{"id":"https://openalex.org/W2222917036","doi":null,"title":"IL-6 precludes the differentiation induced by IL-3 on expansion of CD34+ cells from cord blood.","display_name":"IL-6 precludes the differentiation induced by IL-3 on expansion of CD34+ cells from cord blood.","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W2222917036","mag":"2222917036","pmid":"https://pubmed.ncbi.nlm.nih.gov/12681965"},"language":"en","primary_location":{"id":"pmid:12681965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12681965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002872499","display_name":"Araceli Encabo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Araceli Encabo","raw_affiliation_strings":["Instituto de Biolog\u00eda Celular, Organismo P\u00fablico Valenciano de Investigaci\u00f3n, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biolog\u00eda Celular, Organismo P\u00fablico Valenciano de Investigaci\u00f3n, Valencia, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039768920","display_name":"Emilia Mateu","orcid":"https://orcid.org/0000-0003-0838-9981","observed_orcids":["https://orcid.org/0000-0003-0838-9981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emilia Mateu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067723571","display_name":"Francisco Carbonell\u2010Uberos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisco Carbonell-Uberos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108452207","display_name":"Mar\u00eda Dolores Mi\u00f1ana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Dolores Mi\u00f1ana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8531,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.71774906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"88","issue":"4","first_page":"388","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.925000011920929},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ex-vivo-expansion","display_name":"ex vivo expansion","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/cd133-cells","display_name":"CD133+ cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/long-term-culture-initiating-cells","display_name":"long-term culture-initiating cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":0.949999988079071},{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.8050000071525574},{"id":"https://openalex.org/keywords/thrombopoietin","display_name":"thrombopoietin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/flt3-ligand","display_name":"Flt3 ligand","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cytokine-combinations","display_name":"cytokine combinations","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7017010450363159},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6525301337242126},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.6221031546592712},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5942702889442444},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5504955053329468},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.5344485640525818},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5177432894706726},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4758555591106415},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.4711167812347412},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.4686915874481201},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.4649452269077301},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4597482979297638},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44083502888679504},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.416519433259964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4062296748161316},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40136101841926575},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.341325581073761},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18038582801818848},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12152335047721863},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004336","descriptor_name":"Drug Antagonism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12681965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12681965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d2846ab932f5445584202839f5871216","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d2846ab932f5445584202839f5871216","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 88, Iss 4 (2003)","raw_type":"article"},{"id":"mag:2222917036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12681965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W116758555","https://openalex.org/W157721590","https://openalex.org/W176973267","https://openalex.org/W1524481042","https://openalex.org/W1538762819","https://openalex.org/W1760571723","https://openalex.org/W1863063793","https://openalex.org/W1966973806","https://openalex.org/W1973577066","https://openalex.org/W1977253353","https://openalex.org/W1981441452","https://openalex.org/W1989016250","https://openalex.org/W2022632494","https://openalex.org/W2032235066","https://openalex.org/W2042598375","https://openalex.org/W2043222621","https://openalex.org/W2049462421","https://openalex.org/W2050349923","https://openalex.org/W2054031422","https://openalex.org/W2068409711","https://openalex.org/W2073101215","https://openalex.org/W2084256703","https://openalex.org/W2106883237","https://openalex.org/W2116386021","https://openalex.org/W2134699909","https://openalex.org/W2146416811","https://openalex.org/W2153982932","https://openalex.org/W2211134173","https://openalex.org/W2264208057","https://openalex.org/W2267126247","https://openalex.org/W2281552814","https://openalex.org/W2403174101","https://openalex.org/W2410844431"],"related_works":["https://openalex.org/W2065595938","https://openalex.org/W2083365998","https://openalex.org/W2371603034","https://openalex.org/W2591356115","https://openalex.org/W3144906405","https://openalex.org/W2153982932","https://openalex.org/W1980928686","https://openalex.org/W2175214965","https://openalex.org/W2087423998","https://openalex.org/W2151202221"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,70,216],"OBJECTIVES:":[2],"Ex":[3],"vivo":[4],"expansion":[5,61,143,237,250],"of":[6,25,39,48,55,62,113,131,138,144,171,179,189,199,213,224],"hematopoietic":[7],"progenitor":[8],"cells":[9,27,51,64,73,147],"(HPC)":[10],"from":[11,65,238],"umbilical":[12],"cord":[13],"blood":[14],"(UCB)":[15],"is":[16],"an":[17],"interesting":[18],"strategy":[19],"to":[20,135],"obtain":[21],"a":[22,108,155,227,232],"sufficient":[23],"number":[24,112,160],"transplantable":[26],"for":[28],"adults.":[29],"To":[30],"define":[31],"the":[32,37,53,60,111,136,142,177,190,197,211,222,242],"optimal":[33],"culture":[34,78,230],"conditions":[35],"allowing":[36],"generation":[38],"HPC":[40,236],"that":[41,162,221],"retain":[42],"their":[43],"proliferative":[44],"capacity":[45],"without":[46],"loss":[47],"long-term":[49],"culture-initiating":[50],"(LTC-IC),":[52],"effect":[54,207,234],"different":[56],"cytokine":[57,82,151],"combinations":[58,152],"on":[59,235,248],"CD34+":[63,72,114],"UCB":[66],"was":[67,174,194,203,208],"assessed.":[68],"DESIGN":[69],"METHODS:":[71],"were":[74,126],"cultured":[75],"in":[76,158,226],"serum-free":[77,228],"medium":[79],"with":[80,176],"four":[81],"combinations:":[83],"stem":[84],"cell":[85],"factor":[86],"plus":[87,89,94,98,103,105,166,181,184,186,201],"thrombopoietin":[88],"flk2/flt3":[90],"ligand":[91],"(STF),":[92],"STF":[93,97,102,139,165,180,200],"interleukin-3":[95],"(IL-3),":[96],"interleukin-6":[99],"(IL-6)":[100],"and":[101,115,123,148,205,240,251],"IL-6":[104,132,225],"IL-3.":[106,167],"After":[107],"1-week":[109],"culture,":[110],"CD133+":[116,146],"cells,":[117],"colony":[118],"forming":[119],"units":[120],"(CFU),":[121],"LTC-IC":[122,159,249],"telomerase":[124,172,252],"activity":[125,173,191],"determined.":[127],"RESULTS:":[128],"The":[129,168],"addition":[130,212],"or":[133,183],"IL-3":[134,182,185,202,247],"combination":[137,178,198],"significantly":[140],"enhanced":[141],"CD34+,":[145],"CFU.":[149],"All":[150],"tested":[153],"induced":[154,245],"slight":[156],"increase":[157],"except":[161],"composed":[163],"by":[164,210,246],"greatest":[169],"induction":[170],"observed":[175,195],"IL-6.":[187,214],"Decay":[188],"along":[192],"time":[193],"when":[196],"used,":[204],"this":[206],"reverted":[209],"INTERPRETATION":[215],"CONCLUSIONS:":[217],"Our":[218],"results":[219],"demonstrate":[220],"inclusion":[223],"short-term":[229],"has":[231],"beneficial":[233],"UCB,":[239],"precludes":[241],"negative":[243],"effects":[244],"activity.":[253]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
