{"id":"https://openalex.org/W2223293131","doi":"https://doi.org/10.1038/srep18821","title":"Intracellular Doppler Signatures of Platinum Sensitivity Captured by Biodynamic Profiling in Ovarian Xenografts","display_name":"Intracellular Doppler Signatures of Platinum Sensitivity Captured by Biodynamic Profiling in Ovarian Xenografts","publication_year":2016,"publication_date":"2016-01-06","ids":{"openalex":"https://openalex.org/W2223293131","doi":"https://doi.org/10.1038/srep18821","mag":"2223293131","pmid":"https://pubmed.ncbi.nlm.nih.gov/26732545","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4702146"},"language":"en","primary_location":{"id":"doi:10.1038/srep18821","doi":"https://doi.org/10.1038/srep18821","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep18821","pdf_url":"https://www.nature.com/articles/srep18821.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep18821.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080717984","display_name":"Daniel Merrill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel Merrill","raw_affiliation_strings":["Department of Physics, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319291","display_name":"Ran An","orcid":"https://orcid.org/0000-0002-4849-0120","observed_orcids":["https://orcid.org/0000-0002-4849-0120","https://orcid.org/0000-0003-3216-2891","https://orcid.org/0009-0000-8610-2152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ran An","raw_affiliation_strings":["Animated Dynamics, Inc., West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animated Dynamics, Inc., West Lafayette, Indiana","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102867292","display_name":"Hao Sun","orcid":"https://orcid.org/0000-0001-6400-7365","observed_orcids":["https://orcid.org/0000-0001-6400-7365","https://orcid.org/0009-0008-6083-4126"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Sun","raw_affiliation_strings":["Department of Physics, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109088702","display_name":"Bakhtiyor Yakubov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bakhtiyor Yakubov","raw_affiliation_strings":["Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067743297","display_name":"Daniela Elena Matei","orcid":"https://orcid.org/0000-0003-2169-5035","observed_orcids":["https://orcid.org/0000-0003-2169-5035"]},"institutions":[{"id":"https://openalex.org/I4210110049","display_name":"Richard L. Roudebush VA Medical Center","ror":"https://ror.org/01zpmbk67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110049","https://openalex.org/I4210127612","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Matei","raw_affiliation_strings":["Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana","Indiana University Simon Cancer Center, Roudebush VA Hospital, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana University Simon Cancer Center, Roudebush VA Hospital, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4210110049","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045894719","display_name":"John J. Turek","orcid":"https://orcid.org/0000-0003-4631-7356","observed_orcids":["https://orcid.org/0000-0003-4631-7356"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Turek","raw_affiliation_strings":["Animated Dynamics, Inc., West Lafayette, Indiana","Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animated Dynamics, Inc., West Lafayette, Indiana","institution_ids":[]},{"raw_affiliation_string":"Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090690248","display_name":"David D. Nolte","orcid":"https://orcid.org/0000-0002-4872-9357","observed_orcids":["https://orcid.org/0000-0002-4872-9357","https://orcid.org/0000-0002-4098-5540"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Nolte","raw_affiliation_strings":["Animated Dynamics, Inc., West Lafayette, Indiana","Department of Physics, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animated Dynamics, Inc., West Lafayette, Indiana","institution_ids":[]},{"raw_affiliation_string":"Department of Physics, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080717984","https://openalex.org/A5090690248"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.1738,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.76804702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"18821","last_page":"18821"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11897","display_name":"Digital Holography and Microscopy","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11897","display_name":"Digital Holography and Microscopy","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platinum-sensitivity","display_name":"platinum sensitivity","score":0.7310000061988831},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/3d-spheroids","display_name":"multicellular spheroids","score":0.9390000104904175},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8849999904632568},{"id":"https://openalex.org/keywords/chemotherapy-response-prediction","display_name":"chemotherapy response prediction","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5773760080337524},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.510354220867157},{"id":"https://openalex.org/C518104683","wikidata":"https://www.wikidata.org/wiki/Q880","display_name":"Platinum","level":3,"score":0.4271470308303833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3712853193283081},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3386576473712921},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29504841566085815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2874302268028259},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27254176139831543},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2002144753932953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11849075555801392},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010984","descriptor_name":"Platinum","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018608","descriptor_name":"Ultrasonography, Doppler","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/srep18821","doi":"https://doi.org/10.1038/srep18821","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep18821","pdf_url":"https://www.nature.com/articles/srep18821.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4702146","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4702146","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:26732545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26732545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/9750","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1805/9750","pdf_url":null,"source":{"id":"https://openalex.org/S4306402593","display_name":"Purdue University Indianapolis (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/srep18821","doi":"https://doi.org/10.1038/srep18821","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep18821","pdf_url":"https://www.nature.com/articles/srep18821.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1715274415","display_name":"Tissue-dynamics Imaging for Therapeutic Efficacy in Ovarian Cancer","funder_award_id":"R01EB016582","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G8889035425","display_name":"Three-Dimensional Tissue Dynamics Imaging","funder_award_id":"1263753","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2223293131.pdf","grobid_xml":"https://content.openalex.org/works/W2223293131.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W139955134","https://openalex.org/W1919984048","https://openalex.org/W1941056101","https://openalex.org/W1980120572","https://openalex.org/W1981421409","https://openalex.org/W1983762572","https://openalex.org/W1984623046","https://openalex.org/W1985042290","https://openalex.org/W1994435943","https://openalex.org/W1995321000","https://openalex.org/W2011220656","https://openalex.org/W2014330639","https://openalex.org/W2022775539","https://openalex.org/W2033474014","https://openalex.org/W2036952999","https://openalex.org/W2041997066","https://openalex.org/W2043672528","https://openalex.org/W2052440066","https://openalex.org/W2052596320","https://openalex.org/W2053390754","https://openalex.org/W2057767936","https://openalex.org/W2058086052","https://openalex.org/W2059533688","https://openalex.org/W2061229001","https://openalex.org/W2061801043","https://openalex.org/W2061999521","https://openalex.org/W2078024939","https://openalex.org/W2078206416","https://openalex.org/W2086557921","https://openalex.org/W2121907296","https://openalex.org/W2139799760","https://openalex.org/W2346779087","https://openalex.org/W2395754951"],"related_works":["https://openalex.org/W1990852073","https://openalex.org/W2325843661","https://openalex.org/W2582343714","https://openalex.org/W2578771316","https://openalex.org/W2622474524","https://openalex.org/W2566621792","https://openalex.org/W2343731096","https://openalex.org/W2494318518","https://openalex.org/W2139799760","https://openalex.org/W2462114633"],"abstract_inverted_index":{"Three-dimensional":[0],"(3D)":[1],"tissue":[2],"cultures":[3,9],"are":[4],"replacing":[5],"conventional":[6],"two-dimensional":[7],"(2D)":[8],"for":[10,168],"applications":[11],"in":[12,20,26,71,97,107,114,116,148,155,159,162],"cancer":[13,91],"drug":[14,87,156],"development.":[15],"However,":[16],"direct":[17],"comparisons":[18],"of":[19,40,43,62,111,131],"vitro":[21,98,149,163],"3D":[22,72,100,144],"models":[23,28],"relative":[24],"to":[25,66,69,84,137],"vivo":[27,115,160],"derived":[29],"from":[30,52,119,175],"the":[31,41,60,142],"same":[32],"cell":[33,92,124,133],"lines":[34,93],"have":[35,165],"not":[36],"been":[37],"reported":[38],"because":[39],"lack":[42],"sensitive":[44],"optical":[45],"probes":[46],"that":[47],"can":[48],"extract":[49],"high-content":[50],"information":[51],"deep":[53],"inside":[54],"living":[55,73],"tissue.":[56,74],"Here":[57],"we":[58],"report":[59],"use":[61],"biodynamic":[63],"imaging":[64],"(BDI)":[65],"measure":[67],"response":[68,157,171],"platinum":[70,138],"BDI":[75],"combines":[76],"low-coherence":[77],"digital":[78],"holography":[79],"with":[80],"intracellular":[81],"Doppler":[82],"spectroscopy":[83],"study":[85],"tumor":[86,173],"response.":[88,152],"Human":[89],"ovarian":[90,123],"were":[94],"grown":[95,113,147],"either":[96],"as":[99,105],"multicellular":[101,145],"monoculture":[102],"spheroids":[103,146],"or":[104,177],"xenografts":[106,112],"nude":[108,117],"mice.":[109],"Fragments":[110],"mice":[118],"a":[120],"platinum-sensitive":[121],"human":[122],"line":[125],"showed":[126,150],"rapid":[127],"and":[128,161],"dramatic":[129],"signatures":[130],"induced":[132],"death":[134],"when":[135],"exposed":[136],"ex":[139],"vivo,":[140],"while":[141],"corresponding":[143],"negligible":[151],"The":[153],"differences":[154],"between":[158],"growth":[164],"important":[166],"implications":[167],"predicting":[169],"chemotherapeutic":[170],"using":[172],"biopsies":[174],"patients":[176],"patient-derived":[178],"xenografts.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
