{"id":"https://openalex.org/W2222397998","doi":null,"title":"TP53 as clinical marker in head and neck cancer","display_name":"TP53 as clinical marker in head and neck cancer","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2222397998","mag":"2222397998"},"language":"en","primary_location":{"id":"mag:2222397998","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9789514295409.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034447979","display_name":"Jenni K Peltonen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jenni Peltonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034447979"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.46630001068115234,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9089999794960022},{"id":"https://openalex.org/keywords/p53-immunohistochemistry","display_name":"p53 immunohistochemistry","score":0.7749999761581421},{"id":"https://openalex.org/keywords/dna-binding-domain-mutations","display_name":"DNA-binding domain mutations","score":0.6140000224113464},{"id":"https://openalex.org/keywords/chemical-exposure","display_name":"chemical exposure","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.972000002861023},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.9959999918937683},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-cycle-regulators","display_name":"cell cycle regulators","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.6285461187362671},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6258381605148315},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.613286554813385},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.575488269329071},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.5562870502471924},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5528789758682251},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5450336337089539},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4862993657588959},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.467445969581604},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.433843731880188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4236317276954651},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4144282639026642},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3965224623680115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3759704828262329},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3623315095901489},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3547822833061218},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3375595808029175},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1527896225452423}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2222397998","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9789514295409.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":298,"referenced_works":["https://openalex.org/W34204517","https://openalex.org/W55429855","https://openalex.org/W75121132","https://openalex.org/W91182734","https://openalex.org/W100665217","https://openalex.org/W137901413","https://openalex.org/W149442862","https://openalex.org/W154309594","https://openalex.org/W157610785","https://openalex.org/W165254100","https://openalex.org/W1480254704","https://openalex.org/W1481017128","https://openalex.org/W1489123075","https://openalex.org/W1490442897","https://openalex.org/W1532331378","https://openalex.org/W1536690700","https://openalex.org/W1552426876","https://openalex.org/W1577116496","https://openalex.org/W1597704210","https://openalex.org/W1640635403","https://openalex.org/W1650797637","https://openalex.org/W1676663233","https://openalex.org/W1821135556","https://openalex.org/W1822420866","https://openalex.org/W1832802542","https://openalex.org/W1847864430","https://openalex.org/W1858597869","https://openalex.org/W1903247072","https://openalex.org/W1912423223","https://openalex.org/W1912673154","https://openalex.org/W1927949485","https://openalex.org/W1939472319","https://openalex.org/W1944807566","https://openalex.org/W1963632509","https://openalex.org/W1965702286","https://openalex.org/W1967727795","https://openalex.org/W1969543424","https://openalex.org/W1969939692","https://openalex.org/W1970159404","https://openalex.org/W1970221755","https://openalex.org/W1970672489","https://openalex.org/W1971019079","https://openalex.org/W1971251199","https://openalex.org/W1971359652","https://openalex.org/W1972689092","https://openalex.org/W1973813521","https://openalex.org/W1974177072","https://openalex.org/W1978553767","https://openalex.org/W1978937208","https://openalex.org/W1978955748","https://openalex.org/W1979771543","https://openalex.org/W1981671213","https://openalex.org/W1981989535","https://openalex.org/W1982655297","https://openalex.org/W1982754254","https://openalex.org/W1984085407","https://openalex.org/W1984246346","https://openalex.org/W1985095741","https://openalex.org/W1986076152","https://openalex.org/W1986685145","https://openalex.org/W1987796823","https://openalex.org/W1988007024","https://openalex.org/W1988567392","https://openalex.org/W1990508187","https://openalex.org/W1990956554","https://openalex.org/W1991827918","https://openalex.org/W1992133876","https://openalex.org/W1992295309","https://openalex.org/W1994213997","https://openalex.org/W1994898506","https://openalex.org/W1995530354","https://openalex.org/W1996002383","https://openalex.org/W1996027687","https://openalex.org/W1996254918","https://openalex.org/W1996933787","https://openalex.org/W1996967502","https://openalex.org/W1997022552","https://openalex.org/W1997152230","https://openalex.org/W1998901306","https://openalex.org/W2001326160","https://openalex.org/W2003141153","https://openalex.org/W2009458932","https://openalex.org/W2010703150","https://openalex.org/W2010916313","https://openalex.org/W2011510137","https://openalex.org/W2011912935","https://openalex.org/W2012201975","https://openalex.org/W2012248028","https://openalex.org/W2013392872","https://openalex.org/W2016455125","https://openalex.org/W2017947380","https://openalex.org/W2018150478","https://openalex.org/W2018436722","https://openalex.org/W2018614123","https://openalex.org/W2018764247","https://openalex.org/W2018994731","https://openalex.org/W2019704875","https://openalex.org/W2019878915","https://openalex.org/W2021837778","https://openalex.org/W2022383939","https://openalex.org/W2024064461","https://openalex.org/W2029086873","https://openalex.org/W2030476652","https://openalex.org/W2030945613","https://openalex.org/W2033410478","https://openalex.org/W2034878997","https://openalex.org/W2035468785","https://openalex.org/W2036049002","https://openalex.org/W2036421802","https://openalex.org/W2036433420","https://openalex.org/W2036743876","https://openalex.org/W2037068261","https://openalex.org/W2037268137","https://openalex.org/W2038173255","https://openalex.org/W2038704159","https://openalex.org/W2039070762","https://openalex.org/W2040375321","https://openalex.org/W2040502198","https://openalex.org/W2040616051","https://openalex.org/W2042316019","https://openalex.org/W2042484101","https://openalex.org/W2043296783","https://openalex.org/W2043448575","https://openalex.org/W2043808543","https://openalex.org/W2045309744","https://openalex.org/W2047596219","https://openalex.org/W2048295632","https://openalex.org/W2048937325","https://openalex.org/W2049137769","https://openalex.org/W2051230859","https://openalex.org/W2054109203","https://openalex.org/W2054833997","https://openalex.org/W2055502767","https://openalex.org/W2055993544","https://openalex.org/W2057551676","https://openalex.org/W2057993810","https://openalex.org/W2059918893","https://openalex.org/W2060633778","https://openalex.org/W2060786724","https://openalex.org/W2060872374","https://openalex.org/W2061319335","https://openalex.org/W2062942211","https://openalex.org/W2064810566","https://openalex.org/W2065655591","https://openalex.org/W2066115699","https://openalex.org/W2066383350","https://openalex.org/W2066503677","https://openalex.org/W2067758224","https://openalex.org/W2068054589","https://openalex.org/W2069653944","https://openalex.org/W2069896987","https://openalex.org/W2070045233","https://openalex.org/W2071864203","https://openalex.org/W2072052957","https://openalex.org/W2073482997","https://openalex.org/W2073576377","https://openalex.org/W2075981888","https://openalex.org/W2076068365","https://openalex.org/W2076668993","https://openalex.org/W2077218089","https://openalex.org/W2077482287","https://openalex.org/W2077524581","https://openalex.org/W2077902938","https://openalex.org/W2078109925","https://openalex.org/W2079148941","https://openalex.org/W2079713049","https://openalex.org/W2079852484","https://openalex.org/W2080089035","https://openalex.org/W2080772875","https://openalex.org/W2081184407","https://openalex.org/W2082494479","https://openalex.org/W2082791552","https://openalex.org/W2082980147","https://openalex.org/W2083625623","https://openalex.org/W2085323962","https://openalex.org/W2086708203","https://openalex.org/W2087520788","https://openalex.org/W2088210941","https://openalex.org/W2089533505","https://openalex.org/W2089663915","https://openalex.org/W2090291378","https://openalex.org/W2091470085","https://openalex.org/W2091999349","https://openalex.org/W2094473718","https://openalex.org/W2094897850","https://openalex.org/W2094957670","https://openalex.org/W2095909899","https://openalex.org/W2096276671","https://openalex.org/W2096982298","https://openalex.org/W2097907226","https://openalex.org/W2098426770","https://openalex.org/W2098911357","https://openalex.org/W2099042649","https://openalex.org/W2099459640","https://openalex.org/W2102282815","https://openalex.org/W2102942479","https://openalex.org/W2103799963","https://openalex.org/W2106787323","https://openalex.org/W2108111588","https://openalex.org/W2108828689","https://openalex.org/W2108836663","https://openalex.org/W2110621142","https://openalex.org/W2111630094","https://openalex.org/W2111726305","https://openalex.org/W2112845420","https://openalex.org/W2113363756","https://openalex.org/W2113511308","https://openalex.org/W2114049909","https://openalex.org/W2115371904","https://openalex.org/W2115477652","https://openalex.org/W2116869271","https://openalex.org/W2117248525","https://openalex.org/W2117692326","https://openalex.org/W2118530896","https://openalex.org/W2121619780","https://openalex.org/W2122201262","https://openalex.org/W2123754647","https://openalex.org/W2126207039","https://openalex.org/W2126505611","https://openalex.org/W2126679757","https://openalex.org/W2126994971","https://openalex.org/W2127464082","https://openalex.org/W2128739161","https://openalex.org/W2129141492","https://openalex.org/W2131954674","https://openalex.org/W2131971625","https://openalex.org/W2132057054","https://openalex.org/W2132308636","https://openalex.org/W2133462508","https://openalex.org/W2133500897","https://openalex.org/W2135731259","https://openalex.org/W2135737620","https://openalex.org/W2135911067","https://openalex.org/W2136409533","https://openalex.org/W2137353992","https://openalex.org/W2137569018","https://openalex.org/W2137658888","https://openalex.org/W2138217871","https://openalex.org/W2138936448","https://openalex.org/W2139230093","https://openalex.org/W2142193428","https://openalex.org/W2142723443","https://openalex.org/W2143002115","https://openalex.org/W2146428402","https://openalex.org/W2147208423","https://openalex.org/W2149166037","https://openalex.org/W2149459560","https://openalex.org/W2150097377","https://openalex.org/W2153172903","https://openalex.org/W2153220158","https://openalex.org/W2153354381","https://openalex.org/W2155384808","https://openalex.org/W2156004684","https://openalex.org/W2157290796","https://openalex.org/W2158861003","https://openalex.org/W2162262059","https://openalex.org/W2162910153","https://openalex.org/W2163186602","https://openalex.org/W2163802618","https://openalex.org/W2164202739","https://openalex.org/W2165439041","https://openalex.org/W2168444859","https://openalex.org/W2169326511","https://openalex.org/W2169990287","https://openalex.org/W2170178908","https://openalex.org/W2170229434","https://openalex.org/W2171138371","https://openalex.org/W2171377582","https://openalex.org/W2171474788","https://openalex.org/W2172142216","https://openalex.org/W2187648857","https://openalex.org/W2224685743","https://openalex.org/W2232136071","https://openalex.org/W2234319471","https://openalex.org/W2238407465","https://openalex.org/W2239208807","https://openalex.org/W2240337774","https://openalex.org/W2242796412","https://openalex.org/W2244778660","https://openalex.org/W2244996712","https://openalex.org/W2249278246","https://openalex.org/W2262449009","https://openalex.org/W2287460756","https://openalex.org/W2312641146","https://openalex.org/W2312732552","https://openalex.org/W2316316905","https://openalex.org/W2325712080","https://openalex.org/W2398447713","https://openalex.org/W2399038158","https://openalex.org/W2399107201","https://openalex.org/W2416021499","https://openalex.org/W2426427014","https://openalex.org/W2432533682","https://openalex.org/W3110690930","https://openalex.org/W4233680027","https://openalex.org/W4242297019","https://openalex.org/W7095779489","https://openalex.org/W7099201015"],"related_works":["https://openalex.org/W2161550070","https://openalex.org/W7015637662","https://openalex.org/W2347431815","https://openalex.org/W1967057162","https://openalex.org/W4385331575","https://openalex.org/W2043604338","https://openalex.org/W3120972950","https://openalex.org/W4206701359","https://openalex.org/W2569761894","https://openalex.org/W2092585633"],"abstract_inverted_index":{"The":[0,30,104,187,197,263],"prognosis":[1,56,107,233,310,335],"of":[2,25,38,42,45,108,142,153,159,178,191,199,209,223,245,256,259,265,283,300,324],"patients":[3,179,271,293],"with":[4,101,180,226,294,306,333],"head":[5,62,181,337],"and":[6,57,63,93,117,126,140,182,189,203,220,229,234,309,311,327,338],"neck":[7,64,183,339],"squamous":[8,184],"cell":[9,185,246],"carcinoma":[10],"has":[11,66,113],"improved":[12],"only":[13],"little":[14],"during":[15],"the":[16,22,26,36,39,43,46,74,89,95,109,118,138,143,151,154,157,160,176,200,204,207,210,243,270,279,284,312],"last":[17],"decades.":[18],"Clinical":[19],"markers":[20,255],"for":[21,55,83,106,134],"biological":[23,257,307],"aggressiveness":[24,258,308],"cancer":[27,65],"are":[28],"few.":[29],"most":[31],"reliable":[32],"prognostic":[33],"indicator":[34],"is":[35,72,91],"stage":[37],"disease.":[40],"Research":[41],"significance":[44,152,231,244],"TP53":[47,84,102,135,166,201,217,224,276],"tumor":[48,275],"suppressor":[49],"gene":[50,285],"as":[51,80,253],"a":[52,81,131,171,322],"predictive":[53],"marker":[54,105],"response":[58,110,235,313],"to":[59,76,111,114,122,130,146,149,236,289,314],"treatment":[60,112,238],"in":[61,87,175,273,278,336],"given":[67],"discrepant":[68],"results.":[69],"One":[70],"reason":[71],"probably":[73],"attempt":[75],"use":[77],"p53":[78,161,211],"immunohistochemistry":[79,88,331],"surrogate":[82],"mutations.":[85,103,301],"However,":[86],"protein":[90,212],"analyzed":[92,148,194,329],"thus":[94],"result":[96],"does":[97],"not":[98],"usually":[99],"correlate":[100],"be":[115,123,147],"reliable,":[116],"analytical":[119],"method":[120,133],"needs":[121],"both":[124],"sensitive":[125,132,172],"specific.":[127],"In":[128,163,241],"addition":[129],"mutation":[136,155,218,296],"analysis":[137],"localization":[139,190],"quality":[141,188],"mutations":[144,167,192,202,225,277,303],"have":[145],"reveal":[150],"on":[156,206,232],"function":[158,208],"protein.":[162],"this":[164,266],"study,":[165],"were":[168,193,213],"analyzed,":[169],"using":[170,215],"PCR-SSCP":[173],"method,":[174],"tumors":[177,260],"carcinoma.":[186],"by":[195,330],"sequencing.":[196],"frequency":[198],"effect":[205],"studied":[214],"IARC":[216],"database":[219],"literature.":[221],"Correlation":[222],"chemical":[227],"exposure":[228],"their":[230,274],"radiation":[237,315],"was":[239,261,318],"studied.":[240,262],"addition,":[242],"cycle":[247],"regulators":[248],"cyclin":[249,325],"D1,":[250],"p16,":[251],"p21":[252],"potential":[254],"results":[264],"study":[267],"showed":[268],"that":[269,321],"carrying":[272],"DNA":[280],"binding":[281],"region":[282],"had":[286],"been":[287],"exposed":[288],"chemicals":[290],"more":[291],"than":[292],"no":[295],"or":[297],"other":[298],"types":[299],"These":[302],"also":[304,319],"correlated":[305,332],"treatment.":[316],"It":[317],"shown":[320],"combination":[323],"D1":[326],"p16":[328],"worse":[334],"cancer.":[340]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
