{"id":"https://openalex.org/W2224740352","doi":"https://doi.org/10.1186/s10194-015-0582-9","title":"Cervical non-invasive vagus nerve stimulation (nVNS) for preventive and acute treatment of episodic and chronic migraine and migraine-associated sleep disturbance: preliminary findings from a prospective observational cohort study","display_name":"Cervical non-invasive vagus nerve stimulation (nVNS) for preventive and acute treatment of episodic and chronic migraine and migraine-associated sleep disturbance: preliminary findings from a prospective observational cohort study","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2224740352","doi":"https://doi.org/10.1186/s10194-015-0582-9","mag":"2224740352","pmid":"https://pubmed.ncbi.nlm.nih.gov/26631234","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4668248"},"language":"en","primary_location":{"id":"doi:10.1186/s10194-015-0582-9","doi":"https://doi.org/10.1186/s10194-015-0582-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10194-015-0582-9","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/track/pdf/10.1186/s10194-015-0582-9","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://thejournalofheadacheandpain.biomedcentral.com/track/pdf/10.1186/s10194-015-0582-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004090819","display_name":"Thomas Mehari Kinfe","orcid":"https://orcid.org/0000-0002-4888-543X","observed_orcids":["https://orcid.org/0000-0002-4888-543X"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas M. Kinfe","raw_affiliation_strings":["Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Regina-Pacis-Weg 3, 53113, Bonn, Germany. thomas.kinfe@ukb.uni-bonn.de","Division of Functional Neurosurgery and Neuromodulation, Rheinische Friedrich-Wilhelms University, Regina-Pacis-Weg 3, 53113, Bonn, Germany. thomas.kinfe@ukb.uni-bonn.de","Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Bonn, Germany","Division of Functional Neurosurgery and Neuromodulation, Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Regina-Pacis-Weg 3, 53113, Bonn, Germany. thomas.kinfe@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Division of Functional Neurosurgery and Neuromodulation, Rheinische Friedrich-Wilhelms University, Regina-Pacis-Weg 3, 53113, Bonn, Germany. thomas.kinfe@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Division of Functional Neurosurgery and Neuromodulation, Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066764346","display_name":"Bogdan Pintea","orcid":"https://orcid.org/0000-0002-4759-2539","observed_orcids":["https://orcid.org/0000-0002-4759-2539"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bogdan Pintea","raw_affiliation_strings":["Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Regina-Pacis-Weg 3, 53113, Bonn, Germany. bogdan.pintea@ukb.uni-bonn.de","Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Regina-Pacis-Weg 3, 53113, Bonn, Germany. bogdan.pintea@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048321390","display_name":"Sajjad Muhammad","orcid":"https://orcid.org/0000-0002-6734-7979","observed_orcids":["https://orcid.org/0000-0002-6734-7979"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sajjad Muhammad","raw_affiliation_strings":["Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Regina-Pacis-Weg 3, 53113, Bonn, Germany. sajjad.muhammad@ukb.uni-bonn.de","Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Regina-Pacis-Weg 3, 53113, Bonn, Germany. sajjad.muhammad@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102786994","display_name":"Sebastian Zaremba","orcid":"https://orcid.org/0000-0002-4977-6438","observed_orcids":["https://orcid.org/0000-0002-4977-6438"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Zaremba","raw_affiliation_strings":["Department of Clinical Research, German Centre for Neurodegenerative Diseases (DZNE), Ernst-Robert-Curtius-Str. 12, 53117, Bonn, Germany. sebastian.zaremba@ukb.uni-bonn.de","Sleep Medicine, Department of Neurology, Rheinische Friedrich-Wilhelms University, Sigmund-Freud-Str. 25, D-53105, Bonn, Germany. sebastian.zaremba@ukb.uni-bonn.de","German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany","Sleep Medicine, Department of Neurology, Rheinische Friedrich-Wilhelms University, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, German Centre for Neurodegenerative Diseases (DZNE), Ernst-Robert-Curtius-Str. 12, 53117, Bonn, Germany. sebastian.zaremba@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Sleep Medicine, Department of Neurology, Rheinische Friedrich-Wilhelms University, Sigmund-Freud-Str. 25, D-53105, Bonn, Germany. sebastian.zaremba@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Sleep Medicine, Department of Neurology, Rheinische Friedrich-Wilhelms University, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038367367","display_name":"Sandra Roeske","orcid":"https://orcid.org/0000-0002-8262-4356","observed_orcids":["https://orcid.org/0000-0002-8262-4356"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sandra Roeske","raw_affiliation_strings":["Department of Clinical Research, German Centre for Neurodegenerative Diseases (DZNE), Ernst-Robert-Curtius-Str. 12, 53117, Bonn, Germany. sandra.roeske@dzne.de201","German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, German Centre for Neurodegenerative Diseases (DZNE), Ernst-Robert-Curtius-Str. 12, 53117, Bonn, Germany. sandra.roeske@dzne.de201","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111554611","display_name":"Bruce J. Simon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce J. Simon","raw_affiliation_strings":["electroCore, LLC, 150 Allen Road, Suite 201, Basking Ridge, NJ, 07920, USA. bruce.simon@electrocorellc.com","electroCore, LLC, Basking Ridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"electroCore, LLC, 150 Allen Road, Suite 201, Basking Ridge, NJ, 07920, USA. bruce.simon@electrocorellc.com","institution_ids":[]},{"raw_affiliation_string":"electroCore, LLC, Basking Ridge, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024876270","display_name":"Hartmut Vatter","orcid":"https://orcid.org/0000-0001-9999-7282","observed_orcids":["https://orcid.org/0000-0001-9999-7282"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hartmut Vatter","raw_affiliation_strings":["Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Regina-Pacis-Weg 3, 53113, Bonn, Germany. hartmut.vatter@ukb.uni-bonn.de","Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Regina-Pacis-Weg 3, 53113, Bonn, Germany. hartmut.vatter@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Neurosurgery, Rheinische Friedrich-Wilhelms University, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004090819"],"corresponding_institution_ids":["https://openalex.org/I135140700"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":7.716,"has_fulltext":true,"cited_by_count":111,"citation_normalized_percentile":{"value":0.98269012,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"16","issue":"1","first_page":"101","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.48500001430511475},{"id":"https://openalex.org/keywords/chronic-migraine","display_name":"chronic migraine","score":0.8029999732971191},{"id":"https://openalex.org/keywords/episodic-migraine","display_name":"episodic migraine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/migraine-prevention","display_name":"migraine prophylaxis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/acute-migraine-treatment","display_name":"acute migraine treatment","score":0.972000002861023},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.7480000257492065},{"id":"https://openalex.org/keywords/migraine-disability","display_name":"migraine disability","score":0.8650000095367432},{"id":"https://openalex.org/keywords/depressive-symptoms","display_name":"depressive symptoms","score":0.984000027179718},{"id":"https://openalex.org/keywords/pain-intensity","display_name":"pain intensity","score":0.5350000262260437},{"id":"https://openalex.org/keywords/non-pharmacological-treatment","display_name":"non-pharmacological treatment","score":0.6790000200271606},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.5640000104904175},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.656000018119812},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.38100001215934753},{"id":"https://openalex.org/keywords/time-to-pain-relief","display_name":"time to pain relief","score":0.5170000195503235},{"id":"https://openalex.org/keywords/headache-days-per-month","display_name":"headache days per month","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9268758296966553},{"id":"https://openalex.org/C2780087125","wikidata":"https://www.wikidata.org/wiki/Q2062293","display_name":"Vagus nerve stimulation","level":4,"score":0.8316326141357422},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8155871629714966},{"id":"https://openalex.org/C2910587157","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Chronic Migraine","level":3,"score":0.6878986358642578},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.6334538459777832},{"id":"https://openalex.org/C2991975920","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain medicine","level":3,"score":0.6078964471817017},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5813924074172974},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.505035936832428},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4854479432106018},{"id":"https://openalex.org/C2778581513","wikidata":"https://www.wikidata.org/wiki/Q263962","display_name":"Transcranial magnetic stimulation","level":3,"score":0.4443603754043579},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41922181844711304},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.41403302550315857},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3829832673072815},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3010794222354889},{"id":"https://openalex.org/C2781404750","wikidata":"https://www.wikidata.org/wiki/Q190140","display_name":"Vagus nerve","level":3,"score":0.29912179708480835},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.29844802618026733},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29302483797073364},{"id":"https://openalex.org/C2779526319","wikidata":"https://www.wikidata.org/wiki/Q615057","display_name":"Anesthesiology","level":2,"score":0.16318902373313904}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002574","descriptor_name":"Cervical Vertebrae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055536","descriptor_name":"Vagus Nerve Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s10194-015-0582-9","doi":"https://doi.org/10.1186/s10194-015-0582-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10194-015-0582-9","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/track/pdf/10.1186/s10194-015-0582-9","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3653139","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4668248","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26631234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26631234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of headache and pain","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4668248","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4668248/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Headache Pain","raw_type":"Text"},{"id":"pmh:oai:pub.dzne.de:138310","doi":null,"is_oa":true,"landing_page_url":"https://pub.dzne.de/record/138310","pdf_url":null,"source":{"id":"https://openalex.org/S7407051172","display_name":"DZNE Pub","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801533059","host_organization_name":"German Center for Neurodegenerative Diseases","host_organization_lineage":["https://openalex.org/I2801533059"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The journal of headache and pain 16(1), 101 (2015). doi:10.1186/s10194-015-0582-9","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s10194-015-0582-9","doi":"https://doi.org/10.1186/s10194-015-0582-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10194-015-0582-9","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/track/pdf/10.1186/s10194-015-0582-9","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2224740352.pdf","grobid_xml":"https://content.openalex.org/works/W2224740352.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W24450281","https://openalex.org/W1519170440","https://openalex.org/W1548970190","https://openalex.org/W1801874439","https://openalex.org/W1824012089","https://openalex.org/W1895781480","https://openalex.org/W1967702499","https://openalex.org/W1970665765","https://openalex.org/W1975143761","https://openalex.org/W1978847367","https://openalex.org/W1983153788","https://openalex.org/W1983577654","https://openalex.org/W2020216633","https://openalex.org/W2029991935","https://openalex.org/W2034300480","https://openalex.org/W2035354360","https://openalex.org/W2042426842","https://openalex.org/W2044390161","https://openalex.org/W2047690336","https://openalex.org/W2060898043","https://openalex.org/W2064445431","https://openalex.org/W2067495470","https://openalex.org/W2077023159","https://openalex.org/W2085127525","https://openalex.org/W2086327013","https://openalex.org/W2094473459","https://openalex.org/W2096840793","https://openalex.org/W2098082628","https://openalex.org/W2100840600","https://openalex.org/W2104931365","https://openalex.org/W2114040270","https://openalex.org/W2115043276","https://openalex.org/W2120690350","https://openalex.org/W2126194551","https://openalex.org/W2127508820","https://openalex.org/W2143913926","https://openalex.org/W2151487996","https://openalex.org/W2151940214","https://openalex.org/W2155368884","https://openalex.org/W2157899987","https://openalex.org/W2158520507","https://openalex.org/W2158891457","https://openalex.org/W2162404100","https://openalex.org/W2180068571","https://openalex.org/W2319000318","https://openalex.org/W2638561866","https://openalex.org/W2769724041"],"related_works":["https://openalex.org/W7095767969","https://openalex.org/W2466591301","https://openalex.org/W2974905654","https://openalex.org/W2898654348","https://openalex.org/W7171404470","https://openalex.org/W2143913926","https://openalex.org/W2886869311","https://openalex.org/W2908787064","https://openalex.org/W2808133247","https://openalex.org/W4376279327"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"debilitating":[2],"nature":[3],"of":[4,41,54,70,119,126,132,219,246,361],"migraine":[5,11,55,62,85,110,127,149,247,273,362],"and":[6,52,60,64,66,77,104,124,136,159,179,243,318,350,359,374],"challenges":[7],"associated":[8,185],"with":[9,83,177,182,186,312,322,346,366],"treatment-refractory":[10,33,58,84,367],"have":[12],"a":[13,275,323],"profound":[14],"impact":[15,69],"on":[16,72],"patients.":[17],"With":[18],"the":[19,39,49,68,167,356],"need":[20],"for":[21,48,109],"alternatives":[22],"to":[23,138,281],"pharmacologic":[24],"agents,":[25],"vagus":[26,44],"nerve":[27,45],"stimulation":[28,46],"has":[29],"demonstrated":[30],"efficacy":[31],"in":[32,57,88,190,277,310,316,327,355,364,370],"primary":[34],"headache":[35,120,220],"disorders.":[36],"We":[37],"investigated":[38],"use":[40],"cervical":[42],"non-invasive":[43],"(nVNS)":[47],"acute":[50],"treatment":[51,345],"prevention":[53],"attacks":[56,128,135,248,363],"episodic":[59],"chronic":[61],"(EM":[63],"CM)":[65],"evaluated":[67],"nVNS":[71,97,183,347],"migraine-associated":[73,371],"sleep":[74,142,375],"disturbance,":[75],"disability,":[76,372],"depressive":[78,153],"symptoms.":[79],"METHODS:":[80],"Twenty":[81],"patients":[82,172,311,365],"were":[86,163,314,377],"enrolled":[87,169],"this":[89,343],"3-month,":[90],"open-label,":[91],"prospective":[92],"observational":[93],"study.":[94],"Patients":[95],"administered":[96],"prophylactically":[98],"twice":[99],"daily":[100],"at":[101,197],"prespecified":[102],"times":[103],"acutely":[105,133,271],"as":[106],"adjunctive":[107],"therapy":[108],"attacks.":[111],"Pain":[112],"intensity":[113,193],"(visual":[114],"analogue":[115],"scale":[116],"[VAS]);":[117],"number":[118,125,131,218,245],"days":[121,221],"per":[122,129,222,249],"month":[123,223,250],"month;":[130],"treated":[134,272],"time":[137,279],"achieve":[139,282],"pain":[140,192,283],"relief;":[141],"quality":[143,376],"(Pittsburgh":[144],"Sleep":[145],"Quality":[146],"Index":[147],"[PSQI]);":[148],"disability":[150],"assessment":[151],"(MIDAS);":[152],"symptoms":[154],"(Beck":[155],"Depression":[156],"Inventory(\u00ae)":[157],"[BDI]);":[158],"adverse":[160],"events":[161],"(AEs)":[162],"evaluated.":[164],"RESULTS:":[165],"Of":[166],"20":[168],"patients,":[170],"10":[171],"each":[173],"had":[174],"been":[175],"diagnosed":[176],"EM":[178],"CM.":[180],"Prophylaxis":[181],"was":[184,304,348],"significant":[187],"overall":[188],"reductions":[189],"patient-perceived":[191],"(mean":[194],"VAS":[195],"scores":[196,320],"baseline":[198],"vs":[199,205,225,231,252,258,286,292],"3":[200,226,253,287],"months:":[201,227,254,288],"7.75":[202],"\u00b1":[203,207,229,233,256,260,290,294],"0.64":[204],"4.05":[206],"0.76;":[208],"95":[209,235,262,296],"%":[210,236,263,297],"CI:":[211,237,264,298],"3.3,":[212,238],"4.1;":[213],"p":[214,240,267,301],"<":[215,241,268,302],"0.0001),":[216,242],"mean":[217,244,278],"(baseline":[224,251,285],"14.7":[228],"4.1":[230],"8.9":[232],"3.66;":[234],"8.3;":[239],"7.3":[255],"3.85":[257],"4.45":[259],"2.48;":[261],"0.8,":[265],"4.9;":[266],"0.01).":[269],"For":[270],"attacks,":[274],"reduction":[276],"(minutes)":[280],"relief":[284],"84.5":[289],"39.1":[291],"52.75":[293],"16.42;":[295],"12.6,":[299],"51.0;":[300],"0.002)":[303],"noted.":[305,379],"Significant":[306],"improvements,":[307],"more":[308],"evident":[309],"EM,":[313],"noted":[315],"MIDAS":[317],"BDI":[319],"along":[321],"trend":[324],"toward":[325],"improvement":[326],"PSQI":[328],"daytime":[329],"dysfunction":[330],"subscore":[331],"(p":[332],"=":[333],"0.07).":[334],"No":[335],"severe":[336],"or":[337],"serious":[338],"AEs":[339],"occurred.":[340],"CONCLUSION:":[341],"In":[342],"study,":[344],"safe":[349],"provided":[351],"clinically":[352],"meaningful":[353],"decreases":[354],"frequency,":[357],"intensity,":[358],"duration":[360],"migraine.":[368],"Improvements":[369],"depression,":[373],"also":[378]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
