{"id":"https://openalex.org/W2222906322","doi":null,"title":"[Manifestations of rifampicin-induced hypersensitivity].","display_name":"[Manifestations of rifampicin-induced hypersensitivity].","publication_year":2003,"publication_date":"2003-07-26","ids":{"openalex":"https://openalex.org/W2222906322","mag":"2222906322","pmid":"https://pubmed.ncbi.nlm.nih.gov/13677879"},"language":"fr","primary_location":{"id":"pmid:13677879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13677879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Presse medicale (Paris, France : 1983)","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112709262","display_name":"Soraya Fenniche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167348","display_name":"Abderrahmane Mami Hospital","ror":"https://ror.org/04w40b524","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167348"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Soraya Fenniche","raw_affiliation_strings":["Service Ibn Nafiss, H\u00f4pital Abderrahmen Mami, Ariana 2080, Tunisie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service Ibn Nafiss, H\u00f4pital Abderrahmen Mami, Ariana 2080, Tunisie","institution_ids":["https://openalex.org/I4210167348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108448652","display_name":"Sonia Ma\u00e2lej","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonia Maalej","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113610559","display_name":"L. Fekih","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leila Fekih","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109212097","display_name":"Hela Hass\u00e8ne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hela Hassene","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111466083","display_name":"Dalenda Belhabib","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dalenda Belhabib","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028379330","display_name":"Mohamed Lamine Megdiche","orcid":"https://orcid.org/0000-0003-4037-9441","observed_orcids":["https://orcid.org/0000-0003-4037-9441"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed Lamine Megdiche","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5788,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.69692551,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"32","issue":"25","first_page":"1167","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/anaphylaxis","display_name":"anaphylaxis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":0.7080000042915344},{"id":"https://openalex.org/keywords/type-ii-hypersensitivity","display_name":"type II hypersensitivity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.640999972820282},{"id":"https://openalex.org/keywords/desensitization","display_name":"desensitization","score":0.7559999823570251},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.8610000014305115},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9632096886634827},{"id":"https://openalex.org/C2993280485","wikidata":"https://www.wikidata.org/wiki/Q5958765","display_name":"Hypersensitivity reaction","level":2,"score":0.821215033531189},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.7817017436027527},{"id":"https://openalex.org/C3017924640","wikidata":"https://www.wikidata.org/wiki/Q7860879","display_name":"Delayed hypersensitivity","level":3,"score":0.6366439461708069},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5354957580566406},{"id":"https://openalex.org/C110586980","wikidata":"https://www.wikidata.org/wiki/Q4168588","display_name":"Provocation test","level":3,"score":0.41772815585136414},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37982285022735596},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3653852641582489},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.35013943910598755},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33889007568359375},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2385663390159607},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08573189377784729},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000707","descriptor_name":"Anaphylaxis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000707","descriptor_name":"Anaphylaxis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000904","descriptor_name":"Antibiotics, Antitubercular","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000904","descriptor_name":"Antibiotics, Antitubercular","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003888","descriptor_name":"Desensitization, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017093","descriptor_name":"Liver Failure","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:13677879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13677879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Presse medicale (Paris, France : 1983)","raw_type":"Case Reports"},{"id":"mag:2222906322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13677879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2208226360","https://openalex.org/W1913791334","https://openalex.org/W2046454398","https://openalex.org/W2003093831","https://openalex.org/W2047874813","https://openalex.org/W4401346053","https://openalex.org/W2416514943","https://openalex.org/W3195338883","https://openalex.org/W1998568941","https://openalex.org/W3118409672"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,46],"side":[2],"effects":[3],"of":[4,21,57,66,72,91,95,102,106,111,125,133,149,168,176,181],"rifampicine":[5],"due":[6],"to":[7,139],"an":[8],"immunoallergic":[9],"mechanism":[10],"are":[11],"rare":[12],"and":[13,32,74,129,135,161,179],"usually":[14],"observed":[15,153],"during":[16,183],"discontinued":[17],"treatment":[18,128,170],"or":[19],"administration":[20,71],"high":[22],"doses.":[23],"OBSERVATIONS:":[24],"An":[25,113],"immediate":[26,184],"hypersensitivity":[27,79,116,151],"reaction":[28,47,80,117],"with":[29,104,154],"anaphylactic":[30],"manifestations":[31],"increase":[33],"in":[34,37,60,82,88,158],"IgE":[35],"occurred":[36,48,81],"a":[38,54,61,83,96,173],"39":[39],"year-old":[40,85],"man":[41],"suffering":[42],"from":[43],"resistant":[44],"tuberculosis.":[45],"within":[49],"the":[50,64,89,147,150,156,166,189],"first":[51],"hour":[52],"following":[53],"low":[55],"dose":[56],"rifampicin":[58,134],"administered":[59],"desensitisation":[62,182],"attempt,":[63],"outcome":[65],"which":[67,137,171,187],"was":[68,118],"favourable":[69],"after":[70],"corticosteroids":[73],"antihistamines.":[75],"A":[76],"type":[77],"II":[78],"76":[84],"male":[86],"patient":[87],"form":[90],"thrombopenia":[92],"on":[93,109,123],"D76":[94],"twice":[97,126],"weekly":[98,127],"treatment,":[99],"diagnosed":[100],"because":[101],"hemoptysis":[103],"normalisation":[105],"platelet":[107],"level":[108],"withdrawal":[110,132],"rifampicin.":[112],"immune":[114],"complex":[115],"responsible":[119],"for":[120,163],"hepato-renal":[121],"failure":[122],"D68":[124],"required":[130],"permanent":[131],"dialysis,":[136],"led":[138],"subsequent":[140],"improvement.":[141],"COMMENTS:":[142],"These":[143],"clinical":[144],"cases":[145],"illustrate":[146],"variability":[148],"mechanisms":[152],"rifampicin,":[155],"difficulty":[157],"imputability":[159],"tests":[160],"methods":[162],"immunological":[164],"confirmation,":[165],"interest":[167],"continuous":[169],"avoids":[172],"certain":[174],"number":[175],"these":[177],"accidents,":[178],"that":[180],"hypersensitive":[185],"reactions":[186],"permits":[188],"continuation":[190],"this":[191],"major":[192],"anti-tuberculosis":[193],"drug.":[194]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}