{"id":"https://openalex.org/W2221865611","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.10041","title":"Serum antibodies specific for tumor antigens in colorectal cancer may be useful diagnostic biomarkers","display_name":"Serum antibodies specific for tumor antigens in colorectal cancer may be useful diagnostic biomarkers","publication_year":2006,"publication_date":"2006-06-20","ids":{"openalex":"https://openalex.org/W2221865611","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.10041","mag":"2221865611"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2006.24.18_suppl.10041","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.10041","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.10041","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025625281","display_name":"Hailing Lu","orcid":"https://orcid.org/0000-0002-6418-9688","observed_orcids":["https://orcid.org/0000-0002-6418-9688"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Lu","raw_affiliation_strings":["University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037811471","display_name":"Vivian Goodell A","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Goodell","raw_affiliation_strings":["University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039848435","display_name":"Mary Lenora Disis","orcid":"https://orcid.org/0000-0001-7653-4648","observed_orcids":["https://orcid.org/0000-0001-7653-4648"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. L. Disis","raw_affiliation_strings":["University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"18_suppl","first_page":"10041","last_page":"10041"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6176999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6176999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.14090000092983246,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.8500000238418579},{"id":"https://openalex.org/keywords/serum-antibodies","display_name":"serum antibodies","score":0.8149999976158142},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.8899999856948853},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7839999794960022},{"id":"https://openalex.org/keywords/topoisomerase-ii-alpha","display_name":"TOP2A","score":0.9750000238418579},{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.875},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8009999990463257},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ny-eso-1","display_name":"NY-ESO-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8683337569236755},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7575940489768982},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6493591070175171},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6376644968986511},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5544018745422363},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4627181887626648},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4613284170627594},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.445919007062912},{"id":"https://openalex.org/C192638826","wikidata":"https://www.wikidata.org/wiki/Q908357","display_name":"Tumor M2-PK","level":4,"score":0.4412309229373932},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33058327436447144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07559981942176819},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2006.24.18_suppl.10041","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.10041","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.10041","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5799999833106995,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"},{"score":0.4099999964237213,"display_name":"Peace, justice, and strong institutions","id":"https://metadata.un.org/sdg/16"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2051645918","https://openalex.org/W2167664613","https://openalex.org/W4251774437","https://openalex.org/W2979062215","https://openalex.org/W2973993503","https://openalex.org/W2765634986","https://openalex.org/W2215030003","https://openalex.org/W2112108672","https://openalex.org/W2997143735","https://openalex.org/W4366290155"],"abstract_inverted_index":{"10041":[0],"Background:":[1],"Colorectal":[2,170],"cancer":[3,46,88,123,139,171,205,247,257],"is":[4],"immunogenic":[5],"as":[6,50,133,215,252],"evidenced":[7],"by":[8,107,217],"the":[9,25,62,100,152,163,218,233,238],"presence":[10,63],"of":[11,64,103,151,166,176,193,213,227],"antibodies":[12,177,244],"specific":[13,231],"to":[14,37,53,67,111,161,178,187,245,263],"tumor":[15,26,38,69],"antigens":[16,40,249],"in":[17,42,86,114],"patient":[18],"serum":[19,59],"and":[20,83,91,125,183,199,237],"T":[21],"cell":[22],"infiltration":[23],"at":[24],"site":[27],"predicting":[28],"favorable":[29],"disease":[30],"outcome.":[31],"We":[32,57,97],"questioned":[33],"whether":[34],"antibody":[35,65,109,196],"immunity":[36,66],"associated":[39],"(TAA)":[41],"patients":[43,89,124,172,206],"with":[44,209],"colorectal":[45,87,122,138,204,246,256],"could":[47,202],"be":[48],"used":[49],"a":[51,145,149,191,210,224],"biomarker":[52],"predict":[54],"disease.":[55],"Methods:":[56],"evaluated":[58,99],"samples":[60,130],"for":[61,137,255],"six":[68],"antigens,":[70],"cyclin":[71],"D1,":[72],"HER-2/neu,":[73],"insulin-like":[74],"growth":[75],"factor":[76],"binding":[77],"protein":[78],"2":[79],"(IGFBP2),":[80],"NY-ESO-1,":[81],"p53,":[82],"topoisomerase-II\u03b1":[84],"(TOPO2\u03b1),":[85],"(n=40)":[90],"normal":[92,127],"donors":[93],"(n=200)":[94],"using":[95,140,190],"ELISA.":[96],"then":[98],"diagnostic":[101,164,211],"value":[102],"these":[104,112],"potential":[105],"biomarkers":[106,254],"measuring":[108],"levels":[110,175],"TAA":[113,230],"an":[115],"independent":[116],"sample":[117],"set":[118],"which":[119],"included":[120],"30":[121],"135":[126],"donors.":[128],"The":[129],"were":[131,159],"judged":[132],"positive":[134],"or":[135,148],"negative":[136],"measurements":[141],"derived":[142],"either":[143],"from":[144,207],"single":[146],"marker":[147],"combination":[150,192],"markers.":[153],"Receiver":[154],"operating":[155],"characteristic":[156],"(ROC)":[157],"plots":[158],"generated":[160],"determine":[162],"accuracy":[165],"each":[167],"test.":[168],"Results:":[169],"had":[173],"increased":[174],"p53":[179],"(p=0.002),":[180],"TOPO2\u03b1":[181,198],"(p<0.001),":[182],"IGFBP2":[184],"(p<0.001)":[185],"compared":[186],"controls.":[188],"By":[189],"just":[194],"two":[195],"measurements,":[197],"IGFBP2,":[200],"we":[201],"discriminate":[203],"controls":[208],"power":[212],"0.775":[214],"estimated":[216],"area":[219],"under":[220],"ROC":[221],"curve.":[222],"At":[223],"cutoff":[225],"point":[226],"0.03":[228],"mcg/ml":[229],"IgG,":[232],"sensitivity":[234],"was":[235,240],"100%":[236],"specificity":[239],"58%.":[241],"Conclusions:":[242],"Serum":[243],"related":[248],"may":[250],"serve":[251],"useful":[253],"diagnosis.":[258],"No":[259],"significant":[260],"financial":[261],"relationships":[262],"disclose.":[264]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
