{"id":"https://openalex.org/W222436611","doi":null,"title":"Etudes structurales, fonctionnelles et d'inhibition de l'histone d\u00e9ac\u00e9tylase 7 humaine","display_name":"Etudes structurales, fonctionnelles et d'inhibition de l'histone d\u00e9ac\u00e9tylase 7 humaine","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W222436611","mag":"222436611"},"language":"en","primary_location":{"id":"mag:2809320283","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00551909","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.hal.science/tel-00551909","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041782893","display_name":"Danielle C. Desravines","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Danielle C. Desravines","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041782893"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac7","display_name":"HDAC7","score":0.9570000171661377},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/smrt","display_name":"SMRT","score":0.515999972820282},{"id":"https://openalex.org/keywords/isoform-specificity","display_name":"isoform specificity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/bile-acid-synthesis","display_name":"bile acid synthesis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cholesterol-catabolism","display_name":"cholesterol catabolism","score":0.953000009059906},{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7649999856948853},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.6330000162124634},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5359383821487427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5275019407272339},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41085368394851685},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.3800385594367981},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07752996683120728}],"mesh":[],"locations_count":3,"locations":[{"id":"mag:2809320283","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00551909","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:HAL:tel-00551909v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/tel-00551909v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Other [q-bio.OT]. Universit\u00e9 de Grenoble, 2010. English. &#x27E8;NNT : &#x27E9;","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:222436611","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2010GRENV068","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"mag:2809320283","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00551909","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":264,"referenced_works":["https://openalex.org/W45157614","https://openalex.org/W191075349","https://openalex.org/W1236133676","https://openalex.org/W1491536683","https://openalex.org/W1497456715","https://openalex.org/W1528641956","https://openalex.org/W1544547269","https://openalex.org/W1563624749","https://openalex.org/W1571292136","https://openalex.org/W1576011410","https://openalex.org/W1601992549","https://openalex.org/W1622552814","https://openalex.org/W1629804770","https://openalex.org/W1639694146","https://openalex.org/W1874881634","https://openalex.org/W1884928119","https://openalex.org/W1900565974","https://openalex.org/W1910848366","https://openalex.org/W1923015860","https://openalex.org/W1952721216","https://openalex.org/W1960910882","https://openalex.org/W1962029512","https://openalex.org/W1963587340","https://openalex.org/W1963829486","https://openalex.org/W1963996414","https://openalex.org/W1966868225","https://openalex.org/W1967203779","https://openalex.org/W1967364632","https://openalex.org/W1969691479","https://openalex.org/W1970054449","https://openalex.org/W1970574312","https://openalex.org/W1970896735","https://openalex.org/W1971621147","https://openalex.org/W1971842995","https://openalex.org/W1972149587","https://openalex.org/W1972338617","https://openalex.org/W1972533251","https://openalex.org/W1974112332","https://openalex.org/W1975692560","https://openalex.org/W1977010911","https://openalex.org/W1977209028","https://openalex.org/W1978893041","https://openalex.org/W1979079649","https://openalex.org/W1979186179","https://openalex.org/W1979377700","https://openalex.org/W1979519622","https://openalex.org/W1979947947","https://openalex.org/W1982515690","https://openalex.org/W1982619775","https://openalex.org/W1983094204","https://openalex.org/W1983861034","https://openalex.org/W1985321027","https://openalex.org/W1985854865","https://openalex.org/W1986506019","https://openalex.org/W1989051882","https://openalex.org/W1989819921","https://openalex.org/W1989842018","https://openalex.org/W1989900087","https://openalex.org/W1990861922","https://openalex.org/W1993736467","https://openalex.org/W1995089537","https://openalex.org/W1996103159","https://openalex.org/W1999952815","https://openalex.org/W2000149219","https://openalex.org/W2002698073","https://openalex.org/W2004499293","https://openalex.org/W2006192061","https://openalex.org/W2008904725","https://openalex.org/W2009455776","https://openalex.org/W2009826707","https://openalex.org/W2010004274","https://openalex.org/W2010466297","https://openalex.org/W2011213265","https://openalex.org/W2012852001","https://openalex.org/W2012937658","https://openalex.org/W2013547494","https://openalex.org/W2014776147","https://openalex.org/W2014937237","https://openalex.org/W2017579029","https://openalex.org/W2019027463","https://openalex.org/W2019727148","https://openalex.org/W2019831987","https://openalex.org/W2020845378","https://openalex.org/W2020912062","https://openalex.org/W2022285476","https://openalex.org/W2026086000","https://openalex.org/W2028645925","https://openalex.org/W2028757540","https://openalex.org/W2029130907","https://openalex.org/W2029734909","https://openalex.org/W2029903254","https://openalex.org/W2030776726","https://openalex.org/W2031954417","https://openalex.org/W2032328453","https://openalex.org/W2032462421","https://openalex.org/W2032696829","https://openalex.org/W2032794324","https://openalex.org/W2034299708","https://openalex.org/W2034540576","https://openalex.org/W2035915355","https://openalex.org/W2036479240","https://openalex.org/W2036826769","https://openalex.org/W2037210205","https://openalex.org/W2037587486","https://openalex.org/W2038554263","https://openalex.org/W2040321376","https://openalex.org/W2040506727","https://openalex.org/W2040631816","https://openalex.org/W2040658415","https://openalex.org/W2041336616","https://openalex.org/W2042327228","https://openalex.org/W2043290877","https://openalex.org/W2044216740","https://openalex.org/W2044784487","https://openalex.org/W2044878334","https://openalex.org/W2045077330","https://openalex.org/W2045777307","https://openalex.org/W2047705460","https://openalex.org/W2049118388","https://openalex.org/W2049961455","https://openalex.org/W2051152566","https://openalex.org/W2052373759","https://openalex.org/W2052436173","https://openalex.org/W2053796439","https://openalex.org/W2053916731","https://openalex.org/W2055193239","https://openalex.org/W2058353811","https://openalex.org/W2058892637","https://openalex.org/W2061357909","https://openalex.org/W2064959533","https://openalex.org/W2064966728","https://openalex.org/W2065410511","https://openalex.org/W2065471902","https://openalex.org/W2065782017","https://openalex.org/W2067240980","https://openalex.org/W2067779211","https://openalex.org/W2070312499","https://openalex.org/W2071829685","https://openalex.org/W2073430688","https://openalex.org/W2073806111","https://openalex.org/W2073978750","https://openalex.org/W2074561908","https://openalex.org/W2075770210","https://openalex.org/W2076614498","https://openalex.org/W2078454854","https://openalex.org/W2079720515","https://openalex.org/W2080104036","https://openalex.org/W2081509331","https://openalex.org/W2081685122","https://openalex.org/W2082608241","https://openalex.org/W2082739830","https://openalex.org/W2084194105","https://openalex.org/W2084333983","https://openalex.org/W2085414423","https://openalex.org/W2087823077","https://openalex.org/W2089281168","https://openalex.org/W2089487223","https://openalex.org/W2090520845","https://openalex.org/W2092349389","https://openalex.org/W2096083625","https://openalex.org/W2096501714","https://openalex.org/W2096887947","https://openalex.org/W2097933346","https://openalex.org/W2098249941","https://openalex.org/W2099792852","https://openalex.org/W2099803844","https://openalex.org/W2099959808","https://openalex.org/W2100338355","https://openalex.org/W2100854823","https://openalex.org/W2101979121","https://openalex.org/W2104080300","https://openalex.org/W2104209061","https://openalex.org/W2106515170","https://openalex.org/W2107733280","https://openalex.org/W2107889588","https://openalex.org/W2108014213","https://openalex.org/W2108116956","https://openalex.org/W2110128290","https://openalex.org/W2110378711","https://openalex.org/W2112013199","https://openalex.org/W2112351720","https://openalex.org/W2112957815","https://openalex.org/W2113144329","https://openalex.org/W2113706857","https://openalex.org/W2114063466","https://openalex.org/W2114304598","https://openalex.org/W2115446838","https://openalex.org/W2117691193","https://openalex.org/W2117918599","https://openalex.org/W2118608964","https://openalex.org/W2118650392","https://openalex.org/W2119693327","https://openalex.org/W2120594989","https://openalex.org/W2120881407","https://openalex.org/W2121265934","https://openalex.org/W2121296685","https://openalex.org/W2122308238","https://openalex.org/W2122772601","https://openalex.org/W2122774961","https://openalex.org/W2124258829","https://openalex.org/W2124259172","https://openalex.org/W2124811991","https://openalex.org/W2124915353","https://openalex.org/W2125022522","https://openalex.org/W2125196454","https://openalex.org/W2125601003","https://openalex.org/W2125639616","https://openalex.org/W2127587233","https://openalex.org/W2128021885","https://openalex.org/W2131233236","https://openalex.org/W2131566044","https://openalex.org/W2131965976","https://openalex.org/W2133446638","https://openalex.org/W2134009718","https://openalex.org/W2134544170","https://openalex.org/W2135830745","https://openalex.org/W2135994759","https://openalex.org/W2138039051","https://openalex.org/W2138440003","https://openalex.org/W2139356410","https://openalex.org/W2139929417","https://openalex.org/W2140513365","https://openalex.org/W2141595346","https://openalex.org/W2143027433","https://openalex.org/W2143658931","https://openalex.org/W2143884758","https://openalex.org/W2144249178","https://openalex.org/W2144792857","https://openalex.org/W2146959699","https://openalex.org/W2148463229","https://openalex.org/W2149472608","https://openalex.org/W2149993601","https://openalex.org/W2151464048","https://openalex.org/W2152631096","https://openalex.org/W2153598858","https://openalex.org/W2154572495","https://openalex.org/W2154682388","https://openalex.org/W2156012049","https://openalex.org/W2156407548","https://openalex.org/W2156678798","https://openalex.org/W2156807398","https://openalex.org/W2158747282","https://openalex.org/W2160093177","https://openalex.org/W2161964918","https://openalex.org/W2162953605","https://openalex.org/W2163485494","https://openalex.org/W2164975907","https://openalex.org/W2165186407","https://openalex.org/W2166952064","https://openalex.org/W2167118090","https://openalex.org/W2167398093","https://openalex.org/W2168909179","https://openalex.org/W2168927748","https://openalex.org/W2171347864","https://openalex.org/W2171369831","https://openalex.org/W2177378089","https://openalex.org/W2278119399","https://openalex.org/W2315916150","https://openalex.org/W2324841714","https://openalex.org/W2417065780","https://openalex.org/W2437441859","https://openalex.org/W2569844665","https://openalex.org/W2975890157","https://openalex.org/W4299564444"],"related_works":["https://openalex.org/W2809320283","https://openalex.org/W7167215258","https://openalex.org/W2793494762","https://openalex.org/W7061080135","https://openalex.org/W7478372","https://openalex.org/W2405390152","https://openalex.org/W2028757540","https://openalex.org/W2960307960","https://openalex.org/W2888666209","https://openalex.org/W4414796506"],"abstract_inverted_index":{"Atherosclerosis":[0],"occurs":[1],"due":[2],"to":[3,11,17,26,89,99,202],"accumulation":[4],"of":[5,52,62,107,150],"cholesterol":[6,29,53,69,79],"in":[7,68,146,206],"the":[8,60,65,120,139,147,207],"arteries":[9],"leading":[10,15],"rigid":[12],"plaque":[13],"formation":[14],"eventually":[16],"strokes":[18],"and":[19,91,98,125,194],"heart":[20],"attacks.":[21],"Several":[22,110],"efficient":[23],"drugs":[24,40],"exist":[25],"decrease":[27],"blood":[28],"levels,":[30],"but":[31],"are":[32,156,200],"inefficient":[33],"for":[34,77,174],"treating":[35],"familial":[36],"hypercholesterolemia.":[37],"Therefore":[38],"new":[39,75],"must":[41],"be":[42],"developed.":[43],"It":[44],"was":[45,83,136,144,162,185,189],"observed":[46],"that":[47],"inhibiting":[48],"HDAC7":[49,108,178],"increased":[50],"conversion":[51],"into":[54,85],"excreted":[55],"bile":[56],"acids":[57],"by":[58,179,191],"enhancing":[59],"activity":[61],"7\u03b1-cholesterol":[63],"hydroxylase,":[64],"rate-limiting":[66],"enzyme":[67],"catabolism.":[70],"This":[71,134,187],"represents":[72],"a":[73,131],"potential":[74],"strategy":[76,106],"decreasing":[78],"levels.":[80],"The":[81,168],"project":[82],"divided":[84],"two":[86],"main":[87],"parts:":[88],"understand":[90],"elucidate":[92],"mechanisms":[93],"underlying":[94],"HDAC":[95],"inhibitor":[96,141],"isoform-specificity":[97],"explore":[100],"HDAC7-SMRT":[101],"interaction":[102,176,188],"as":[103,164],"an":[104],"alternative":[105],"inhibition.":[109],"protein":[111],"engineering":[112],"steps":[113],"were":[114,128,172],"carried":[115],"out":[116],"on":[117,166],"HDAC7,":[118],"using":[119],"ESPRIT":[121,161],"technology.":[122],"Crystallisation":[123,154],"trials":[124],"inhibition":[126],"tests":[127],"performed":[129],"with":[130,158,177],"promising":[132],"compound.":[133,160],"compound":[135],"derived":[137],"from":[138],"pan-HDAC":[140],"SAHA,":[142],"which":[143],"substituted":[145],"meta":[148],"positions":[149],"its":[151],"phenyl":[152],"cap.":[153],"trails":[155],"ongoing":[157,201],"this":[159],"applied":[163],"well":[165],"SMRT.":[167],"generated":[169],"soluble":[170],"fragments":[171],"tested":[173],"their":[175],"15N-HSQC":[180],"NMR.":[181],"A":[182],"interacting":[183],"fragment":[184],"identified.":[186],"confirmed":[190],"fluorescence":[192],"anisotropy":[193],"surface":[195],"Plasmon":[196],"resonance.":[197],"NMR":[198],"experiments":[199],"assign":[203],"residues":[204],"involved":[205],"interaction.":[208]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
