{"id":"https://openalex.org/W2222001997","doi":"https://doi.org/10.1021/jacs.5b10043","title":"A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms","display_name":"A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms","publication_year":2015,"publication_date":"2015-11-17","ids":{"openalex":"https://openalex.org/W2222001997","doi":"https://doi.org/10.1021/jacs.5b10043","mag":"2222001997","pmid":"https://pubmed.ncbi.nlm.nih.gov/26575890","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4758209"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.5b10043","doi":"https://doi.org/10.1021/jacs.5b10043","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.5b10043","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4758209","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062477581","display_name":"Jeffrey S. Derrick","orcid":"https://orcid.org/0000-0002-3879-2897","observed_orcids":["https://orcid.org/0000-0002-3879-2897"]},"institutions":[{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeffrey S. Derrick","raw_affiliation_strings":["Department\rof Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea","institution_ids":["https://openalex.org/I48566637"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard A. Kerr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Kerr","raw_affiliation_strings":["Department\rof Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Younwoo Nam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Younwoo Nam","raw_affiliation_strings":["Department\rof Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea","institution_ids":["https://openalex.org/I48566637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100859889","display_name":"Shin Bi Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Shin Bi Oh","raw_affiliation_strings":["Asan\rInstitute for Life Sciences, Asan Medical Center, Seoul 05505, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan\rInstitute for Life Sciences, Asan Medical Center, Seoul 05505, Korea","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027470004","display_name":"Hyuck Jin Lee","orcid":"https://orcid.org/0000-0001-8769-2967","observed_orcids":["https://orcid.org/0000-0001-8769-2967"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Hyuck Jin Lee","raw_affiliation_strings":["Department\rof Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea","Department\rof Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea","institution_ids":["https://openalex.org/I48566637"]},{"raw_affiliation_string":"Department\rof Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022589784","display_name":"Kaylin G. Earnest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaylin G. Earnest","raw_affiliation_strings":["Department\rof Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015538862","display_name":"Nayoung Suh","orcid":"https://orcid.org/0000-0002-2755-9520","observed_orcids":["https://orcid.org/0000-0002-2755-9520"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nayoung Suh","raw_affiliation_strings":["Asan\rInstitute for Life Sciences, Asan Medical Center, Seoul 05505, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan\rInstitute for Life Sciences, Asan Medical Center, Seoul 05505, Korea","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027750348","display_name":"Kristy L. Peck","orcid":"https://orcid.org/0000-0001-9103-430X","observed_orcids":["https://orcid.org/0000-0001-9103-430X"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristy L. Peck","raw_affiliation_strings":["Department\rof Chemistry, University of Nevada, Reno 89557, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Nevada, Reno 89557, United States","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075999884","display_name":"Mehmet \u00d6zbil","orcid":"https://orcid.org/0000-0002-1465-7674","observed_orcids":["https://orcid.org/0000-0002-1465-7674"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet Ozbil","raw_affiliation_strings":["Department\rof Chemistry, University of Miami, Coral Gables, Florida 33146, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Miami, Coral Gables, Florida 33146, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032576632","display_name":"Kyle J. Korshavn","orcid":"https://orcid.org/0000-0003-2623-1838","observed_orcids":["https://orcid.org/0000-0003-2623-1838"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle J. Korshavn","raw_affiliation_strings":["Department\rof Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006414766","display_name":"Ayyalusamy Ramamoorthy","orcid":"https://orcid.org/0000-0003-1964-1900","observed_orcids":["https://orcid.org/0000-0003-1964-1900"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayyalusamy Ramamoorthy","raw_affiliation_strings":["Biophysics, University of Michigan, Ann Arbor, Michigan 48109, United States","Department\rof Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics, University of Michigan, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department\rof Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031493178","display_name":"Rajeev S. Prabhakar","orcid":"https://orcid.org/0000-0003-1137-1272","observed_orcids":["https://orcid.org/0000-0003-1137-1272"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajeev Prabhakar","raw_affiliation_strings":["Department\rof Chemistry, University of Miami, Coral Gables, Florida 33146, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Miami, Coral Gables, Florida 33146, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076088772","display_name":"Edward J. Merino","orcid":"https://orcid.org/0000-0003-4968-9868","observed_orcids":["https://orcid.org/0000-0003-4968-9868"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J. Merino","raw_affiliation_strings":["Department\rof Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052912332","display_name":"Jason Shearer","orcid":"https://orcid.org/0000-0001-7469-7304","observed_orcids":["https://orcid.org/0000-0001-7469-7304"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason Shearer","raw_affiliation_strings":["Department\rof Chemistry, University of Nevada, Reno 89557, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Nevada, Reno 89557, United States","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101621819","display_name":"Joo\u2010Yong Lee","orcid":"https://orcid.org/0000-0002-3041-0145","observed_orcids":["https://orcid.org/0000-0002-3041-0145"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Joo-Yong Lee","raw_affiliation_strings":["Asan\rInstitute for Life Sciences, Asan Medical Center, Seoul 05505, Korea","Department\rof Convergence Medicine, University of Ulsan College of Medicine, Seoul 05505, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan\rInstitute for Life Sciences, Asan Medical Center, Seoul 05505, Korea","institution_ids":["https://openalex.org/I2801680663"]},{"raw_affiliation_string":"Department\rof Convergence Medicine, University of Ulsan College of Medicine, Seoul 05505, Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082782774","display_name":"Brandon T. Ruotolo","orcid":"https://orcid.org/0000-0002-6084-2328","observed_orcids":["https://orcid.org/0000-0002-6084-2328"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brandon T. Ruotolo","raw_affiliation_strings":["Department\rof Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008307832","display_name":"Mi Hee Lim","orcid":"https://orcid.org/0000-0003-3377-4996","observed_orcids":["https://orcid.org/0000-0003-3377-4996"]},"institutions":[{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Mi Hee Lim","raw_affiliation_strings":["Department\rof Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea","institution_ids":["https://openalex.org/I48566637"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5008307832","https://openalex.org/A5052912332","https://openalex.org/A5082782774","https://openalex.org/A5101621819"],"corresponding_institution_ids":["https://openalex.org/I134113660","https://openalex.org/I27837315","https://openalex.org/I2801680663","https://openalex.org/I40542001","https://openalex.org/I48566637"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.3745,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.93411619,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"137","issue":"46","first_page":"14785","last_page":"14797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-n-dimethyl-p-phenylenediamine","display_name":"N,N-dimethyl-p-phenylenediamine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/amyloidogenic-peptides","display_name":"amyloidogenic peptides","score":0.9210000038146973},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7789999842643738},{"id":"https://openalex.org/keywords/off-pathway-aggregation","display_name":"off-pathway aggregation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/anti-amyloidogenic-activity","display_name":"anti-amyloidogenic activity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/intramolecular-cross-linking","display_name":"intramolecular crosslinking","score":0.9760000109672546},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.6119999885559082},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9769999980926514},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8769999742507935},{"id":"https://openalex.org/keywords/chemical-chaperones","display_name":"chemical chaperones","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8333224654197693},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7280266284942627},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6616479158401489},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.6226885318756104},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6035430431365967},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5599377751350403},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5537494421005249},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.42082923650741577},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.41072720289230347},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3929063081741333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37364569306373596},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20911157131195068},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07175442576408386},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/jacs.5b10043","doi":"https://doi.org/10.1021/jacs.5b10043","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.5b10043","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:26575890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26575890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4758209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4758209","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},{"id":"pmh:oai:osti.gov:1345989","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1345989","pdf_url":"https://www.osti.gov/servlets/purl/1345989","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:scholarworks.unist.ac.kr:201301/17991","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.unist.ac.kr/handle/201301/17991","pdf_url":null,"source":{"id":"https://openalex.org/S4306401118","display_name":"Scholarworks@UNIST (Ulsan National Institute of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I48566637","host_organization_name":"Ulsan National Institute of Science and Technology","host_organization_lineage":["https://openalex.org/I48566637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"ARTICLE"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4758209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4758209","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1126863173","display_name":null,"funder_award_id":"DE-AC-02-98CH10886","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G1286251239","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G132563423","display_name":null,"funder_award_id":"AC-02-98CH10886","funder_id":"https://openalex.org/F4320338289","funder_display_name":"Brookhaven National Laboratory"},{"id":"https://openalex.org/G1336448005","display_name":null,"funder_award_id":"DE-AC02-98CH10886","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G1572106353","display_name":null,"funder_award_id":"DE-AC02- 98CH10886","funder_id":"https://openalex.org/F4320338289","funder_display_name":"Brookhaven National Laboratory"},{"id":"https://openalex.org/G206755211","display_name":null,"funder_award_id":"1UL1 RR-026314-01","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2081059816","display_name":"Development of Bio-Inspired Synthetic Metallopeptidases: Insight from Theoretical Studies","funder_award_id":"1152846","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2098694499","display_name":null,"funder_award_id":"NRF-2012R1A1A2006801","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2181794581","display_name":null,"funder_award_id":"15-BD-0403","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2296435231","display_name":"Factors Influencing Coordinated Ni(II) Cysteinate Basicity and Redox Potentials","funder_award_id":"1362662","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G256255926","display_name":null,"funder_award_id":"NRF-2014S1A2A2028270","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3176177282","display_name":null,"funder_award_id":"NRF-2014R1A2A2A01004877","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G325765397","display_name":null,"funder_award_id":"UL1-RR026314","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3340344701","display_name":null,"funder_award_id":"15-BD-0403","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G338944111","display_name":null,"funder_award_id":"DEAC-02-98CH10886","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3900339846","display_name":null,"funder_award_id":"2014R1A2A2A01004877","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4470510902","display_name":null,"funder_award_id":"DE-AC02-98CH10886","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G498139845","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G5094664921","display_name":null,"funder_award_id":"DE-AC02-98CH10886","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5115535283","display_name":"Conferring in vivo metabolic resistance to a highly selective anti-AML agent","funder_award_id":"R21CA185370","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5264540014","display_name":"Center for Clinical and Translational Science and Training","funder_award_id":"UL1TR001425","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5292656900","display_name":null,"funder_award_id":"-AC02-98 CH 10886","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G549834383","display_name":null,"funder_award_id":"DEAC0298CH10886","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G6600267462","display_name":"Cincinnati Center for Clinical and Translational Sciences and Training","funder_award_id":"1ul1rr026314-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7217644330","display_name":"Case Center for Synchrotron Bioscience","funder_award_id":"P30EB009998","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7698487631","display_name":null,"funder_award_id":"NRF-2014H1A2A1019838","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8386466029","display_name":null,"funder_award_id":"2015-7012","funder_id":"https://openalex.org/F4320323011","funder_display_name":"Asan Institute for Life Sciences, Asan Medical Center"},{"id":"https://openalex.org/G8507651203","display_name":null,"funder_award_id":"AC02-98CH10886","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G8834945290","display_name":null,"funder_award_id":"CHE-1362662","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G9000341515","display_name":null,"funder_award_id":"1UL1RR026314","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321348","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320323011","display_name":"Asan Institute for Life Sciences, Asan Medical Center","ror":"https://ror.org/03s5q0090"},{"id":"https://openalex.org/F4320326308","display_name":"Daegu Gyeongbuk Institute of Science and Technology","ror":"https://ror.org/03frjya69"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320332682","display_name":"Medical School, University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"},{"id":"https://openalex.org/F4320338289","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2222001997.pdf","grobid_xml":"https://content.openalex.org/works/W2222001997.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W35546497","https://openalex.org/W1599715713","https://openalex.org/W1753952923","https://openalex.org/W1963712466","https://openalex.org/W1963992886","https://openalex.org/W1976544813","https://openalex.org/W1983177571","https://openalex.org/W1987494660","https://openalex.org/W1989810100","https://openalex.org/W1997738202","https://openalex.org/W2001221518","https://openalex.org/W2002793086","https://openalex.org/W2002911779","https://openalex.org/W2006483299","https://openalex.org/W2006961468","https://openalex.org/W2011817526","https://openalex.org/W2014093955","https://openalex.org/W2017578362","https://openalex.org/W2019812098","https://openalex.org/W2022756726","https://openalex.org/W2026587302","https://openalex.org/W2028206276","https://openalex.org/W2037393746","https://openalex.org/W2044627978","https://openalex.org/W2045934933","https://openalex.org/W2046066151","https://openalex.org/W2054698767","https://openalex.org/W2060515706","https://openalex.org/W2061381487","https://openalex.org/W2065100984","https://openalex.org/W2067174909","https://openalex.org/W2068769189","https://openalex.org/W2071692831","https://openalex.org/W2071929706","https://openalex.org/W2075420978","https://openalex.org/W2080100823","https://openalex.org/W2086957099","https://openalex.org/W2087277033","https://openalex.org/W2090718260","https://openalex.org/W2095360134","https://openalex.org/W2095718086","https://openalex.org/W2101542438","https://openalex.org/W2103945336","https://openalex.org/W2106301585","https://openalex.org/W2121963977","https://openalex.org/W2127522551","https://openalex.org/W2128003707","https://openalex.org/W2128572087","https://openalex.org/W2133035474","https://openalex.org/W2134967712","https://openalex.org/W2142002702","https://openalex.org/W2142262450","https://openalex.org/W2142632602","https://openalex.org/W2143981217","https://openalex.org/W2147344153","https://openalex.org/W2150999725","https://openalex.org/W2165186407","https://openalex.org/W2170644095","https://openalex.org/W2171268876","https://openalex.org/W2317233863","https://openalex.org/W2322725454","https://openalex.org/W2325973372","https://openalex.org/W2335327790","https://openalex.org/W2501073592","https://openalex.org/W3014251530","https://openalex.org/W4210975612"],"related_works":["https://openalex.org/W3014252920","https://openalex.org/W4390192977","https://openalex.org/W61106745","https://openalex.org/W2156032277","https://openalex.org/W2751765238","https://openalex.org/W4285808198","https://openalex.org/W304809820","https://openalex.org/W4405902016","https://openalex.org/W2924658488","https://openalex.org/W1972124855"],"abstract_inverted_index":{"Chemical":[0],"reagents":[1],"targeting":[2],"and":[3,62,84,87,117,148,167],"controlling":[4],"amyloidogenic":[5,30],"peptides":[6,31],"have":[7,67],"received":[8],"much":[9],"attention":[10],"for":[11,28,56,75,201],"helping":[12],"identify":[13],"their":[14],"roles":[15],"in":[16,109,158,165,168],"the":[17,52,57,139,159,176,182,194],"pathogenesis":[18],"of":[19,40,112,125,144,171,184],"protein-misfolding":[20],"disorders.":[21],"Herein,":[22],"we":[23],"report":[24],"a":[25,41,72,80,130],"novel":[26],"strategy":[27],"redirecting":[29],"into":[32],"nontoxic,":[33],"off-pathway":[34],"aggregates,":[35],"which":[36],"utilizes":[37],"redox":[38],"properties":[39],"small":[42,81,131],"molecule":[43,82,132],"(DMPD,":[44],"N,N-dimethyl-p-phenylenediamine)":[45],"to":[46,70,136],"trigger":[47],"covalent":[48],"adduct":[49],"formation":[50],"with":[51,105,175],"peptide.":[53],"In":[54],"addition,":[55],"first":[58,177],"time,":[59],"biochemical,":[60],"biophysical,":[61],"molecular":[63],"dynamics":[64],"simulation":[65],"studies":[66,170],"been":[68],"performed":[69],"demonstrate":[71],"mechanistic":[73,179],"understanding":[74],"such":[76],"an":[77],"interaction":[78],"between":[79],"(DMPD)":[83,133],"amyloid-\u03b2":[85],"(A\u03b2)":[86],"its":[88,94],"subsequent":[89],"anti-amyloidogenic":[90],"activity,":[91],"which,":[92],"upon":[93],"transformation,":[95],"generates":[96],"ligand-peptide":[97],"adducts":[98],"via":[99],"primary":[100],"amine-dependent":[101],"intramolecular":[102],"cross-linking":[103],"correlated":[104],"structural":[106,195],"compaction.":[107],"Furthermore,":[108],"vivo":[110,169],"efficacy":[111],"DMPD":[113,172],"toward":[114,173],"amyloid":[115,142,149,202],"pathology":[116],"cognitive":[118,156],"impairment":[119],"was":[120],"evaluated":[121],"employing":[122],"5xFAD":[123],"mice":[124],"Alzheimer's":[126],"disease":[127],"(AD).":[128],"Such":[129],"is":[134],"indicated":[135],"noticeably":[137],"reduce":[138],"overall":[140],"cerebral":[141],"load":[143],"soluble":[145],"A\u03b2":[146,174],"forms":[147],"deposits":[150],"as":[151,153,197],"well":[152],"significantly":[154],"improve":[155],"defects":[157],"AD":[160],"mouse":[161],"model.":[162],"Overall,":[163],"our":[164],"vitro":[166],"molecular-level":[178],"investigations":[180],"present":[181],"feasibility":[183],"developing":[185],"new,":[186],"innovative":[187],"approaches":[188],"that":[189],"employ":[190],"redox-active":[191],"compounds":[192],"without":[193],"complexity":[196],"next-generation":[198],"chemical":[199],"tools":[200],"management.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
