{"id":"https://openalex.org/W2221253263","doi":"https://doi.org/10.1016/j.pbiomolbio.2015.12.012","title":"Rate-dependent force, intracellular calcium, and action potential voltage alternans are modulated by sarcomere length and heart failure induced-remodeling of thin filament regulation in human heart failure: A myocyte modeling study","display_name":"Rate-dependent force, intracellular calcium, and action potential voltage alternans are modulated by sarcomere length and heart failure induced-remodeling of thin filament regulation in human heart failure: A myocyte modeling study","publication_year":2015,"publication_date":"2015-12-24","ids":{"openalex":"https://openalex.org/W2221253263","doi":"https://doi.org/10.1016/j.pbiomolbio.2015.12.012","mag":"2221253263","pmid":"https://pubmed.ncbi.nlm.nih.gov/26724571","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4808409"},"language":"en","primary_location":{"id":"doi:10.1016/j.pbiomolbio.2015.12.012","doi":"https://doi.org/10.1016/j.pbiomolbio.2015.12.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pbiomolbio.2015.12.012","pdf_url":null,"source":{"id":"https://openalex.org/S181418318","display_name":"Progress in Biophysics and Molecular Biology","issn_l":"0079-6107","issn":["0079-6107","1873-1732"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Progress in Biophysics and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.pbiomolbio.2015.12.012","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Melanie A. Zile","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie A. Zile","raw_affiliation_strings":["Institute for Computational Medicine and Department of Biomedical Engineering at Johns Hopkins University, 3400N Charles St, 316 Hackerman Hall, Baltimore, MD 21218, USA. Electronic address: mzile@jhu.edu","Institute for Computational Medicine and Department of Biomedical Engineering at Johns Hopkins University, 3400N Charles St, 316 Hackerman Hall, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering at Johns Hopkins University, 3400N Charles St, 316 Hackerman Hall, Baltimore, MD 21218, USA. Electronic address: mzile@jhu.edu","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering at Johns Hopkins University, 3400N Charles St, 316 Hackerman Hall, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070924694","display_name":"Natalia A. Trayanova","orcid":"https://orcid.org/0000-0002-8661-063X","observed_orcids":["https://orcid.org/0000-0002-8661-063X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Natalia A. Trayanova","raw_affiliation_strings":["Institute for Computational Medicine and Department of Biomedical Engineering at Johns Hopkins University, 3400N Charles St, 316 Hackerman Hall, Baltimore, MD 21218, USA. Electronic address: ntrayan1@jhu.edu","Institute for Computational Medicine and Department of Biomedical Engineering at Johns Hopkins University, 3400N Charles St, 316 Hackerman Hall, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering at Johns Hopkins University, 3400N Charles St, 316 Hackerman Hall, Baltimore, MD 21218, USA. Electronic address: ntrayan1@jhu.edu","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering at Johns Hopkins University, 3400N Charles St, 316 Hackerman Hall, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070924694"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":2.1788,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.89284507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"120","issue":"1-3","first_page":"270","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7979999780654907},{"id":"https://openalex.org/keywords/microvolt-t-wave-alternans","display_name":"microvolt T-wave alternans","score":0.921999990940094},{"id":"https://openalex.org/keywords/sarcomere-length","display_name":"sarcomere length","score":0.8799999952316284},{"id":"https://openalex.org/keywords/thin-filament-regulation","display_name":"thin filament regulation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-uptake","display_name":"sarcoplasmic reticulum calcium uptake","score":0.9340000152587891},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cross-bridge-cycling","display_name":"cross-bridge cycling","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pacing-rate","display_name":"pacing rate","score":0.7210000157356262},{"id":"https://openalex.org/keywords/ventricular-arrhythmia-risk","display_name":"ventricular arrhythmia risk","score":0.8119999766349792},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.8625625371932983},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7284435033798218},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.5948879718780518},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5880717635154724},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5861943960189819},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5744966268539429},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5497843623161316},{"id":"https://openalex.org/C2776329151","wikidata":"https://www.wikidata.org/wiki/Q4683968","display_name":"CrossBridge","level":3,"score":0.5166171193122864},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4518047869205475},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3576928377151489},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32713574171066284},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.23363494873046875},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.13438770174980164}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.pbiomolbio.2015.12.012","doi":"https://doi.org/10.1016/j.pbiomolbio.2015.12.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pbiomolbio.2015.12.012","pdf_url":null,"source":{"id":"https://openalex.org/S181418318","display_name":"Progress in Biophysics and Molecular Biology","issn_l":"0079-6107","issn":["0079-6107","1873-1732"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Progress in Biophysics and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:26724571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26724571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in biophysics and molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4103835","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4808409","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4808409","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4808409","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Prog Biophys Mol Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.pbiomolbio.2015.12.012","doi":"https://doi.org/10.1016/j.pbiomolbio.2015.12.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pbiomolbio.2015.12.012","pdf_url":null,"source":{"id":"https://openalex.org/S181418318","display_name":"Progress in Biophysics and Molecular Biology","issn_l":"0079-6107","issn":["0079-6107","1873-1732"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Progress in Biophysics and Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1588488841","display_name":"Exploration of Arrhythmogenic Triggers and Substrates in Heart Failure","funder_award_id":"R01HL126802","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2669271375","display_name":"Virtual Electrophysiology Laboratory","funder_award_id":"DP1HL123271","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2810576921","display_name":"Resynchronizing the Failing Heart: Insights from a Multiscale Cardiac Model","funder_award_id":"R01HL103428","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3279651255","display_name":"Biomedical Engineering Training Program","funder_award_id":"T32GM007057","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G407926607","display_name":"CDI Type-II: Collaborative Research: From Ion Channels to Blood Flow and Heart Sounds: A New Paradigm in Cyber-Enabled Multiphysical Analysis of Heart Function","funder_award_id":"1124804","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7730036676","display_name":null,"funder_award_id":"R01 HL103428","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G814569518","display_name":null,"funder_award_id":"DP1HL123271","funder_id":"https://openalex.org/F4320337383","funder_display_name":"National Center for Chronic Disease Prevention and Health Promotion"},{"id":"https://openalex.org/G983294019","display_name":null,"funder_award_id":"DP1 HL123271","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337383","display_name":"National Center for Chronic Disease Prevention and Health Promotion","ror":"https://ror.org/021rths28"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1573593763","https://openalex.org/W1586929063","https://openalex.org/W1902438448","https://openalex.org/W1940548743","https://openalex.org/W1953269516","https://openalex.org/W1964747697","https://openalex.org/W1966543040","https://openalex.org/W1969308249","https://openalex.org/W1969921961","https://openalex.org/W1974396072","https://openalex.org/W1977252918","https://openalex.org/W1978063892","https://openalex.org/W1981723678","https://openalex.org/W1985843589","https://openalex.org/W1986706069","https://openalex.org/W1987247541","https://openalex.org/W1988750762","https://openalex.org/W1991735468","https://openalex.org/W1995974815","https://openalex.org/W1996382853","https://openalex.org/W2002341470","https://openalex.org/W2005609804","https://openalex.org/W2009775227","https://openalex.org/W2019201408","https://openalex.org/W2036663915","https://openalex.org/W2044110796","https://openalex.org/W2045631799","https://openalex.org/W2053064317","https://openalex.org/W2056063595","https://openalex.org/W2056840703","https://openalex.org/W2058581105","https://openalex.org/W2063561937","https://openalex.org/W2067149824","https://openalex.org/W2070092583","https://openalex.org/W2074438321","https://openalex.org/W2075175982","https://openalex.org/W2077129671","https://openalex.org/W2082967245","https://openalex.org/W2088469773","https://openalex.org/W2090606926","https://openalex.org/W2094168815","https://openalex.org/W2094905898","https://openalex.org/W2095800268","https://openalex.org/W2097847010","https://openalex.org/W2106436142","https://openalex.org/W2106474320","https://openalex.org/W2120566104","https://openalex.org/W2122264744","https://openalex.org/W2124766034","https://openalex.org/W2127247170","https://openalex.org/W2130321115","https://openalex.org/W2133430515","https://openalex.org/W2136281373","https://openalex.org/W2141573806","https://openalex.org/W2145264435","https://openalex.org/W2152714883","https://openalex.org/W2154252560","https://openalex.org/W2154890342","https://openalex.org/W2155135498","https://openalex.org/W2156305681","https://openalex.org/W2162418013","https://openalex.org/W2162718501","https://openalex.org/W2163071496","https://openalex.org/W2163108689","https://openalex.org/W2169400659","https://openalex.org/W2177491097","https://openalex.org/W2251458329","https://openalex.org/W2334859129","https://openalex.org/W2340144859","https://openalex.org/W2417105162","https://openalex.org/W2547303920","https://openalex.org/W2768019923","https://openalex.org/W2916392902","https://openalex.org/W6703927456"],"related_works":["https://openalex.org/W2312801605","https://openalex.org/W2088469773","https://openalex.org/W3023837291","https://openalex.org/W1940548743","https://openalex.org/W2485385566","https://openalex.org/W2594925144","https://openalex.org/W2888590168","https://openalex.org/W2028684776","https://openalex.org/W2133981834","https://openalex.org/W2407287461"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}