{"id":"https://openalex.org/W2221620140","doi":"https://doi.org/10.4025/actascihealthsci.v28i1.1113","title":"Efeito ansiol\u00edtico da espermina microinjetada na subst\u00e2ncia cinzenta periaquedutal dorsal de ratos","display_name":"Efeito ansiol\u00edtico da espermina microinjetada na subst\u00e2ncia cinzenta periaquedutal dorsal de ratos","publication_year":2006,"publication_date":"2006-03-13","ids":{"openalex":"https://openalex.org/W2221620140","doi":"https://doi.org/10.4025/actascihealthsci.v28i1.1113","mag":"2221620140"},"language":"pt","primary_location":{"id":"doi:10.4025/actascihealthsci.v28i1.1113","doi":"https://doi.org/10.4025/actascihealthsci.v28i1.1113","is_oa":true,"landing_page_url":"https://doi.org/10.4025/actascihealthsci.v28i1.1113","pdf_url":"https://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/download/1113/560","source":{"id":"https://openalex.org/S32570389","display_name":"Acta Scientiarum Health Sciences","issn_l":"1679-9291","issn":["1679-9291","1807-8648"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310312356","host_organization_name":"Universidade Estadual de Maring\u00e1","host_organization_lineage":["https://openalex.org/P4310312356"],"host_organization_lineage_names":["Universidade Estadual de Maring\u00e1"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Scientiarum. Health Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/download/1113/560","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113445994","display_name":"Jos\u00e9 Geraldo Pereira da Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105683","display_name":"Universidade Regional de Blumenau","ror":"https://ror.org/01nsn0t21","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210105683"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Geraldo Pereira da Cruz","raw_affiliation_strings":["FURB","Departamento de Ci\u00eancias Naturais, Centro de Ci\u00eancias Exatas e Naturais, Universidade Regional de Blumenau, Blumenau, Santa Catarina, Brasil","receptores das poliaminas na subst\u00e2ncia cinzenta periaquedutal dorsal, sobre a ansiedade. Grupos de ratos"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FURB","institution_ids":["https://openalex.org/I4210105683"]},{"raw_affiliation_string":"Departamento de Ci\u00eancias Naturais, Centro de Ci\u00eancias Exatas e Naturais, Universidade Regional de Blumenau, Blumenau, Santa Catarina, Brasil","institution_ids":["https://openalex.org/I4210105683"]},{"raw_affiliation_string":"receptores das poliaminas na subst\u00e2ncia cinzenta periaquedutal dorsal, sobre a ansiedade. Grupos de ratos","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082818558","display_name":"A.P. Carobrez","orcid":"https://orcid.org/0000-0002-0354-0948","observed_orcids":["https://orcid.org/0000-0002-0354-0948"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ant\u00f4nio De P\u00e1dua Carobrez","raw_affiliation_strings":["Universidade Federal de Santa Catarina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Santa Catarina","institution_ids":["https://openalex.org/I4104125"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.14991466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"28","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.13670000433921814,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spermine","display_name":"spermine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/polyamine-receptors","display_name":"polyamine receptors","score":0.7400000095367432},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.7960000038146973},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.9869999885559082},{"id":"https://openalex.org/keywords/arcaine","display_name":"arcaine","score":0.7490000128746033},{"id":"https://openalex.org/keywords/ifenprodil","display_name":"ifenprodil","score":0.9950000047683716},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.9070000052452087},{"id":"https://openalex.org/keywords/microinjection","display_name":"microinjection","score":0.7269999980926514},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.9503876566886902},{"id":"https://openalex.org/C2909233451","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjections","level":3,"score":0.8352549076080322},{"id":"https://openalex.org/C2776109719","wikidata":"https://www.wikidata.org/wiki/Q424597","display_name":"Spermine","level":3,"score":0.8126130104064941},{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.6341758966445923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5897454023361206},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4679267406463623},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46758270263671875},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.4423433542251587},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.4333752989768982},{"id":"https://openalex.org/C2780376555","wikidata":"https://www.wikidata.org/wiki/Q5991156","display_name":"Ifenprodil","level":4,"score":0.4315554201602936},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3403344750404358},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.277718722820282},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.25977230072021484},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.23971834778785706},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2188163697719574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20450150966644287},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4025/actascihealthsci.v28i1.1113","doi":"https://doi.org/10.4025/actascihealthsci.v28i1.1113","is_oa":true,"landing_page_url":"https://doi.org/10.4025/actascihealthsci.v28i1.1113","pdf_url":"https://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/download/1113/560","source":{"id":"https://openalex.org/S32570389","display_name":"Acta Scientiarum Health Sciences","issn_l":"1679-9291","issn":["1679-9291","1807-8648"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310312356","host_organization_name":"Universidade Estadual de Maring\u00e1","host_organization_lineage":["https://openalex.org/P4310312356"],"host_organization_lineage_names":["Universidade Estadual de Maring\u00e1"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Scientiarum. Health Science","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:6de3324c1be7475f857c3dca20ad5dfd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6de3324c1be7475f857c3dca20ad5dfd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Scientiarum. Health Sciences, Vol 28, Iss 1 (2008)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:be575e11701f40bcb398e75b6d4f7e9d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/be575e11701f40bcb398e75b6d4f7e9d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Scientiarum. Health Sciences, Vol 28, Iss 1, Pp 43-47 (2006)","raw_type":"article"},{"id":"pmh:oai:redalyc.org:307223966007","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=307223966007","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Scientiarum. Health Sciences (Brasil) Num.1 Vol.28","raw_type":"art\u00edculo cient\u00edfico"}],"best_oa_location":{"id":"doi:10.4025/actascihealthsci.v28i1.1113","doi":"https://doi.org/10.4025/actascihealthsci.v28i1.1113","is_oa":true,"landing_page_url":"https://doi.org/10.4025/actascihealthsci.v28i1.1113","pdf_url":"https://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/download/1113/560","source":{"id":"https://openalex.org/S32570389","display_name":"Acta Scientiarum Health Sciences","issn_l":"1679-9291","issn":["1679-9291","1807-8648"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310312356","host_organization_name":"Universidade Estadual de Maring\u00e1","host_organization_lineage":["https://openalex.org/P4310312356"],"host_organization_lineage_names":["Universidade Estadual de Maring\u00e1"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Scientiarum. Health Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2221620140.pdf","grobid_xml":"https://content.openalex.org/works/W2221620140.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1867012516","https://openalex.org/W1898334791","https://openalex.org/W1987079466","https://openalex.org/W1987944310","https://openalex.org/W2016463786","https://openalex.org/W2021258345","https://openalex.org/W2027398184","https://openalex.org/W2033877263","https://openalex.org/W2036137643","https://openalex.org/W2041561931","https://openalex.org/W2043164992","https://openalex.org/W2054503088","https://openalex.org/W2058011300","https://openalex.org/W2061932481","https://openalex.org/W2078457630","https://openalex.org/W2082761047","https://openalex.org/W2097799026","https://openalex.org/W2433412704","https://openalex.org/W2433531373","https://openalex.org/W4243637897"],"related_works":["https://openalex.org/W7026624603","https://openalex.org/W4313491867","https://openalex.org/W2054503088","https://openalex.org/W1995753639","https://openalex.org/W2003847276","https://openalex.org/W2048603708","https://openalex.org/W2043164992","https://openalex.org/W2273189989","https://openalex.org/W1984588850","https://openalex.org/W2304840118"],"abstract_inverted_index":{"To":[0],"investigate":[1],"a":[2,132],"possible":[3],"effect":[4,63],"of":[5,21,25,48,68,79,104,119],"the":[6,13,35,46,52,61,66,90,97,102,110,120],"spermine":[7,26,69,98],"and":[8,31,50,136],"its":[9],"polyamins":[10],"receptors":[11],"in":[12,18,34,45,51,55,101,106,134],"dorsal":[14],"periaqueductal":[15],"grey":[16],"(DPAG)":[17],"anxiety.":[19],"Groups":[20],"rats":[22,107],"received":[23],"microinjections":[24],"(2.5":[27,70],"nmol)":[28,71,84,88],"into":[29,72,89],"DPAG":[30,73,129],"were":[32],"tested":[33],"elevated":[36,111],"plus-maze":[37],"apparatus.":[38],"Results":[39],"indicated":[40],"an":[41],"overall":[42],"significant":[43],"increase":[44],"percentage":[47],"entries":[49],"time":[53],"spent":[54],"open":[56],"arms.":[57],"In":[58],"another":[59],"experiment":[60],"anxiolytic":[62],"obtained":[64],"after":[65],"microinjection":[67,78],"was":[74],"block":[75],"by":[76],"previous":[77],"polyamines":[80,115],"antagonists,":[81],"arcaine":[82],"(4":[83],"or":[85],"ifenprodil":[86],"(5":[87],"same":[91],"site.":[92],"These":[93],"results":[94,123],"indicate":[95],"that":[96,114,125],"receptor":[99],"interaction":[100],"modulation":[103],"anxiety":[105,137],"exposed":[108],"to":[109],"plus-maze.":[112],"Considering":[113],"are":[116],"natural":[117],"component":[118],"brain,":[121],"these":[122],"suggest":[124],"polyamine":[126],"system":[127],"within":[128],"may":[130],"play":[131],"role":[133],"aversion":[135]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}