{"id":"https://openalex.org/W2223300916","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.tps279","title":"A multicenter dose-finding randomized controlled phase IIb study of the aptamer AS1411 in patients with primary refractory or relapsed AML.","display_name":"A multicenter dose-finding randomized controlled phase IIb study of the aptamer AS1411 in patients with primary refractory or relapsed AML.","publication_year":2010,"publication_date":"2010-05-20","ids":{"openalex":"https://openalex.org/W2223300916","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.tps279","mag":"2223300916"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2010.28.15_suppl.tps279","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.tps279","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.tps279","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015493242","display_name":"Robert Kenneth Stuart","orcid":"https://orcid.org/0000-0001-7549-8008","observed_orcids":["https://orcid.org/0000-0001-7549-8008"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. K. Stuart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005591514","display_name":"Andrew H. Wei","orcid":"https://orcid.org/0000-0002-7514-3298","observed_orcids":["https://orcid.org/0000-0002-7514-3298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Wei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103467162","display_name":"Ian D. Lewis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. D. Lewis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057920623","display_name":"Elihu H. Estey","orcid":"https://orcid.org/0000-0002-0987-8077","observed_orcids":["https://orcid.org/0000-0002-0987-8077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Estey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068685482","display_name":"Fredrik Erlandsson","orcid":"https://orcid.org/0000-0002-3176-1078","observed_orcids":["https://orcid.org/0000-0002-3176-1078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Erlandsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037299848","display_name":"Gary John Schiller","orcid":"https://orcid.org/0000-0002-7508-3467","observed_orcids":["https://orcid.org/0000-0002-7508-3467"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. J. Schiller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"15_suppl","first_page":"TPS279","last_page":"TPS279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/as1411","display_name":"AS1411","score":0.8980000019073486},{"id":"https://openalex.org/keywords/aptamers","display_name":"aptamers","score":0.8159999847412109},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/relapsed-refractory-aml","display_name":"relapsed/refractory AML","score":0.843999981880188},{"id":"https://openalex.org/keywords/nucleolin","display_name":"nucleolin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cytarabine","display_name":"cytarabine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/dose-finding","display_name":"dose-finding","score":0.6589999794960022},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.46299999952316284},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.38199999928474426},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.49799999594688416},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.7039999961853027},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6748225092887878},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.6132007837295532},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5236058831214905},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4726138412952423},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.4485343098640442},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4457222521305084},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.4327007532119751},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41908296942710876},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37898215651512146},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3621557056903839},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3526403605937958},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33461111783981323},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1721726655960083},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.14549332857131958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13876065611839294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11771097779273987},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2010.28.15_suppl.tps279","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.tps279","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.tps279","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1709396952","https://openalex.org/W2524165769","https://openalex.org/W2593536741","https://openalex.org/W2555823404","https://openalex.org/W2556094713","https://openalex.org/W7098696657","https://openalex.org/W2504553056","https://openalex.org/W2324104299","https://openalex.org/W1985290031","https://openalex.org/W2118908256"],"abstract_inverted_index":{"Article":[0,7],"Tools":[1,8],"Trials":[2],"in":[3,55,211,239,243,307,321,395],"Progress":[4],"Poster":[5],"Session":[6],"OPTIONS":[9],"&":[10,20],"TOOLS":[11],"Export":[12],"Citation":[13,15],"Track":[14],"Add":[16],"To":[17],"Favorites":[18],"Rights":[19],"Permissions":[21],"COMPANION":[22],"ARTICLES":[23],"No":[24],"companion":[25],"articles":[26,69,78,89,98,107,118],"ARTICLE":[27],"CITATION":[28],"DOI:":[29],"10.1200/jco.2010.28.15_suppl.tps279":[30],"Journal":[31],"of":[32,51,126,142,155,160,199,224,303,310,315,418,435,437,450,455,458,528],"Clinical":[33,529],"Oncology":[34,530],"-":[35],"published":[36],"online":[37],"before":[38,473],"print":[39],"May":[40],"20,":[41],"2010":[42,524],"A":[43,230],"multicenter":[44],"dose-finding":[45],"randomized":[46,232,332],"controlled":[47,233],"phase":[48,208,234,296],"IIb":[49,297],"study":[50,420],"the":[52,203,222,294,301,308,419,428,456,497],"aptamer":[53,205,215],"AS1411":[54,201,214,238,254,262,311,337,344,357,459,493],"patients":[56,244,329],"with":[57,185,241,245,253,376,384,398,427],"primary":[58,381,416],"refractory":[59,248,382],"or":[60,270,351,393,503,507],"relapsed":[61,246],"AML.":[62,249],"R.":[63],"K.":[64,66],"StuartxR.":[65],"StuartSearch":[67],"for":[68,77,88,97,106,117],"by":[70,79,90,99,108,119,525],"this":[71,80,91,100,109,120],"author":[72,81,92,101,110,121],",":[73,82,93,102,111],"A.":[74],"WeixA.":[75],"WeiSearch":[76],"I.":[83],"D.":[84,86],"LewisxI.":[85],"LewisSearch":[87],"E.":[94],"EsteyxE.":[95],"EsteySearch":[96],"F.":[103],"ErlandssonxF.":[104],"ErlandssonSearch":[105],"G.":[112],"J.":[113,115],"SchillerxG.":[114],"SchillerSearch":[116],"Show":[122],"More":[123],"Medical":[124,144],"University":[125,141,154],"South":[127],"Carolina,":[128],"Charleston,":[129],"SC;":[130],"The":[131,213,285,415],"Alfred":[132],"Hospital,":[133,138],"Melbourne,":[134],"Australia;":[135,140],"Royal":[136],"Adelaide":[137],"Adelaide,":[139],"Washington":[143],"Center,":[145],"Seattle,":[146],"WA;":[147],"Antisoma":[148,519,521,522],"Research":[149,513],"Ltd.,":[150],"London,":[151],"United":[152],"Kingdom;":[153],"California,":[156],"Los":[157,162],"Angeles":[158],"School":[159],"Medicine,":[161],"Angeles,":[163],"CA":[164],"https://doi.org/10.1200/jco.2010.28.15_suppl.tps279":[165],"Abstract":[166,167],"TPS279":[168],"Background:":[169],"Aptamers":[170],"are":[171,406,433],"small":[172],"synthetic":[173],"oligonucleotides":[174],"that":[175],"form":[176],"stable":[177],"nuclease-resistant":[178],"3D":[179],"structures":[180],"and":[181,187,227,247,364,410,441,446,448,468,474],"bind":[182],"target":[183],"proteins":[184],"specificity":[186],"affinity":[188],"similar":[189],"to":[190,206,293,334,422,482,488,491],"antibodies.":[191],"These":[192,290],"\"chemical":[193],"antibodies\"":[194],"represent":[195],"a":[196,304,313,316],"new":[197],"class":[198],"therapeutics.":[200],"is":[202,219,421],"first":[204,396],"enter":[207],"II":[209,235],"trials":[210],"cancer.":[212],"binds":[216],"nucleolin,":[217],"which":[218,299],"overexpressed":[220],"on":[221,388,464],"surface":[223],"cancer":[225],"cells,":[226],"induces":[228],"apoptosis.":[229],"70-patient":[231],"trial":[236],"evaluated":[237],"combination":[240,286],"cytarabine":[242,258,266,271,319,341,348,352,365,483,495],"Patients":[250,373,477],"were":[251],"treated":[252,324],"10":[255],"mg/kg/day":[256,264,339,346],"+":[257,265,340,347,494],"3":[259,267,272,335],"g/m2/day":[260,268,273,354],"(AS1411-10),":[261],"40":[263,338],"(AS1411-40),":[269],"alone":[274,355,484],"(control).":[275,356],"CR+CRp":[276],"rates":[277,425],"were:":[278],"AS1411-10,":[279],"21%;":[280],"AS1411-40,":[281],"19%;":[282],"control,":[283],"5%.":[284],"was":[287],"well":[288],"tolerated.":[289],"findings":[291],"led":[292],"current":[295],"study,":[298],"tests":[300],"value":[302],"further":[305],"doubling":[306],"dose":[309,320],"against":[312],"background":[314],"slightly":[317],"higher":[318],"less":[322],"heavily":[323],"AML":[325,383,394],"patients.":[326],"Methods:":[327],"90":[328],"will":[330,358,366,460,485],"be":[331,359,367,461,486],"1:1:1":[333],"arms:":[336],"4":[342,349,353],"g/m2/day,":[343,350],"80":[345],"administered":[360,368],"CI":[361],"days":[362,371],"1-7,":[363],"bid":[369],"IV":[370],"4-7.":[372],"aged":[374],"18-70":[375],"ECOG":[377],"0-2":[378],"must":[379],"have":[380],">":[385,399],"20%":[386],"blasts":[387],"baseline":[389],"bone":[390,465],"marrow":[391,401,466],"assessment":[392,449,454],"relapse":[397],"5%":[400],"blasts.":[402],"Key":[403],"exclusion":[404],"criteria":[405],"APL,":[407],"secondary":[408],"AML,":[409],"clinically":[411],"active":[412],"CNS":[413],"leukemia.":[414],"objective":[417],"compare":[423],"response":[424],"(CR+CRi)":[426],"three":[429],"regimens.":[430],"Secondary":[431],"objectives":[432],"comparisons":[434],"duration":[436],"remission,":[438],"disease-free":[439],"survival":[440],"overall":[442],"survival,":[443],"hematologic":[444],"recovery":[445],"safety,":[447],"pharmacokinetics.":[451],"Exploratory":[452],"pharmacodynamic":[453],"effects":[457],"carried":[462],"out":[463],"aspirate":[467],"trephine":[469],"biopsy":[470],"samples":[471],"taken":[472],"after":[475],"treatment.":[476],"who":[478],"do":[479],"not":[480],"respond":[481],"eligible":[487],"cross":[489],"over":[490],"receive":[492],"at":[496],"investigator's":[498],"discretion.":[499],"Author":[500],"Disclosure":[501],"Employment":[502],"Leadership":[504],"Position":[505],"Consultant":[506],"Advisory":[508],"Role":[509],"Stock":[510],"Ownership":[511],"Honoraria":[512],"Funding":[514],"Expert":[515],"Testimony":[516],"Other":[517],"Remuneration":[518],"AntiCancer,":[520],"\u00a9":[523],"American":[526],"Society":[527]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
