{"id":"https://openalex.org/W2222574765","doi":"https://doi.org/10.1042/bj1880137","title":"The effect of fluoride on the state of aggregation of adenylate cyclase in rat liver plasma membranes","display_name":"The effect of fluoride on the state of aggregation of adenylate cyclase in rat liver plasma membranes","publication_year":1980,"publication_date":"1980-04-15","ids":{"openalex":"https://openalex.org/W2222574765","doi":"https://doi.org/10.1042/bj1880137","mag":"2222574765","pmid":"https://pubmed.ncbi.nlm.nih.gov/7406875","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1162547"},"language":"en","primary_location":{"id":"doi:10.1042/bj1880137","doi":"https://doi.org/10.1042/bj1880137","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1880137","pdf_url":"https://portlandpress.com/biochemj/article-pdf/188/1/137/574506/bj1880137.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/188/1/137/574506/bj1880137.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"B R Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B R Martin","raw_affiliation_strings":["Department ofBiochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQW, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofBiochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQW, U.K","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J M Stein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J M Stein","raw_affiliation_strings":["Department ofBiochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQW, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofBiochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQW, U.K","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001732955","display_name":"E L Kennedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E L Kennedy","raw_affiliation_strings":["Department ofBiochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQW, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofBiochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQW, U.K","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028914156","display_name":"Christine A. Doberska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C A Doberska","raw_affiliation_strings":["Department ofBiochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQW, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofBiochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQW, U.K","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":null,"apc_paid":null,"fwci":1.6486,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.83489561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"188","issue":"1","first_page":"137","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.2029999941587448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/fluoride","display_name":"fluoride","score":0.9929999709129333},{"id":"https://openalex.org/keywords/state-of-aggregation","display_name":"aggregation state","score":0.7139999866485596},{"id":"https://openalex.org/keywords/liver-plasma-membrane","display_name":"liver plasma membrane","score":0.8270000219345093},{"id":"https://openalex.org/keywords/enzyme-activation","display_name":"enzyme activation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/enzyme-inactivation","display_name":"enzyme inactivation","score":0.699999988079071},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.6710000038146973},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.35499998927116394},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.935333251953125},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.9338751435279846},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.7871885895729065},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.7519938945770264},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.725421130657196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5907785296440125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4025804102420807},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.373360276222229},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3283352851867676},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2512199878692627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24591371417045593},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.12959933280944824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05633264780044556}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005459","descriptor_name":"Fluorides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006165","descriptor_name":"Guanylyl Imidodiphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012969","descriptor_name":"Sodium Fluoride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj1880137","doi":"https://doi.org/10.1042/bj1880137","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1880137","pdf_url":"https://portlandpress.com/biochemj/article-pdf/188/1/137/574506/bj1880137.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1162547","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1162547","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:7406875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7406875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj1880137","doi":"https://doi.org/10.1042/bj1880137","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1880137","pdf_url":"https://portlandpress.com/biochemj/article-pdf/188/1/137/574506/bj1880137.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2222574765.pdf","grobid_xml":"https://content.openalex.org/works/W2222574765.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1546236203","https://openalex.org/W1551160005","https://openalex.org/W1995687061","https://openalex.org/W2050807790","https://openalex.org/W2081363427","https://openalex.org/W2169503005","https://openalex.org/W2237107303","https://openalex.org/W2399814777","https://openalex.org/W2418662542"],"related_works":["https://openalex.org/W1553946369","https://openalex.org/W1534116154","https://openalex.org/W2055300146","https://openalex.org/W1990145032","https://openalex.org/W1978474807","https://openalex.org/W1538010644","https://openalex.org/W1981619173","https://openalex.org/W1530432631","https://openalex.org/W2046687446","https://openalex.org/W1966096605"],"abstract_inverted_index":{"Irradiation":[0],"inactivation":[1],"was":[2,49,66],"used":[3],"to":[4,32,41,70,105],"monitor":[5],"changes":[6],"in":[7,13,18,26],"the":[8,19,27,101,106],"state":[9],"of":[10,21,64,73,94,100,108,110],"adenylate":[11,81,111],"cyclase":[12,48,82,112],"rat":[14],"liver":[15],"plasma":[16],"membranes":[17],"presence":[20],"F-.F-":[22],"caused":[23],"a":[24,71],"decrease":[25],"target":[28],"size":[29],"from":[30,39],"328000":[31],"237000":[33],"at":[34,43,53,77],"0":[35,55],"degrees":[36,45,56,60],"C":[37,57],"and":[38,58,75,88],"329000":[40],"219000":[42],"30":[44,59],"C.":[46,61],"Adenylate":[47],"activated":[50,85],"by":[51],"F-":[52,65,95],"both":[54],"The":[62,98],"effect":[63],"biphasic,":[67],"activating":[68],"up":[69],"concentration":[72],"10mM":[74],"inhibiting":[76],"higher":[78],"concentrations.":[79],"If":[80],"weas":[83],"maximally":[84],"with":[86,103],"glucagon":[87],"p[NH]ppG":[89],"([beta":[90],"gamma-imido]GTP)":[91],"all":[92],"concentrations":[93],"were":[96],"inhibitory.":[97],"implications":[99],"results":[102],"respect":[104],"mechanism":[107],"activation":[109],"are":[113],"discussed.":[114]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}