016bm-i pizishk\u012b-i B\u0101bul/Majallah-i da\u0304nishga\u0304h-i \u0312ulu\u0304m-i pizishki\u0304-i Ba\u0304bul","raw_type":null}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:b4aef92ab0214a6da5fabe1a889bcd6d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b4aef92ab0214a6da5fabe1a889bcd6d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Majallah-i D\u0101nishg\u0101h-i \u0312Ul\u016bm-i Pizishk\u012b-i B\u0101bul, Vol 12, Iss 4, Pp 7-13 (2010)","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2102239047","https://openalex.org/W2141923412","https://openalex.org/W2014108789","https://openalex.org/W2146735962","https://openalex.org/W2137352589","https://openalex.org/W2073881209","https://openalex.org/W3029561723","https://openalex.org/W2027649652","https://openalex.org/W2768927785","https://openalex.org/W2021450389"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVE:":[2],"Polycystic":[3],"ovary":[4],"syndrome":[5],"is":[6,47],"one":[7,105],"of":[8,23,35,52,66,146,230],"the":[9,21,48,64,116,132,144,147],"most":[10,31,49],"common":[11,32,50],"items":[12],"in":[13,84,166,176,243,253],"endocrine":[14],"diseases":[15],"and":[16,25,27,43,55,69,73,79,81,127,142,152,158,164,186,190,210,214,223,240,246,258],"involved":[17],"patients":[18,117],"are":[19,37],"at":[20,143],"risk":[22],"diabetes":[24],"atherosclerosis":[26],"cardiovascular":[28],"disease.":[29],"The":[30,228],"clinical":[33,92],"features":[34],"PCOS":[36,86],"insulin":[38,53,76,159],"resistance,":[39],"hyperandrogenemia,":[40,56],"non":[41],"ovulation":[42],"infertility.":[44],"Since":[45],"obesity":[46],"cause":[51],"resistance":[54,77],"so":[57],"this":[58,231],"study":[59,94,148,232],"was":[60,95],"designed":[61],"to":[62,109,121],"evaluate":[63],"effects":[65],"weight":[67,179,203],"reduction":[68],"treatment":[70,122],"with":[71,101,123],"metformin":[72,125,239],"flutamide":[74,128,241],"on":[75,97],"indices":[78,245],"hyperandrogenism":[80],"lipid":[82,157],"serum":[83],"overweight-obese":[85,99],"patients.":[87],"METHODS:":[88],"This":[89],"double":[90,113],"blind":[91,114],"trial":[93,112],"performed":[96],"40":[98],"women":[100],"PCOS.":[102],"After":[103],"a":[104,110,173],"month":[106],"diet,":[107],"according":[108],"control":[111],"design,":[115],"were":[118,162],"randomly":[119],"allocated":[120],"placebo,":[124],"(500mg/TDS)":[126],"(250":[129],"mg/BID)":[130],"for":[131],"following":[133],"6":[134],"months":[135],"while":[136],"continuing":[137],"hypocaloric":[138],"dieting.":[139],"At":[140],"baseline":[141],"end":[145],"anthropometric":[149,244],"parameters,":[150],"hirsutism":[151,191,215],"menses,":[153],"sex":[154],"hormones,":[155],"SHBG,":[156],"sensitivity":[160],"determinations":[161],"measured":[163],"compared":[165],"two":[167],"groups.FINDINGS:":[168],"Metformin":[169,248],"(12.2\u00b16.07":[170],"kg)":[171,198],"has":[172,199,249],"significant":[174],"effect":[175],"decreasing":[177],"body":[178,202],"(p=0.000),":[180,182,192,204,206,216],"BMI":[181,205],"waist":[183,207,257],"circumference":[184,188,208,212,260],"(p=0.000)":[185,189,209],"hip":[187,259],"total":[193,217],"testosterone":[194,218],"(p=0.032).":[195],"Flutamide":[196],"(6.5\u00b15.1":[197],"effectively":[200],"decreased":[201],"waist/hip":[211],"(p=0.005)":[213],"(p":[219],"=0.024),":[220],"cholesterol":[221],"(p=0.011)":[222],"LDL":[224],"levels":[225],"(p=0.013).":[226],"CONCLUSION:":[227],"results":[229],"showed":[233],"that":[234],"safe":[235],"drugs":[236],"such":[237],"as":[238],"reduced":[242],"hirsutism.":[247],"been":[250],"more":[251],"effective":[252],"reducing":[254],"weight,":[255],"BMI,":[256],"rather":[261],"than":[262],"flutamide.":[263]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}